Aryl Hydrocarbon Receptor Activation and Cytochrome P450 1A Induction by the Mitogen-Activated Protein Kinase Inhibitor U0126 in Hepatocytes

Molecular Pharmacology

Volumn 65, Issue 4, 2004, Pages 934-943

  Andrieux, Lise ^a   Langouët, Sophie ^a   Fautrel, Alain ^a   Ezan, Fréderic ^b   Krauser, Joel A ^c   Savouret, Jean F ^d   Guengerich, F Peter ^c   Baffet, Georges ^b   Guillouzo, André ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; RESVERATROL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER CYTOSOL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TRANSACTIVATION; XENOBIOTIC RESPONSIVE ELEMENT;

ANIMALS; BUTADIENES; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ENZYME INHIBITORS; HEPATOCYTES; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 1842585605     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.4.934     Document Type: Article

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