How scaffolds shape MAPK signaling: What we know and opportunities for systems approaches

Frontiers in Physiology

Volumn 3 DEC, Issue , 2012, Pages

  Witzel, Franziska ^a,b   Maddison, Louise ^c   Blüthgen, Nils ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

MAPK and ERK signaling; Mathematical modeling; Scaffold; Signaling; Ste5; Ultrasensitivity

Indexed keywords

B RAF KINASE; CARRIER PROTEIN; KINASE SUPPRESSOR OF RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN STE5; RAF PROTEIN; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INTRACELLULAR SIGNALING; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REVIEW; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STIMULUS RESPONSE; STOICHIOMETRY; STRUCTURE ANALYSIS; SYSTEMS BIOLOGY; TISSUE SPECIFICITY; UPREGULATION; ZINC FINGER MOTIF;

EID: 84884170206     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: None     Document Type: Review

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