Glucagon regulates hepatic kisspeptin to impair insulin secretion

Cell Metabolism

Volumn 19, Issue 4, 2014, Pages 667-681

  Song, Woo Jin ^a,b   Mondal, Prosenjit ^a,b   Wolfe, Andrew ^a,b   Alonso, Laura C ^c   Stamateris, Rachel ^c   Ong, Benny W T ^a,b   Lim, Owen C ^a,b   Yang, Kil S ^a,b   Radovick, Sally ^a,b   Novaira, Horacio J ^a,b   Farber, Emily A ^d   Farber, Charles R ^d   Turner, Stephen D ^d   Hussain, Mehboob A ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; ISOBUTYLMETHYLXANTHINE; KISSPEPTIN; KISSPEPTIN1; LIVER EXTRACT; METASTIN; UNCLASSIFIED DRUG; INSULIN; KISS1 PROTEIN, MOUSE; LUCIFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GLUCOSE MONITORING; CALORIC INTAKE; CONTROLLED STUDY; GENE SILENCING; GLUCAGON BLOOD LEVEL; GLUCAGON RELEASE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLUCAGONEMIA; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; INSULIN TREATMENT; LIPID DIET; LIVER METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; BIOLOGICAL MODEL; BLOOD; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUCAGON; GLUCONEOGENESIS; IMMUNOHISTOCHEMISTRY; INSULIN; KISSPEPTINS; LIVER; LUCIFERASES; MICE; MICE, INBRED NOD; MODELS, BIOLOGICAL;

EID: 84897504321     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.03.005     Document Type: Article

References (38)

1. A. Akinci, D. Cetin, and N. Ilhan Plasma kisspeptin levels in girls with premature thelarche J. Clin. Res. Pediatr. Endocrinol. 4 2012 61 65
2. L.C. Alonso, T. Yokoe, P. Zhang, D.K. Scott, S.K. Kim, C.P. O'Donnell, and A. Garcia-Ocaña Glucose infusion in mice: a new model to induce beta-cell replication Diabetes 56 2007 1792 1801
3. T. Barrett, T.O. Suzek, D.B. Troup, S.E. Wilhite, W.C. Ngau, P. Ledoux, D. Rudnev, A.E. Lash, W. Fujibuchi, and R. Edgar NCBI GEO: mining millions of expression profiles - database and tools Nucleic Acids Res. 33 Database issue 2005 D562 D566
4. J.E. Bowe, V.L. Foot, S.A. Amiel, G.C. Huang, M. Lamb, J. Lakey, P.M. Jones, and S.J. Persaud GPR54 peptide agonists stimulate insulin secretion from murine, porcine and human islets Islets 4 2012 20 23
5. J.C. Brüning, J. Winnay, S. Bonner-Weir, S.I. Taylor, D. Accili, and C.R. Kahn Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles Cell 88 1997 561 572
6. A. Cetković, D. Miljic, A. Ljubić, M. Patterson, M. Ghatei, J. Stamenković, M. Nikolic-Djurovic, S. Pekic, M. Doknic, and A. Glišić et al. Plasma kisspeptin levels in pregnancies with diabetes and hypertensive disease as a potential marker of placental dysfunction and adverse perinatal outcome Endocr. Res. 37 2012 78 88
7. M. Chen, O. Gavrilova, W.Q. Zhao, A. Nguyen, J. Lorenzo, L. Shen, L. Nackers, S. Pack, W. Jou, and L.S. Weinstein Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency J. Clin. Invest. 115 2005 3217 3227
8. D. D'Alessio The role of dysregulated glucagon secretion in type 2 diabetes Diabetes Obes. Metab. 13 Suppl 1 2011 126 132
9. D.J. Drucker The biology of incretin hormones Cell Metab. 3 2006 153 165
10. A. El Ouaamari, D. Kawamori, E. Dirice, C.W. Liew, J.L. Shadrach, J. Hu, H. Katsuta, J. Hollister-Lock, W.J. Qian, A.J. Wagers, and R.N. Kulkarni Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states Cell Rep. 3 2013 401 410
11. G.A. Gonzalez, and M.R. Montminy Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 Cell 59 1989 675 680
12. A.C. Hauge-Evans, C.C. Richardson, H.M. Milne, M.R. Christie, S.J. Persaud, and P.M. Jones A role for kisspeptin in islet function Diabetologia 49 2006 2131 2135
13. L. He, A. Sabet, S. Djedjos, R. Miller, X. Sun, M.A. Hussain, S. Radovick, and F.E. Wondisford Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein Cell 137 2009 635 646
14. Y. Horikoshi, H. Matsumoto, Y. Takatsu, T. Ohtaki, C. Kitada, S. Usuki, and M. Fujino Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans J. Clin. Endocrinol. Metab. 88 2003 914 919
15. R.A. Jamison, R. Stark, J. Dong, S. Yonemitsu, D. Zhang, G.I. Shulman, and R.G. Kibbey Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats Am. J. Physiol. Endocrinol. Metab. 301 2011 E1174 E1183
16. T.J. Kieffer, R.S. Heller, C.A. Leech, G.G. Holz, and J.F. Habener Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells Diabetes 46 1997 1087 1093
17. L.S. Kirschner, D.F. Kusewitt, L. Matyakhina, W.H. Towns 2nd, J.A. Carney, H. Westphal, and C.A. Stratakis A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues Cancer Res. 65 2005 4506 4514
18. E. Lammert, O. Cleaver, and D. Melton Induction of pancreatic differentiation by signals from blood vessels Science 294 2001 564 567
19. D.K. Lee, T. Nguyen, G.P. O'Neill, R. Cheng, Y. Liu, A.D. Howard, N. Coulombe, C.P. Tan, A.T. Tang-Nguyen, S.R. George, and B.F. O'Dowd Discovery of a receptor related to the galanin receptors FEBS Lett. 446 1999 103 107
20. Z. Liu, C. Ren, W. Jones, P. Chen, S.B. Seminara, Y.M. Chan, N.F. Smith, J.M. Covey, J. Wang, and K.K. Chan LC-MS/MS quantification of a neuropeptide fragment kisspeptin-10 (NSC 741805) and characterization of its decomposition product and pharmacokinetics in rats J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 926 2013 1 8
21. J.J. Logie, F.C. Denison, S.C. Riley, T. Ramaesh, S. Forbes, J.E. Norman, and R.M. Reynolds Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre-eclampsia Clin. Endocrinol. (Oxf.) 76 2012 887 893
22. C. Longuet, A.M. Robledo, E.D. Dean, C. Dai, S. Ali, I. McGuinness, V. de Chavez, P.M. Vuguin, M.J. Charron, A.C. Powers, and D.J. Drucker Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor Diabetes 62 2013 1196 1205
23. J.F. Louet, A.R. Chopra, J.V. Sagen, J. An, B. York, M. Tannour-Louet, P.K. Saha, R.D. Stevens, B.R. Wenner, and O.R. Ilkayeva et al. The coactivator SRC-1 is an essential coordinator of hepatic glucose production Cell Metab. 12 2010 606 618
24. J.J. Meier, and M.A. Nauck Is secretion of glucagon-like peptide-1 reduced in type 2 diabetes mellitus? Nat. Clin. Pract. Endocrinol. Metab. 4 2008 606 607
25. C.M. Niswender, B.S. Willis, A. Wallen, I.R. Sweet, T.L. Jetton, B.R. Thompson, C. Wu, A.J. Lange, and G.S. McKnight Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A Genesis 43 2005 109 119
26. H.J. Novaira, M.L. Sonko, G. Hoffman, Y. Koo, C. Ko, A. Wolfe, and S. Radovick Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism Mol. Endocrinol 28 2013 225 238
27. T. Ohtaki, Y. Shintani, S. Honda, H. Matsumoto, A. Hori, K. Kanehashi, Y. Terao, S. Kumano, Y. Takatsu, and Y. Masuda et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor Nature 411 2001 613 617
28. S.A. Qureshi, M. Rios Candelore, D. Xie, X. Yang, L.M. Tota, V.D. Ding, Z. Li, A. Bansal, C. Miller, and S.M. Cohen et al. A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects Diabetes 53 2004 3267 3273
29. S.B. Seminara, and U.B. Kaiser New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1 Endocrinology 146 2005 1686 1688
30. P. Sherline, A. Lynch, and W.H. Glinsmann Cyclic AMP and adrenergic receptor control of rat liver glycogen metabolism Endocrinology 91 1972 680 690
31. R.A. Silvestre, E.M. Egido, R. Hernández, and J. Marco Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas J. Endocrinol. 196 2008 283 290
32. J.T. Smith, B.V. Acohido, D.K. Clifton, and R.A. Steiner KiSS-1 neurones are direct targets for leptin in the ob/ob mouse J. Neuroendocrinol. 18 2006 298 303
33. W.J. Song, M. Seshadri, U. Ashraf, T. Mdluli, P. Mondal, M. Keil, M. Azevedo, L.S. Kirschner, C.A. Stratakis, and M.A. Hussain Snapin mediates incretin action and augments glucose-dependent insulin secretion Cell Metab. 13 2011 308 319
34. G. Tang, Y. Wang, S. Park, N.S. Bajpayee, D. Vi, Y. Nagaoka, L. Birnbaumer, and M. Jiang Go2 G protein mediates galanin inhibitory effects on insulin release from pancreatic β cells Proc. Natl. Acad. Sci. USA 109 2012 2636 2641
35. J. Vikman, and B. Ahrén Inhibitory effect of kisspeptins on insulin secretion from isolated mouse islets Diabetes Obes. Metab. 11 Suppl 4 2009 197 201
36. F. Wahab, T. Riaz, and M. Shahab Study on the effect of peripheral kisspeptin administration on basal and glucose-induced insulin secretion under fed and fasting conditions in the adult male rhesus monkey (Macaca mulatta) Horm. Metab. Res. 43 2011 37 42
37. P. Yi, J.S. Park, and D.A. Melton Betatrophin: a hormone that controls pancreatic β cell proliferation Cell 153 2013 747 758
38. X. Zhang, D.T. Odom, S.H. Koo, M.D. Conkright, G. Canettieri, J. Best, H. Chen, R. Jenner, E. Herbolsheimer, and E. Jacobsen et al. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues Proc. Natl. Acad. Sci. USA 102 2005 4459 4464