Fate of leptin after intracerebroventricular injection into the mouse brain

Endocrinology

Volumn 139, Issue 11, 1998, Pages 4556-4562

  Maness, Lawrence M ^a,d   Kastin, Abba J ^a   Farrell, Catherine L ^b   Banks, William A ^c  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b AMGEN INC   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BLOOD CEREBROSPINAL FLUID BARRIER; CONTROLLED STUDY; DRUG PENETRATION; ENZYME DEGRADATION; IMAGE ANALYSIS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLIC REGULATION; MIDDLE CEREBRAL ARTERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN TRANSPORT;

EID: 0031766974     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.11.6319     Document Type: Article

References (13)

1. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549
2. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
3. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C, Kuijper JL 1995 Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96:2065-2070
4. Zhang Y, Proenca R, Maffel M, Barone M, Leopold L, Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
5. Malik KF, Young WS, III 1996 Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice. Endocrinology 137:1497-1500
6. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P 1996 Localization of leptin receptor mRNA and the long form splice varient (ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 387:113-116
7. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir, C, Sanker, S, Moriarty, A, Moore, KJ, Smutko, JS, Mays, GG, Woolf, EA, Monroe, CA, Tepper, RI 1995 Indentification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271
8. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM 1996 Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311
9. Maness LM, Banks WA, Zadina JE, Kastin AJ 1996 Periveniticular penetration and disappearance of icv Tyr-MIF-1, DAMGO, tyrosine, and albumin. Peptides 17:247-250
10. Greenblatt DJ, Koch-Weser J 1975 Clinical pharmacokinetics. N Engl J Med 293:702-705
11. Reed DJ, Woodbury DM, Jacobs L, Squires R 1965 factors affecting distribution of iodide in brain and cerebrospinal fluid. Am J Physiol 209:757-764
12. Davson H, Welch K, Segal MB 1987 The return of cerebrospinal fluid to the blood: the drainage mechanism. In: The Physiology and Pathophysiology of the Cerebrospinal Fluid. Churchill Livingstone, Edinburgh, pp 485-521
13. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG 1996 Identification of targets of leptin action in the rat hypothalamus. J Clin Invest 98:1101-1106