Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents

Hepatology

Volumn 60, Issue 5, 2014, Pages 1508-1518

  Vercauteren, Koen ^a   Van Den Eede, Naomi ^a   Mesalam, Ahmed Atef ^a   Belouzard, Sandrine ^b   Catanese, Maria Teresa ^c,d   Bankwitz, Dorothea ^e   Wong Staal, Flossie ^f   Cortese, Riccardo ^g   Dubuisson, Jean ^b   Rice, Charles M ^c   Pietschmann, Thomas ^e   Leroux Roels, Geert ^a   Nicosia, Alfredo ^g,h   Meuleman, Philip ^a  

^a Department of Clinical Chemistry Microbiology and Immunology CEVAC   (Belgium)

^b UNIV LILLE   (France)

^c ROCKEFELLER UNIVERSITY   (United States)

^d GUY S HOSPITAL   (United Kingdom)

^e INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^f iTherX Pharmaceuticals Inc   (United States)

^g CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^h UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; HIGH DENSITY LIPOPROTEIN; MONOCLONAL ANTIBODY; SCAVENGER RECEPTOR BI; SCAVENGER RECEPTOR BI SCAVENGER RECEPTOR BI; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; VIRUS RNA; IODIXANOL; IODOBENZOIC ACID DERIVATIVE; LIPOPROTEIN; SCARB1 PROTEIN, HUMAN; SCAVENGER RECEPTOR B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ANTIVIRAL THERAPY; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; INFECTION PREVENTION; LIVER CELL; LIVER TRANSPLANTATION; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REINFECTION; TREATMENT DURATION; ULTRACENTRIFUGATION; VIRAL CLEARANCE; VIRION; VIRUS CELL INTERACTION; VIRUS INFECTIVITY; VIRUS NEUTRALIZATION; VIRUS PARTICLE; VIRUS RESISTANCE; VIRUS STRAIN; VIRUS TRANSMISSION; ANIMAL; DRUG EFFECTS; HEPACIVIRUS; IMMUNOLOGY; PATHOGENICITY; SCID MOUSE; TREATMENT OUTCOME; TUMOR CELL LINE; VIROLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; HEPACIVIRUS; HEPATITIS C; HUMANS; LIPOPROTEINS; MICE, SCID; SCAVENGER RECEPTORS, CLASS B; TREATMENT OUTCOME; TRIIODOBENZOIC ACIDS;

EID: 84922233514     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27196     Document Type: Article

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