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Volumn 61, Issue , 2014, Pages 207-220

The neuroanatomical function of leptin in the hypothalamus

Author keywords

Feeding; Hypothalamus; Leptin; Neuropeptides; Ob R

Indexed keywords

AGOUTI RELATED PROTEIN; ARGIPRESSIN; BRAIN DERIVED NEUROTROPHIC FACTOR; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; GALANIN; GALANIN LIKE PEPTIDE; LEPTIN; LEPTIN RECEPTOR; MELANIN CONCENTRATING HORMONE; MELANOCORTIN; NEUROPEPTIDE Y; NEUROTENSIN; OB RB RECEPTOR; OREXIN; OXYTOCIN; PROOPIOMELANOCORTIN; RELEASING FACTOR; STEROIDOGENIC FACTOR 1; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; ALPHA INTERMEDIN; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; PROTIRELIN; THYROTROPIN;

EID: 84916199422     PISSN: 08910618     EISSN: 18736300     Source Type: Journal    
DOI: 10.1016/j.jchemneu.2014.05.004     Document Type: Article
Times cited : (61)

References (234)
  • 1
    • 0034733888 scopus 로고    scopus 로고
    • Investigation of the melanocyte stimulating hormones on food intake. Lack of evidence to support a role for the melanocortin-3-receptor
    • Abbott C., Rossi M., Kim M.S., Alahmed S.H., Taylor G.M., Ghatei M.A., Smith D.M., Bloom S.R. Investigation of the melanocyte stimulating hormones on food intake. Lack of evidence to support a role for the melanocortin-3-receptor. Brain Res. 2000, 869:203-210.
    • (2000) Brain Res. , vol.869 , pp. 203-210
    • Abbott, C.1    Rossi, M.2    Kim, M.S.3    Alahmed, S.H.4    Taylor, G.M.5    Ghatei, M.A.6    Smith, D.M.7    Bloom, S.R.8
  • 2
    • 0028606308 scopus 로고
    • Differential effects of melanocortin peptides on neural melanocortin receptors
    • Adan R.A.H., Cone R.D., Burbach J.P.H., Gispen W.H. Differential effects of melanocortin peptides on neural melanocortin receptors. Mol. Pharmacol. 1994, 46:1182-1190.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 1182-1190
    • Adan, R.A.H.1    Cone, R.D.2    Burbach, J.P.H.3    Gispen, W.H.4
  • 3
    • 84964125510 scopus 로고
    • Localization of a "feeding center" in the hypothalamus of the rat
    • Anand B., Brobeck J. Localization of a "feeding center" in the hypothalamus of the rat. Proc. Soc. Exp. Biol. Med. 1951, 77:323-324.
    • (1951) Proc. Soc. Exp. Biol. Med. , vol.77 , pp. 323-324
    • Anand, B.1    Brobeck, J.2
  • 4
    • 0020625975 scopus 로고
    • Immunoreactive corticotropin-releasing hormone in the hypothalamo-infundibular tract
    • Antoni F., Palkovits M., Makara G., Linton E., Lowry P., Kiss J. Immunoreactive corticotropin-releasing hormone in the hypothalamo-infundibular tract. Neuroendocrinology 1983, 36:415-423.
    • (1983) Neuroendocrinology , vol.36 , pp. 415-423
    • Antoni, F.1    Palkovits, M.2    Makara, G.3    Linton, E.4    Lowry, P.5    Kiss, J.6
  • 5
    • 0021018267 scopus 로고
    • Paraventricular hypothalamic lesions and medial hypothalamic knife cuts produce similar hyperphagia syndromes
    • Aravich P., Sclafani A. Paraventricular hypothalamic lesions and medial hypothalamic knife cuts produce similar hyperphagia syndromes. Behav. Neurosci. 1983, 97:970-983.
    • (1983) Behav. Neurosci. , vol.97 , pp. 970-983
    • Aravich, P.1    Sclafani, A.2
  • 6
    • 0024509745 scopus 로고
    • Influence of oxytocin on feeding behavior in the rat
    • Arletti R., Benelli A., Bertolini A. Influence of oxytocin on feeding behavior in the rat. Peptides 1989, 10:89-93.
    • (1989) Peptides , vol.10 , pp. 89-93
    • Arletti, R.1    Benelli, A.2    Bertolini, A.3
  • 7
    • 84864711337 scopus 로고    scopus 로고
    • Deconstruction of a neural circuit for hunger
    • Atasoy D., Betley J.N., Su H.H., Sternson S.M. Deconstruction of a neural circuit for hunger. Nature 2012, 488:172-177.
    • (2012) Nature , vol.488 , pp. 172-177
    • Atasoy, D.1    Betley, J.N.2    Su, H.H.3    Sternson, S.M.4
  • 9
    • 0021918223 scopus 로고
    • An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat
    • Bai F.L., Yamano M., Shiotani Y., Emson P.C., Smith a.D., Powell J.F., Tohyama M. An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res. 1985, 331:172-175.
    • (1985) Brain Res. , vol.331 , pp. 172-175
    • Bai, F.L.1    Yamano, M.2    Shiotani, Y.3    Emson, P.C.4    Smith, A.5    Powell, J.F.6    Tohyama, M.7
  • 10
    • 0029099078 scopus 로고
    • Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat
    • Baker R.A., Herkenham M. Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat. J. Comp. Neurol. 1995, 358:518-530.
    • (1995) J. Comp. Neurol. , vol.358 , pp. 518-530
    • Baker, R.A.1    Herkenham, M.2
  • 11
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks W.a., Kastin A.J., Huang W., Jaspan J.B., Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996, 17:305-311.
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 12
    • 0028704537 scopus 로고
    • Neurotrophins: a family of proteins supporting the survival of neurons
    • Barde Y.A. Neurotrophins: a family of proteins supporting the survival of neurons. Prog. Clin. Biol. Res. 1994, 390:45-56.
    • (1994) Prog. Clin. Biol. Res. , vol.390 , pp. 45-56
    • Barde, Y.A.1
  • 13
    • 0345168238 scopus 로고    scopus 로고
    • The role of leptin receptor signaling in feeding and neuroendocrine function
    • Bates S.H., Myers M.G. The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol. Metab. 2003, 14:447-452.
    • (2003) Trends Endocrinol. Metab. , vol.14 , pp. 447-452
    • Bates, S.H.1    Myers, M.G.2
  • 14
    • 0036069863 scopus 로고    scopus 로고
    • The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: lessons learned from lesioning studies
    • Bellinger L.L., Bernardis L.L. The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: lessons learned from lesioning studies. Physiol. Behav. 2002, 76:431-442.
    • (2002) Physiol. Behav. , vol.76 , pp. 431-442
    • Bellinger, L.L.1    Bernardis, L.L.2
  • 15
    • 0022591930 scopus 로고
    • Meal patterns of rats with dorsomedial hypothalamic nuclei lesions or sham operations
    • Bellinger L.L., Mendel V.E., Bernardis L.L., Castonguay T.W. Meal patterns of rats with dorsomedial hypothalamic nuclei lesions or sham operations. Physiol. Behav. 1986, 36:693-698.
    • (1986) Physiol. Behav. , vol.36 , pp. 693-698
    • Bellinger, L.L.1    Mendel, V.E.2    Bernardis, L.L.3    Castonguay, T.W.4
  • 16
    • 0031856907 scopus 로고    scopus 로고
    • The dorsomedial hypothalamic nucleus revisited: 1998 update
    • Bernardis L.L., Bellinger L.L. The dorsomedial hypothalamic nucleus revisited: 1998 update. Proc. Soc. Exp. Biol. Med. 1998, 218:284-306.
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.218 , pp. 284-306
    • Bernardis, L.L.1    Bellinger, L.L.2
  • 17
    • 0142116115 scopus 로고    scopus 로고
    • Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression
    • Bi S., Robinson B.M., Moran T.H. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003, 285:R1030-R1036.
    • (2003) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.285 , pp. R1030-R1036
    • Bi, S.1    Robinson, B.M.2    Moran, T.H.3
  • 18
    • 0026022088 scopus 로고
    • Effects of intracerebroventricular administration of neuropeptide Y on energy metabolism
    • Billington C.J., Briggs J.E., Grace M., Levine A.S. Effects of intracerebroventricular administration of neuropeptide Y on energy metabolism. Am. J. Physiol. 1991, 260:R321-R327.
    • (1991) Am. J. Physiol. , vol.260 , pp. R321-R327
    • Billington, C.J.1    Briggs, J.E.2    Grace, M.3    Levine, A.S.4
  • 19
    • 42449086900 scopus 로고    scopus 로고
    • Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome
    • Bingham N.C., Anderson K.K., Reuter A.L., Stallings N.R., Parker K.L. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 2008, 149:2138-2148.
    • (2008) Endocrinology , vol.149 , pp. 2138-2148
    • Bingham, N.C.1    Anderson, K.K.2    Reuter, A.L.3    Stallings, N.R.4    Parker, K.L.5
  • 20
    • 0032517162 scopus 로고    scopus 로고
    • Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers
    • Bittencourt J.C., Elias C.F. Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers. Brain Res. 1998, 805:1-19.
    • (1998) Brain Res. , vol.805 , pp. 1-19
    • Bittencourt, J.C.1    Elias, C.F.2
  • 22
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjørbæk C., Uotani S., Da Silva B., Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 1997, 272:32686-32695.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32686-32695
    • Bjørbæk, C.1    Uotani, S.2    Da Silva, B.3    Flier, J.S.4
  • 24
    • 0031665574 scopus 로고    scopus 로고
    • Up-regulation of blood-brain barrier short-form leptin receptor gene products in rats fed a high fat diet
    • Boado R., Golden P., Levin N., Pardridge W. Up-regulation of blood-brain barrier short-form leptin receptor gene products in rats fed a high fat diet. J. Neurochem. 1998, 71:1761-1764.
    • (1998) J. Neurochem. , vol.71 , pp. 1761-1764
    • Boado, R.1    Golden, P.2    Levin, N.3    Pardridge, W.4
  • 25
    • 0033406160 scopus 로고    scopus 로고
    • Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin/hypocretin and neuropeptide Y
    • Broberger C. Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin/hypocretin and neuropeptide Y. Brain Res. 1999, 848:101-113.
    • (1999) Brain Res. , vol.848 , pp. 101-113
    • Broberger, C.1
  • 26
    • 0032576536 scopus 로고    scopus 로고
    • Hypocretin/orexin- and hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related
    • Broberger C., De Lecea L.D.E., Sutcliffe J.G., Hokfelt T. Hypocretin/orexin- and hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related. J. Comp. Neurol. 1998, 402:460-474.
    • (1998) J. Comp. Neurol. , vol.402 , pp. 460-474
    • Broberger, C.1    De Lecea, L.D.E.2    Sutcliffe, J.G.3    Hokfelt, T.4
  • 27
    • 0032443807 scopus 로고    scopus 로고
    • The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
    • Broberger C., Johansen J., Johansson C., Schalling M., Hökfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:15043-15048.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 15043-15048
    • Broberger, C.1    Johansen, J.2    Johansson, C.3    Schalling, M.4    Hökfelt, T.5
  • 28
    • 0030829873 scopus 로고    scopus 로고
    • Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus
    • Broberger C., Landry M., Wong H., Walsh J.N., Hokfelt T. Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 1997, 66:393-408.
    • (1997) Neuroendocrinology , vol.66 , pp. 393-408
    • Broberger, C.1    Landry, M.2    Wong, H.3    Walsh, J.N.4    Hokfelt, T.5
  • 29
    • 0035851884 scopus 로고    scopus 로고
    • Leptin access into the brain: a saturated transport mechanism in obesity
    • Burguera B., Couce M.E. Leptin access into the brain: a saturated transport mechanism in obesity. Physiol. Behav. 2001, 74:717-720.
    • (2001) Physiol. Behav. , vol.74 , pp. 717-720
    • Burguera, B.1    Couce, M.E.2
  • 30
    • 31544465224 scopus 로고    scopus 로고
    • The melanocortin system and energy balance
    • Butler A.A. The melanocortin system and energy balance. Peptides 2006, 27:281-290.
    • (2006) Peptides , vol.27 , pp. 281-290
    • Butler, A.A.1
  • 31
    • 0034909815 scopus 로고    scopus 로고
    • Hypothalamic circuitry of neuropeptide Y regulation of neuroendocrine function and food intake via the Y5 receptor subtype
    • Campbell R.E., Michael M.H., Cowley M.A., Smith M.S., Grove L. Hypothalamic circuitry of neuropeptide Y regulation of neuroendocrine function and food intake via the Y5 receptor subtype. Neuroendocrinology 2001, 74:106-119.
    • (2001) Neuroendocrinology , vol.74 , pp. 106-119
    • Campbell, R.E.1    Michael, M.H.2    Cowley, M.A.3    Smith, M.S.4    Grove, L.5
  • 32
    • 24944544808 scopus 로고    scopus 로고
    • Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis
    • Cerri M., Morrison S.F. Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis. Neuroscience 2005, 135:627-638.
    • (2005) Neuroscience , vol.135 , pp. 627-638
    • Cerri, M.1    Morrison, S.F.2
  • 33
    • 0036141083 scopus 로고    scopus 로고
    • The feeding response to melanin-concentrating hormone is attenuated by antagonism of the NPY Y(1)-receptor in the rat
    • Chaffer C.L., Morris M.J. The feeding response to melanin-concentrating hormone is attenuated by antagonism of the NPY Y(1)-receptor in the rat. Endocrinology 2002, 143:191-197.
    • (2002) Endocrinology , vol.143 , pp. 191-197
    • Chaffer, C.L.1    Morris, M.J.2
  • 34
    • 79955635264 scopus 로고    scopus 로고
    • Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity
    • Chao P.-T., Yang L., Aja S., Moran T.H., Bi S. Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity. Cell Metab. 2011, 13:573-583.
    • (2011) Cell Metab. , vol.13 , pp. 573-583
    • Chao, P.-T.1    Yang, L.2    Aja, S.3    Moran, T.H.4    Bi, S.5
  • 35
    • 0032731180 scopus 로고    scopus 로고
    • Mapping of cocaine and amphetamine regulated transcript (CART) mRNA expression in the hypothalamus of elderly human
    • Charnay Y., Perrin C., Vallet P.G., Greggio B., Kovari E., Bouras C. Mapping of cocaine and amphetamine regulated transcript (CART) mRNA expression in the hypothalamus of elderly human. J. Chem. Neuroanat. 1999, 17:123-128.
    • (1999) J. Chem. Neuroanat. , vol.17 , pp. 123-128
    • Charnay, Y.1    Perrin, C.2    Vallet, P.G.3    Greggio, B.4    Kovari, E.5    Bouras, C.6
  • 36
    • 77749310482 scopus 로고    scopus 로고
    • Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus
    • Chee M.J.S., Myers M.G., Price C.J., Colmers W.F. Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus. J. Neurosci. 2010, 30:3380-3390.
    • (2010) J. Neurosci. , vol.30 , pp. 3380-3390
    • Chee, M.J.S.1    Myers, M.G.2    Price, C.J.3    Colmers, W.F.4
  • 37
    • 0030928715 scopus 로고    scopus 로고
    • Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
    • Cheung C.C., Clifton D.K., Steiner R.A. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997, 138:4489-4492.
    • (1997) Endocrinology , vol.138 , pp. 4489-4492
    • Cheung, C.C.1    Clifton, D.K.2    Steiner, R.A.3
  • 38
    • 0035857750 scopus 로고    scopus 로고
    • Distribution of galanin messenger RNA-expressing cells in murine brain and their regulation by leptin in regions of the hypothalamus
    • Cheung C.C., Hohmann J.G., Clifton D.K., Steiner R.a. Distribution of galanin messenger RNA-expressing cells in murine brain and their regulation by leptin in regions of the hypothalamus. Neuroscience 2001, 103:423-432.
    • (2001) Neuroscience , vol.103 , pp. 423-432
    • Cheung, C.C.1    Hohmann, J.G.2    Clifton, D.K.3    Steiner, R.4
  • 40
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • Cone R.D. Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 2005, 8:571-578.
    • (2005) Nat. Neurosci. , vol.8 , pp. 571-578
    • Cone, R.D.1
  • 41
    • 33845572889 scopus 로고    scopus 로고
    • Studies on the physiological functions of the melanocortin system
    • Cone R.D. Studies on the physiological functions of the melanocortin system. Endocr. Rev. 2006, 27:736-749.
    • (2006) Endocr. Rev. , vol.27 , pp. 736-749
    • Cone, R.D.1
  • 44
    • 0038374250 scopus 로고    scopus 로고
    • Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers
    • Couturier C., Jockers R. Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers. J. Biol. Chem. 2003, 278:26604-26611.
    • (2003) J. Biol. Chem. , vol.278 , pp. 26604-26611
    • Couturier, C.1    Jockers, R.2
  • 46
    • 1942473005 scopus 로고    scopus 로고
    • Galanin-like peptide as a possible link between metabolism and reproduction in the macaque
    • Cunningham M.J. Galanin-like peptide as a possible link between metabolism and reproduction in the macaque. J. Clin. Endocrinol. Metab. 2004, 89:1760-1766.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 1760-1766
    • Cunningham, M.J.1
  • 47
    • 8644284900 scopus 로고    scopus 로고
    • Characterization of subpopulations of neurons producing melanin-concentrating hormone in the rat ventral diencephalon
    • Cvetkovic V., Brischoux F., Jacquemard C. Characterization of subpopulations of neurons producing melanin-concentrating hormone in the rat ventral diencephalon. J. Neurochem. 2004, 91:911-919.
    • (2004) J. Neurochem. , vol.91 , pp. 911-919
    • Cvetkovic, V.1    Brischoux, F.2    Jacquemard, C.3
  • 52
    • 0030793449 scopus 로고    scopus 로고
    • Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding
    • Devos R. Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. J. Biol. Chem. 1997, 272:18304-18310.
    • (1997) J. Biol. Chem. , vol.272 , pp. 18304-18310
    • Devos, R.1
  • 54
    • 0038173575 scopus 로고    scopus 로고
    • Lateral hypothalamic neuropeptides in reward and drug addiction
    • DiLeone R.J., Georgescu D., Nestler E.J. Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci. 2003, 73:759-768.
    • (2003) Life Sci. , vol.73 , pp. 759-768
    • DiLeone, R.J.1    Georgescu, D.2    Nestler, E.J.3
  • 55
    • 34547206180 scopus 로고    scopus 로고
    • Involvement of neuropeptide Y Y1 receptors in the regulation of neuroendocrine corticotropin-releasing hormone neuronal activity
    • Dimitrov E.L., DeJoseph M.R., Brownfield M.S., Urban J.H. Involvement of neuropeptide Y Y1 receptors in the regulation of neuroendocrine corticotropin-releasing hormone neuronal activity. Endocrinology 2007, 148:3666-3673.
    • (2007) Endocrinology , vol.148 , pp. 3666-3673
    • Dimitrov, E.L.1    DeJoseph, M.R.2    Brownfield, M.S.3    Urban, J.H.4
  • 56
    • 0033794189 scopus 로고    scopus 로고
    • Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats
    • Dube M.G., Horvath T.L., Kalra P.S., Kalra S.P. Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides 2000, 21:1557-1560.
    • (2000) Peptides , vol.21 , pp. 1557-1560
    • Dube, M.G.1    Horvath, T.L.2    Kalra, P.S.3    Kalra, S.P.4
  • 57
    • 15444366416 scopus 로고    scopus 로고
    • Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3
    • Dunn S.L., Björnholm M., Bates S.H., Chen Z., Seifert M., Myers M.G. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol. Endocrinol. 2005, 19:925-938.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 925-938
    • Dunn, S.L.1    Björnholm, M.2    Bates, S.H.3    Chen, Z.4    Seifert, M.5    Myers, M.G.6
  • 58
    • 0034595765 scopus 로고    scopus 로고
    • Cocaine-and amphetamine-regulated transcript, glucagon-like peptide-1 and corticotrophin releasing factor inhibit feeding via agouti-related protein independent pathways in the rat
    • Edwards C.M.B., Abbott C.R., Sunter D., Kim M.S., Dakin C.L., Murphy K.G., Abusnana S., Taheri S., Rossi M., Bloom S.R. Cocaine-and amphetamine-regulated transcript, glucagon-like peptide-1 and corticotrophin releasing factor inhibit feeding via agouti-related protein independent pathways in the rat. Brain Res. 2000, 866:128-134.
    • (2000) Brain Res. , vol.866 , pp. 128-134
    • Edwards, C.M.B.1    Abbott, C.R.2    Sunter, D.3    Kim, M.S.4    Dakin, C.L.5    Murphy, K.G.6    Abusnana, S.7    Taheri, S.8    Rossi, M.9    Bloom, S.R.10
  • 64
    • 0035710726 scopus 로고    scopus 로고
    • Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
    • Elmquist J.K. Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Int. J. Obes. Relat. Metab. Disord. 2001, 25(Suppl. 5):S78-S82.
    • (2001) Int. J. Obes. Relat. Metab. Disord. , vol.25 , pp. S78-S82
    • Elmquist, J.K.1
  • 68
    • 0033082380 scopus 로고    scopus 로고
    • From lesions to leptin: hypothalamic control of food intake and body weight
    • Elmquist J.K., Elias C.F., Saper C.B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 1999, 22:221-232.
    • (1999) Neuron , vol.22 , pp. 221-232
    • Elmquist, J.K.1    Elias, C.F.2    Saper, C.B.3
  • 70
    • 80052156758 scopus 로고    scopus 로고
    • Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance
    • Enriori P.J., Sinnayah P., Simonds S.E., Garcia Rudaz C., Cowley M.A. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J. Neurosci. 2011, 31:12189-12197.
    • (2011) J. Neurosci. , vol.31 , pp. 12189-12197
    • Enriori, P.J.1    Sinnayah, P.2    Simonds, S.E.3    Garcia Rudaz, C.4    Cowley, M.A.5
  • 71
    • 0036893007 scopus 로고    scopus 로고
    • Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis
    • Fekete C. Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Endocrinology 2002, 143:4513-4519.
    • (2002) Endocrinology , vol.143 , pp. 4513-4519
    • Fekete, C.1
  • 72
    • 0342858793 scopus 로고    scopus 로고
    • α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression
    • Fekete C., Legradi G., Mihaly E., Huang Q., Tatro J.B., Rand W.M., Emerson C.H., Lechan R.M. α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J. Neurosci. 2000, 20:1550-1558.
    • (2000) J. Neurosci. , vol.20 , pp. 1550-1558
    • Fekete, C.1    Legradi, G.2    Mihaly, E.3    Huang, Q.4    Tatro, J.B.5    Rand, W.M.6    Emerson, C.H.7    Lechan, R.M.8
  • 73
    • 0742287871 scopus 로고    scopus 로고
    • Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus
    • Fetissov S.O., Byrne L.C., Hassani H., Ernfors P., Hokfelt T. Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus. J. Comp. Neurol. 2004, 470:256-265.
    • (2004) J. Comp. Neurol. , vol.470 , pp. 256-265
    • Fetissov, S.O.1    Byrne, L.C.2    Hassani, H.3    Ernfors, P.4    Hokfelt, T.5
  • 74
    • 0037458468 scopus 로고    scopus 로고
    • Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat
    • Figlewicz D.P., Evans S.B., Murphy J., Hoen M., Baskin D.G. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain Res. 2003, 964:107-115.
    • (2003) Brain Res. , vol.964 , pp. 107-115
    • Figlewicz, D.P.1    Evans, S.B.2    Murphy, J.3    Hoen, M.4    Baskin, D.G.5
  • 78
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signalling pathways activated by leptin
    • Frühbeck G. Intracellular signalling pathways activated by leptin. Biochem. J. 2006, 393:7-20.
    • (2006) Biochem. J. , vol.393 , pp. 7-20
    • Frühbeck, G.1
  • 79
  • 80
    • 0041704635 scopus 로고    scopus 로고
    • Co-existence of leptin- and orexin-receptors in feeding-regulating neurons in the hypothalamic arcuate nucleus-a triple labeling study
    • Funahashi H., Yamada S., Kageyama H., Takenoya F., Guan J.-L., Shioda S. Co-existence of leptin- and orexin-receptors in feeding-regulating neurons in the hypothalamic arcuate nucleus-a triple labeling study. Peptides 2003, 24:687-694.
    • (2003) Peptides , vol.24 , pp. 687-694
    • Funahashi, H.1    Yamada, S.2    Kageyama, H.3    Takenoya, F.4    Guan, J.-L.5    Shioda, S.6
  • 82
    • 0346751981 scopus 로고    scopus 로고
    • Neurons synthesizing melanin-concentrating hormone identified by selective reporter gene expression after transfection in vitro: transmitter responses
    • Gao X.-B., Ghosh P.K., van den Pol A.N. Neurons synthesizing melanin-concentrating hormone identified by selective reporter gene expression after transfection in vitro: transmitter responses. J. Neurophysiol. 2003, 90:3978-3985.
    • (2003) J. Neurophysiol. , vol.90 , pp. 3978-3985
    • Gao, X.-B.1    Ghosh, P.K.2    van den Pol, A.N.3
  • 83
    • 44949092261 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity
    • Garza J.C., Kim C.S., Liu J., Zhang W., Lu X.-Y. Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity. J. Endocrinol. 2008, 197:471-482.
    • (2008) J. Endocrinol. , vol.197 , pp. 471-482
    • Garza, J.C.1    Kim, C.S.2    Liu, J.3    Zhang, W.4    Lu, X.-Y.5
  • 84
    • 77952223502 scopus 로고    scopus 로고
    • Identifying the efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus using a novel conditional tracing approach
    • Gautron L., Lazarus M., Scott M.M., Saper C.B., Elmquist J.K. Identifying the efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus using a novel conditional tracing approach. J. Comp. Neurol. 2010, 518:2090-2108.
    • (2010) J. Comp. Neurol. , vol.518 , pp. 2090-2108
    • Gautron, L.1    Lazarus, M.2    Scott, M.M.3    Saper, C.B.4    Elmquist, J.K.5
  • 85
    • 0023184531 scopus 로고
    • Localization of neuropeptide Y messenger ribonucleic acid in rat and mouse brain by in situ hybridization
    • Gehlert D., Chronwall B., Schafer M., O'Donohue T. Localization of neuropeptide Y messenger ribonucleic acid in rat and mouse brain by in situ hybridization. Synapse 1987, 1:25-31.
    • (1987) Synapse , vol.1 , pp. 25-31
    • Gehlert, D.1    Chronwall, B.2    Schafer, M.3    O'Donohue, T.4
  • 87
    • 0022550539 scopus 로고
    • Mechanism of thyrotropin releasing hormone stimulation of pituitary hormone secretion
    • Gershengorn M.C. Mechanism of thyrotropin releasing hormone stimulation of pituitary hormone secretion. Annu. Rev. Physiol. 1986, 48:515-526.
    • (1986) Annu. Rev. Physiol. , vol.48 , pp. 515-526
    • Gershengorn, M.C.1
  • 88
    • 78651063747 scopus 로고    scopus 로고
    • Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin
    • Ghamari-Langroudi M., Srisai D., Cone R.D. Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:355-360.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 355-360
    • Ghamari-Langroudi, M.1    Srisai, D.2    Cone, R.D.3
  • 89
    • 78649413249 scopus 로고    scopus 로고
    • Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity
    • Ghamari-Langroudi M., Vella K.R., Srisai D., Sugrue M.L., Hollenberg A.N., Cone R.D. Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity. Mol. Endocrinol. 2010, 24:2366-2381.
    • (2010) Mol. Endocrinol. , vol.24 , pp. 2366-2381
    • Ghamari-Langroudi, M.1    Vella, K.R.2    Srisai, D.3    Sugrue, M.L.4    Hollenberg, A.N.5    Cone, R.D.6
  • 91
    • 0036162117 scopus 로고    scopus 로고
    • The neuroanatomical axis for control of energy balance
    • Grill H.J., Kaplan J.M. The neuroanatomical axis for control of energy balance. Front. Neuroendocrinol. 2002, 23:2-40.
    • (2002) Front. Neuroendocrinol. , vol.23 , pp. 2-40
    • Grill, H.J.1    Kaplan, J.M.2
  • 92
    • 0034752125 scopus 로고    scopus 로고
    • Novel expression of neuropeptide Y (NPY) mRNA in hypothalamic regions during development: region-specific effects of maternal deprivation on NPY and Agouti-related protein mRNA
    • Grove K.L., Brogan R.S., Smith M.S. Novel expression of neuropeptide Y (NPY) mRNA in hypothalamic regions during development: region-specific effects of maternal deprivation on NPY and Agouti-related protein mRNA. Endocrinology 2001, 142:4771-4776.
    • (2001) Endocrinology , vol.142 , pp. 4771-4776
    • Grove, K.L.1    Brogan, R.S.2    Smith, M.S.3
  • 93
    • 0032569615 scopus 로고    scopus 로고
    • Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice
    • Guan X.M., Yu H., Trumbauer M., Frazier E., Van der Ploeg L.H., Chen H. Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice. Neuroreport 1998, 9:3415-3419.
    • (1998) Neuroreport , vol.9 , pp. 3415-3419
    • Guan, X.M.1    Yu, H.2    Trumbauer, M.3    Frazier, E.4    Van der Ploeg, L.H.5    Chen, H.6
  • 94
    • 0025309932 scopus 로고
    • Localization of preprogalanin mRNA in rat brain: in situ hybridization study with a synthetic oligonucleotide probe
    • Gundlach A.L., Wisden W., Morris B.J., Hunt S.P. Localization of preprogalanin mRNA in rat brain: in situ hybridization study with a synthetic oligonucleotide probe. Neurosci. Lett. 1990, 114:241-247.
    • (1990) Neurosci. Lett. , vol.114 , pp. 241-247
    • Gundlach, A.L.1    Wisden, W.2    Morris, B.J.3    Hunt, S.P.4
  • 95
    • 0031963436 scopus 로고    scopus 로고
    • Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
    • Hâkansson M.L., Brown H., Ghilardi N., Skoda R.C., Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 1998, 18:559-572.
    • (1998) J. Neurosci. , vol.18 , pp. 559-572
    • Hâkansson, M.L.1    Brown, H.2    Ghilardi, N.3    Skoda, R.C.4    Meister, B.5
  • 96
    • 0345085697 scopus 로고    scopus 로고
    • Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus
    • Håkansson M.L., de Lecea L., Sutcliffe J.G., Yanagisawa M., Meister B. Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus. J. Neuroendocrinol. 1999, 11:653-663.
    • (1999) J. Neuroendocrinol. , vol.11 , pp. 653-663
    • Håkansson, M.L.1    de Lecea, L.2    Sutcliffe, J.G.3    Yanagisawa, M.4    Meister, B.5
  • 97
    • 0032424694 scopus 로고    scopus 로고
    • Transcription factor STAT3 in leptin target neurons of the rat hypothalamus
    • Håkansson M.L., Meister B. Transcription factor STAT3 in leptin target neurons of the rat hypothalamus. Neuroendocrinology 1998, 68:420-427.
    • (1998) Neuroendocrinology , vol.68 , pp. 420-427
    • Håkansson, M.L.1    Meister, B.2
  • 99
    • 25644432796 scopus 로고    scopus 로고
    • A role for lateral hypothalamic orexin neurons in reward seeking
    • Harris G.C., Wimmer M., Aston-jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 2005, 437:556-559.
    • (2005) Nature , vol.437 , pp. 556-559
    • Harris, G.C.1    Wimmer, M.2    Aston-jones, G.3
  • 102
    • 0032899719 scopus 로고    scopus 로고
    • Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    • Haynes W.G., Morgan D.a., Djalali A., Sivitz W.I., Mark A.L. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 1999, 33:542-547.
    • (1999) Hypertension , vol.33 , pp. 542-547
    • Haynes, W.G.1    Morgan, D.2    Djalali, A.3    Sivitz, W.I.4    Mark, A.L.5
  • 103
    • 0035794211 scopus 로고    scopus 로고
    • Modulation of circulating leptin levels by its soluble receptor
    • Huang L., Wang Z., Li C. Modulation of circulating leptin levels by its soluble receptor. J. Biol. Chem. 2001, 276:6343-6349.
    • (2001) J. Biol. Chem. , vol.276 , pp. 6343-6349
    • Huang, L.1    Wang, Z.2    Li, C.3
  • 104
    • 0041938628 scopus 로고    scopus 로고
    • Effects of leptin on melanin-concentrating hormone expression in the brain of lean and obese Lep(ob)/Lep(ob) mice
    • Huang Q., Viale A., Picard F., Nahon J.-L., Richard D. Effects of leptin on melanin-concentrating hormone expression in the brain of lean and obese Lep(ob)/Lep(ob) mice. Neuroendocrinology 1999, 4:145-153.
    • (1999) Neuroendocrinology , vol.4 , pp. 145-153
    • Huang, Q.1    Viale, A.2    Picard, F.3    Nahon, J.-L.4    Richard, D.5
  • 105
    • 0035313069 scopus 로고    scopus 로고
    • Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation
    • Hubschle T., Thom E., Watson A., Roth J., Klaus S., Meyerhof W., Hübschle T. Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J. Neurosci. 2001, 21:2413-2424.
    • (2001) J. Neurosci. , vol.21 , pp. 2413-2424
    • Hubschle, T.1    Thom, E.2    Watson, A.3    Roth, J.4    Klaus, S.5    Meyerhof, W.6    Hübschle, T.7
  • 106
    • 11144358404 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription 3 in regulation of hypothalamic TRH gene expression by leptin
    • Huo L., Münzberg H., Nillni E.a., Bjørbæk C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic TRH gene expression by leptin. Endocrinology 2004, 145:2516-2523.
    • (2004) Endocrinology , vol.145 , pp. 2516-2523
    • Huo, L.1    Münzberg, H.2    Nillni, E.3    Bjørbæk, C.4
  • 107
    • 0034597394 scopus 로고    scopus 로고
    • Human cocaine- and amphetamine regulated transcript (CART) mRNA is highly expressed in limbic- and sensory related brain regions
    • Hurd Y.L., Fagergren P. Human cocaine- and amphetamine regulated transcript (CART) mRNA is highly expressed in limbic- and sensory related brain regions. J. Comp. Neurol. 2000, 425:583-598.
    • (2000) J. Comp. Neurol. , vol.425 , pp. 583-598
    • Hurd, Y.L.1    Fagergren, P.2
  • 108
    • 0000739329 scopus 로고
    • Alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain
    • Jacobowitz D.M., O'Donohue T.L. alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain. Proc. Natl. Acad. Sci. U. S. A. 1978, 75:6300-6304.
    • (1978) Proc. Natl. Acad. Sci. U. S. A. , vol.75 , pp. 6300-6304
    • Jacobowitz, D.M.1    O'Donohue, T.L.2
  • 109
    • 0033969792 scopus 로고    scopus 로고
    • Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats
    • Jain M.R., Horvath T.L., Kalra P.S., Kalra S.P. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Regul. Pept. 2000, 87:19-24.
    • (2000) Regul. Pept. , vol.87 , pp. 19-24
    • Jain, M.R.1    Horvath, T.L.2    Kalra, P.S.3    Kalra, S.P.4
  • 111
    • 0034455629 scopus 로고    scopus 로고
    • Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat
    • Jureus A., Cunningham M., McClain M., Clifton D.K., Steiner R.A. Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat. Endocrinology 2000, 141:2703-2706.
    • (2000) Endocrinology , vol.141 , pp. 2703-2706
    • Jureus, A.1    Cunningham, M.2    McClain, M.3    Clifton, D.K.4    Steiner, R.A.5
  • 112
    • 0242660829 scopus 로고    scopus 로고
    • Neuropeptide Y: a physiological orexigen modulated by the feedback action of ghrelin and leptin
    • Kalra S.P., Kalra P.S. Neuropeptide Y: a physiological orexigen modulated by the feedback action of ghrelin and leptin. Endocrine 2003, 22:49-56.
    • (2003) Endocrine , vol.22 , pp. 49-56
    • Kalra, S.P.1    Kalra, P.S.2
  • 113
    • 1442276966 scopus 로고    scopus 로고
    • Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons
    • Kang L., Routh V.H., Kuzhikandathil E.V., Gaspers L.D., Levin B.E. Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons. Diabetes 2004, 53:549-559.
    • (2004) Diabetes , vol.53 , pp. 549-559
    • Kang, L.1    Routh, V.H.2    Kuzhikandathil, E.V.3    Gaspers, L.D.4    Levin, B.E.5
  • 114
    • 0033395851 scopus 로고    scopus 로고
    • Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor
    • Kastin A.J., Pan W., Maness L.M., Koletsky R.J., Ernsberger P. Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides 1999, 20:1449-1453.
    • (1999) Peptides , vol.20 , pp. 1449-1453
    • Kastin, A.J.1    Pan, W.2    Maness, L.M.3    Koletsky, R.J.4    Ernsberger, P.5
  • 115
    • 19344370719 scopus 로고    scopus 로고
    • Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia
    • Kawaguchi M., Scott K.A., Moran T.H., Bi S. Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288:R1800-R1805.
    • (2005) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.288 , pp. R1800-R1805
    • Kawaguchi, M.1    Scott, K.A.2    Moran, T.H.3    Bi, S.4
  • 116
    • 33645451436 scopus 로고    scopus 로고
    • Rostral elements of sympatho-motor circuitry: a virally mediated transsynaptic tracing study
    • Kerman I.A., Akil H., Watson S.J. Rostral elements of sympatho-motor circuitry: a virally mediated transsynaptic tracing study. J. Neurosci. 2006, 26:3423-3433.
    • (2006) J. Neurosci. , vol.26 , pp. 3423-3433
    • Kerman, I.A.1    Akil, H.2    Watson, S.J.3
  • 117
    • 38049089460 scopus 로고    scopus 로고
    • Distinct populations of presympathetic-premotor neurons express orexin or melanin-concentrating hormone in the rat lateral hypothalamus
    • Kerman I.A., Bernard R. Distinct populations of presympathetic-premotor neurons express orexin or melanin-concentrating hormone in the rat lateral hypothalamus. J. Comp. Neurol. 2007, 505:586-601.
    • (2007) J. Comp. Neurol. , vol.505 , pp. 586-601
    • Kerman, I.A.1    Bernard, R.2
  • 118
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • Kernie S.G., Liebl D.J., Parada L.F. BDNF regulates eating behavior and locomotor activity in mice. EMBO J. 2000, 19:1290-1300.
    • (2000) EMBO J. , vol.19 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.J.2    Parada, L.F.3
  • 119
    • 0035996843 scopus 로고    scopus 로고
    • Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor
    • Kim M.S., Rossi M., Abbott C.R., AlAhmed S.H., Smith D.M., Bloom S.R. Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor. Peptides 2002, 23:1069-1076.
    • (2002) Peptides , vol.23 , pp. 1069-1076
    • Kim, M.S.1    Rossi, M.2    Abbott, C.R.3    AlAhmed, S.H.4    Smith, D.M.5    Bloom, S.R.6
  • 121
    • 31944452253 scopus 로고    scopus 로고
    • The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight
    • King B.M. The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. Physiol. Behav. 2006, 87:221-244.
    • (2006) Physiol. Behav. , vol.87 , pp. 221-244
    • King, B.M.1
  • 123
    • 0035100001 scopus 로고    scopus 로고
    • Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain
    • Kokkotou E.G., Tritos N.a., Mastaitis J.W., Slieker L., Maratos-Flier E. Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology 2001, 142:680-686.
    • (2001) Endocrinology , vol.142 , pp. 680-686
    • Kokkotou, E.G.1    Tritos, N.2    Mastaitis, J.W.3    Slieker, L.4    Maratos-Flier, E.5
  • 124
  • 125
    • 33646139871 scopus 로고    scopus 로고
    • Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus
    • Komori T., Morikawa Y., Nanjo K., Senba E. Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. Neuroscience 2006, 139:1107-1115.
    • (2006) Neuroscience , vol.139 , pp. 1107-1115
    • Komori, T.1    Morikawa, Y.2    Nanjo, K.3    Senba, E.4
  • 126
    • 0030715274 scopus 로고    scopus 로고
    • Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland
    • Koylu E.O., Couceyro P.R., Lambert P.D., Ling N.C., DeSouza E.B., Kuhar M.J. Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J. Neuroendocrinol. 1997, 9:823-833.
    • (1997) J. Neuroendocrinol. , vol.9 , pp. 823-833
    • Koylu, E.O.1    Couceyro, P.R.2    Lambert, P.D.3    Ling, N.C.4    DeSouza, E.B.5    Kuhar, M.J.6
  • 127
    • 84885089652 scopus 로고    scopus 로고
    • Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP
    • Krashes M.J., Shah B.P., Koda S., Lowell B.B. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab. 2013, 18:588-595.
    • (2013) Cell Metab. , vol.18 , pp. 588-595
    • Krashes, M.J.1    Shah, B.P.2    Koda, S.3    Lowell, B.B.4
  • 129
    • 33645529851 scopus 로고    scopus 로고
    • Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat
    • Kuramochi M., Onaka T., Kohno D., Kato S., Yada T. Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat. Endocrinology 2006, 147:1744-1752.
    • (2006) Endocrinology , vol.147 , pp. 1744-1752
    • Kuramochi, M.1    Onaka, T.2    Kohno, D.3    Kato, S.4    Yada, T.5
  • 130
    • 0025086236 scopus 로고
    • Stimulation of feeding by galanin: anatomical localization and behavioral specificity of this peptide's effects in the brain
    • Kyrkouli S.E., Stanley B.G., Seirafi R.D., Leibowitz S.F. Stimulation of feeding by galanin: anatomical localization and behavioral specificity of this peptide's effects in the brain. Peptides 1990, 11:995-1001.
    • (1990) Peptides , vol.11 , pp. 995-1001
    • Kyrkouli, S.E.1    Stanley, B.G.2    Seirafi, R.D.3    Leibowitz, S.F.4
  • 131
    • 33746639546 scopus 로고    scopus 로고
    • Galanin in the PVN increases nutrient intake and changes peripheral hormone levels in the rat
    • Kyrkouli S.E., Strubbe J.H., Scheurink A.J.W. Galanin in the PVN increases nutrient intake and changes peripheral hormone levels in the rat. Physiol. Behav. 2006, 89:103-109.
    • (2006) Physiol. Behav. , vol.89 , pp. 103-109
    • Kyrkouli, S.E.1    Strubbe, J.H.2    Scheurink, A.J.W.3
  • 134
    • 84878589012 scopus 로고    scopus 로고
    • Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action
    • Laque A., Zhang Y., Gettys S., Nguyen T.-A., Bui K., Morrison C.D., Münzberg H. Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action. Am. J. Physiol. Endocrinol. Metab. 2013, 304:E999-E1011.
    • (2013) Am. J. Physiol. Endocrinol. Metab. , vol.304 , pp. E999-E1011
    • Laque, A.1    Zhang, Y.2    Gettys, S.3    Nguyen, T.-A.4    Bui, K.5    Morrison, C.D.6    Münzberg, H.7
  • 135
    • 84875821516 scopus 로고    scopus 로고
    • Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models
    • Lee S.J., Kirigiti M., Lindsley S.R., Loche A., Madden C.J., Morrison S.F., Smith M.S., Grove K.L. Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models. J. Comp. Neurol. 2013, 521:1891-1914.
    • (2013) J. Comp. Neurol. , vol.521 , pp. 1891-1914
    • Lee, S.J.1    Kirigiti, M.2    Lindsley, S.R.3    Loche, A.4    Madden, C.J.5    Morrison, S.F.6    Smith, M.S.7    Grove, K.L.8
  • 136
    • 84884172338 scopus 로고    scopus 로고
    • Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice
    • Lee S.J., Verma S., Simonds S.E., Kirigiti M.a., Kievit P., Lindsley S.R., Loche A., Smith M.S., Cowley M.A., Grove K.L. Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice. J. Neurosci. 2013, 33:15306-15317.
    • (2013) J. Neurosci. , vol.33 , pp. 15306-15317
    • Lee, S.J.1    Verma, S.2    Simonds, S.E.3    Kirigiti, M.4    Kievit, P.5    Lindsley, S.R.6    Loche, A.7    Smith, M.S.8    Cowley, M.A.9    Grove, K.L.10
  • 137
    • 0000659858 scopus 로고    scopus 로고
    • Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus
    • Légrádi G., Emerson C.H., Ahima R.S., Flier J.S., Lechan R.M. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 1997, 138:2569-2576.
    • (1997) Endocrinology , vol.138 , pp. 2569-2576
    • Légrádi, G.1    Emerson, C.H.2    Ahima, R.S.3    Flier, J.S.4    Lechan, R.M.5
  • 138
    • 0031730916 scopus 로고    scopus 로고
    • The arcuate nucleus is the major source for hormone neurons in the hypothalamic paraventricular nucleus
    • Legradi G., Lechan R.M. The arcuate nucleus is the major source for hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 1998, 139:3262-3270.
    • (1998) Endocrinology , vol.139 , pp. 3262-3270
    • Legradi, G.1    Lechan, R.M.2
  • 139
    • 0033304761 scopus 로고    scopus 로고
    • Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus
    • Légrádi G., Lechan R.M. Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 1999, 140:3643-3652.
    • (1999) Endocrinology , vol.140 , pp. 3643-3652
    • Légrádi, G.1    Lechan, R.M.2
  • 141
    • 37249065139 scopus 로고    scopus 로고
    • LRb signals act within a distributed network of leptin-responsive neurones to mediate leptin action
    • Leinninger G.M., Myers M.G. LRb signals act within a distributed network of leptin-responsive neurones to mediate leptin action. Acta Physiol. 2008, 192:49-59.
    • (2008) Acta Physiol. , vol.192 , pp. 49-59
    • Leinninger, G.M.1    Myers, M.G.2
  • 143
    • 77956107701 scopus 로고    scopus 로고
    • Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons
    • Louis G.W., Leinninger G.M., Rhodes C.J., Myers M.G. Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons. J. Neurosci. 2010, 30:11278-11287.
    • (2010) J. Neurosci. , vol.30 , pp. 11278-11287
    • Louis, G.W.1    Leinninger, G.M.2    Rhodes, C.J.3    Myers, M.G.4
  • 144
    • 0041319087 scopus 로고    scopus 로고
    • Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses
    • Lu X.-Y., Barsh G.S., Akil H., Watson S.J. Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J. Neurosci. 2003, 23:7863-7872.
    • (2003) J. Neurosci. , vol.23 , pp. 7863-7872
    • Lu, X.-Y.1    Barsh, G.S.2    Akil, H.3    Watson, S.J.4
  • 145
    • 33847105586 scopus 로고    scopus 로고
    • Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin
    • Ma X., Zubcevic L., Brüning J.C., Ashcroft F.M., Burdakov D. Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin. J. Neurosci. 2007, 27:1529-1533.
    • (2007) J. Neurosci. , vol.27 , pp. 1529-1533
    • Ma, X.1    Zubcevic, L.2    Brüning, J.C.3    Ashcroft, F.M.4    Burdakov, D.5
  • 146
    • 0029086473 scopus 로고
    • Threading analysis suggests that the obese gene product may be a helical cytokine
    • Madej T., Boguski M., Bryant S. Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Lett. 1995, 373:13-18.
    • (1995) FEBS Lett. , vol.373 , pp. 13-18
    • Madej, T.1    Boguski, M.2    Bryant, S.3
  • 149
    • 0031766974 scopus 로고    scopus 로고
    • Fate of leptin after intracerebroventricular injection into the mouse brain
    • Maness L.M., Kastin A.J., Farrell C.L., Banks W.a. Fate of leptin after intracerebroventricular injection into the mouse brain. Endocrinology 1998, 139:4556-4562.
    • (1998) Endocrinology , vol.139 , pp. 4556-4562
    • Maness, L.M.1    Kastin, A.J.2    Farrell, C.L.3    Banks, W.4
  • 153
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 1996, 387:113-116.
    • (1996) FEBS Lett. , vol.387 , pp. 113-116
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 154
    • 0035830716 scopus 로고    scopus 로고
    • Hypothalamic dorsomedial nucleus neurons innervate thyrotropin-releasing hormone-synthesizing neurons in the paraventricular nucleus
    • Mihály E., Fekete C., Légrádi G., Lechan R.M. Hypothalamic dorsomedial nucleus neurons innervate thyrotropin-releasing hormone-synthesizing neurons in the paraventricular nucleus. Brain Res. 2001, 891:20-31.
    • (2001) Brain Res. , vol.891 , pp. 20-31
    • Mihály, E.1    Fekete, C.2    Légrádi, G.3    Lechan, R.M.4
  • 155
    • 0032971214 scopus 로고    scopus 로고
    • Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats
    • Minokoshi Y., Haque M.S., Shimazu T. Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats. Diabetes 1999, 48:287-292.
    • (1999) Diabetes , vol.48 , pp. 287-292
    • Minokoshi, Y.1    Haque, M.S.2    Shimazu, T.3
  • 156
    • 0032915413 scopus 로고    scopus 로고
    • Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
    • Mizuno T.M., Mobbs C.V. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 1999, 140:814-817.
    • (1999) Endocrinology , vol.140 , pp. 814-817
    • Mizuno, T.M.1    Mobbs, C.V.2
  • 157
    • 0033921908 scopus 로고    scopus 로고
    • Centrally administered murine-leptin stimulates the hypothalamus-pituitary-adrenal axis through arginine-vasopressin
    • Morimoto I., Yamamoto S., Kai K., Fujihira T., Morita E., Eto S. Centrally administered murine-leptin stimulates the hypothalamus-pituitary-adrenal axis through arginine-vasopressin. Neuroendocrinology 2000, 71:366-374.
    • (2000) Neuroendocrinology , vol.71 , pp. 366-374
    • Morimoto, I.1    Yamamoto, S.2    Kai, K.3    Fujihira, T.4    Morita, E.5    Eto, S.6
  • 158
    • 33644665508 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling
    • Morrison C.D., Morton G.J., Niswender K.D., Gelling R.W., Schwartz M.W. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am. J. Physiol. Endocrinol. Metab. 2005, 289:E1051-E1057.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289 , pp. E1051-E1057
    • Morrison, C.D.1    Morton, G.J.2    Niswender, K.D.3    Gelling, R.W.4    Schwartz, M.W.5
  • 159
    • 33646500989 scopus 로고    scopus 로고
    • Expression of melanocortin MC3 and MC4 receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus
    • Mounien L., Bizet P., Boutelet I., Vaudry H., Jegou S. Expression of melanocortin MC3 and MC4 receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus. Neuroendocrinology 2005, 82:164-170.
    • (2005) Neuroendocrinology , vol.82 , pp. 164-170
    • Mounien, L.1    Bizet, P.2    Boutelet, I.3    Vaudry, H.4    Jegou, S.5
  • 160
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • Mountjoy K.G., Mortrud M.T., Low M.J., Simerly R.B., Cone R.D. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endocrinol. 1994, 8:1298-1308.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 161
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • Münzberg H., Flier J.S., Bjørbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004, 145:4880-4889.
    • (2004) Endocrinology , vol.145 , pp. 4880-4889
    • Münzberg, H.1    Flier, J.S.2    Bjørbaek, C.3
  • 162
    • 17844401180 scopus 로고    scopus 로고
    • Molecular and anatomical determinants of central leptin resistance
    • Münzberg H., Myers M.G. Molecular and anatomical determinants of central leptin resistance. Nat. Neurosci. 2005, 8:566-570.
    • (2005) Nat. Neurosci. , vol.8 , pp. 566-570
    • Münzberg, H.1    Myers, M.G.2
  • 164
    • 2342444310 scopus 로고    scopus 로고
    • Leptin receptor signaling and the regulation of mammalian physiology
    • Myers M.G. Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog. Horm. Res. 2004, 59:287-304.
    • (2004) Recent Prog. Horm. Res. , vol.59 , pp. 287-304
    • Myers, M.G.1
  • 166
    • 0033601302 scopus 로고    scopus 로고
    • Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus
    • Ohtaki T. Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus. J. Biol. Chem. 1999, 274:37041-37045.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37041-37045
    • Ohtaki, T.1
  • 167
    • 0037139340 scopus 로고    scopus 로고
    • The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
    • Oldfield B.J., Giles M.E., Watson A., Anderson C., Colvill L.M., McKinley M.J. The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 2002, 110:515-526.
    • (2002) Neuroscience , vol.110 , pp. 515-526
    • Oldfield, B.J.1    Giles, M.E.2    Watson, A.3    Anderson, C.4    Colvill, L.M.5    McKinley, M.J.6
  • 168
    • 0025948540 scopus 로고
    • Brain oxytocin receptor antagonism blunts the effects of anorexigenic treatments in rats: evidence for central oxytocin inhibition of food intake
    • Olson B.R., Drutarosky M.D., Stricker E.M., Verbalis J.G. Brain oxytocin receptor antagonism blunts the effects of anorexigenic treatments in rats: evidence for central oxytocin inhibition of food intake. Endocrinology 1991, 129:785-791.
    • (1991) Endocrinology , vol.129 , pp. 785-791
    • Olson, B.R.1    Drutarosky, M.D.2    Stricker, E.M.3    Verbalis, J.G.4
  • 169
    • 79951948090 scopus 로고    scopus 로고
    • Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells
    • Patterson C.M., Leshan R.L., Jones J.C., Myers M.G. Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells. Brain Res. 2011, 1378:18-28.
    • (2011) Brain Res. , vol.1378 , pp. 18-28
    • Patterson, C.M.1    Leshan, R.L.2    Jones, J.C.3    Myers, M.G.4
  • 171
    • 84875077224 scopus 로고    scopus 로고
    • Leptin activates oxytocin neurons of the hypothalamic paraventricular nucleus in both control and diet-induced obese rodents
    • Perello M., Raingo J. Leptin activates oxytocin neurons of the hypothalamic paraventricular nucleus in both control and diet-induced obese rodents. PLOS ONE 2013, 8:e59625.
    • (2013) PLOS ONE , vol.8 , pp. e59625
    • Perello, M.1    Raingo, J.2
  • 172
    • 33745178513 scopus 로고    scopus 로고
    • The role of intracerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone neurons in the hypothalamic paraventricular nucleus
    • Perello M., Stuart R.C., Nillni E.a. The role of intracerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 2006, 147:3296-3306.
    • (2006) Endocrinology , vol.147 , pp. 3296-3306
    • Perello, M.1    Stuart, R.C.2    Nillni, E.3
  • 175
    • 84880419521 scopus 로고    scopus 로고
    • Flipping the tanycyte switch: how circulating signals gain direct access to the metabolic brain
    • Prevot V., Langlet F., Dehouck B. Flipping the tanycyte switch: how circulating signals gain direct access to the metabolic brain. Aging (Milano) 2013, 5:332-334.
    • (2013) Aging (Milano) , vol.5 , pp. 332-334
    • Prevot, V.1    Langlet, F.2    Dehouck, B.3
  • 176
    • 0034792085 scopus 로고    scopus 로고
    • Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    • Rios M., Fan G., Fekete C., Kelly J., Bates B., Kuehn R., Lechan R.M., Jaenisch R. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol. Endocrinol. 2001, 15:1748-1757.
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1748-1757
    • Rios, M.1    Fan, G.2    Fekete, C.3    Kelly, J.4    Bates, B.5    Kuehn, R.6    Lechan, R.M.7    Jaenisch, R.8
  • 177
    • 1542358816 scopus 로고    scopus 로고
    • Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob Mice
    • Roseberry A.G., Liu H., Jackson A.C., Cai X., Friedman J.M. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob Mice. Neuron 2004, 41:711-722.
    • (2004) Neuron , vol.41 , pp. 711-722
    • Roseberry, A.G.1    Liu, H.2    Jackson, A.C.3    Cai, X.4    Friedman, J.M.5
  • 179
    • 49249113885 scopus 로고    scopus 로고
    • Spontaneous discharge characteristic of neurons in the ventromedial nucleus of the rat hypothalamus in vivo
    • Sabatier N., Leng G. Spontaneous discharge characteristic of neurons in the ventromedial nucleus of the rat hypothalamus in vivo. Eur. J. Neurosci. 2008, 28:693-706.
    • (2008) Eur. J. Neurosci. , vol.28 , pp. 693-706
    • Sabatier, N.1    Leng, G.2
  • 180
    • 0031789878 scopus 로고    scopus 로고
    • Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and Neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus
    • Sahu A. Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and Neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology 1998, 139:4739-4742.
    • (1998) Endocrinology , vol.139 , pp. 4739-4742
    • Sahu, A.1
  • 181
    • 0031789878 scopus 로고    scopus 로고
    • Leptin decreases food intake induced by melanin-concentrating hormone (MCH), Galanin (GAL) and Neuropeptide Y (NPY) in the rat
    • Sahu A. Leptin decreases food intake induced by melanin-concentrating hormone (MCH), Galanin (GAL) and Neuropeptide Y (NPY) in the rat. Endocrinology 1998, 139:4739-4742.
    • (1998) Endocrinology , vol.139 , pp. 4739-4742
    • Sahu, A.1
  • 184
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • Saladin R., Devos P., Guerre-Millo M., Leturge A., Girard J., Al E. Transient increase in obese gene expression after food intake or insulin administration. Nature 1995, 377:527-529.
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    Devos, P.2    Guerre-Millo, M.3    Leturge, A.4    Girard, J.5    Al, E.6
  • 185
    • 0018790626 scopus 로고
    • An autoradiographic study of the efferent connections of the lateral hypothalamic area in the rat
    • Saper C.B., Swanson L.W., Cowan W.M. An autoradiographic study of the efferent connections of the lateral hypothalamic area in the rat. J. Comp. Neurol. 1979, 183:689-706.
    • (1979) J. Comp. Neurol. , vol.183 , pp. 689-706
    • Saper, C.B.1    Swanson, L.W.2    Cowan, W.M.3
  • 187
    • 84880678420 scopus 로고    scopus 로고
    • Functional organization of neuronal and humoral signals regulating feeding behavior
    • Schwartz G.J., Zeltser L.M. Functional organization of neuronal and humoral signals regulating feeding behavior. Annu. Rev. Nutr. 2013, 33:1-21.
    • (2013) Annu. Rev. Nutr. , vol.33 , pp. 1-21
    • Schwartz, G.J.1    Zeltser, L.M.2
  • 192
    • 78650023056 scopus 로고    scopus 로고
    • Galanin-like peptide and the regulation of feeding behavior and energy metabolism
    • Shiba K., Kageyama H., Takenoya F., Shioda S. Galanin-like peptide and the regulation of feeding behavior and energy metabolism. FEBS J. 2010, 277:5006-5013.
    • (2010) FEBS J. , vol.277 , pp. 5006-5013
    • Shiba, K.1    Kageyama, H.2    Takenoya, F.3    Shioda, S.4
  • 194
    • 0033166333 scopus 로고    scopus 로고
    • Leptin effects on feeding-related hypothalamic and peripheral neuronal activities in normal and obese rats
    • Shiraishi T., Sasaki K., Niijima A., Oomura Y. Leptin effects on feeding-related hypothalamic and peripheral neuronal activities in normal and obese rats. Nutrition 1999, 15:576-579.
    • (1999) Nutrition , vol.15 , pp. 576-579
    • Shiraishi, T.1    Sasaki, K.2    Niijima, A.3    Oomura, Y.4
  • 195
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • Spanswick D., Smith M.a., Groppi V.E., Logan S.D., Ashford M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 1997, 390:521-525.
    • (1997) Nature , vol.390 , pp. 521-525
    • Spanswick, D.1    Smith, M.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.L.5
  • 196
    • 0000555383 scopus 로고
    • Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior
    • Stanley B.G., Leibowitz S. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. U. S. A. 1985, 82:3940-3943.
    • (1985) Proc. Natl. Acad. Sci. U. S. A. , vol.82 , pp. 3940-3943
    • Stanley, B.G.1    Leibowitz, S.2
  • 200
    • 27744457512 scopus 로고    scopus 로고
    • Topographic mapping of VMH→arcuate nucleus microcircuits and their reorganization by fasting
    • Sternson S.M., Shepherd G.M.G., Friedman J.M. Topographic mapping of VMH→arcuate nucleus microcircuits and their reorganization by fasting. Nat. Neurosci. 2005, 8:1356-1363.
    • (2005) Nat. Neurosci. , vol.8 , pp. 1356-1363
    • Sternson, S.M.1    Shepherd, G.M.G.2    Friedman, J.M.3
  • 201
    • 0035051365 scopus 로고    scopus 로고
    • Distribution of galanin-like peptide in the rat brain
    • Takatsu Y., Matsumoto H., Ohtaki T. Distribution of galanin-like peptide in the rat brain. Endocrinology 2001, 142:1626-1634.
    • (2001) Endocrinology , vol.142 , pp. 1626-1634
    • Takatsu, Y.1    Matsumoto, H.2    Ohtaki, T.3
  • 205
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia L.A. The leptin receptor. J. Biol. Chem. 1997, 272:6093-6096.
    • (1997) J. Biol. Chem. , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 207
    • 0029852865 scopus 로고    scopus 로고
    • Organization of projections from the dorsomedial nucleus of the hypothalamus: a immuno-PHA-L study in the rat
    • Thompson R.H., Canteras N.S., Swanson L.W. Organization of projections from the dorsomedial nucleus of the hypothalamus: a immuno-PHA-L study in the rat. J. Comp. Neurol. 1996, 376:143-173.
    • (1996) J. Comp. Neurol. , vol.376 , pp. 143-173
    • Thompson, R.H.1    Canteras, N.S.2    Swanson, L.W.3
  • 208
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • Thornton J.E., Cheung C.C., Clifton D.K., Steiner R.A. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 1997, 138:5063-5066.
    • (1997) Endocrinology , vol.138 , pp. 5063-5066
    • Thornton, J.E.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 209
    • 73249136773 scopus 로고    scopus 로고
    • Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues
    • Toda C., Shiuchi T., Lee S., Yamato-esaki M., Fujino Y., Suzuki A., Okamoto S., Minokoshi Y. Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes 2009, 58:2757-2765.
    • (2009) Diabetes , vol.58 , pp. 2757-2765
    • Toda, C.1    Shiuchi, T.2    Lee, S.3    Yamato-esaki, M.4    Fujino, Y.5    Suzuki, A.6    Okamoto, S.7    Minokoshi, Y.8
  • 210
    • 0027765548 scopus 로고
    • Neuroendocrine regulation of thyrotropin-releasing hormone (TRH) in the tuberoinfundibular system
    • Toni R., Lechan R. Neuroendocrine regulation of thyrotropin-releasing hormone (TRH) in the tuberoinfundibular system. J. Endocrinol. Invest. 1993, 16:715-753.
    • (1993) J. Endocrinol. Invest. , vol.16 , pp. 715-753
    • Toni, R.1    Lechan, R.2
  • 211
    • 0035937540 scopus 로고    scopus 로고
    • Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus
    • Tritos N.A., Mastaitis J.W., Kokkotou E., Maratos-Flier E. Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus. Brain Res. 2001, 895:160-166.
    • (2001) Brain Res. , vol.895 , pp. 160-166
    • Tritos, N.A.1    Mastaitis, J.W.2    Kokkotou, E.3    Maratos-Flier, E.4
  • 215
    • 84868265622 scopus 로고    scopus 로고
    • Contribution of the mesolimbic dopamine system in mediating the effects of leptin and ghrelin on feeding
    • van Zessen R., van der Plasse G., Adan R.a.H. Contribution of the mesolimbic dopamine system in mediating the effects of leptin and ghrelin on feeding. Proc. Nutr. Soc. 2012, 71:435-445.
    • (2012) Proc. Nutr. Soc. , vol.71 , pp. 435-445
    • van Zessen, R.1    van der Plasse, G.2    Adan, R.3
  • 216
    • 0034704344 scopus 로고    scopus 로고
    • Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding
    • Volkoff H., Peter R.E. Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding. Brain Res. 2000, 887:125-133.
    • (2000) Brain Res. , vol.887 , pp. 125-133
    • Volkoff, H.1    Peter, R.E.2
  • 217
    • 79960190012 scopus 로고    scopus 로고
    • Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
    • Vong L., Ye C., Yang Z., Choi B., Chua S., Lowell B.B. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 2011, 71:142-154.
    • (2011) Neuron , vol.71 , pp. 142-154
    • Vong, L.1    Ye, C.2    Yang, Z.3    Choi, B.4    Chua, S.5    Lowell, B.B.6
  • 218
    • 0033561832 scopus 로고    scopus 로고
    • Neurochemical characterization of hypothalamic cocaine-amphetamine-regulated transcript neurons
    • Vrang N., Larsen P.J., Clausen J.T., Kristensen P. Neurochemical characterization of hypothalamic cocaine-amphetamine-regulated transcript neurons. J. Neurosci. 1999, 19:RC5.
    • (1999) J. Neurosci. , vol.19 , pp. RC5
    • Vrang, N.1    Larsen, P.J.2    Clausen, J.T.3    Kristensen, P.4
  • 220
    • 0025062613 scopus 로고
    • Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin-diabetic rats
    • White J.D., Olchovsky D., Kershay M., Berelowitz M. Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin-diabetic rats. Endocrinology 1990, 126:765-772.
    • (1990) Endocrinology , vol.126 , pp. 765-772
    • White, J.D.1    Olchovsky, D.2    Kershay, M.3    Berelowitz, M.4
  • 222
  • 226
    • 0032823747 scopus 로고    scopus 로고
    • Centrally administered murine leptin stimulates plasma arginine-vasopressin secretion and increases the level of mRNA expression in the supraoptic nucleus of conscious rats
    • Yamamoto S., Morimoto I., Kai K., Arao T., Fujihira T., Morita E., Kannan H., Eto S. Centrally administered murine leptin stimulates plasma arginine-vasopressin secretion and increases the level of mRNA expression in the supraoptic nucleus of conscious rats. Neuroendocrinology 1999, 70:207-212.
    • (1999) Neuroendocrinology , vol.70 , pp. 207-212
    • Yamamoto, S.1    Morimoto, I.2    Kai, K.3    Arao, T.4    Fujihira, T.5    Morita, E.6    Kannan, H.7    Eto, S.8
  • 228
    • 2542450776 scopus 로고    scopus 로고
    • Modulation of direct leptin signaling by soluble leptin receptor
    • Yang G., Ge H., Boucher A., Yu X., Li C. Modulation of direct leptin signaling by soluble leptin receptor. Mol. Endocrinol. 2004, 18:1354-1362.
    • (2004) Mol. Endocrinol. , vol.18 , pp. 1354-1362
    • Yang, G.1    Ge, H.2    Boucher, A.3    Yu, X.4    Li, C.5
  • 232
    • 54349113070 scopus 로고    scopus 로고
    • Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight
    • Zhang R., Dhillon H., Yin H., Yoshimura A., Lowell B.B., Maratos-Flier E., Flier J.S. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology 2008, 149:5654-5661.
    • (2008) Endocrinology , vol.149 , pp. 5654-5661
    • Zhang, R.1    Dhillon, H.2    Yin, H.3    Yoshimura, A.4    Lowell, B.B.5    Maratos-Flier, E.6    Flier, J.S.7
  • 233
    • 79551512119 scopus 로고    scopus 로고
    • Leptin receptor expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits
    • Zhang Y., Kerman I.A., Laque A., Nguyen P., Faouzi M., Louis W., Jones J.C., Rhodes C., Münzberg H. Leptin receptor expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J. Neurosci. 2011, 31:1873-1884.
    • (2011) J. Neurosci. , vol.31 , pp. 1873-1884
    • Zhang, Y.1    Kerman, I.A.2    Laque, A.3    Nguyen, P.4    Faouzi, M.5    Louis, W.6    Jones, J.C.7    Rhodes, C.8    Münzberg, H.9


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