Processive phosphorylation of ERK MAP kinase in mammalian cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 31, 2011, Pages 12675-12680

  Aoki, Kazuhiro ^a,b   Yamada, Masashi ^a   Kunida, Katsuyuki ^a   Yasuda, Shuhei ^a   Matsuda, Michiyuki ^a  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; CHEMICAL REACTION; COMPUTER MODEL; ENZYME SUBSTRATE COMPLEX; HELA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; KINETICS; MAMMAL CELL; MATHEMATICAL COMPUTING; PRIORITY JOURNAL; PROCESSIVE PHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS;

ALGORITHMS; AMINO ACID SEQUENCE; BLOTTING, WESTERN; CELL NUCLEUS; COMPUTER SIMULATION; CYTOPLASM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEK293 CELLS; HELA CELLS; HUMANS; KINETICS; LUMINESCENT PROTEINS; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN KINASES; RNA INTERFERENCE;

MAMMALIA;

EID: 79961243052     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1104030108     Document Type: Article

References (34)

1. Qi M, Elion EA (2005) MAP kinase pathways. JCell Sci 118:3569-3572.
2. Chang L, Karin M (2001) Mammalian MAP kinase signalling cascades. Nature 410:37-40.
3. Chen Z, et al. (2001) MAP kinases. ChemRev 101:2449-2476.
4. Nishida E, Gotoh Y (1993) The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 18:128-131.
5. Songyang Z, et al. (1996) A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol 16:6486-6493.
6. Ferrell JE, Jr, Machleder EM (1998) The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science 280:895-898.
7. Xiong W, Ferrell JE, Jr (2003) A positive-feedback-based bistable 'memory module'that governs a cell fate decision. Nature 426:460-465.
8. Santos SD, Verveer PJ, Bastiaens PI (2007) Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol 9:324-330.
9. Daniels MA, et al. (2006) Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 444:724-729.
10. Lin J, Harding A, Giurisato E, Shaw AS (2009) KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs. Mol Cell Biol 29:2082-2091.
11. Ferrell JE, Jr, Bhatt RR (1997) Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase. J Biol Chem 272:19008-19016.
12. Huang CY, Ferrell JE, Jr (1996) Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 93:10078-10083.
13. Markevich NI, Hoek JB, Kholodenko BN (2004) Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J Cell Biol 164:353-359.
14. Haystead TA, Dent P, Wu J, Haystead CM, Sturgill TW (1992) Ordered phosphorylation of p42mapk by MAP kinase kinase. FEBS Lett 306:17-22.
15. Burack WR, Sturgill TW (1997) The activating dual phosphorylation of MAPK by MEK is nonprocessive. Biochemistry (Mosc) 36:5929-5933.
16. Colman-Lerner A, et al. (2005) Regulated cell-to-cell variation in a cell-fate decision system. Nature 437:699-706.
17. Poritz MA, Malmstrom S, Kim MK, Rossmeissl PJ, Kamb A (2001) Graded mode of transcriptional induction in yeast pheromone signalling revealed by single-cell analysis. Yeast 18:1331-1338.
18. Takahashi S, Pryciak PM (2008) Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade. Curr Biol 18:1184-1191.
19. Mackeigan JP, Murphy LO, Dimitri CA, Blenis J (2005) Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells. Mol Cell Biol 25:4676-4682.
20. Whitehurst A, Cobb MH, White MA (2004) Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal- response pathways. Mol Cell Biol 24:10145-10150.
21. Levchenko A, Bruck J, Sternberg PW (2000) Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc Natl Acad Sci USA 97:5818-5823.
22. Burack WR, Shaw AS (2000) Signal transduction: hanging on a scaffold. Curr Opin Cell Biol 12:211-216.
23. Kolch W (2005) Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 6:827-837.
24. Patwardhan P, MillerWT (2007) Processive phosphorylation: mechanism and biological importance. Cellular Signalling 19:2218-2226.
25. Shaw AS, Filbert EL (2009) Scaffold proteins and immune-cell signalling. Nat Rev Immunol 9:47-56.
26. Amit I, et al. (2007) A module of negative feedback regulators defines growth factor signaling. Nat Genet 39:503-512.
27. Kinoshita E, Kinoshita-Kikuta E, Takiyama K, Koike T (2006) Phosphate-binding tag, a new tool to visualize phosphorylated proteins. Mol Cell Proteomics 5:749-757.
28. Schilling M, et al. (2009) Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Mol Syst Biol 5:334-1-18.
29. Ellis RJ (2001) Macromolecular crowding: an important but neglected aspect of the intracellular environment. Curr Opin Struct Biol 11:114-119.
30. Minton AP (2006) How can biochemical reactions within cells differ from those in test tubes? J Cell Sci 119:2863-2869.
31. Shtilerman MD, Ding TT, Lansbury PT, Jr (2002) Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease? Biochemistry (Mosc) 41:3855-3860.
32. Takahashi K, Tanase-Nicola S, ten Wolde PR (2010) Spatio-temporal correlations can drastically change the response of a MAPK pathway. Proc Natl Acad Sci USA 107:2473-2478.
33. Reynolds AR, Tischer C, Verveer PJ, Rocks O, Bastiaens PI (2003) EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation. Nat Cell Biol 5:447-453.
34. Fujioka A, et al. (2006) Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J Biol Chem 281:8917-8926.