메뉴 건너뛰기




Volumn 397, Issue 1-2, 2014, Pages 4-14

Connecting metabolism and reproduction: Roles of central energy sensors and key molecular mediators

Author keywords

Energy balance; GnRH; Kisspeptins; Leptin; Puberty; Reproduction

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KISSPEPTIN; NEUROPEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; STAT3 PROTEIN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

EID: 84914133446     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2014.09.027     Document Type: Review
Times cited : (116)

References (125)
  • 1
    • 84874407275 scopus 로고    scopus 로고
    • PI3K: an attractive candidate for the central integration of metabolism and reproduction
    • Acosta-Martinez M. PI3K: an attractive candidate for the central integration of metabolism and reproduction. Front. Endocrinol 2012, 2:110.
    • (2012) Front. Endocrinol , vol.2 , pp. 110
    • Acosta-Martinez, M.1
  • 3
    • 70350389400 scopus 로고    scopus 로고
    • Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons
    • Al-Qassab H., Smith M.A., Irvine E.E., Guillermet-Guibert J., Claret M., Choudhury A.I., et al. Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab 2009, 10:343-354.
    • (2009) Cell Metab , vol.10 , pp. 343-354
    • Al-Qassab, H.1    Smith, M.A.2    Irvine, E.E.3    Guillermet-Guibert, J.4    Claret, M.5    Choudhury, A.I.6
  • 4
    • 53549133638 scopus 로고    scopus 로고
    • The Creb1 coactivator Crtc1 is required for energy balance and fertility
    • Altarejos J.Y., Goebel N., Conkright M.D., Inoue H., Xie J., Arias C.M., et al. The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat. Med 2008, 14:1112-1117.
    • (2008) Nat. Med , vol.14 , pp. 1112-1117
    • Altarejos, J.Y.1    Goebel, N.2    Conkright, M.D.3    Inoue, H.4    Xie, J.5    Arias, C.M.6
  • 6
    • 77953148020 scopus 로고    scopus 로고
    • Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells
    • Backholer K., Smith J.T., Rao A., Pereira A., Iqbal J., Ogawa S., et al. Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology 2010, 151:2233-2243.
    • (2010) Endocrinology , vol.151 , pp. 2233-2243
    • Backholer, K.1    Smith, J.T.2    Rao, A.3    Pereira, A.4    Iqbal, J.5    Ogawa, S.6
  • 7
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • Bates S.H., Stearns W.H., Dundon T.A., Schubert M., Tso A.W., Wang Y., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003, 421:856-859.
    • (2003) Nature , vol.421 , pp. 856-859
    • Bates, S.H.1    Stearns, W.H.2    Dundon, T.A.3    Schubert, M.4    Tso, A.W.5    Wang, Y.6
  • 10
    • 64149086946 scopus 로고    scopus 로고
    • Kisspeptin stimulation of insulin secretion: mechanisms of action in mouse islets and rats
    • Bowe J.E., King A.J., Kinsey-Jones J.S., Foot V.L., Li X.F., O'Byrne K.T., et al. Kisspeptin stimulation of insulin secretion: mechanisms of action in mouse islets and rats. Diabetologia 2009, 52:855-862.
    • (2009) Diabetologia , vol.52 , pp. 855-862
    • Bowe, J.E.1    King, A.J.2    Kinsey-Jones, J.S.3    Foot, V.L.4    Li, X.F.5    O'Byrne, K.T.6
  • 11
  • 12
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bruning J.C., Gautam D., Burks D.J., Gillette J., Schubert M., Orban P.C., et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000, 289:2122-2125.
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1    Gautam, D.2    Burks, D.J.3    Gillette, J.4    Schubert, M.5    Orban, P.C.6
  • 13
    • 64549127790 scopus 로고    scopus 로고
    • PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
    • Canto C., Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr. Opin. Lipidol 2009, 20:98-105.
    • (2009) Curr. Opin. Lipidol , vol.20 , pp. 98-105
    • Canto, C.1    Auwerx, J.2
  • 14
    • 0032739022 scopus 로고    scopus 로고
    • Neuroendocrine regulation and actions of leptin
    • Casanueva F.F., Dieguez C. Neuroendocrine regulation and actions of leptin. Front. Neuroendocrinol 1999, 20:317-363.
    • (1999) Front. Neuroendocrinol , vol.20 , pp. 317-363
    • Casanueva, F.F.1    Dieguez, C.2
  • 15
    • 33750591860 scopus 로고    scopus 로고
    • Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats
    • Castellano J.M., Navarro V.M., Fernandez-Fernandez R., Roa J., Vigo E., Pineda R., et al. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 2006, 55:2602-2610.
    • (2006) Diabetes , vol.55 , pp. 2602-2610
    • Castellano, J.M.1    Navarro, V.M.2    Fernandez-Fernandez, R.3    Roa, J.4    Vigo, E.5    Pineda, R.6
  • 18
    • 35348820823 scopus 로고    scopus 로고
    • Targeting the mTOR signaling network in cancer
    • Chiang G.G., Abraham R.T. Targeting the mTOR signaling network in cancer. Trends Mol. Med 2007, 13:433-442.
    • (2007) Trends Mol. Med , vol.13 , pp. 433-442
    • Chiang, G.G.1    Abraham, R.T.2
  • 20
    • 34247886103 scopus 로고    scopus 로고
    • The role of CNS fuel sensing in energy and glucose regulation
    • Cota D., Proulx K., Seeley R.J. The role of CNS fuel sensing in energy and glucose regulation. Gastroenterology 2007, 132:2158-2168.
    • (2007) Gastroenterology , vol.132 , pp. 2158-2168
    • Cota, D.1    Proulx, K.2    Seeley, R.J.3
  • 21
    • 49049114337 scopus 로고    scopus 로고
    • The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    • Cota D., Matter E.K., Woods S.C., Seeley R.J. The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J. Neurosci 2008, 28:7202-7208.
    • (2008) J. Neurosci , vol.28 , pp. 7202-7208
    • Cota, D.1    Matter, E.K.2    Woods, S.C.3    Seeley, R.J.4
  • 22
    • 39549114798 scopus 로고    scopus 로고
    • The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats
    • Coyral-Castel S., Tosca L., Ferreira G., Jeanpierre E., Rame C., Lomet D., et al. The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats. J. Neuroendocrinol 2008, 20:335-346.
    • (2008) J. Neuroendocrinol , vol.20 , pp. 335-346
    • Coyral-Castel, S.1    Tosca, L.2    Ferreira, G.3    Jeanpierre, E.4    Rame, C.5    Lomet, D.6
  • 25
    • 33846032275 scopus 로고    scopus 로고
    • Gastrointestinal regulation of food intake
    • Cummings D.E., Overduin J. Gastrointestinal regulation of food intake. J. Clin. Invest 2007, 117:13-23.
    • (2007) J. Clin. Invest , vol.117 , pp. 13-23
    • Cummings, D.E.1    Overduin, J.2
  • 27
    • 78650956096 scopus 로고    scopus 로고
    • Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
    • Donato J., Cravo R.M., Frazao R., Gautron L., Scott M.M., Lachey J., et al. Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J. Clin. Invest 2011, 121:355-368.
    • (2011) J. Clin. Invest , vol.121 , pp. 355-368
    • Donato, J.1    Cravo, R.M.2    Frazao, R.3    Gautron, L.4    Scott, M.M.5    Lachey, J.6
  • 28
    • 84876452980 scopus 로고    scopus 로고
    • Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus-estrus transition
    • Donato J., Lee C., Ratra D., Franci C.R., Canteras N.S., Elias C.F. Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus-estrus transition. Neuroscience 2013, 241:67-79.
    • (2013) Neuroscience , vol.241 , pp. 67-79
    • Donato, J.1    Lee, C.2    Ratra, D.3    Franci, C.R.4    Canteras, N.S.5    Elias, C.F.6
  • 29
    • 84855220278 scopus 로고    scopus 로고
    • Leptin action in pubertal development: recent advances and unanswered questions
    • Elias C.F. Leptin action in pubertal development: recent advances and unanswered questions. Trends Endocrinol. Metab 2012, 23:9-15.
    • (2012) Trends Endocrinol. Metab , vol.23 , pp. 9-15
    • Elias, C.F.1
  • 30
    • 84873718098 scopus 로고    scopus 로고
    • Leptin signaling and circuits in puberty and fertility
    • Elias C.F., Purohit D. Leptin signaling and circuits in puberty and fertility. Cell. Mol. Life Sci 2012, 70:841-862.
    • (2012) Cell. Mol. Life Sci , vol.70 , pp. 841-862
    • Elias, C.F.1    Purohit, D.2
  • 31
    • 84902957730 scopus 로고    scopus 로고
    • Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice
    • Evans M.C., Rizwan M., Mayer C., Boehm U., Anderson G.M. Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice. J. Neuroendocrinol 2014, 26:468-479.
    • (2014) J. Neuroendocrinol , vol.26 , pp. 468-479
    • Evans, M.C.1    Rizwan, M.2    Mayer, C.3    Boehm, U.4    Anderson, G.M.5
  • 34
    • 33744459206 scopus 로고    scopus 로고
    • Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies
    • Fernandez-Fernandez R., Tena-Sempere M., Navarro V.M., Barreiro M.L., Castellano J.M., Aguilar E., et al. Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies. Neuroendocrinology 2005, 82:245-255.
    • (2005) Neuroendocrinology , vol.82 , pp. 245-255
    • Fernandez-Fernandez, R.1    Tena-Sempere, M.2    Navarro, V.M.3    Barreiro, M.L.4    Castellano, J.M.5    Aguilar, E.6
  • 36
    • 0012104541 scopus 로고    scopus 로고
    • Neuroendocrine regulation of pituitary function: general principles
    • Humana Press, Totowa, NJ, P.M. Conn, M.E. Freeman (Eds.)
    • Fink G. Neuroendocrine regulation of pituitary function: general principles. Neuroendocrinology in Physiology and Medicine 2000, 107-134. Humana Press, Totowa, NJ. P.M. Conn, M.E. Freeman (Eds.).
    • (2000) Neuroendocrinology in Physiology and Medicine , pp. 107-134
    • Fink, G.1
  • 37
    • 67349194989 scopus 로고    scopus 로고
    • Effects of ghrelin on Kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat
    • Forbes S., Li X.F., Kinsey-Jones J., O'Byrne K. Effects of ghrelin on Kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat. Neurosci. Lett 2009, 460:143-147.
    • (2009) Neurosci. Lett , vol.460 , pp. 143-147
    • Forbes, S.1    Li, X.F.2    Kinsey-Jones, J.3    O'Byrne, K.4
  • 39
    • 0035834586 scopus 로고    scopus 로고
    • Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats
    • Furuta M., Funabashi T., Kimura F. Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem. Biophys. Res. Commun 2001, 288:780-785.
    • (2001) Biochem. Biophys. Res. Commun , vol.288 , pp. 780-785
    • Furuta, M.1    Funabashi, T.2    Kimura, F.3
  • 40
    • 35748958765 scopus 로고    scopus 로고
    • The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells
    • Galardo M.N., Riera M.F., Pellizzari E.H., Cigorraga S.B., Meroni S.B. The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells. J. Mol. Endocrinol 2007, 39:279-288.
    • (2007) J. Mol. Endocrinol , vol.39 , pp. 279-288
    • Galardo, M.N.1    Riera, M.F.2    Pellizzari, E.H.3    Cigorraga, S.B.4    Meroni, S.B.5
  • 42
    • 77953525385 scopus 로고    scopus 로고
    • The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat
    • Garcia-Galiano D., Navarro V.M., Roa J., Ruiz-Pino F., Sanchez-Garrido M.A., Pineda R., et al. The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat. J. Neurosci 2010, 30:7783-7792.
    • (2010) J. Neurosci , vol.30 , pp. 7783-7792
    • Garcia-Galiano, D.1    Navarro, V.M.2    Roa, J.3    Ruiz-Pino, F.4    Sanchez-Garrido, M.A.5    Pineda, R.6
  • 44
  • 45
    • 42449138247 scopus 로고    scopus 로고
    • Photoperiod influences the central effects of ghrelin on food intake, GH and LH secretion in sheep
    • Harrison J.L., Miller D.W., Findlay P.A., Adam C.L. Photoperiod influences the central effects of ghrelin on food intake, GH and LH secretion in sheep. Neuroendocrinology 2008, 87:182-192.
    • (2008) Neuroendocrinology , vol.87 , pp. 182-192
    • Harrison, J.L.1    Miller, D.W.2    Findlay, P.A.3    Adam, C.L.4
  • 47
    • 77954517914 scopus 로고    scopus 로고
    • Luteinizing hormone stimulates mammalian target of rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase: modulation of glycogen synthase kinase 3 and AMP-activated protein kinase
    • Hou X., Arvisais E.W., Davis J.S. Luteinizing hormone stimulates mammalian target of rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase: modulation of glycogen synthase kinase 3 and AMP-activated protein kinase. Endocrinology 2010, 151:2846-2857.
    • (2010) Endocrinology , vol.151 , pp. 2846-2857
    • Hou, X.1    Arvisais, E.W.2    Davis, J.S.3
  • 48
    • 57349185737 scopus 로고    scopus 로고
    • Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels
    • Huang W., Acosta-Martinez M., Horton T.H., Levine J.E. Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels. Am. J. Physiol. Endocrinol. Metab 2008, 295:E1439-E1446.
    • (2008) Am. J. Physiol. Endocrinol. Metab , vol.295 , pp. E1439-E1446
    • Huang, W.1    Acosta-Martinez, M.2    Horton, T.H.3    Levine, J.E.4
  • 49
    • 33847235398 scopus 로고    scopus 로고
    • Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview
    • Huyghe E., Zairi A., Nohra J., Kamar N., Plante P., Rostaing L. Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview. Transpl. Int 2007, 20:305-311.
    • (2007) Transpl. Int , vol.20 , pp. 305-311
    • Huyghe, E.1    Zairi, A.2    Nohra, J.3    Kamar, N.4    Plante, P.5    Rostaing, L.6
  • 50
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 51
    • 29344456423 scopus 로고    scopus 로고
    • Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep
    • Iqbal J., Kurose Y., Canny B., Clarke I.J. Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep. Endocrinology 2006, 147:510-519.
    • (2006) Endocrinology , vol.147 , pp. 510-519
    • Iqbal, J.1    Kurose, Y.2    Canny, B.3    Clarke, I.J.4
  • 52
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn B.B., Alquier T., Carling D., Hardie D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005, 1:15-25.
    • (2005) Cell Metab , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 53
    • 59649129909 scopus 로고    scopus 로고
    • Follicle-stimulating hormone inhibits adenosine 5'-monophosphate-activated protein kinase activation and promotes cell proliferation of primary granulosa cells in culture through an Akt-dependent pathway
    • Kayampilly P.P., Menon K.M. Follicle-stimulating hormone inhibits adenosine 5'-monophosphate-activated protein kinase activation and promotes cell proliferation of primary granulosa cells in culture through an Akt-dependent pathway. Endocrinology 2009, 150:929-935.
    • (2009) Endocrinology , vol.150 , pp. 929-935
    • Kayampilly, P.P.1    Menon, K.M.2
  • 54
    • 84861326693 scopus 로고    scopus 로고
    • AMPK activation by dihydrotestosterone reduces FSH-stimulated cell proliferation in rat granulosa cells by inhibiting ERK signaling pathway
    • Kayampilly P.P., Menon K.M. AMPK activation by dihydrotestosterone reduces FSH-stimulated cell proliferation in rat granulosa cells by inhibiting ERK signaling pathway. Endocrinology 2012, 153:2831-2838.
    • (2012) Endocrinology , vol.153 , pp. 2831-2838
    • Kayampilly, P.P.1    Menon, K.M.2
  • 56
    • 51649085619 scopus 로고    scopus 로고
    • Acylated ghrelin inhibits spontaneous LH pulsatility and responsiveness to naloxone, but not that to GnRH, in young men. Evidence for a central inhibitory action of ghrelin on the gonadal axis
    • Lanfranco F., Bonelli L., Baldi M., Me E., Broglio F., Ghigo E. Acylated ghrelin inhibits spontaneous LH pulsatility and responsiveness to naloxone, but not that to GnRH, in young men. Evidence for a central inhibitory action of ghrelin on the gonadal axis. J. Clin. Endocrinol. Metab 2008, 93(9):3633-3639.
    • (2008) J. Clin. Endocrinol. Metab , vol.93 , Issue.9 , pp. 3633-3639
    • Lanfranco, F.1    Bonelli, L.2    Baldi, M.3    Me, E.4    Broglio, F.5    Ghigo, E.6
  • 58
    • 70350418625 scopus 로고    scopus 로고
    • MTOR signaling at a glance
    • Laplante M., Sabatini D.M. mTOR signaling at a glance. J. Cell Sci 2009, 122:3589-3594.
    • (2009) J. Cell Sci , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 59
    • 33846837280 scopus 로고    scopus 로고
    • Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty
    • Lebrethon M.C., Aganina A., Fournier M., Gerard A., Parent A.S., Bourguignon J.P. Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty. J. Neuroendocrinol 2007, 19:181-188.
    • (2007) J. Neuroendocrinol , vol.19 , pp. 181-188
    • Lebrethon, M.C.1    Aganina, A.2    Fournier, M.3    Gerard, A.4    Parent, A.S.5    Bourguignon, J.P.6
  • 60
    • 77954895859 scopus 로고    scopus 로고
    • Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion
    • Lehman M.N., Coolen L.M., Goodman R.L. Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion. Endocrinology 2010, 151:3479-3489.
    • (2010) Endocrinology , vol.151 , pp. 3479-3489
    • Lehman, M.N.1    Coolen, L.M.2    Goodman, R.L.3
  • 61
    • 0036753494 scopus 로고    scopus 로고
    • Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    • Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 2002, 10:457-468.
    • (2002) Mol. Cell , vol.10 , pp. 457-468
    • Loewith, R.1    Jacinto, E.2    Wullschleger, S.3    Lorberg, A.4    Crespo, J.L.5    Bonenfant, D.6
  • 63
    • 34748840772 scopus 로고    scopus 로고
    • Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line
    • Luque R.M., Kineman R.D., Tena-Sempere M. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology 2007, 148:4601-4611.
    • (2007) Endocrinology , vol.148 , pp. 4601-4611
    • Luque, R.M.1    Kineman, R.D.2    Tena-Sempere, M.3
  • 64
    • 84899485312 scopus 로고    scopus 로고
    • Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone
    • Martin C., Navarro V.M., Simavli S., Vong L., Carroll R.S., Lowell B.B., et al. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J. Neurosci 2014, 6047-6056.
    • (2014) J. Neurosci , pp. 6047-6056
    • Martin, C.1    Navarro, V.M.2    Simavli, S.3    Vong, L.4    Carroll, R.S.5    Lowell, B.B.6
  • 65
    • 15044350668 scopus 로고    scopus 로고
    • The expanding TOR signaling network
    • Martin D.E., Hall M.N. The expanding TOR signaling network. Curr. Opin. Cell Biol 2005, 17:158-166.
    • (2005) Curr. Opin. Cell Biol , vol.17 , pp. 158-166
    • Martin, D.E.1    Hall, M.N.2
  • 67
    • 33645882953 scopus 로고    scopus 로고
    • Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats
    • Martini A.C., Fernandez-Fernandez R., Tovar S., Navarro V.M., Vigo E., Vazquez M.J., et al. Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology 2006, 147:2374-2382.
    • (2006) Endocrinology , vol.147 , pp. 2374-2382
    • Martini, A.C.1    Fernandez-Fernandez, R.2    Tovar, S.3    Navarro, V.M.4    Vigo, E.5    Vazquez, M.J.6
  • 69
    • 80055024323 scopus 로고    scopus 로고
    • MTOR kinase inhibition results in oocyte loss characterized by empty follicles in human ovarian cortical strips cultured in vitro
    • 1154-9 e1
    • McLaughlin M., Patrizio P., Kayisli U., Luk J., Thomson T.C., Anderson R.A., et al. mTOR kinase inhibition results in oocyte loss characterized by empty follicles in human ovarian cortical strips cultured in vitro. Fertil. Steril 2011, 96. 1154-9 e1.
    • (2011) Fertil. Steril , vol.96
    • McLaughlin, M.1    Patrizio, P.2    Kayisli, U.3    Luk, J.4    Thomson, T.C.5    Anderson, R.A.6
  • 70
    • 0347627140 scopus 로고    scopus 로고
    • Amino acid signalling and the integration of metabolism
    • Meijer A.J., Dubbelhuis P.F. Amino acid signalling and the integration of metabolism. Biochem. Biophys. Res. Commun 2004, 313:397-403.
    • (2004) Biochem. Biophys. Res. Commun , vol.313 , pp. 397-403
    • Meijer, A.J.1    Dubbelhuis, P.F.2
  • 71
    • 42949164617 scopus 로고    scopus 로고
    • Sex steroids and leptin regulate the "first Kiss" (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts
    • Morelli A., Marini M., Mancina R., Luconi M., Vignozzi L., Fibbi B., et al. Sex steroids and leptin regulate the "first Kiss" (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts. J. Sex. Med 2008, 5:1097-1113.
    • (2008) J. Sex. Med , vol.5 , pp. 1097-1113
    • Morelli, A.1    Marini, M.2    Mancina, R.3    Luconi, M.4    Vignozzi, L.5    Fibbi, B.6
  • 73
    • 83555176139 scopus 로고    scopus 로고
    • Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility
    • Navarro V.M., Tena-Sempere M. Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat. Rev. Endocrinol 2012, 8:40-53.
    • (2012) Nat. Rev. Endocrinol , vol.8 , pp. 40-53
    • Navarro, V.M.1    Tena-Sempere, M.2
  • 74
    • 33646356466 scopus 로고    scopus 로고
    • Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis
    • Navarro V.M., Fernandez-Fernandez R., Nogueiras R., Vigo E., Tovar S., Chartrel N., et al. Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis. J. Physiol 2006, 573:237-249.
    • (2006) J. Physiol , vol.573 , pp. 237-249
    • Navarro, V.M.1    Fernandez-Fernandez, R.2    Nogueiras, R.3    Vigo, E.4    Tovar, S.5    Chartrel, N.6
  • 77
    • 84866995270 scopus 로고    scopus 로고
    • Luteinizing hormone/human chorionic gonadotropin-mediated activation of mTORC1 signaling is required for androgen synthesis by theca-interstitial cells
    • Palaniappan M., Menon K.M. Luteinizing hormone/human chorionic gonadotropin-mediated activation of mTORC1 signaling is required for androgen synthesis by theca-interstitial cells. Mol. Endocrinol 2012, 26:1732-1742.
    • (2012) Mol. Endocrinol , vol.26 , pp. 1732-1742
    • Palaniappan, M.1    Menon, K.M.2
  • 78
    • 34548604499 scopus 로고    scopus 로고
    • Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    • Parton L.E., Ye C.P., Coppari R., Enriori P.J., Choi B., Zhang C.Y., et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 2007, 449:228-232.
    • (2007) Nature , vol.449 , pp. 228-232
    • Parton, L.E.1    Ye, C.P.2    Coppari, R.3    Enriori, P.J.4    Choi, B.5    Zhang, C.Y.6
  • 79
    • 84864067222 scopus 로고    scopus 로고
    • Kisspeptins and reproduction: physiological roles and regulatory mechanisms
    • Pinilla L., Aguilar E., Dieguez C., Millar R.P., Tena-Sempere M. Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiol. Rev 2012, 92:1235-1316.
    • (2012) Physiol. Rev , vol.92 , pp. 1235-1316
    • Pinilla, L.1    Aguilar, E.2    Dieguez, C.3    Millar, R.P.4    Tena-Sempere, M.5
  • 80
    • 77953915672 scopus 로고    scopus 로고
    • Insulin and NPY pathways and the control of GnRH function and puberty onset
    • Pralong F.P. Insulin and NPY pathways and the control of GnRH function and puberty onset. Mol. Cell. Endocrinol 2010, 324:82-86.
    • (2010) Mol. Cell. Endocrinol , vol.324 , pp. 82-86
    • Pralong, F.P.1
  • 81
    • 79953211082 scopus 로고    scopus 로고
    • Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels
    • Qiu J., Fang Y., Bosch M.A., Ronnekleiv O.K., Kelly M.J. Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels. Endocrinology 2011, 152:1503-1514.
    • (2011) Endocrinology , vol.152 , pp. 1503-1514
    • Qiu, J.1    Fang, Y.2    Bosch, M.A.3    Ronnekleiv, O.K.4    Kelly, M.J.5
  • 82
    • 84897507249 scopus 로고    scopus 로고
    • Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels
    • Qiu J., Zhang C., Borgquist A., Nestor C.C., Smith A.W., Bosch M.A., et al. Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels. Cell Metab 2014, 19:682-693.
    • (2014) Cell Metab , vol.19 , pp. 682-693
    • Qiu, J.1    Zhang, C.2    Borgquist, A.3    Nestor, C.C.4    Smith, A.W.5    Bosch, M.A.6
  • 83
    • 84874623222 scopus 로고    scopus 로고
    • Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from kiss1 cells
    • Qiu X., Dowling A.R., Marino J.S., Faulkner L.D., Bryant B., Bruning J.C., et al. Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from kiss1 cells. Endocrinology 2013, 154:1337-1348.
    • (2013) Endocrinology , vol.154 , pp. 1337-1348
    • Qiu, X.1    Dowling, A.R.2    Marino, J.S.3    Faulkner, L.D.4    Bryant, B.5    Bruning, J.C.6
  • 84
    • 66649136446 scopus 로고    scopus 로고
    • Leptin indirectly regulates gonadotropin-releasing hormone neuronal function
    • Quennell J.H., Mulligan A.C., Tups A., Liu X., Phipps S.J., Kemp C.J., et al. Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology 2009, 150:2805-2812.
    • (2009) Endocrinology , vol.150 , pp. 2805-2812
    • Quennell, J.H.1    Mulligan, A.C.2    Tups, A.3    Liu, X.4    Phipps, S.J.5    Kemp, C.J.6
  • 85
    • 79953209692 scopus 로고    scopus 로고
    • Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice
    • Quennell J.H., Howell C.S., Roa J., Augustine R.A., Grattan D.R., Anderson G.M. Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology 2011, 152:1541-1550.
    • (2011) Endocrinology , vol.152 , pp. 1541-1550
    • Quennell, J.H.1    Howell, C.S.2    Roa, J.3    Augustine, R.A.4    Grattan, D.R.5    Anderson, G.M.6
  • 86
    • 84916603593 scopus 로고    scopus 로고
    • Chemical identity of hypothalamic neurons engaged by leptin in reproductive control
    • Ratra D.V., Elias C.F. Chemical identity of hypothalamic neurons engaged by leptin in reproductive control. J. Chem. Neuroanat 2014.
    • (2014) J. Chem. Neuroanat
    • Ratra, D.V.1    Elias, C.F.2
  • 89
    • 84867764901 scopus 로고    scopus 로고
    • Direct regulation of GnRH neuron excitability by arcuate nucleus POMC and NPY neuron neuropeptides in female mice
    • Roa J., Herbison A.E. Direct regulation of GnRH neuron excitability by arcuate nucleus POMC and NPY neuron neuropeptides in female mice. Endocrinology 2012, 153:5587-5599.
    • (2012) Endocrinology , vol.153 , pp. 5587-5599
    • Roa, J.1    Herbison, A.E.2
  • 90
    • 77956191511 scopus 로고    scopus 로고
    • Energy balance and puberty onset: emerging role of central mTOR signaling
    • Roa J., Tena-Sempere M. Energy balance and puberty onset: emerging role of central mTOR signaling. Trends Endocrinol. Metab 2010, 21:519-528.
    • (2010) Trends Endocrinol. Metab , vol.21 , pp. 519-528
    • Roa, J.1    Tena-Sempere, M.2
  • 91
    • 70350266820 scopus 로고    scopus 로고
    • The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system
    • Roa J., Garcia-Galiano D., Varela L., Sanchez-Garrido M.A., Pineda R., Castellano J.M., et al. The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology 2009, 150:5016-5026.
    • (2009) Endocrinology , vol.150 , pp. 5016-5026
    • Roa, J.1    Garcia-Galiano, D.2    Varela, L.3    Sanchez-Garrido, M.A.4    Pineda, R.5    Castellano, J.M.6
  • 93
    • 79955768198 scopus 로고    scopus 로고
    • Glucosensing by GnRH neurons: inhibition by androgens and involvement of AMP-activated protein kinase
    • Roland A.V., Moenter S.M. Glucosensing by GnRH neurons: inhibition by androgens and involvement of AMP-activated protein kinase. Mol. Endocrinol 2011, 25:847-858.
    • (2011) Mol. Endocrinol , vol.25 , pp. 847-858
    • Roland, A.V.1    Moenter, S.M.2
  • 94
    • 77955241269 scopus 로고    scopus 로고
    • Nutritional and metabolic mechanisms in the ovary and their role in mediating the effects of diet on folliculogenesis: a perspective
    • Scaramuzzi R.J., Brown H.M., Dupont J. Nutritional and metabolic mechanisms in the ovary and their role in mediating the effects of diet on folliculogenesis: a perspective. Reprod. Domest. Anim 2010, 45(Suppl. 3):32-41.
    • (2010) Reprod. Domest. Anim , vol.45 , pp. 32-41
    • Scaramuzzi, R.J.1    Brown, H.M.2    Dupont, J.3
  • 95
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell 2000, 103:253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 96
    • 0141844771 scopus 로고    scopus 로고
    • Neuroendocrine regulation of reproductive cyclicity
    • Vol. Humana Press, Totowa, NJ, P.M. Conn, M.E. Freeman (Eds.)
    • Schwartz N.B. Neuroendocrine regulation of reproductive cyclicity. Neuroendocrinology in Physiology and Medicine 2000, 135-146. Vol. Humana Press, Totowa, NJ. P.M. Conn, M.E. Freeman (Eds.).
    • (2000) Neuroendocrinology in Physiology and Medicine , pp. 135-146
    • Schwartz, N.B.1
  • 97
    • 39749129636 scopus 로고    scopus 로고
    • Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas
    • Silvestre R.A., Egido E.M., Hernandez R., Marco J. Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas. J. Endocrinol 2008, 196:283-290.
    • (2008) J. Endocrinol , vol.196 , pp. 283-290
    • Silvestre, R.A.1    Egido, E.M.2    Hernandez, R.3    Marco, J.4
  • 98
    • 0038649174 scopus 로고    scopus 로고
    • Central orexin A has site-specific effects on luteinizing hormone release in female rats
    • Small C.J., Goubillon M.L., Murray J.F., Siddiqui A., Grimshaw S.E., Young H., et al. Central orexin A has site-specific effects on luteinizing hormone release in female rats. Endocrinology 2003, 144:3225-3236.
    • (2003) Endocrinology , vol.144 , pp. 3225-3236
    • Small, C.J.1    Goubillon, M.L.2    Murray, J.F.3    Siddiqui, A.4    Grimshaw, S.E.5    Young, H.6
  • 101
    • 84867112902 scopus 로고    scopus 로고
    • Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis
    • Tanwar P.S., Kaneko-Tarui T., Zhang L., Teixeira J.M. Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis. Hum. Mol. Genet 2012, 21:4394-4405.
    • (2012) Hum. Mol. Genet , vol.21 , pp. 4394-4405
    • Tanwar, P.S.1    Kaneko-Tarui, T.2    Zhang, L.3    Teixeira, J.M.4
  • 102
    • 35948995689 scopus 로고    scopus 로고
    • Roles of ghrelin and leptin in the control of reproductive function
    • Tena-Sempere M. Roles of ghrelin and leptin in the control of reproductive function. Neuroendocrinology 2007, 86:229-241.
    • (2007) Neuroendocrinology , vol.86 , pp. 229-241
    • Tena-Sempere, M.1
  • 103
    • 56649102174 scopus 로고    scopus 로고
    • Ghrelin as a pleotrophic modulator of gonadal function and reproduction
    • Tena-Sempere M. Ghrelin as a pleotrophic modulator of gonadal function and reproduction. Nat. Clin. Pract. Endocrinol. Metab 2008, 4:666-674.
    • (2008) Nat. Clin. Pract. Endocrinol. Metab , vol.4 , pp. 666-674
    • Tena-Sempere, M.1
  • 104
    • 35648974703 scopus 로고    scopus 로고
    • Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis
    • Tena-Sempere M. Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis. Vitam. Horm 2008, 77:285-300.
    • (2008) Vitam. Horm , vol.77 , pp. 285-300
    • Tena-Sempere, M.1
  • 105
    • 84890546876 scopus 로고    scopus 로고
    • Interaction between energy homeostasis and reproduction: central effects of leptin and ghrelin on the reproductive axis
    • Tena-Sempere M. Interaction between energy homeostasis and reproduction: central effects of leptin and ghrelin on the reproductive axis. Horm. Metab. Res 2013, 45:919-927.
    • (2013) Horm. Metab. Res , vol.45 , pp. 919-927
    • Tena-Sempere, M.1
  • 106
    • 84877997143 scopus 로고    scopus 로고
    • Ghrelin, the gonadal axis and the onset of puberty
    • Tena-Sempere M. Ghrelin, the gonadal axis and the onset of puberty. Endocr. Dev 2013, 25:69-82.
    • (2013) Endocr. Dev , vol.25 , pp. 69-82
    • Tena-Sempere, M.1
  • 108
    • 84903765478 scopus 로고    scopus 로고
    • Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity
    • Tolson K.P., Garcia C., Yen S., Simonds S., Stefanidis A., Lawrence A., et al. Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity. J. Clin. Invest 2014, 124:3075-3079.
    • (2014) J. Clin. Invest , vol.124 , pp. 3075-3079
    • Tolson, K.P.1    Garcia, C.2    Yen, S.3    Simonds, S.4    Stefanidis, A.5    Lawrence, A.6
  • 109
    • 24944486315 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells
    • Tosca L., Froment P., Solnais P., Ferre P., Foufelle F., Dupont J. Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells. Endocrinology 2005, 146:4500-4513.
    • (2005) Endocrinology , vol.146 , pp. 4500-4513
    • Tosca, L.1    Froment, P.2    Solnais, P.3    Ferre, P.4    Foufelle, F.5    Dupont, J.6
  • 110
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • Tsang C.K., Qi H., Liu L.F., Zheng X.F. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov. Today 2007, 12:112-124.
    • (2007) Drug Discov. Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.4
  • 111
    • 70349315117 scopus 로고    scopus 로고
    • Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status
    • Villanueva E.C., Munzberg H., Cota D., Leshan R.L., Kopp K., Ishida-Takahashi R., et al. Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology 2009, 150:4541-4551.
    • (2009) Endocrinology , vol.150 , pp. 4541-4551
    • Villanueva, E.C.1    Munzberg, H.2    Cota, D.3    Leshan, R.L.4    Kopp, K.5    Ishida-Takahashi, R.6
  • 112
    • 8744313973 scopus 로고    scopus 로고
    • Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey
    • Vulliemoz N.R., Xiao E., Xia-Zhang L., Germond M., Rivier J., Ferin M. Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey. J. Clin. Endocrinol. Metab 2004, 89:5718-5723.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 5718-5723
    • Vulliemoz, N.R.1    Xiao, E.2    Xia-Zhang, L.3    Germond, M.4    Rivier, J.5    Ferin, M.6
  • 113
    • 40849116453 scopus 로고    scopus 로고
    • Astressin B, a nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey
    • Vulliemoz N.R., Xiao E., Xia-Zhang L., Rivier J., Ferin M. Astressin B, a nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey. Endocrinology 2008, 149:869-874.
    • (2008) Endocrinology , vol.149 , pp. 869-874
    • Vulliemoz, N.R.1    Xiao, E.2    Xia-Zhang, L.3    Rivier, J.4    Ferin, M.5
  • 114
    • 44349194320 scopus 로고    scopus 로고
    • Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential
    • Wen J.P., Lv W.S., Yang J., Nie A.F., Cheng X.B., Yang Y., et al. Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential. Biochem. Biophys. Res. Commun 2008, 371:756-761.
    • (2008) Biochem. Biophys. Res. Commun , vol.371 , pp. 756-761
    • Wen, J.P.1    Lv, W.S.2    Yang, J.3    Nie, A.F.4    Cheng, X.B.5    Yang, Y.6
  • 115
    • 84866285290 scopus 로고    scopus 로고
    • Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons
    • Wen J.P., Liu C., Bi W.K., Hu Y.T., Chen Q., Huang H., et al. Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons. J. Endocrinol 2012, 214:177-189.
    • (2012) J. Endocrinol , vol.214 , pp. 177-189
    • Wen, J.P.1    Liu, C.2    Bi, W.K.3    Hu, Y.T.4    Chen, Q.5    Huang, H.6
  • 116
    • 80052935067 scopus 로고    scopus 로고
    • The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus
    • Williams K.W., Sohn J.W., Donato J., Lee C.E., Zhao J.J., Elmquist J.K., et al. The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus. J. Neurosci 2011, 31:13147-13156.
    • (2011) J. Neurosci , vol.31 , pp. 13147-13156
    • Williams, K.W.1    Sohn, J.W.2    Donato, J.3    Lee, C.E.4    Zhao, J.J.5    Elmquist, J.K.6
  • 117
    • 84885914511 scopus 로고    scopus 로고
    • Adiponectin protects Leydig cells against proinflammatory cytokines by suppressing the nuclear factor-kappaB signaling pathway
    • Wu L., Xu B., Fan W., Zhu X., Wang G., Zhang A. Adiponectin protects Leydig cells against proinflammatory cytokines by suppressing the nuclear factor-kappaB signaling pathway. FEBS J. 2013, 280:3920-3927.
    • (2013) FEBS J. , vol.280 , pp. 3920-3927
    • Wu, L.1    Xu, B.2    Fan, W.3    Zhu, X.4    Wang, G.5    Zhang, A.6
  • 118
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S., Loewith R., Hall M.N. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 119
    • 84874376748 scopus 로고    scopus 로고
    • Cross-talk between metabolism and reproduction: the role of POMC and SF1 neurons
    • Xu Y., Faulkner L.D., Hill J.W. Cross-talk between metabolism and reproduction: the role of POMC and SF1 neurons. Front. Endocrinol 2012, 2:98.
    • (2012) Front. Endocrinol , vol.2 , pp. 98
    • Xu, Y.1    Faulkner, L.D.2    Hill, J.W.3
  • 120
    • 79960024518 scopus 로고    scopus 로고
    • MTOR controls ovarian follicle growth by regulating granulosa cell proliferation
    • Yu J., Yaba A., Kasiman C., Thomson T., Johnson J. mTOR controls ovarian follicle growth by regulating granulosa cell proliferation. PLoS ONE 2011, 6:e21415.
    • (2011) PLoS ONE , vol.6 , pp. e21415
    • Yu, J.1    Yaba, A.2    Kasiman, C.3    Thomson, T.4    Johnson, J.5
  • 121
    • 84859914883 scopus 로고    scopus 로고
    • Cross talk between estradiol and mTOR kinase in the regulation of ovarian granulosa proliferation
    • Yu J., Thomson T.C., Johnson J. Cross talk between estradiol and mTOR kinase in the regulation of ovarian granulosa proliferation. Reprod. Sci 2012, 19:143-151.
    • (2012) Reprod. Sci , vol.19 , pp. 143-151
    • Yu, J.1    Thomson, T.C.2    Johnson, J.3
  • 122
    • 34548820963 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition
    • Zhang C., Bosch M.A., Levine J.E., Ronnekleiv O.K., Kelly M.J. Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition. J. Neurosci 2007, 27:10153-10164.
    • (2007) J. Neurosci , vol.27 , pp. 10153-10164
    • Zhang, C.1    Bosch, M.A.2    Levine, J.E.3    Ronnekleiv, O.K.4    Kelly, M.J.5
  • 123
    • 84877816563 scopus 로고    scopus 로고
    • Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
    • Zhang X.M., Li L., Xu J.J., Wang N., Liu W.J., Lin X.H., et al. Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression. Gene 2013, 523:82-87.
    • (2013) Gene , vol.523 , pp. 82-87
    • Zhang, X.M.1    Li, L.2    Xu, J.J.3    Wang, N.4    Liu, W.J.5    Lin, X.H.6
  • 124
    • 79958208151 scopus 로고    scopus 로고
    • Activation of PI3K/mTOR signaling pathway contributes to induction of vascular endothelial growth factor by hCG in bovine developing luteal cells
    • Zhang Z., Yu D., Yin D., Wang Z. Activation of PI3K/mTOR signaling pathway contributes to induction of vascular endothelial growth factor by hCG in bovine developing luteal cells. Anim. Reprod. Sci 2011, 125:42-48.
    • (2011) Anim. Reprod. Sci , vol.125 , pp. 42-48
    • Zhang, Z.1    Yu, D.2    Yin, D.3    Wang, Z.4
  • 125
    • 84887064714 scopus 로고    scopus 로고
    • Leptin signaling in GABA neurons, but not glutamate neurons, is required for reproductive function
    • Zuure W.A., Roberts A.L., Quennell J.H., Anderson G.M. Leptin signaling in GABA neurons, but not glutamate neurons, is required for reproductive function. J. Neurosci 2013, 33:17874-17883.
    • (2013) J. Neurosci , vol.33 , pp. 17874-17883
    • Zuure, W.A.1    Roberts, A.L.2    Quennell, J.H.3    Anderson, G.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.