Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1

Journal of Physiology

Volumn 504, Issue 3, 1997, Pages 527-535

  Harvey, J ^a   McKenna, F ^a   Herson, P S ^a   Spanswick, D ^a   Ashford, M L J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIAZOXIDE; GLIBENCLAMIDE; INSULIN; LEPTIN; POTASSIUM CHANNEL; POTASSIUM ION; TOLBUTAMIDE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; HYPERPOLARIZATION; INSULIN RELEASE; NONHUMAN; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; VOLTAGE CLAMP; CONCENTRATION (PARAMETERS); CRI G1 CELL LINE; ENZYME INHIBITION; MEMBRANE CONDUCTANCE; PANCREAS ISLET BETA CELL; RAT; VOLTAGE CLAMP TECHNIQUE; WHOLE CELL PATCH CLAMP;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOTRANSFORMATION; CELL LINE; ELECTROPHYSIOLOGY; HYPOGLYCEMIC AGENTS; INSULIN; ION CHANNEL GATING; LEPTIN; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PROTEINS; RATS; TOLBUTAMIDE;

EID: 0030729888     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1997.527bd.x     Document Type: Article

References (25)

1. ASHCROFT, S. J. H. & ASHCROFT, F. M. (1990). Properties and functions of ATP-sensitive K-channels. Cellular Signalling 2, 197-214.
2. ASHCROFT, S. J. H. & ASHCROFT, F. M. (1992). The sulphonylurea receptor. Biochimica et Biophysica Acta 1175, 45-59.
3. ASHCROFT, F. M. & RORSMAN, P. (1991). The electrophysiology of the pancreatic β-cell. Progress in Biophysics and Molecular Biology 54, 87-143.
4. CAMPFIELD, L. A., SMITH, F. J., GIUSEZ, Y., DEVOS, R. & BURN, P. (1995). Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546-549.
5. CARO, J. F., SINHA, M. K., KOLACZYNSKI, J. W., ZHANG, P. L. & CONSIDINE, R. V. (1996). Leptin: the tale of an obesity gene. Diabetes 45, 1455-1462
6. CARRINGTON, C. A., RUBERY, E. D., PEARSON, E. C. & HALES, C. N. (1986). Five new insulin-producing cell lines with differing secretory properties. Journal of Endocrinology 109, 193-200.
7. CONSIDINE, R. V., CONSIDINE, E. L., WILLIAMS, C. J., NYCE, M. R., ZHANG, P. L., OPENTANOVA, I., OHANNESIAN, J. P. KOLACZYNSKI, J. W., BAUER, T. L., MOORE, J. H. & CARO, J. F. (1996). Mutation screening and identification of a sequence variation in the human ob gene coding. Biochemical and Biophysical Research Communications, 220, 735-739.
8. EMILSSON, V., LIU, Y.-L., CAWTHORNE, M. A., MORTON, N. M. & DAVENPORT, M. (1997). Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46, 313-316.
9. HALAAS, J. L., GAJIWALA, K. S., MAFFEI, M., COHEN, S. L., CHAIT, B. T., RABINOWITZ, D., LALLONE, R. L., BURLEY, S. K. & FREIDMAN, J. M. (1995). Weight reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546.
10. JACOB, R. J., DZIURA, J., MEDWICK, M. B., LEONE, P., CAPRIO, S., DURING, M., SHULMAN, G. I. & SHERWIN, R. S. (1997). The effect of leptin is enhanced by microinjection into the ventromedical hypothalamus. Diabetes 46, 150-152.
11. KEIFFER, T. J., HELLER, R. S. & HABENER, J. F. (1996). Leptin receptors expressed on pancreatic β-cells. Biochemical and Biophysical Research Communications 224, 522-527.
12. ATP channels by diazoxide in CRI-G1 insulin-secreting cells. British Journal of Pharmacology 107, 34-43.
13. LEE, G., PROENCA, R., MONTEZ, J. M., CARROLL, K. M., DARVISHZADEH, J. G., LEE, J. I. & FREIDMAN, J. M. (1996). Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632-635.
14. + channel present in rat cortical neurones. Journal of Physiology 488, 319-337.
15. LEVIN, N., NELSON, C., GURNEY, A., VANDLEN, R. & DE SAUVAGE, F. (1996). Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proceedings of the National Academy of Sciences of the USA 93, 1726-1730.
16. MAFFEI, M., STOFFEL, M., BARONE, M., MOON, B., DAMMERMAN, M., RAVUSSIN, E., BOGARDUS, C., LUDWIG, D. S., FLIER, J. S., TALLEY, M., AUERBACH, S. & FRIEDMAN, J. M. (1996). Absence of mutations in the human OB gene in obese/diabetic subjects. Diabetes 45, 679-682.
17. MASUZAKI, H., OGAWA, Y., ISSE, N., SATOH, N., OKAZAKI, T., SHIGEMOTO, M., MORI, K., TAMURA, N., HOSADA, K., YOSHIMA, Y., JINGAMI, H., KAWADA, T. & NAKAO, K. (1995). Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44, 855-858.
18. PELLEYMOUNTER, M. A., CULLEN, M. J., BAKER, M. B., HECHT, R., WINTERS, D., BOONE, T. & COLLINS, F. (1995). Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543.
19. PREVARSKAYA, N. B., SKRYMA, R. N., VACHER, P., DANIEL, N., DJIANE, J. & DUFY, B. (1995). Role of tyrosine phosphorylation in potassium channel activation; functional association with prolactin receptor and JAK2 tyrosine kinase. Journal of Biological Chemistry 41, 24292-24299.
20. SINHA, M. K., OPENTANOVA, I., OHANNESIAN, J. P., KOLACZYNSKI, J. W., HEIMAN, M. L., HALE, J., BECKER, G. W., BOWSHER, R. R., STEPHENS, T. W. & CARO, J. F. (1996). Evidence of free and bound leptin in human circulation: studies in lean and obese subjects and during short-term fasting. Journal of Clinical Investigation 98, 1277-1282.
21. STEPHENS, T. W., BASINSKI, M., BRISTOW, P. K., BUE-VALLESKEY, J. M., BURGETT, S. G., CRAFT, L., HALE, J., HOFFMA, J., HSUING, H. M., KRIACIUNAS, A., MACKELLAR, W., ROSTECK, P. R. JR, SCHONER, B., SMITH, D., TINSLEY, F. C., ZHANG, X. Y. & HEIMAN, M. (1995). The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530-532.
22. STURGESS, N. C., KOZLOWSKI, R. Z., CARRINGTON, C. A., HALES, C. N. & ASHFORD, M. L. J. (1988). Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line. British Journal of Pharmacology 95, 83-94.
23. TARTAGLIA, L. A., DEMBSKI, M., WENG, X., DENG, X., CULPEPPER, J., DEVOS, R., RICHARDS, G. J., CAMPFIELD, L. A., CLARK, F. T., DEEDS, J., MUIR, C., SANKER, S., MORIARTY, A., MOORE, K. J., SMUTKO, J. S., MAYS, G. G., WOOLF, E. A., MONROE, C. A. & TEPPER, R. I. (1995). Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271.
24. + channel in mouse pancreatic β-cells. Pflügers Archiv 407, 493-499.
25. ZHANG, Y., PROENCA, R., MAFFEI, M., BARONE, M., LEOPOLD, L. & FREIDMAN, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432.