메뉴 건너뛰기




Volumn 63, Issue 2, 2015, Pages 134-142

The molecular mechanism of species-specific recognition of lipopolysaccharides by the MD-2/TLR4 receptor complex

Author keywords

Innate immunity; Lipid A; Lipopolysaccharide; MD 2; Selectivity; TLR4

Indexed keywords

LIPID A; LIPOPOLYSACCHARIDE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4;

EID: 84912047328     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2014.06.034     Document Type: Article
Times cited : (46)

References (89)
  • 1
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S., Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4:499-511.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 3
    • 0345714779 scopus 로고    scopus 로고
    • Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at Toll-like receptor 4 in human endothelial cells
    • Coats S., Reife R., Bainbridge B., Pham T., Darveau R. Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at Toll-like receptor 4 in human endothelial cells. Infect. Immun. 2003, 71:6799-6807.
    • (2003) Infect. Immun. , vol.71 , pp. 6799-6807
    • Coats, S.1    Reife, R.2    Bainbridge, B.3    Pham, T.4    Darveau, R.5
  • 4
    • 34047262709 scopus 로고    scopus 로고
    • Antagonistic lipopolysaccharides block E. coli lipopolysaccharide function at human TLR4 via interaction with the human MD-2 lipopolysaccharide binding site
    • Coats S.R., Do C.T., Karimi-Naser L.M., Braham P.H., Darveau R.P. Antagonistic lipopolysaccharides block E. coli lipopolysaccharide function at human TLR4 via interaction with the human MD-2 lipopolysaccharide binding site. Cell. Microbiol. 2007, 9:1191-1202.
    • (2007) Cell. Microbiol. , vol.9 , pp. 1191-1202
    • Coats, S.R.1    Do, C.T.2    Karimi-Naser, L.M.3    Braham, P.H.4    Darveau, R.P.5
  • 6
    • 84855288788 scopus 로고    scopus 로고
    • Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa
    • Cullen T.W., Giles D.K., Wolf L.N., Ecobichon C., Boneca I.G., Trent M.S. Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa. PLoS Pathog. 2011, 7:e1002454.
    • (2011) PLoS Pathog. , vol.7 , pp. e1002454
    • Cullen, T.W.1    Giles, D.K.2    Wolf, L.N.3    Ecobichon, C.4    Boneca, I.G.5    Trent, M.S.6
  • 7
    • 4544337512 scopus 로고    scopus 로고
    • Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both Toll-like receptors 2 and 4
    • Darveau R., Pham T., Lemley K., Reife R.A., Bainbridge B.W., Coats S.R., Howald W., et al. Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both Toll-like receptors 2 and 4. Infect. Immun. 2004, 72:5041-5051.
    • (2004) Infect. Immun. , vol.72 , pp. 5041-5051
    • Darveau, R.1    Pham, T.2    Lemley, K.3    Reife, R.A.4    Bainbridge, B.W.5    Coats, S.R.6    Howald, W.7
  • 10
    • 0033584935 scopus 로고    scopus 로고
    • Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa
    • Ernst R.K., Yi E.C., Guo L., Lim K.B., Burns J.L., Hackett M., Miller S.I. Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa. Science 1999, 286:1561-1565.
    • (1999) Science , vol.286 , pp. 1561-1565
    • Ernst, R.K.1    Yi, E.C.2    Guo, L.3    Lim, K.B.4    Burns, J.L.5    Hackett, M.6    Miller, S.I.7
  • 12
    • 84866072549 scopus 로고    scopus 로고
    • Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling
    • Fekonja O., Benčina M., Jerala R. Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling. J. Biol. Chem. 2012, 287:30993-31002.
    • (2012) J. Biol. Chem. , vol.287 , pp. 30993-31002
    • Fekonja, O.1    Benčina, M.2    Jerala, R.3
  • 13
    • 66349131309 scopus 로고    scopus 로고
    • Naturally occurring lipid A mutants in Neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy
    • Fransen F., Heckenberg S.G.B., Hamstra H.J., Feller M., Boog C.J.P., van Putten J.P.M., van de Beek D., et al. Naturally occurring lipid A mutants in Neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy. PLoS Pathog. 2009, 5:e1000396.
    • (2009) PLoS Pathog. , vol.5 , pp. e1000396
    • Fransen, F.1    Heckenberg, S.G.B.2    Hamstra, H.J.3    Feller, M.4    Boog, C.J.P.5    van Putten, J.P.M.6    van de Beek, D.7
  • 15
    • 0026088437 scopus 로고
    • Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes
    • Golenbock D.T., Hampton R.Y., Qureshi N., Takayama K., Raetz C.R. Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J. Biol. Chem. 1991, 266:19490-19498.
    • (1991) J. Biol. Chem. , vol.266 , pp. 19490-19498
    • Golenbock, D.T.1    Hampton, R.Y.2    Qureshi, N.3    Takayama, K.4    Raetz, C.R.5
  • 16
    • 3142546368 scopus 로고    scopus 로고
    • Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition
    • Gruber A., Mancek M., Wagner H., Kirschning C.J., Jerala R. Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition. J. Biol. Chem. 2004, 279:28475-28482.
    • (2004) J. Biol. Chem. , vol.279 , pp. 28475-28482
    • Gruber, A.1    Mancek, M.2    Wagner, H.3    Kirschning, C.J.4    Jerala, R.5
  • 17
    • 0031909562 scopus 로고    scopus 로고
    • PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance
    • Gunn J.S., Lim K.B., Krueger J., Kim K., Guo L., Hackett M., Miller S.I. PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance. Mol. Microbiol. 1998, 27:1171-1182.
    • (1998) Mol. Microbiol. , vol.27 , pp. 1171-1182
    • Gunn, J.S.1    Lim, K.B.2    Krueger, J.3    Kim, K.4    Guo, L.5    Hackett, M.6    Miller, S.I.7
  • 18
    • 0030984298 scopus 로고    scopus 로고
    • Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ
    • Guo L., Lim K.B., Gunn J.S., Bainbridge B., Darveau R.P., Hackett M., Miller S.I. Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ. Science 1997, 276:250-253.
    • (1997) Science , vol.276 , pp. 250-253
    • Guo, L.1    Lim, K.B.2    Gunn, J.S.3    Bainbridge, B.4    Darveau, R.P.5    Hackett, M.6    Miller, S.I.7
  • 19
    • 34547553097 scopus 로고    scopus 로고
    • The physicochemistry of endotoxins in relation to bioactivity
    • Gutsmann T., Schromm A.B., Brandenburg K. The physicochemistry of endotoxins in relation to bioactivity. Int. J. Med. Microbiol. 2007, 297:341-352.
    • (2007) Int. J. Med. Microbiol. , vol.297 , pp. 341-352
    • Gutsmann, T.1    Schromm, A.B.2    Brandenburg, K.3
  • 21
    • 33845496485 scopus 로고    scopus 로고
    • Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors
    • Hajjar A.M., Harvey M.D., Shaffer S.A., Goodlett D.R., Sjöstedt A., Edebro H., Forsman M., et al. Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect. Immun. 2006, 74:6730-6738.
    • (2006) Infect. Immun. , vol.74 , pp. 6730-6738
    • Hajjar, A.M.1    Harvey, M.D.2    Shaffer, S.A.3    Goodlett, D.R.4    Sjöstedt, A.5    Edebro, H.6    Forsman, M.7
  • 22
    • 0037318057 scopus 로고    scopus 로고
    • Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC
    • Heine H., Müller-Loennies S., Brade L., Lindner B., Brade H. Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC. Eur. J. Biochem. 2003, 270:440-450.
    • (2003) Eur. J. Biochem. , vol.270 , pp. 440-450
    • Heine, H.1    Müller-Loennies, S.2    Brade, L.3    Lindner, B.4    Brade, H.5
  • 23
    • 84888306556 scopus 로고    scopus 로고
    • Prognostic value of endotoxemia in patients with Gram-negative bacteremia is bacterial species dependent
    • Hurley J.C., Opal S.M. Prognostic value of endotoxemia in patients with Gram-negative bacteremia is bacterial species dependent. J. Innate Immun. 2013, 5:555-564.
    • (2013) J. Innate Immun. , vol.5 , pp. 555-564
    • Hurley, J.C.1    Opal, S.M.2
  • 24
    • 0029154722 scopus 로고
    • The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated
    • Ingalls R.R., Rice P.A., Qureshi N., Takayama K., Lin J.S., Golenbock D.T. The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated. Infect. Immun. 1995, 63:3125-3130.
    • (1995) Infect. Immun. , vol.63 , pp. 3125-3130
    • Ingalls, R.R.1    Rice, P.A.2    Qureshi, N.3    Takayama, K.4    Lin, J.S.5    Golenbock, D.T.6
  • 25
    • 84863692469 scopus 로고    scopus 로고
    • The lipopolysaccharide from Capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in MD-2 binding
    • Ittig S., Lindner B., Stenta M., Manfredi P., Zdorovenko E., Knirel Y.A., dal Peraro M., et al. The lipopolysaccharide from Capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in MD-2 binding. PLoS Pathog. 2012, 8:e1002667.
    • (2012) PLoS Pathog. , vol.8 , pp. e1002667
    • Ittig, S.1    Lindner, B.2    Stenta, M.3    Manfredi, P.4    Zdorovenko, E.5    Knirel, Y.A.6    dal Peraro, M.7
  • 26
    • 33751100626 scopus 로고    scopus 로고
    • The plant immune system
    • Jones J.D.G., Dangl J.L. The plant immune system. Nature 2006, 444:323-329.
    • (2006) Nature , vol.444 , pp. 323-329
    • Jones, J.D.G.1    Dangl, J.L.2
  • 27
    • 77951207782 scopus 로고    scopus 로고
    • Comprehensive structure characterization of lipid A extracted from Yersinia pestis for determination of its phosphorylation configuration
    • Jones J.W., Cohen I.E., Tureĉek F., Goodlett D.R., Ernst R.K. Comprehensive structure characterization of lipid A extracted from Yersinia pestis for determination of its phosphorylation configuration. J. Am. Soc. Mass Spectrom. 2010, 21:785-799.
    • (2010) J. Am. Soc. Mass Spectrom. , vol.21 , pp. 785-799
    • Jones, J.W.1    Cohen, I.E.2    Tureĉek, F.3    Goodlett, D.R.4    Ernst, R.K.5
  • 28
    • 0036073290 scopus 로고    scopus 로고
    • Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature
    • Kawahara K., Tsukano H., Watanabe H., Lindner B., Matsuura M. Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature. Infect. Immun. 2002, 70:4092-4098.
    • (2002) Infect. Immun. , vol.70 , pp. 4092-4098
    • Kawahara, K.1    Tsukano, H.2    Watanabe, H.3    Lindner, B.4    Matsuura, M.5
  • 29
    • 0035889228 scopus 로고    scopus 로고
    • Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
    • Kawai T., Takeuchi O., Fujita T., Inoue J., Mühlradt P.F., Sato S., Hoshino K., et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 2001, 167:5887-5894.
    • (2001) J. Immunol. , vol.167 , pp. 5887-5894
    • Kawai, T.1    Takeuchi, O.2    Fujita, T.3    Inoue, J.4    Mühlradt, P.F.5    Sato, S.6    Hoshino, K.7
  • 30
    • 23644454440 scopus 로고    scopus 로고
    • MD-2 and Der p 2 - a tale of two cousins or distant relatives?
    • Keber M.M., Gradisar H., Jerala R. MD-2 and Der p 2 - a tale of two cousins or distant relatives?. J. Endotoxin Res. 2005, 11:186-192.
    • (2005) J. Endotoxin Res. , vol.11 , pp. 186-192
    • Keber, M.M.1    Gradisar, H.2    Jerala, R.3
  • 31
    • 0037989109 scopus 로고    scopus 로고
    • Francisella novicida LPS has greater immunobiological activity in mice than F. tularensis LPS, and contributes to F. novicida murine pathogenesis
    • Kieffer T.L., Cowley S., Nano F.E., Elkins K.L. Francisella novicida LPS has greater immunobiological activity in mice than F. tularensis LPS, and contributes to F. novicida murine pathogenesis. Microbes Infect. 2003, 5:397-403.
    • (2003) Microbes Infect. , vol.5 , pp. 397-403
    • Kieffer, T.L.1    Cowley, S.2    Nano, F.E.3    Elkins, K.L.4
  • 32
    • 84875489091 scopus 로고    scopus 로고
    • Lipopolysaccharide of Yersinia pestis, the cause of plague: structure, genetics, biological properties
    • Knirel Y.A., Anisimov A.P. Lipopolysaccharide of Yersinia pestis, the cause of plague: structure, genetics, biological properties. Acta Naturae. 2012, 4:46-58.
    • (2012) Acta Naturae. , vol.4 , pp. 46-58
    • Knirel, Y.A.1    Anisimov, A.P.2
  • 37
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., Hoffmann J.A. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996, 86:973-983.
    • (1996) Cell. , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 38
    • 45849140258 scopus 로고    scopus 로고
    • Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia
    • Lembo A., Pelletier M., Iyer R., Timko M., Dudda J.C., West T.E., Wilson C.B., et al. Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia. J. Immunol. 2008, 180:7574-7581.
    • (2008) J. Immunol. , vol.180 , pp. 7574-7581
    • Lembo, A.1    Pelletier, M.2    Iyer, R.3    Timko, M.4    Dudda, J.C.5    West, T.E.6    Wilson, C.B.7
  • 40
    • 0037226464 scopus 로고    scopus 로고
    • Lipopolysaccharide from Rhodobacter sphaeroides is an agonist in equine cells
    • Lohmann K.L., Vandenplas M., Barton M.H., Moore J.N. Lipopolysaccharide from Rhodobacter sphaeroides is an agonist in equine cells. J. Endotoxin Res. 2003, 9:33-37.
    • (2003) J. Endotoxin Res. , vol.9 , pp. 33-37
    • Lohmann, K.L.1    Vandenplas, M.2    Barton, M.H.3    Moore, J.N.4
  • 41
    • 33748640336 scopus 로고    scopus 로고
    • Structural similarity between the hydrophobic fluorescent probe and lipid A as a ligand of MD-2
    • Mancek-Keber M., Jerala R. Structural similarity between the hydrophobic fluorescent probe and lipid A as a ligand of MD-2. FASEB J. 2006, 20:1836-1842.
    • (2006) FASEB J. , vol.20 , pp. 1836-1842
    • Mancek-Keber, M.1    Jerala, R.2
  • 43
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R., Preston-Hurlburt P., Janeway C. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388:394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway, C.3
  • 44
    • 77950591965 scopus 로고    scopus 로고
    • MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation
    • Meng J., Lien E., Golenbock D.T. MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation. J. Biol. Chem. 2010, 285:8695-8702.
    • (2010) J. Biol. Chem. , vol.285 , pp. 8695-8702
    • Meng, J.1    Lien, E.2    Golenbock, D.T.3
  • 45
    • 77956241008 scopus 로고    scopus 로고
    • MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA
    • Meng J., Drolet J.R., Monks B.G., Golenbock D.T. MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA. J. Biol. Chem. 2010, 285:27935-27943.
    • (2010) J. Biol. Chem. , vol.285 , pp. 27935-27943
    • Meng, J.1    Drolet, J.R.2    Monks, B.G.3    Golenbock, D.T.4
  • 47
    • 0030873605 scopus 로고    scopus 로고
    • Structural characterization of the lipid A component of Helicobacter pylori rough- and smooth-form lipopolysaccharides
    • Moran A., Lindner B., Walsh E. Structural characterization of the lipid A component of Helicobacter pylori rough- and smooth-form lipopolysaccharides. J. Bacteriol. 1997, 179:6453-6463.
    • (1997) J. Bacteriol. , vol.179 , pp. 6453-6463
    • Moran, A.1    Lindner, B.2    Walsh, E.3
  • 49
    • 33646829832 scopus 로고    scopus 로고
    • Structural regions of MD-2 that determine the agonist-antagonist activity of lipid IVa
    • Muroi M., Tanamoto K. Structural regions of MD-2 that determine the agonist-antagonist activity of lipid IVa. J. Biol. Chem. 2006, 281:5484-5491.
    • (2006) J. Biol. Chem. , vol.281 , pp. 5484-5491
    • Muroi, M.1    Tanamoto, K.2
  • 51
    • 70349695688 scopus 로고    scopus 로고
    • Structural and biological diversity of lipopolysaccharides from Burkholderia pseudomallei and Burkholderia thailandensis
    • Novem V., Shui G., Wang D., Bendt A.K., Sim S.H., Liu Y., Thong T.W., et al. Structural and biological diversity of lipopolysaccharides from Burkholderia pseudomallei and Burkholderia thailandensis. Clin. Vaccine Immunol. 2009, 16:1420-1428.
    • (2009) Clin. Vaccine Immunol. , vol.16 , pp. 1420-1428
    • Novem, V.1    Shui, G.2    Wang, D.3    Bendt, A.K.4    Sim, S.H.5    Liu, Y.6    Thong, T.W.7
  • 52
    • 34250813748 scopus 로고    scopus 로고
    • Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa
    • Ohto U., Fukase K., Miyake K., Satow Y. Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science(80-.) 2007, 316:1632-1634.
    • (2007) Science(80-.) , vol.316 , pp. 1632-1634
    • Ohto, U.1    Fukase, K.2    Miyake, K.3    Satow, Y.4
  • 53
    • 84860832650 scopus 로고    scopus 로고
    • Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
    • Ohto U., Fukase K., Miyake K., Shimizu T. Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:7421-7426.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 7421-7426
    • Ohto, U.1    Fukase, K.2    Miyake, K.3    Shimizu, T.4
  • 54
    • 79959536183 scopus 로고    scopus 로고
    • The ectodomain of the Toll-like receptor 4 prevents constitutive receptor activation
    • Panter G., Jerala R. The ectodomain of the Toll-like receptor 4 prevents constitutive receptor activation. J. Biol. Chem. 2011, 286:23334-23344.
    • (2011) J. Biol. Chem. , vol.286 , pp. 23334-23344
    • Panter, G.1    Jerala, R.2
  • 55
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • Park B.S., Song D.H., Kim H.M., Choi B.-S., Lee H., Lee J.-O. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 2009, 458:1191-1195.
    • (2009) Nature , vol.458 , pp. 1191-1195
    • Park, B.S.1    Song, D.H.2    Kim, H.M.3    Choi, B.-S.4    Lee, H.5    Lee, J.-O.6
  • 56
    • 2942595715 scopus 로고    scopus 로고
    • A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2
    • Que-Gewirth N.L.S., Ribeiro A.A., Kalb S.R., Cotter R.J., Bulach D.M., Adler B., Girons I.S., et al. A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2. J. Biol. Chem. 2004, 279:25420-25429.
    • (2004) J. Biol. Chem. , vol.279 , pp. 25420-25429
    • Que-Gewirth, N.L.S.1    Ribeiro, A.A.2    Kalb, S.R.3    Cotter, R.J.4    Bulach, D.M.5    Adler, B.6    Girons, I.S.7
  • 57
    • 0023901618 scopus 로고
    • Location of fatty acids in lipid A obtained from lipopolysaccharide of Rhodopseudomonas sphaeroides ATCC 17023
    • Qureshi N., Honovich J.P., Hara H., Cotter R.J., Takayama K. Location of fatty acids in lipid A obtained from lipopolysaccharide of Rhodopseudomonas sphaeroides ATCC 17023. J. Biol. Chem. 1988, 263:5502-5504.
    • (1988) J. Biol. Chem. , vol.263 , pp. 5502-5504
    • Qureshi, N.1    Honovich, J.P.2    Hara, H.3    Cotter, R.J.4    Takayama, K.5
  • 58
    • 0026019704 scopus 로고
    • Diphosphoryl lipid A obtained from the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides is an endotoxin antagonist in mice
    • Qureshi N., Takayama K., Kurtz R. Diphosphoryl lipid A obtained from the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides is an endotoxin antagonist in mice. Infect. Immun. 1991, 59:441-444.
    • (1991) Infect. Immun. , vol.59 , pp. 441-444
    • Qureshi, N.1    Takayama, K.2    Kurtz, R.3
  • 60
    • 0030968308 scopus 로고    scopus 로고
    • Structure of the monophosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis
    • Qureshi N., Kaltashov I., Walker K., Doroshenko V., Cotter R.J., Takayama K., Sievert T.R., et al. Structure of the monophosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis. J. Biol. Chem. 1997, 272:10594-10600.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10594-10600
    • Qureshi, N.1    Kaltashov, I.2    Walker, K.3    Doroshenko, V.4    Cotter, R.J.5    Takayama, K.6    Sievert, T.R.7
  • 61
    • 0027255391 scopus 로고
    • Bacterial endotoxins: extraordinary lipids that activate eucaryotic signal transduction
    • Raetz C.R. Bacterial endotoxins: extraordinary lipids that activate eucaryotic signal transduction. J. Bacteriol. 1993, 175:5745-5753.
    • (1993) J. Bacteriol. , vol.175 , pp. 5745-5753
    • Raetz, C.R.1
  • 66
    • 67649386535 scopus 로고    scopus 로고
    • Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin
    • Resman N., Vasl J., Oblak A., Pristovsek P., Gioannini T.L., Weiss J.P., Jerala R. Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin. J. Biol. Chem. 2009, 284:15052-15060.
    • (2009) J. Biol. Chem. , vol.284 , pp. 15052-15060
    • Resman, N.1    Vasl, J.2    Oblak, A.3    Pristovsek, P.4    Gioannini, T.L.5    Weiss, J.P.6    Jerala, R.7
  • 67
    • 84896737910 scopus 로고    scopus 로고
    • Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions
    • Resman N., Oblak A., Gioannini T.L., Weiss J.P., Jerala R. Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions. J. Immunol. 2014, 192:1887-1895.
    • (2014) J. Immunol. , vol.192 , pp. 1887-1895
    • Resman, N.1    Oblak, A.2    Gioannini, T.L.3    Weiss, J.P.4    Jerala, R.5
  • 68
    • 0033546340 scopus 로고    scopus 로고
    • Structural analysis of the lipopolysaccharide from Chlamydia trachomatis serotype L2
    • Rund S., Lindner B., Brade H., Holst O. Structural analysis of the lipopolysaccharide from Chlamydia trachomatis serotype L2. J. Biol. Chem. 1999, 274:16819-16824.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16819-16824
    • Rund, S.1    Lindner, B.2    Brade, H.3    Holst, O.4
  • 70
    • 0034117771 scopus 로고    scopus 로고
    • Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity
    • Seydel U., Oikawa M., Fukase K., Kusumoto S., Brandenburg K. Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity. Eur. J. Biochem. 2000, 267:3032-3039.
    • (2000) Eur. J. Biochem. , vol.267 , pp. 3032-3039
    • Seydel, U.1    Oikawa, M.2    Fukase, K.3    Kusumoto, S.4    Brandenburg, K.5
  • 71
    • 84866009995 scopus 로고    scopus 로고
    • Virulence properties of the Legionella pneumophila cell envelope
    • Shevchuk O., Jäger J., Steinert M. Virulence properties of the Legionella pneumophila cell envelope. Front. Microbiol. 2011, 2:74.
    • (2011) Front. Microbiol. , vol.2 , pp. 74
    • Shevchuk, O.1    Jäger, J.2    Steinert, M.3
  • 72
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 1999, 189:1777-1782.
    • (1999) J. Exp. Med. , vol.189 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5    Miyake, K.6    Kimoto, M.7
  • 73
    • 83455169259 scopus 로고    scopus 로고
    • Neisseria meningitidis lipid A mutant LPSs function as LPS antagonists in humans by inhibiting TLR 4-dependent cytokine production
    • Sprong T., Ley P.v., Abdollahi-Roodsaz S., Joosten L., Meer J.v., Netea M., Deuren M.v. Neisseria meningitidis lipid A mutant LPSs function as LPS antagonists in humans by inhibiting TLR 4-dependent cytokine production. Innate Immun. 2011, 17:517-525.
    • (2011) Innate Immun. , vol.17 , pp. 517-525
    • Sprong, T.1    Ley, P.2    Abdollahi-Roodsaz, S.3    Joosten, L.4    Meer, J.5    Netea, M.6    Deuren, M.7
  • 74
    • 48849095429 scopus 로고    scopus 로고
    • Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis
    • Steeghs L., Keestra A.M., van Mourik A., Uronen-Hansson H., van der Ley P., Callard R., Klein N., et al. Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis. Infect. Immun. 2008, 76:3801-3807.
    • (2008) Infect. Immun. , vol.76 , pp. 3801-3807
    • Steeghs, L.1    Keestra, A.M.2    van Mourik, A.3    Uronen-Hansson, H.4    van der Ley, P.5    Callard, R.6    Klein, N.7
  • 75
    • 21744458868 scopus 로고    scopus 로고
    • Equine endotoxaemia-A state-of-the-art review of therapy
    • Sykes B., Furr M. Equine endotoxaemia-A state-of-the-art review of therapy. Aust. Vet. J. 2005, 83:45-50.
    • (2005) Aust. Vet. J. , vol.83 , pp. 45-50
    • Sykes, B.1    Furr, M.2
  • 76
    • 0024515391 scopus 로고
    • Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide
    • Takayama K., Qureshi N., Beutler B., Kirkland T.N. Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide. Infect. Immun. 1989, 57:1336-1338.
    • (1989) Infect. Immun. , vol.57 , pp. 1336-1338
    • Takayama, K.1    Qureshi, N.2    Beutler, B.3    Kirkland, T.N.4
  • 77
    • 0034653876 scopus 로고    scopus 로고
    • Salmonella-type heptaacylated lipid A is inactive and acts as an antagonist of lipopolysaccharide action on human line cells
    • Tanamoto K., Azumi S. Salmonella-type heptaacylated lipid A is inactive and acts as an antagonist of lipopolysaccharide action on human line cells. J. Immunol. 2000, 164:3149-3156.
    • (2000) J. Immunol. , vol.164 , pp. 3149-3156
    • Tanamoto, K.1    Azumi, S.2
  • 79
    • 41449105582 scopus 로고    scopus 로고
    • Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss
    • Temperley N.D., Berlin S., Paton I.R., Griffin D.K., Burt D.W. Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss. BMC Genomics 2008, 9:62.
    • (2008) BMC Genomics , vol.9 , pp. 62
    • Temperley, N.D.1    Berlin, S.2    Paton, I.R.3    Griffin, D.K.4    Burt, D.W.5
  • 80
    • 77954100856 scopus 로고    scopus 로고
    • Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2
    • Vasl J., Oblak A., Gioannini T.L., Weiss J.P., Jerala R. Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2. J. Immunol. 2009, 183:5138-5145.
    • (2009) J. Immunol. , vol.183 , pp. 5138-5145
    • Vasl, J.1    Oblak, A.2    Gioannini, T.L.3    Weiss, J.P.4    Jerala, R.5
  • 81
    • 0036453946 scopus 로고    scopus 로고
    • Structural analysis of Francisella tularensis lipopolysaccharide
    • Vinogradov E., Perry M.B., Conlan J.W. Structural analysis of Francisella tularensis lipopolysaccharide. Eur. J. Biochem. 2002, 269:6112-6118.
    • (2002) Eur. J. Biochem. , vol.269 , pp. 6112-6118
    • Vinogradov, E.1    Perry, M.B.2    Conlan, J.W.3
  • 83
    • 10344259135 scopus 로고    scopus 로고
    • MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of Francisella novicida LpxE expressed in Escherichia coli
    • Wang X., Karbarz M.J., McGrath S.C., Cotter R.J., Raetz C.R.H. MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of Francisella novicida LpxE expressed in Escherichia coli. J. Biol. Chem. 2004, 279:49470-49478.
    • (2004) J. Biol. Chem. , vol.279 , pp. 49470-49478
    • Wang, X.1    Karbarz, M.J.2    McGrath, S.C.3    Cotter, R.J.4    Raetz, C.R.H.5
  • 84
    • 33646906020 scopus 로고    scopus 로고
    • Expression cloning and periplasmic orientation of the Francisella novicida lipid A 4'-phosphatase LpxF
    • Wang X., McGrath S.C., Cotter R.J., Raetz C.R.H. Expression cloning and periplasmic orientation of the Francisella novicida lipid A 4'-phosphatase LpxF. J. Biol. Chem. 2006, 281:9321-9330.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9321-9330
    • Wang, X.1    McGrath, S.C.2    Cotter, R.J.3    Raetz, C.R.H.4
  • 85
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    • Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., Takeuchi O., et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003, 301:640-643.
    • (2003) Science , vol.301 , pp. 640-643
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3    Hoshino, K.4    Kaisho, T.5    Sanjo, H.6    Takeuchi, O.7
  • 86
    • 0029451046 scopus 로고
    • The lipopolysaccharide of Legionella pneumophila serogroup 1 (strain Philadelphia 1): chemical structure and biological significance
    • Zähringer U., Knirel Y.A., Lindner B., Helbig J.H., Sonesson A., Marre R., Rietschel E.T. The lipopolysaccharide of Legionella pneumophila serogroup 1 (strain Philadelphia 1): chemical structure and biological significance. Prog. Clin. Biol. Res. 1995, 392:113-139.
    • (1995) Prog. Clin. Biol. Res. , vol.392 , pp. 113-139
    • Zähringer, U.1    Knirel, Y.A.2    Lindner, B.3    Helbig, J.H.4    Sonesson, A.5    Marre, R.6    Rietschel, E.T.7
  • 87
    • 34247515977 scopus 로고    scopus 로고
    • Modulation of innate immune responses with synthetic lipid A derivatives
    • Zhang Y., Gaekwad J., Wolfert M.A., Boons G.-J. Modulation of innate immune responses with synthetic lipid A derivatives. J. Am. Chem. Soc. 2007, 129:5200-5216.
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 5200-5216
    • Zhang, Y.1    Gaekwad, J.2    Wolfert, M.A.3    Boons, G.-J.4
  • 88
    • 0346251037 scopus 로고    scopus 로고
    • Neisseria meningitidis lipooligosaccharide structure-dependent activation of the macrophage CD14/Toll-like receptor 4 pathway
    • Zughaier S.M., Tzeng Y.-L., Zimmer S.M., Datta A., Carlson R.W., Stephens D.S. Neisseria meningitidis lipooligosaccharide structure-dependent activation of the macrophage CD14/Toll-like receptor 4 pathway. Infect. Immun. 2004, 72:371-380.
    • (2004) Infect. Immun. , vol.72 , pp. 371-380
    • Zughaier, S.M.1    Tzeng, Y.-L.2    Zimmer, S.M.3    Datta, A.4    Carlson, R.W.5    Stephens, D.S.6
  • 89
    • 17744369711 scopus 로고    scopus 로고
    • Differential induction of the Toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins
    • Zughaier S.M., Zimmer S.M., Datta A., Carlson R.W., Stephens D.S. Differential induction of the Toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins. Infect. Immun. 2005, 73:2940-2950.
    • (2005) Infect. Immun. , vol.73 , pp. 2940-2950
    • Zughaier, S.M.1    Zimmer, S.M.2    Datta, A.3    Carlson, R.W.4    Stephens, D.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.