A single mechanism can explain network-wide insulin resistance in adipocytes from obese patients with type 2 diabetes

Journal of Biological Chemistry

Volumn 289, Issue 48, 2014, Pages 33215-33230

  Nyman, Elin ^a   Rajan, Meenu Rohini ^a   Fagerholm, Siri ^a   Brännmark, Cecilia ^a   Cedersund, Gunnar ^a   Strålfors, Peter ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELL CULTURE; INSULIN; PROTEINS; SIGNALING;

CELLULAR MECHANISMS; EXPERIMENTAL VERIFICATION; INSULIN RESISTANCE; NUCLEAR TRANSCRIPTION FACTORS; PROTEIN SYNTHESIS; RIBOSOMAL PROTEINS; SIGNAL ATTENUATION; SIGNALING NETWORKS;

CELL SIGNALING;

GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN S6; RAPAMYCIN; TRANSCRIPTION FACTOR ELK 1; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; MAPK1 PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

ADIPOCYTE; ARTICLE; AUTOPHAGY; AUTOPHOSPHORYLATION; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FEEDBACK SYSTEM; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SIMULATION; STEADY STATE; ADULT; AGED; BIOLOGICAL MODEL; CLINICAL TRIAL; DIABETES MELLITUS; FEMALE; GENETICS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADIPOCYTES; ADULT; AGED; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; OBESITY; TOR SERINE-THREONINE KINASES;

EID: 84912084626     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.608927     Document Type: Article

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