Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations

PLoS Pathogens

Volumn 5, Issue 6, 2009, Pages

  Pietschmann, Thomas ^a,c   Zayas, Margarita ^a   Meuleman, Philip ^b   Long, Gang ^a   Appel, Nicole ^a,d   Koutsoudakis, George ^a,e   Kallis, Stephanie ^a   Leroux Roels, Geert ^b   Lohmann, Volker ^a   Bartenschlager, Ralf ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^e HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; CASEIN KINASE I; GLYCOPROTEIN E1; GLYCOPROTEIN E2; HELICASE; MONTIRELIN; NONSTRUCTURAL PROTEIN 4B; NONSTRUCTURAL PROTEIN 5A; NUCLEASE; CORE PROTEIN; HEPATITIS C ANTIGEN; NS 5 PROTEIN, HEPATITIS C VIRUS; NS-5 PROTEIN, HEPATITIS C VIRUS; NS3 PROTEIN, HEPATITIS C VIRUS; NS4B PROTEIN, FLAVIVIRUS; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GENE MUTATION; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN PHOSPHORYLATION; RNA REPLICATION; VIRUS MUTATION; VIRUS PARTICLE; VIRUS REPLICATION; CELL LINE; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; MUTATION; PATHOGENICITY; PHYSIOLOGY; VIRION; VIRUS CULTURE;

CERCOPITHECINE HERPESVIRUS 1; HEPATITIS C VIRUS;

CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPACIVIRUS; HEPATITIS C ANTIGENS; HUMANS; MUTATION; VIRAL CORE PROTEINS; VIRAL ENVELOPE PROTEINS; VIRAL NONSTRUCTURAL PROTEINS; VIRION; VIRUS CULTIVATION; VIRUS REPLICATION;

EID: 67650882702     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000475     Document Type: Article

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