Mass and information feedbacks through receptor endocytosis govern insulin signaling as revealed using a parameter-free modeling framework

Journal of Biological Chemistry

Volumn 285, Issue 26, 2010, Pages 20171-20179

  Brännmark, Cecilia ^a   Palmér, Robert ^a   Glad, S Torkel ^a   Cedersund, Gunnar ^a,b   Strålfors, Peter ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTES; CENTRAL OBSERVATIONS; CO-EXISTING; CONTROL TARGET; DATA ANALYSIS; FEEDBACK MECHANISMS; HORMONAL CONTROL; INFORMATION FEEDBACK; INFORMATION TRANSFERS; INSULIN RECEPTOR SUBSTRATE-1; INSULIN RECEPTORS; INSULIN RESISTANCE; INSULIN SIGNALING; MATHEMATICAL MODELING; MODEL PARAMETERS; MODEL-BASED; MULTIPLE FEEDBACK; PARAMETER-FREE MODELING; RECEPTOR ENDOCYTOSIS; SIGNAL PATHWAYS; SIGNALING NETWORKS; THEORETICAL PREDICTION; THERAPEUTIC TARGETS; TYPE-2 DIABETES;

FEEDBACK; FORECASTING; INSULIN; PHOSPHORYLATION;

SIGNALING;

INSULIN; INSULIN RECEPTOR;

ADIPOCYTE; ARTICLE; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; ENDOCYTOSIS; FEEDBACK SYSTEM; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; MOLECULAR MODEL; PREDICTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADIPOCYTES; CELLS, CULTURED; COMPUTER SIMULATION; ENDOCYTOSIS; FEEDBACK, PHYSIOLOGICAL; HUMANS; IMMUNOBLOTTING; INSULIN RECEPTOR SUBSTRATE PROTEINS; MODELS, BIOLOGICAL; PHOSPHORYLATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 77953783032     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.106849     Document Type: Article

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