Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

Molecular Systems Biology

Volumn 10, Issue 1, 2014, Pages

  Ahmed, Shoeb ^a   Grant, Kyle G ^a   Edwards, Laura E ^b   Rahman, Anisur ^a   Cirit, Murat ^a   Goshe, Michael B ^b   Haugh, Jason M ^a  

^a North Carolina State University   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

growth factor receptors; mathematical model; mitogen activated protein kinases; negative feedback; nucleocytoplasmic shuttling

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; EPIFLUORESCENCE MICROSCOPY; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; 3T3 CELL LINE; ACTIVE TRANSPORT; ANIMAL; CHEMISTRY; FEEDBACK SYSTEM; GENETICS; KINETICS; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN TRANSPORT; THEORETICAL MODEL;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, PHYSIOLOGICAL; KINETICS; MICE; MODELS, THEORETICAL; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTORS, GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 84898662770     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.1002/msb.134708     Document Type: Article

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