Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

Journal of Pathology

Volumn 231, Issue 4, 2013, Pages 424-432

  Gerlinger, Marco ^a,b   Quezada, Sergio A ^c   Peggs, Karl S ^c   Furness, Andrew J S ^c,d   Fisher, Rosalie ^d   Marafioti, Teresa ^e   Shende, Vishvesh H ^e   McGranahan, Nicholas ^a,f   Rowan, Andrew J ^a   Hazell, Steven ^d   Hamm, David ^g   Robins, Harlan S ^h   Pickering, Lisa ^d   Gore, Martin ^d   Nicol, David L ^d   Larkin, James ^d   Swanton, Charles ^a,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d ROYAL MARSDEN HOSPITAL   (United Kingdom)

^e UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

^g ADAPTIVE BIOTECHNOLOGIES   (United States)

^h Fred Hutchinson Cancer Research Center   (United States)

Author keywords

biomarker; cancer immunity; immunotherapy; intratumour heterogeneity; T cell

Indexed keywords

DNA; EVEROLIMUS; SUNITINIB; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CLONE; CELL HETEROGENEITY; CELL POPULATION; CLONAL VARIATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; KIDNEY CARCINOMA; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TUMOR IMMUNITY; UNFRACTIONATED CLEAR CELL RENAL CELL CARCINOMA;

BIOMARKER; CANCER IMMUNITY; IMMUNOTHERAPY; INTRATUMOUR HETEROGENEITY; T CELL;

CARCINOMA, RENAL CELL; CLONE CELLS; DNA, NEOPLASM; FEMALE; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNITY, CELLULAR; KIDNEY NEOPLASMS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; NEOPLASM STAGING; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS;

EID: 84887511784     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4284     Document Type: Article

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