Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes

Chemico-Biological Interactions

Volumn 179, Issue 2-3, 2009, Pages 288-296

  Vrzal, Radim ^a   Stejskalova, Lucie ^b   Monostory, Katalin ^c   Maurel, Patrick ^d,e   Bachleda, Petr ^f   Pavek, Petr ^b   Dvorak, Zdenek ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^c CHEMICAL RESEARCH CENTER   (Hungary)

^d INSERM   (France)

^e UNIV MONTPELLIER   (France)

^f UNIVERSITY HOSPITAL OLOMOUC   (Czech Republic)

Author keywords

Cytochrome P450; Dioxin receptor; Drug metabolism; Glucocorticoids; Human liver

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 METHYLCHOLANTHRENE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; MIFEPRISTONE; TYROSINE AMINOTRANSFERASE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DRUG EFFECT; DRUG MECHANISM; ENZYME MECHANISM; ENZYME REGULATION; FEMALE; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER CELL CULTURE; MALE; POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION;

ADULT; AGED; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CZECH REPUBLIC; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FEMALE; FRANCE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; HUNGARY; MALE; METHYLCHOLANTHRENE; MIDDLE AGED; RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN;

EID: 62549089278     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.10.035     Document Type: Article

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