Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

Molecular Systems Biology

Volumn 7, Issue , 2011, Pages

  Fritsche Guenther, Raphaela ^a   Witzel, Franziska ^a,b   Sieber, Anja ^a   Herr, Ricarda ^c   Schmidt, Nadine ^a   Braun, Sandra ^c   Brummer, Tilman ^c   Sers, Christine ^a   Blüthgen, Nils ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

expression noise; MAPK signalling; negative feedback; Raf; robustness

Indexed keywords

B RAF KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; RAF PROTEIN; THREONINE; TYROSINE; SMALL INTERFERING RNA;

ARTICLE; CELL STRAIN HCT116; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; BIOLOGICAL MODEL; CELL LINE; CELL PROLIFERATION; DRUG EFFECT; FEEDBACK SYSTEM; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; MATHEMATICAL COMPUTING; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PHYSIOLOGY;

BASE SEQUENCE; CELL LINE; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, PHYSIOLOGICAL; GENE SILENCING; HUMANS; MAP KINASE SIGNALING SYSTEM; MATHEMATICAL COMPUTING; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-RAF; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 79957573284     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2011.27     Document Type: Article

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