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Volumn 61, Issue 1, 2014, Pages S26-S33

HCV animal models and liver disease

Author keywords

Animal models; Antiviral therapy; Pathology; Viral hepatitis

Indexed keywords

VIRUS PROTEIN; ANTIVIRUS AGENT; VIRUS VACCINE;

EID: 84913554793     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.07.013     Document Type: Review
Times cited : (38)

References (139)
  • 1
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Q.L. Choo, G. Kuo, A.J. Weiner, L.R. Overby, D.W. Bradley, and M. Houghton Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome Science 244 1989 359 362
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 3
    • 2542530063 scopus 로고    scopus 로고
    • A critical role for the chimpanzee model in the study of hepatitis C
    • J. Bukh A critical role for the chimpanzee model in the study of hepatitis C Hepatology 39 2004 1469 1475
    • (2004) Hepatology , vol.39 , pp. 1469-1475
    • Bukh, J.1
  • 4
    • 79953314182 scopus 로고    scopus 로고
    • HCV animal models: A journey of more than 30 years
    • P. Meuleman, and G. Leroux-Roels HCV animal models: a journey of more than 30 years Viruses 1 2009 222 240
    • (2009) Viruses , vol.1 , pp. 222-240
    • Meuleman, P.1    Leroux-Roels, G.2
  • 5
    • 84860287115 scopus 로고    scopus 로고
    • Animal models for the study of hepatitis C virus infection and related liver disease
    • J. Bukh Animal models for the study of hepatitis C virus infection and related liver disease Gastroenterology 142 2012 e1273
    • (2012) Gastroenterology , vol.142 , pp. 1273
    • Bukh, J.1
  • 7
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of HCV RNA replication in cell culture
    • K.J. Blight, A.A. Kolykhalov, and C.M. Rice Efficient initiation of HCV RNA replication in cell culture Science 290 2000 1972 1974
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 8
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • E. Foy, K. Li, C. Wang, R. Sumpter Jr., M. Ikeda, and S.M. Lemon Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease Science 300 2003 1145 1148
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3    Sumpter, R.4    Ikeda, M.5    Lemon, S.M.6
  • 9
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • E. Meylan, J. Curran, K. Hofmann, D. Moradpour, M. Binder, and R. Bartenschlager Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus Nature 437 2005 1167 1172
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6
  • 10
    • 68949105585 scopus 로고    scopus 로고
    • Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factor-induced signal transduction by cleavage of the T-cell protein tyrosine phosphatase
    • E.D. Brenndorfer, J. Karthe, L. Frelin, P. Cebula, A. Erhardt, and J. Schulte am Esch Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factor-induced signal transduction by cleavage of the T-cell protein tyrosine phosphatase Hepatology 49 2009 1810 1820
    • (2009) Hepatology , vol.49 , pp. 1810-1820
    • Brenndorfer, E.D.1    Karthe, J.2    Frelin, L.3    Cebula, P.4    Erhardt, A.5    Schulte Am Esch, J.6
  • 11
    • 0032737567 scopus 로고    scopus 로고
    • Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate
    • T.F. Baumert, J. Vergalla, J. Satoi, M. Thomson, M. Lechmann, and D. Herion Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate Gastroenterology 117 1999 1397 1407
    • (1999) Gastroenterology , vol.117 , pp. 1397-1407
    • Baumert, T.F.1    Vergalla, J.2    Satoi, J.3    Thomson, M.4    Lechmann, M.5    Herion, D.6
  • 12
    • 0037416146 scopus 로고    scopus 로고
    • Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes
    • B. Bartosch, J. Dubuisson, and F.L. Cosset Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes J Exp Med 197 2003 633 642
    • (2003) J Exp Med , vol.197 , pp. 633-642
    • Bartosch, B.1    Dubuisson, J.2    Cosset, F.L.3
  • 13
    • 0038471344 scopus 로고    scopus 로고
    • Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
    • M. Hsu, J. Zhang, M. Flint, C. Logvinoff, C. Cheng-Mayer, and C.M. Rice Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles Proc Natl Acad Sci U S A 100 2003 7271 7276
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7271-7276
    • Hsu, M.1    Zhang, J.2    Flint, M.3    Logvinoff, C.4    Cheng-Mayer, C.5    Rice, C.M.6
  • 14
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • T. Wakita, T. Pietschmann, T. Kato, T. Date, M. Miyamoto, and Z. Zhao Production of infectious hepatitis C virus in tissue culture from a cloned viral genome Nat Med 11 2005 791 796
    • (2005) Nat Med , vol.11 , pp. 791-796
    • Wakita, T.1    Pietschmann, T.2    Kato, T.3    Date, T.4    Miyamoto, M.5    Zhao, Z.6
  • 17
    • 84879420038 scopus 로고    scopus 로고
    • The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection
    • R. Bartenschlager, V. Lohmann, and F. Penin The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection Nat Rev Microbiol 11 2013 482 496
    • (2013) Nat Rev Microbiol , vol.11 , pp. 482-496
    • Bartenschlager, R.1    Lohmann, V.2    Penin, F.3
  • 18
    • 79251561245 scopus 로고    scopus 로고
    • Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virus
    • T. Shimakami, C. Welsch, D. Yamane, D.R. McGivern, M. Yi, and S. Zeuzem Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virus Gastroenterology 140 2011 667 675
    • (2011) Gastroenterology , vol.140 , pp. 667-675
    • Shimakami, T.1    Welsch, C.2    Yamane, D.3    McGivern, D.R.4    Yi, M.5    Zeuzem, S.6
  • 19
    • 84860817692 scopus 로고    scopus 로고
    • Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains
    • Y.P. Li, S. Ramirez, J.M. Gottwein, T.K. Scheel, L. Mikkelsen, and R.H. Purcell Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains Proc Natl Acad Sci U S A 109 2012 E1101 E1110
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 1101-E1110
    • Li, Y.P.1    Ramirez, S.2    Gottwein, J.M.3    Scheel, T.K.4    Mikkelsen, L.5    Purcell, R.H.6
  • 20
    • 84870372937 scopus 로고    scopus 로고
    • Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system
    • Y.P. Li, S. Ramirez, S.B. Jensen, R.H. Purcell, J.M. Gottwein, and J. Bukh Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system Proc Natl Acad Sci U S A 109 2012 19757 19762
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 19757-19762
    • Li, Y.P.1    Ramirez, S.2    Jensen, S.B.3    Purcell, R.H.4    Gottwein, J.M.5    Bukh, J.6
  • 21
    • 84867398704 scopus 로고    scopus 로고
    • Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone
    • T. Date, T. Kato, J. Kato, H. Takahashi, K. Morikawa, and D. Akazawa Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone J Virol 86 2012 10805 10820
    • (2012) J Virol , vol.86 , pp. 10805-10820
    • Date, T.1    Kato, T.2    Kato, J.3    Takahashi, H.4    Morikawa, K.5    Akazawa, D.6
  • 22
    • 84893053264 scopus 로고    scopus 로고
    • Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors
    • S. Ramirez, Y.P. Li, S.B. Jensen, J. Pedersen, J.M. Gottwein, and J. Bukh Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors Hepatology 59 2014 395 407
    • (2014) Hepatology , vol.59 , pp. 395-407
    • Ramirez, S.1    Li, Y.P.2    Jensen, S.B.3    Pedersen, J.4    Gottwein, J.M.5    Bukh, J.6
  • 24
    • 45749124737 scopus 로고    scopus 로고
    • Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems
    • J.M. Gottwein, and J. Bukh Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems Adv Virus Res 71 2008 51 133
    • (2008) Adv Virus Res , vol.71 , pp. 51-133
    • Gottwein, J.M.1    Bukh, J.2
  • 25
    • 34250699025 scopus 로고    scopus 로고
    • Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues
    • K.M. Olsavsky, J.L. Page, M.C. Johnson, H. Zarbl, S.C. Strom, and C.J. Omiecinski Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues Toxicol Appl Pharmacol 222 2007 42 56
    • (2007) Toxicol Appl Pharmacol , vol.222 , pp. 42-56
    • Olsavsky, K.M.1    Page, J.L.2    Johnson, M.C.3    Zarbl, H.4    Strom, S.C.5    Omiecinski, C.J.6
  • 26
    • 1842427904 scopus 로고    scopus 로고
    • The maintenance and generation of membrane polarity in hepatocytes
    • L. Wang, and J.L. Boyer The maintenance and generation of membrane polarity in hepatocytes Hepatology 39 2004 892 899
    • (2004) Hepatology , vol.39 , pp. 892-899
    • Wang, L.1    Boyer, J.L.2
  • 27
    • 77958051586 scopus 로고    scopus 로고
    • Advances and challenges in studying hepatitis C virus in its native environment
    • T. Sheahan, C.T. Jones, and A. Ploss Advances and challenges in studying hepatitis C virus in its native environment Expert Rev Gastroenterol Hepatol 4 2010 541 550
    • (2010) Expert Rev Gastroenterol Hepatol , vol.4 , pp. 541-550
    • Sheahan, T.1    Jones, C.T.2    Ploss, A.3
  • 28
    • 77957341223 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in primary cultures of human adult hepatocytes
    • P. Podevin, A. Carpentier, V. Pene, L. Aoudjehane, M. Carriere, and S. Zaidi Production of infectious hepatitis C virus in primary cultures of human adult hepatocytes Gastroenterology 139 2010 1355 1364
    • (2010) Gastroenterology , vol.139 , pp. 1355-1364
    • Podevin, P.1    Carpentier, A.2    Pene, V.3    Aoudjehane, L.4    Carriere, M.5    Zaidi, S.6
  • 30
    • 82455175215 scopus 로고    scopus 로고
    • Expression of paramyxovirus v proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells
    • L. Andrus, S. Marukian, C.T. Jones, M.T. Catanese, T.P. Sheahan, and J.W. Schoggins Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells Hepatology 54 2011 1901 1912
    • (2011) Hepatology , vol.54 , pp. 1901-1912
    • Andrus, L.1    Marukian, S.2    Jones, C.T.3    Catanese, M.T.4    Sheahan, T.P.5    Schoggins, J.W.6
  • 31
    • 82455188188 scopus 로고    scopus 로고
    • Hepatitis C virus induces interferon-lambda and interferon-stimulated genes in primary liver cultures
    • S. Marukian, L. Andrus, T.P. Sheahan, C.T. Jones, E.D. Charles, and A. Ploss Hepatitis C virus induces interferon-lambda and interferon-stimulated genes in primary liver cultures Hepatology 54 2011 1913 1923
    • (2011) Hepatology , vol.54 , pp. 1913-1923
    • Marukian, S.1    Andrus, L.2    Sheahan, T.P.3    Jones, C.T.4    Charles, E.D.5    Ploss, A.6
  • 32
    • 84865572917 scopus 로고    scopus 로고
    • Efficient replication of primary or culture hepatitis C virus isolates in human liver slices: A relevant ex vivo model of liver infection
    • S. Lagaye, H. Shen, B. Saunier, M. Nascimbeni, J. Gaston, and P. Bourdoncle Efficient replication of primary or culture hepatitis C virus isolates in human liver slices: a relevant ex vivo model of liver infection Hepatology 56 2012 861 872
    • (2012) Hepatology , vol.56 , pp. 861-872
    • Lagaye, S.1    Shen, H.2    Saunier, B.3    Nascimbeni, M.4    Gaston, J.5    Bourdoncle, P.6
  • 33
    • 84861206498 scopus 로고    scopus 로고
    • Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation
    • X. Wu, J.M. Robotham, E. Lee, S. Dalton, N.M. Kneteman, and D.M. Gilbert Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation PLoS Pathog 8 2012 e1002617
    • (2012) PLoS Pathog , vol.8 , pp. 1002617
    • Wu, X.1    Robotham, J.M.2    Lee, E.3    Dalton, S.4    Kneteman, N.M.5    Gilbert, D.M.6
  • 34
    • 84863982020 scopus 로고    scopus 로고
    • Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus
    • P. Roelandt, S. Obeid, J. Paeshuyse, J. Vanhove, A. Van Lommel, and Y. Nahmias Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus J Hepatol 57 2012 246 251
    • (2012) J Hepatol , vol.57 , pp. 246-251
    • Roelandt, P.1    Obeid, S.2    Paeshuyse, J.3    Vanhove, J.4    Van Lommel, A.5    Nahmias, Y.6
  • 36
    • 84922233514 scopus 로고    scopus 로고
    • Successful anti-SR-BI mAb therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents
    • [Epub ahead of print].
    • K. Vercauteren, N. Van Den Eede, A.A. Mesalam, S. Belouzard, M.T. Catanese, and D. Bankwitz Successful anti-SR-BI mAb therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents Hepatology 2014 [Epub ahead of print]. http://dx.doi.org/10.1002/hep.27196
    • (2014) Hepatology
    • Vercauteren, K.1    Van Den Eede, N.2    Mesalam, A.A.3    Belouzard, S.4    Catanese, M.T.5    Bankwitz, D.6
  • 38
    • 0037195180 scopus 로고    scopus 로고
    • Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees
    • J. Bukh, T. Pietschmann, V. Lohmann, N. Krieger, K. Faulk, and R.E. Engle Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees Proc Natl Acad Sci U S A 99 2002 14416 14421
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14416-14421
    • Bukh, J.1    Pietschmann, T.2    Lohmann, V.3    Krieger, N.4    Faulk, K.5    Engle, R.E.6
  • 39
    • 84886772600 scopus 로고    scopus 로고
    • Hepatic cells derived from induced pluripotent stem cells of pigtail macaques support hepatitis C virus infection
    • M. Sourisseau, O. Goldman, W. He, J.L. Gori, H.P. Kiem, and V. Gouon-Evans Hepatic cells derived from induced pluripotent stem cells of pigtail macaques support hepatitis C virus infection Gastroenterology 145 2013 e967
    • (2013) Gastroenterology , vol.145 , pp. 967
    • Sourisseau, M.1    Goldman, O.2    He, W.3    Gori, J.L.4    Kiem, H.P.5    Gouon-Evans, V.6
  • 40
    • 0027662272 scopus 로고
    • Lack of susceptibility of various primates and woodchucks to hepatitis C virus
    • K. Abe, T. Kurata, Y. Teramoto, J. Shiga, and T. Shikata Lack of susceptibility of various primates and woodchucks to hepatitis C virus J Med Primatol 22 1993 433 434
    • (1993) J Med Primatol , vol.22 , pp. 433-434
    • Abe, K.1    Kurata, T.2    Teramoto, Y.3    Shiga, J.4    Shikata, T.5
  • 42
    • 84885335829 scopus 로고    scopus 로고
    • Hepatitis C virus infection and related liver disease: The quest for the best animal model
    • L. Mailly, E. Robinet, P. Meuleman, T.F. Baumert, and M.B. Zeisel Hepatitis C virus infection and related liver disease: the quest for the best animal model Front Microbiol 4 2013 213
    • (2013) Front Microbiol , vol.4 , pp. 213
    • Mailly, L.1    Robinet, E.2    Meuleman, P.3    Baumert, T.F.4    Zeisel, M.B.5
  • 43
    • 77957660356 scopus 로고    scopus 로고
    • Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors
    • J. Bitzegeio, D. Bankwitz, K. Hueging, S. Haid, C. Brohm, and M.B. Zeisel Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors PLoS Pathog 6 2010 e1000978
    • (2010) PLoS Pathog , vol.6 , pp. 1000978
    • Bitzegeio, J.1    Bankwitz, D.2    Hueging, K.3    Haid, S.4    Brohm, C.5    Zeisel, M.B.6
  • 44
    • 60149090028 scopus 로고    scopus 로고
    • Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
    • A. Ploss, M.J. Evans, V.A. Gaysinskaya, M. Panis, H.N. You, and Y.P. de Jong Human occludin is a hepatitis C virus entry factor required for infection of mouse cells Nature 457 2009 882 886
    • (2009) Nature , vol.457 , pp. 882-886
    • Ploss, A.1    Evans, M.J.2    Gaysinskaya, V.A.3    Panis, M.4    You, H.N.5    De Jong, Y.P.6
  • 45
    • 84894132965 scopus 로고    scopus 로고
    • Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells
    • A. Frentzen, Anggakusuma, E. Gurlevik, K. Hueging, S. Knocke, and C. Ginkel Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells Hepatology 59 2014 78 88
    • (2014) Hepatology , vol.59 , pp. 78-88
    • Frentzen, A.1    Anggakusuma2    Gurlevik, E.3    Hueging, K.4    Knocke, S.5    Ginkel, C.6
  • 46
    • 33749177118 scopus 로고    scopus 로고
    • The hepatitis C virus and immune evasion: Non-structural 3/4A transgenic mice are resistant to lethal tumour necrosis factor alpha mediated liver disease
    • L. Frelin, E.D. Brenndorfer, G. Ahlen, M. Weiland, C. Hultgren, and M. Alheim The hepatitis C virus and immune evasion: non-structural 3/4A transgenic mice are resistant to lethal tumour necrosis factor alpha mediated liver disease Gut 55 2006 1475 1483
    • (2006) Gut , vol.55 , pp. 1475-1483
    • Frelin, L.1    Brenndorfer, E.D.2    Ahlen, G.3    Weiland, M.4    Hultgren, C.5    Alheim, M.6
  • 51
    • 0031712813 scopus 로고    scopus 로고
    • The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
    • K. Moriya, H. Fujie, Y. Shintani, H. Yotsuyanagi, T. Tsutsumi, and K. Ishibashi The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice Nat Med 4 1998 1065 1067
    • (1998) Nat Med , vol.4 , pp. 1065-1067
    • Moriya, K.1    Fujie, H.2    Shintani, Y.3    Yotsuyanagi, H.4    Tsutsumi, T.5    Ishibashi, K.6
  • 52
    • 14244261930 scopus 로고    scopus 로고
    • Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis
    • Y. Kamegaya, Y. Hiasa, L. Zukerberg, N. Fowler, J.T. Blackard, and W. Lin Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis Hepatology 41 2005 660 667
    • (2005) Hepatology , vol.41 , pp. 660-667
    • Kamegaya, Y.1    Hiasa, Y.2    Zukerberg, L.3    Fowler, N.4    Blackard, J.T.5    Lin, W.6
  • 53
    • 0036063623 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice
    • M. Majumder, A.K. Ghosh, R. Steele, X.Y. Zhou, N.J. Phillips, and R. Ray Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice Virology 294 2002 94 105
    • (2002) Virology , vol.294 , pp. 94-105
    • Majumder, M.1    Ghosh, A.K.2    Steele, R.3    Zhou, X.Y.4    Phillips, N.J.5    Ray, R.6
  • 54
    • 84871333031 scopus 로고    scopus 로고
    • Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver
    • S. Sekiguchi, K. Kimura, T. Chiyo, T. Ohtsuki, Y. Tobita, and Y. Tokunaga Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver PLoS One 7 2012 e51656
    • (2012) PLoS One , vol.7 , pp. 51656
    • Sekiguchi, S.1    Kimura, K.2    Chiyo, T.3    Ohtsuki, T.4    Tobita, Y.5    Tokunaga, Y.6
  • 55
    • 28844440938 scopus 로고    scopus 로고
    • In vivo clearance of hepatitis C virus nonstructural 3/4A-expressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes
    • G. Ahlen, J. Nystrom, I. Pult, L. Frelin, C. Hultgren, and M. Sallberg In vivo clearance of hepatitis C virus nonstructural 3/4A-expressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes J Infect Dis 192 2005 2112 2116
    • (2005) J Infect Dis , vol.192 , pp. 2112-2116
    • Ahlen, G.1    Nystrom, J.2    Pult, I.3    Frelin, L.4    Hultgren, C.5    Sallberg, M.6
  • 56
    • 79955527858 scopus 로고    scopus 로고
    • Heterologous T cells can help restore function in dysfunctional hepatitis C virus nonstructural 3/4A-specific T cells during therapeutic vaccination
    • A. Chen, G. Ahlen, E.D. Brenndorfer, A. Brass, F. Holmstrom, and M. Chen Heterologous T cells can help restore function in dysfunctional hepatitis C virus nonstructural 3/4A-specific T cells during therapeutic vaccination J Immunol 186 2011 5107 5118
    • (2011) J Immunol , vol.186 , pp. 5107-5118
    • Chen, A.1    Ahlen, G.2    Brenndorfer, E.D.3    Brass, A.4    Holmstrom, F.5    Chen, M.6
  • 57
    • 0036158719 scopus 로고    scopus 로고
    • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    • H. Lerat, M. Honda, M.R. Beard, K. Loesch, J. Sun, and Y. Yang Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus Gastroenterology 122 2002 352 365
    • (2002) Gastroenterology , vol.122 , pp. 352-365
    • Lerat, H.1    Honda, M.2    Beard, M.R.3    Loesch, K.4    Sun, J.5    Yang, Y.6
  • 58
    • 70450245165 scopus 로고    scopus 로고
    • Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice
    • H. Lerat, H.L. Kammoun, I. Hainault, E. Merour, M.R. Higgs, and C. Callens Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice J Biol Chem 284 2009 33466 33474
    • (2009) J Biol Chem , vol.284 , pp. 33466-33474
    • Lerat, H.1    Kammoun, H.L.2    Hainault, I.3    Merour, E.4    Higgs, M.R.5    Callens, C.6
  • 59
    • 84865146104 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent
    • P. Chouteau, N. Defer, A. Florimond, J. Calderaro, M. Higgs, and A. Gaudin Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent J Hepatol 57 2012 499 507
    • (2012) J Hepatol , vol.57 , pp. 499-507
    • Chouteau, P.1    Defer, N.2    Florimond, A.3    Calderaro, J.4    Higgs, M.5    Gaudin, A.6
  • 60
    • 79958291149 scopus 로고    scopus 로고
    • A genetically humanized mouse model for hepatitis C virus infection
    • M. Dorner, J.A. Horwitz, J.B. Robbins, W.T. Barry, Q. Feng, and K. Mu A genetically humanized mouse model for hepatitis C virus infection Nature 474 2011 208 211
    • (2011) Nature , vol.474 , pp. 208-211
    • Dorner, M.1    Horwitz, J.A.2    Robbins, J.B.3    Barry, W.T.4    Feng, Q.5    Mu, K.6
  • 61
    • 84859965965 scopus 로고    scopus 로고
    • Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
    • E. Giang, M. Dorner, J.C. Prentoe, M. Dreux, M.J. Evans, and J. Bukh Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus Proc Natl Acad Sci U S A 109 2012 6205 6210
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 6205-6210
    • Giang, E.1    Dorner, M.2    Prentoe, J.C.3    Dreux, M.4    Evans, M.J.5    Bukh, J.6
  • 62
    • 84902272542 scopus 로고    scopus 로고
    • Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells
    • Anggakusuma, C.C. Colpitts, L.M. Schang, H. Rachmawati, A. Frentzen, and S. Pfaender Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells Gut 63 7 2013 1137 1149
    • (2013) Gut , vol.63 , Issue.7 , pp. 1137-1149
    • Anggakusuma1    Colpitts, C.C.2    Schang, L.M.3    Rachmawati, H.4    Frentzen, A.5    Pfaender, S.6
  • 63
    • 79955752803 scopus 로고    scopus 로고
    • Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines
    • A. Frentzen, K. Huging, J. Bitzegeio, M. Friesland, S. Haid, and J. Gentzsch Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines PLoS Pathog 7 2011 e1002029
    • (2011) PLoS Pathog , vol.7 , pp. 1002029
    • Frentzen, A.1    Huging, K.2    Bitzegeio, J.3    Friesland, M.4    Haid, S.5    Gentzsch, J.6
  • 64
    • 0041888351 scopus 로고    scopus 로고
    • Replication of hepatitis C virus subgenomes in nonhepatic epithelial and mouse hepatoma cells
    • Q. Zhu, J.T. Guo, and C. Seeger Replication of hepatitis C virus subgenomes in nonhepatic epithelial and mouse hepatoma cells J Virol 77 2003 9204 9210
    • (2003) J Virol , vol.77 , pp. 9204-9210
    • Zhu, Q.1    Guo, J.T.2    Seeger, C.3
  • 65
    • 33750804220 scopus 로고    scopus 로고
    • Replication of a hepatitis C virus replicon clone in mouse cells
    • S.L. Uprichard, J. Chung, F.V. Chisari, and T. Wakita Replication of a hepatitis C virus replicon clone in mouse cells Virol J 3 2006 89
    • (2006) Virol J , vol.3 , pp. 89
    • Uprichard, S.L.1    Chung, J.2    Chisari, F.V.3    Wakita, T.4
  • 67
    • 84884150486 scopus 로고    scopus 로고
    • Completion of the entire hepatitis C virus life cycle in genetically humanized mice
    • M. Dorner, J.A. Horwitz, B.M. Donovan, R.N. Labitt, W.C. Budell, and T. Friling Completion of the entire hepatitis C virus life cycle in genetically humanized mice Nature 501 2013 237 241
    • (2013) Nature , vol.501 , pp. 237-241
    • Dorner, M.1    Horwitz, J.A.2    Donovan, B.M.3    Labitt, R.N.4    Budell, W.C.5    Friling, T.6
  • 68
    • 17744378552 scopus 로고    scopus 로고
    • Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus
    • M. Dandri, M.R. Burda, E. Torok, J.M. Pollok, A. Iwanska, and G. Sommer Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus Hepatology 33 2001 981 988
    • (2001) Hepatology , vol.33 , pp. 981-988
    • Dandri, M.1    Burda, M.R.2    Torok, E.3    Pollok, J.M.4    Iwanska, A.5    Sommer, G.6
  • 71
    • 38049164210 scopus 로고    scopus 로고
    • Repopulation of adult and neonatal mice with human hepatocytes: A chimeric animal model
    • K.D. Bissig, T.T. Le, N.B. Woods, and I.M. Verma Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model Proc Natl Acad Sci U S A 104 2007 20507 20511
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20507-20511
    • Bissig, K.D.1    Le, T.T.2    Woods, N.B.3    Verma, I.M.4
  • 72
    • 77949725830 scopus 로고    scopus 로고
    • Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment
    • K.D. Bissig, S.F. Wieland, P. Tran, M. Isogawa, T.T. Le, and F.V. Chisari Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment J Clin Invest 120 2010 924 930
    • (2010) J Clin Invest , vol.120 , pp. 924-930
    • Bissig, K.D.1    Wieland, S.F.2    Tran, P.3    Isogawa, M.4    Le, T.T.5    Chisari, F.V.6
  • 73
    • 0025781894 scopus 로고
    • Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene
    • E.P. Sandgren, R.D. Palmiter, J.L. Heckel, C.C. Daugherty, R.L. Brinster, and J.L. Degen Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene Cell 66 1991 245 256
    • (1991) Cell , vol.66 , pp. 245-256
    • Sandgren, E.P.1    Palmiter, R.D.2    Heckel, J.L.3    Daugherty, C.C.4    Brinster, R.L.5    Degen, J.L.6
  • 74
    • 0029875835 scopus 로고    scopus 로고
    • Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinemia type i
    • K. Overturf, M. Al-Dhalimy, R. Tanguay, M. Brantly, C.N. Ou, and M. Finegold Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinemia type I Nat Genet 12 1996 266 273
    • (1996) Nat Genet , vol.12 , pp. 266-273
    • Overturf, K.1    Al-Dhalimy, M.2    Tanguay, R.3    Brantly, M.4    Ou, C.N.5    Finegold, M.6
  • 75
    • 0031279135 scopus 로고    scopus 로고
    • Hepatocytes break the rules of senescence in serial transplantation studies. is there a limit to their replicative capacity?
    • N. Fausto Hepatocytes break the rules of senescence in serial transplantation studies. Is there a limit to their replicative capacity? Am J Pathol 151 1997 1187 1189
    • (1997) Am J Pathol , vol.151 , pp. 1187-1189
    • Fausto, N.1
  • 76
    • 0034007745 scopus 로고    scopus 로고
    • Liver regeneration
    • N. Fausto Liver regeneration J Hepatol 32 2000 19 31
    • (2000) J Hepatol , vol.32 , pp. 19-31
    • Fausto, N.1
  • 79
    • 0034802517 scopus 로고    scopus 로고
    • Woodchuck hepatocytes remain permissive for hepadnavirus infection and mouse liver repopulation after cryopreservation
    • M. Dandri, M.R. Burda, A. Gocht, E. Torok, J.M. Pollok, and C.E. Rogler Woodchuck hepatocytes remain permissive for hepadnavirus infection and mouse liver repopulation after cryopreservation Hepatology 34 2001 824 833
    • (2001) Hepatology , vol.34 , pp. 824-833
    • Dandri, M.1    Burda, M.R.2    Gocht, A.3    Torok, E.4    Pollok, J.M.5    Rogler, C.E.6
  • 80
    • 0041592517 scopus 로고    scopus 로고
    • A simple and rapid method to determine the zygosity of uPA-transgenic SCID mice
    • P. Meuleman, P. Vanlandschoot, and G. Leroux-Roels A simple and rapid method to determine the zygosity of uPA-transgenic SCID mice Biochem Biophys Res Commun 308 2003 375 378
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 375-378
    • Meuleman, P.1    Vanlandschoot, P.2    Leroux-Roels, G.3
  • 81
    • 77955853940 scopus 로고    scopus 로고
    • Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice
    • T. Vanwolleghem, L. Libbrecht, B.E. Hansen, I. Desombere, T. Roskams, and P. Meuleman Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice J Hepatol 53 2010 468 476
    • (2010) J Hepatol , vol.53 , pp. 468-476
    • Vanwolleghem, T.1    Libbrecht, L.2    Hansen, B.E.3    Desombere, I.4    Roskams, T.5    Meuleman, P.6
  • 82
    • 77955852811 scopus 로고    scopus 로고
    • Host and viral determinants for engraftment of virus permissive human hepatocytes into chimeric immunodeficient mice
    • E. Robinet, and T.F. Baumert Host and viral determinants for engraftment of virus permissive human hepatocytes into chimeric immunodeficient mice J Hepatol 53 2010 421 423
    • (2010) J Hepatol , vol.53 , pp. 421-423
    • Robinet, E.1    Baumert, T.F.2
  • 84
    • 77950960661 scopus 로고    scopus 로고
    • Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: Replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models
    • J. Bukh, P. Meuleman, R. Tellier, R.E. Engle, S.M. Feinstone, and G. Eder Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models J Infect Dis 201 2010 1381 1389
    • (2010) J Infect Dis , vol.201 , pp. 1381-1389
    • Bukh, J.1    Meuleman, P.2    Tellier, R.3    Engle, R.E.4    Feinstone, S.M.5    Eder, G.6
  • 85
    • 79952205644 scopus 로고    scopus 로고
    • In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus
    • P. Meuleman, J. Bukh, L. Verhoye, A. Farhoudi, T. Vanwolleghem, and R.Y. Wang In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus Hepatology 53 2011 755 762
    • (2011) Hepatology , vol.53 , pp. 755-762
    • Meuleman, P.1    Bukh, J.2    Verhoye, L.3    Farhoudi, A.4    Vanwolleghem, T.5    Wang, R.Y.6
  • 86
    • 36348950345 scopus 로고    scopus 로고
    • Cell culture adaptation of hepatitis C virus and in vivo viability of an adapted variant
    • A. Kaul, I. Woerz, P. Meuleman, G. Leroux-Roels, and R. Bartenschlager Cell culture adaptation of hepatitis C virus and in vivo viability of an adapted variant J Virol 81 2007 13168 13179
    • (2007) J Virol , vol.81 , pp. 13168-13179
    • Kaul, A.1    Woerz, I.2    Meuleman, P.3    Leroux-Roels, G.4    Bartenschlager, R.5
  • 87
    • 56449110274 scopus 로고    scopus 로고
    • Role of the hepatitis C virus core+1 open reading frame and core cis-acting RNA elements in viral RNA translation and replication
    • N. Vassilaki, P. Friebe, P. Meuleman, S. Kallis, A. Kaul, and G. Paranhos-Baccala Role of the hepatitis C virus core+1 open reading frame and core cis-acting RNA elements in viral RNA translation and replication J Virol 82 2008 11503 11515
    • (2008) J Virol , vol.82 , pp. 11503-11515
    • Vassilaki, N.1    Friebe, P.2    Meuleman, P.3    Kallis, S.4    Kaul, A.5    Paranhos-Baccala, G.6
  • 88
    • 61449181271 scopus 로고    scopus 로고
    • HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice
    • M.A. Joyce, K.A. Walters, S.E. Lamb, M.M. Yeh, L.F. Zhu, and N. Kneteman HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice PLoS Pathog 5 2009 e1000291
    • (2009) PLoS Pathog , vol.5 , pp. 1000291
    • Joyce, M.A.1    Walters, K.A.2    Lamb, S.E.3    Yeh, M.M.4    Zhu, L.F.5    Kneteman, N.6
  • 89
    • 59249089462 scopus 로고    scopus 로고
    • Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes
    • K.A. Walters, A.J. Syder, S.L. Lederer, D.L. Diamond, B. Paeper, and C.M. Rice Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes PLoS Pathog 5 2009 e1000269
    • (2009) PLoS Pathog , vol.5 , pp. 1000269
    • Walters, K.A.1    Syder, A.J.2    Lederer, S.L.3    Diamond, D.L.4    Paeper, B.5    Rice, C.M.6
  • 90
    • 67650882702 scopus 로고    scopus 로고
    • Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations
    • T. Pietschmann, M. Zayas, P. Meuleman, G. Long, N. Appel, and G. Koutsoudakis Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations PLoS Pathog 5 2009 e1000475
    • (2009) PLoS Pathog , vol.5 , pp. 1000475
    • Pietschmann, T.1    Zayas, M.2    Meuleman, P.3    Long, G.4    Appel, N.5    Koutsoudakis, G.6
  • 91
    • 77956147218 scopus 로고    scopus 로고
    • Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation
    • S. Fafi-Kremer, I. Fofana, E. Soulier, P. Carolla, P. Meuleman, and G. Leroux-Roels Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation J Exp Med 207 2010 2019 2031
    • (2010) J Exp Med , vol.207 , pp. 2019-2031
    • Fafi-Kremer, S.1    Fofana, I.2    Soulier, E.3    Carolla, P.4    Meuleman, P.5    Leroux-Roels, G.6
  • 92
    • 80052283930 scopus 로고    scopus 로고
    • Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A
    • J.M. Gottwein, T.B. Jensen, C.K. Mathiesen, P. Meuleman, S.B. Serre, and J.B. Lademann Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A J Virol 85 2011 8913 8928
    • (2011) J Virol , vol.85 , pp. 8913-8928
    • Gottwein, J.M.1    Jensen, T.B.2    Mathiesen, C.K.3    Meuleman, P.4    Serre, S.B.5    Lademann, J.B.6
  • 93
    • 84869143643 scopus 로고    scopus 로고
    • Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host
    • R.J. Brown, N. Hudson, G. Wilson, S.U. Rehman, S. Jabbari, and K. Hu Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host J Virol 86 2012 11956 11966
    • (2012) J Virol , vol.86 , pp. 11956-11966
    • Brown, R.J.1    Hudson, N.2    Wilson, G.3    Rehman, S.U.4    Jabbari, S.5    Hu, K.6
  • 95
    • 84894864720 scopus 로고    scopus 로고
    • Hepatitis C virus induced up-regulation of microRNA-27: A novel mechanism for hepatic steatosis
    • R. Singaravelu, R. Chen, R.K. Lyn, D.M. Jones, S. O'Hara, and Y. Rouleau Hepatitis C virus induced up-regulation of microRNA-27: a novel mechanism for hepatic steatosis Hepatology 59 2014 98 108
    • (2014) Hepatology , vol.59 , pp. 98-108
    • Singaravelu, R.1    Chen, R.2    Lyn, R.K.3    Jones, D.M.4    O'Hara, S.5    Rouleau, Y.6
  • 96
    • 46249125111 scopus 로고    scopus 로고
    • Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain
    • T. Vanwolleghem, J. Bukh, P. Meuleman, I. Desombere, J.C. Meunier, and H. Alter Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain Hepatology 47 2008 1846 1855
    • (2008) Hepatology , vol.47 , pp. 1846-1855
    • Vanwolleghem, T.1    Bukh, J.2    Meuleman, P.3    Desombere, I.4    Meunier, J.C.5    Alter, H.6
  • 97
    • 38049083122 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
    • M. Law, T. Maruyama, J. Lewis, E. Giang, A.W. Tarr, and Z. Stamataki Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge Nat Med 14 2008 25 27
    • (2008) Nat Med , vol.14 , pp. 25-27
    • Law, M.1    Maruyama, T.2    Lewis, J.3    Giang, E.4    Tarr, A.W.5    Stamataki, Z.6
  • 98
    • 84880575939 scopus 로고    scopus 로고
    • Neutralizing antibodies induced by cell culture-derived hepatitis C virus protect against infection in mice
    • D. Akazawa, M. Moriyama, H. Yokokawa, N. Omi, N. Watanabe, and T. Date Neutralizing antibodies induced by cell culture-derived hepatitis C virus protect against infection in mice Gastroenterology 145 2013 e441 e444
    • (2013) Gastroenterology , vol.145 , pp. 441-e444
    • Akazawa, D.1    Moriyama, M.2    Yokokawa, H.3    Omi, N.4    Watanabe, N.5    Date, T.6
  • 99
    • 34848881891 scopus 로고    scopus 로고
    • Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse
    • T. Vanwolleghem, P. Meuleman, L. Libbrecht, T. Roskams, R. De Vos, and G. Leroux-Roels Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse Gastroenterology 133 2007 1144 1155
    • (2007) Gastroenterology , vol.133 , pp. 1144-1155
    • Vanwolleghem, T.1    Meuleman, P.2    Libbrecht, L.3    Roskams, T.4    De Vos, R.5    Leroux-Roels, G.6
  • 101
    • 63349109767 scopus 로고    scopus 로고
    • HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus
    • N.M. Kneteman, A.Y. Howe, T. Gao, J. Lewis, D. Pevear, and G. Lund HCV796: a selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus Hepatology 49 2009 745 752
    • (2009) Hepatology , vol.49 , pp. 745-752
    • Kneteman, N.M.1    Howe, A.Y.2    Gao, T.3    Lewis, J.4    Pevear, D.5    Lund, G.6
  • 103
    • 78651071881 scopus 로고    scopus 로고
    • Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase
    • F. Narjes, B. Crescenzi, M. Ferrara, J. Habermann, S. Colarusso, and R. Ferreira Mdel Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase J Med Chem 54 2011 289 301
    • (2011) J Med Chem , vol.54 , pp. 289-301
    • Narjes, F.1    Crescenzi, B.2    Ferrara, M.3    Habermann, J.4    Colarusso, S.5    Ferreira Mdel, R.6
  • 104
    • 79954911259 scopus 로고    scopus 로고
    • Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice
    • E. Ohara, N. Hiraga, M. Imamura, E. Iwao, N. Kamiya, and I. Yamada Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice J Hepatol 54 2011 872 878
    • (2011) J Hepatol , vol.54 , pp. 872-878
    • Ohara, E.1    Hiraga, N.2    Imamura, M.3    Iwao, E.4    Kamiya, N.5    Yamada, I.6
  • 105
    • 80054713474 scopus 로고    scopus 로고
    • A human monoclonal antibody targeting scavenger receptor class B type i precludes hepatitis C virus infection and viral spread in vitro and in vivo
    • P. Meuleman, M.T. Catanese, L. Verhoye, I. Desombere, A. Farhoudi, and C.T. Jones A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo Hepatology 55 2012 364 372
    • (2012) Hepatology , vol.55 , pp. 364-372
    • Meuleman, P.1    Catanese, M.T.2    Verhoye, L.3    Desombere, I.4    Farhoudi, A.5    Jones, C.T.6
  • 106
    • 84862652238 scopus 로고    scopus 로고
    • Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice
    • K. Lacek, K. Vercauteren, K. Grzyb, M. Naddeo, L. Verhoye, and M.P. Slowikowski Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice J Hepatol 57 2012 17 23
    • (2012) J Hepatol , vol.57 , pp. 17-23
    • Lacek, K.1    Vercauteren, K.2    Grzyb, K.3    Naddeo, M.4    Verhoye, L.5    Slowikowski, M.P.6
  • 107
    • 12444253844 scopus 로고    scopus 로고
    • Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers
    • E.C. Hsu, B. Hsi, M. Hirota-Tsuchihara, J. Ruland, C. Iorio, and F. Sarangi Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers Nat Biotechnol 21 2003 519 525
    • (2003) Nat Biotechnol , vol.21 , pp. 519-525
    • Hsu, E.C.1    Hsi, B.2    Hirota-Tsuchihara, M.3    Ruland, J.4    Iorio, C.5    Sarangi, F.6
  • 108
    • 0029082193 scopus 로고
    • Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinemia type i
    • M. Grompe, S. Lindstedt, M. Al-Dhalimy, N.G. Kennaway, J. Papaconstantinou, and C.A. Torres-Ramos Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinemia type I Nat Genet 10 1995 453 460
    • (1995) Nat Genet , vol.10 , pp. 453-460
    • Grompe, M.1    Lindstedt, S.2    Al-Dhalimy, M.3    Kennaway, N.G.4    Papaconstantinou, J.5    Torres-Ramos, C.A.6
  • 111
    • 33644777664 scopus 로고    scopus 로고
    • Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus
    • P. Meuleman, L. Libbrecht, S. Wieland, R. De Vos, N. Habib, and A. Kramvis Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus J Virol 80 2006 2797 2807
    • (2006) J Virol , vol.80 , pp. 2797-2807
    • Meuleman, P.1    Libbrecht, L.2    Wieland, S.3    De Vos, R.4    Habib, N.5    Kramvis, A.6
  • 112
    • 40449096921 scopus 로고    scopus 로고
    • Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein
    • J. Petersen, M. Dandri, W. Mier, M. Lutgehetmann, T. Volz, and F. von Weizsacker Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein Nat Biotechnol 26 2008 335 341
    • (2008) Nat Biotechnol , vol.26 , pp. 335-341
    • Petersen, J.1    Dandri, M.2    Mier, W.3    Lutgehetmann, M.4    Volz, T.5    Von Weizsacker, F.6
  • 113
    • 56349163205 scopus 로고    scopus 로고
    • The human liver-uPA-SCID mouse: A model for the evaluation of antiviral compounds against HBV and HCV
    • P. Meuleman, and G. Leroux-Roels The human liver-uPA-SCID mouse: a model for the evaluation of antiviral compounds against HBV and HCV Antiviral Res 80 2008 231 238
    • (2008) Antiviral Res , vol.80 , pp. 231-238
    • Meuleman, P.1    Leroux-Roels, G.2
  • 114
    • 77954226664 scopus 로고    scopus 로고
    • In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice
    • M. Lutgehetmann, T. Volz, A. Kopke, T. Broja, E. Tigges, and A.W. Lohse In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice Hepatology 52 2010 16 24
    • (2010) Hepatology , vol.52 , pp. 16-24
    • Lutgehetmann, M.1    Volz, T.2    Kopke, A.3    Broja, T.4    Tigges, E.5    Lohse, A.W.6
  • 115
    • 84856514985 scopus 로고    scopus 로고
    • IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
    • L. Belloni, L. Allweiss, F. Guerrieri, N. Pediconi, T. Volz, and T. Pollicino IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome J Clin Invest 122 2012 529 537
    • (2012) J Clin Invest , vol.122 , pp. 529-537
    • Belloni, L.1    Allweiss, L.2    Guerrieri, F.3    Pediconi, N.4    Volz, T.5    Pollicino, T.6
  • 116
    • 84857442747 scopus 로고    scopus 로고
    • Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation
    • M. Lutgehetmann, L.V. Mancke, T. Volz, M. Helbig, L. Allweiss, and T. Bornscheuer Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation Hepatology 55 2012 685 694
    • (2012) Hepatology , vol.55 , pp. 685-694
    • Lutgehetmann, M.1    Mancke, L.V.2    Volz, T.3    Helbig, M.4    Allweiss, L.5    Bornscheuer, T.6
  • 117
    • 84861716805 scopus 로고    scopus 로고
    • Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA/SCID mice
    • T. Volz, M. Lutgehetmann, L. Allweiss, M. Warlich, J. Bierwolf, and J.M. Pollok Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA/SCID mice Antivir Ther 17 2012 623 631
    • (2012) Antivir Ther , vol.17 , pp. 623-631
    • Volz, T.1    Lutgehetmann, M.2    Allweiss, L.3    Warlich, M.4    Bierwolf, J.5    Pollok, J.M.6
  • 118
    • 33644856082 scopus 로고    scopus 로고
    • Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers
    • J.B. Sacci Jr., U. Alam, D. Douglas, J. Lewis, D.L. Tyrrell, and A.F. Azad Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers Int J Parasitol 36 2006 353 360
    • (2006) Int J Parasitol , vol.36 , pp. 353-360
    • Sacci, J.B.1    Alam, U.2    Douglas, D.3    Lewis, J.4    Tyrrell, D.L.5    Azad, A.F.6
  • 121
    • 84899474267 scopus 로고    scopus 로고
    • Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum
    • M.C. Behet, L. Foquet, G.J. van Gemert, E.M. Bijker, P. Meuleman, and G. Leroux-Roels Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum Malar J 13 2014 136
    • (2014) Malar J , vol.13 , pp. 136
    • Behet, M.C.1    Foquet, L.2    Van Gemert, G.J.3    Bijker, E.M.4    Meuleman, P.5    Leroux-Roels, G.6
  • 122
    • 84892931367 scopus 로고    scopus 로고
    • Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection
    • L. Foquet, C.C. Hermsen, G.J. van Gemert, E. Van Braeckel, K.E. Weening, and R. Sauerwein Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection J Clin Invest 124 2014 140 144
    • (2014) J Clin Invest , vol.124 , pp. 140-144
    • Foquet, L.1    Hermsen, C.C.2    Van Gemert, G.J.3    Van Braeckel, E.4    Weening, K.E.5    Sauerwein, R.6
  • 123
    • 84894103255 scopus 로고    scopus 로고
    • Persistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection
    • K. Giersch, M. Helbig, T. Volz, L. Allweiss, L.V. Mancke, and A.W. Lohse Persistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection J Hepatol 60 2014 538 544
    • (2014) J Hepatol , vol.60 , pp. 538-544
    • Giersch, K.1    Helbig, M.2    Volz, T.3    Allweiss, L.4    Mancke, L.V.5    Lohse, A.W.6
  • 124
    • 70349690193 scopus 로고    scopus 로고
    • UPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: Methandienone as a case study
    • L. Lootens, P. Meuleman, O.J. Pozo, P. Van Eenoo, G. Leroux-Roels, and F.T. Delbeke UPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: methandienone as a case study Clin Chem 55 2009 1783 1793
    • (2009) Clin Chem , vol.55 , pp. 1783-1793
    • Lootens, L.1    Meuleman, P.2    Pozo, O.J.3    Van Eenoo, P.4    Leroux-Roels, G.5    Delbeke, F.T.6
  • 126
    • 78049374383 scopus 로고    scopus 로고
    • Chimeric mice with humanized liver: Tools for the study of drug metabolism, excretion, and toxicity
    • S.C. Strom, J. Davila, and M. Grompe Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity Methods Mol Biol 640 2010 491 509
    • (2010) Methods Mol Biol , vol.640 , pp. 491-509
    • Strom, S.C.1    Davila, J.2    Grompe, M.3
  • 127
    • 84899484617 scopus 로고    scopus 로고
    • 'Humanized' mouse detects deadly drug side effects
    • Cohen J. Toxicology 'Humanized' mouse detects deadly drug side effects Science 344 2014 244 245
    • (2014) Science , vol.344 , pp. 244-245
    • Toxicology, C.J.1
  • 128
    • 84901011638 scopus 로고    scopus 로고
    • Application of chimeric mice with humanized liver for study of human-specific drug metabolism
    • T.J. Bateman, V.G. Reddy, M. Kakuni, Y. Morikawa, and S. Kumar Application of chimeric mice with humanized liver for study of human-specific drug metabolism Drug Metab Dispos 42 2014 1055 1065
    • (2014) Drug Metab Dispos , vol.42 , pp. 1055-1065
    • Bateman, T.J.1    Reddy, V.G.2    Kakuni, M.3    Morikawa, Y.4    Kumar, S.5
  • 129
    • 84900460907 scopus 로고    scopus 로고
    • Fialuridine induces acute liver failure in chimeric TK-NOG mice: A model for detecting hepatic drug toxicity prior to human testing
    • D. Xu, T. Nishimura, S. Nishimura, H. Zhang, M. Zheng, and Y.Y. Guo Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing PLoS Med 11 2014 e1001628
    • (2014) PLoS Med , vol.11 , pp. 1001628
    • Xu, D.1    Nishimura, T.2    Nishimura, S.3    Zhang, H.4    Zheng, M.5    Guo, Y.Y.6
  • 130
    • 0034954716 scopus 로고    scopus 로고
    • Transplantation of human hepatocytes into tolerized genetically immunocompetent rats
    • E.C. Ouyang, C.H. Wu, C. Walton, K. Promrat, and G.Y. Wu Transplantation of human hepatocytes into tolerized genetically immunocompetent rats World J Gastroenterol 7 2001 324 330
    • (2001) World J Gastroenterol , vol.7 , pp. 324-330
    • Ouyang, E.C.1    Wu, C.H.2    Walton, C.3    Promrat, K.4    Wu, G.Y.5
  • 132
    • 84890386754 scopus 로고    scopus 로고
    • Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice
    • T.L. Gutti, J.S. Knibbe, E. Makarov, J. Zhang, G.R. Yannam, and S. Gorantla Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice Am J Pathol 184 2014 101 109
    • (2014) Am J Pathol , vol.184 , pp. 101-109
    • Gutti, T.L.1    Knibbe, J.S.2    Makarov, E.3    Zhang, J.4    Yannam, G.R.5    Gorantla, S.6
  • 133
    • 79953196869 scopus 로고    scopus 로고
    • A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease
    • M.L. Washburn, M.T. Bility, L. Zhang, G.I. Kovalev, A. Buntzman, and J.A. Frelinger A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease Gastroenterology 140 2011 1334 1344
    • (2011) Gastroenterology , vol.140 , pp. 1334-1344
    • Washburn, M.L.1    Bility, M.T.2    Zhang, L.3    Kovalev, G.I.4    Buntzman, A.5    Frelinger, J.A.6
  • 136
    • 0034885745 scopus 로고    scopus 로고
    • Studies of hepatitis C virus in chimpanzees and their importance for vaccine development
    • J. Bukh, X. Forns, S.U. Emerson, and R.H. Purcell Studies of hepatitis C virus in chimpanzees and their importance for vaccine development Intervirology 44 2001 132 142
    • (2001) Intervirology , vol.44 , pp. 132-142
    • Bukh, J.1    Forns, X.2    Emerson, S.U.3    Purcell, R.H.4
  • 137
    • 32244435842 scopus 로고    scopus 로고
    • A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
    • A. Folgori, S. Capone, L. Ruggeri, A. Meola, E. Sporeno, and B.B. Ercole A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees Nat Med 12 2006 190 197
    • (2006) Nat Med , vol.12 , pp. 190-197
    • Folgori, A.1    Capone, S.2    Ruggeri, L.3    Meola, A.4    Sporeno, E.5    Ercole, B.B.6
  • 138
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • R.E. Lanford, E.S. Hildebrandt-Eriksen, A. Petri, R. Persson, M. Lindow, and M.E. Munk Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection Science 327 2010 198 201
    • (2010) Science , vol.327 , pp. 198-201
    • Lanford, R.E.1    Hildebrandt-Eriksen, E.S.2    Petri, A.3    Persson, R.4    Lindow, M.5    Munk, M.E.6
  • 139
    • 78751691624 scopus 로고    scopus 로고
    • Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents
    • D.B. Olsen, M.E. Davies, L. Handt, K. Koeplinger, N.R. Zhang, and S.W. Ludmerer Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents Antimicrob Agents Chemother 55 2011 937 939
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 937-939
    • Olsen, D.B.1    Davies, M.E.2    Handt, L.3    Koeplinger, K.4    Zhang, N.R.5    Ludmerer, S.W.6


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