Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression

Drug Metabolism and Disposition

Volumn 36, Issue 2, 2008, Pages 339-348

  Svecova, Lucie ^a   Vrzal, Radim ^b   Burysek, Ladislav ^e   Anzenbacherova, Eva ^b   Cerveny, Lukas ^c   Grim, Jiri ^d   Trejtnar, Frantisek ^a   Kunes, Jiri ^a   Pour, Milan ^a   Staud, Frantisek ^a   Anzenbacher, Pavel ^b   Dvorak, Zdenek ^b   Pavek, Petr ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

^d UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^e Gen Trend sro Ceské Budějovice ^*  (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

AZOLE ANTIBODIES MYCOTIC; CLOTRIMAZOLE; CYTOCHROME P450 3A4; ECONAZOLE; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; MICONAZOLE; OXICONAZOLE; PREGNANE X RECEPTOR; PYRROLE DERIVATIVE; RIFAMPICIN; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG METABOLISM; ENZYMURIA; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

AGED; ANIMALS; ANTIFUNGAL AGENTS; AZOLES; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE EXPRESSION; GENES, REPORTER; HEPATOCYTES; HUMANS; MALE; MIDDLE AGED; PROMOTER REGIONS (GENETICS); RECEPTORS, STEROID; RIFAMPIN; RNA, MESSENGER; TRANSFECTION;

EID: 38749114272     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.018341     Document Type: Article

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