Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent

Journal of Hepatology

Volumn 57, Issue 3, 2012, Pages 499-507

  Chouteau, Philippe ^a,b   Defer, Nicole ^a   Florimond, Alexandre ^a,b   Caldéraro, Julien ^b,c   Higgs, Martin ^a   Gaudin, Aurore ^a   Mérour, Emilie ^a   Dhumeaux, Daniel ^a,b   Lerat, Hervé ^a,b   Pawlotsky, Jean Michel ^a,b,c  

^a INSERM U955   (France)

^b UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^c HENRI MONDOR HOSPITAL   (France)

Author keywords

Ductular reaction; Fibrosis; Hepatic progenitor cells; Hepatitis C virus; Hepatocyte proliferation; Reactive oxygen species

Indexed keywords

CARBON TETRACHLORIDE; MATRIX METALLOPROTEINASE; REACTIVE OXYGEN METABOLITE; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COMPARTMENTALIZATION; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL DIVISION; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INJECTION VOLUME; FIBROGENESIS; GENE EXPRESSION; HEPATIC PROGENITOR CELL; HEPATITIS C; HEPATITIS C VIRUS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIVER; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; MALE; MOUSE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; STEM CELL; TRANSGENIC MOUSE; VIRUS STRAIN; WESTERN BLOTTING; WILD TYPE;

ANIMALS; BILE DUCTS; CARBON TETRACHLORIDE; CELL PROLIFERATION; CHEMOKINE CCL5; EXTRACELLULAR MATRIX; GENE EXPRESSION; HEPACIVIRUS; HEPATITIS C, CHRONIC; HEPATOCYTES; KERATIN-19; LIVER CIRRHOSIS; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 7; MICE; MICE, TRANSGENIC; OPEN READING FRAMES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; STEM CELLS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; VIRAL PROTEINS;

EID: 84865146104     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.04.019     Document Type: Article

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