MD-2 and Der p 2 - A tale of two cousins or distant relatives?

Journal of Endotoxin Research

Volumn 11, Issue 3, 2005, Pages 186-192

  Keber, Mateja Manček ^a   Gradišar, Helena ^a   Jerala, Roman ^a  

^a NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

Author keywords

Dendrogram; Der p 2; MD 2; ML superfamily; Tertiary structure

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYSTEINE; LIPID BINDING PROTEIN; PROTEIN DER P 2; PROTEIN MD 2; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

BACTERIAL IMMUNITY; BINDING AFFINITY; CONFERENCE PAPER; CONTROLLED STUDY; GRAM NEGATIVE BACTERIUM; HUMAN; INNATE IMMUNITY; INSECT; MOLECULAR MODEL; NONHUMAN; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN LIPID INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; TEMPERATURE DEPENDENCE;

ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ANTIGENS, SURFACE; CARRIER PROTEINS; ELECTROSTATICS; ESCHERICHIA COLI; EVOLUTION; GRAM-NEGATIVE BACTERIA; IMMUNITY, NATURAL; INSECTS; LYMPHOCYTE ANTIGEN 96; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY; VERTEBRATES;

ACARI; HEXAPODA; NEGIBACTERIA; VERTEBRATA;

EID: 23644454440     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805105X35206     Document Type: Conference Paper

References (32)

1. Janeway Jr CA, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002; 20: 197-216.
2. Poltorak A, He X, Smirnova I et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-2088.
3. Qureshi ST, Lariviere L, Leveque G et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 1999; 189: 615-625.
4. Shimazu R, Akashi S, Ogata H et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999; 189: 1777-1782.
5. Nagai T, Ibata K, Park ES, Kubota M, Mikoshiba K, Miyawaki A. A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol 2002; 20: 87-90.
6. Re F, Strominger JL. Monomeric recombinant MD-2 binds Toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness. J Biol Chem 2002; 277: 23427-23432.
7. Viriyakosol S, Tobias PS, Kitchens RL, Kirkland TN. MD-2 binds to bacterial lipopolysaccharide. J Biol Chem 2001; 276: 38044-38051.
8. Akashi S, Saitoh S, Wakabayashi Y et al. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med 2003; 198: 1035-1042.
9. Schromm AB, Lien E, Henneke P et al. Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J Exp Med 2001; 194: 79-58.
10. Re F, Strominger JL. Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness. J Immunol 2003; 171: 5272-5276.
11. Mancek M, Pristovsek P, Jerala R. Identification of LPS-binding peptide fragment of MD-2, a Toll-receptor accessory protein. Biochem Biophys Res Commun 2002; 292: 880-885.
12. Visintin A, Latz E, Monks BG, Espevik T, Golenbock DT. Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction. J Biol Chem 2003; 278: 48313-48320.
13. Kawasaki K, Nogawa H, Nishijima M. Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and Taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis. J Immunol 2003; 170: 413-420.
14. Inohara N, Nunez G. ML - a conserved domain involved in innate immunity and lipid metabolism. Trends Biochem Sci 2002; 27: 219-221.
15. Derewenda U, Li J, Derewenda Z et al. The crystal structure of a major dust mite allergen Der p 2, and its biological implications. J Mol Biol 2002; 318: 189-197.
16. Wright CS, Li SC, Rastinejad F. Crystal structure of human GM2-activator protein with a novel beta-cup topology. J Mol Biol 2000; 304: 411-422.
17. Wright CS, Zhao Q, Rastinejad F. Structural analysis of lipid complexes of GM2-activator protein. J Mol Biol 2003; 331: 951-964.
18. Friedland N, Liou HL, Lobel P, Stock AM. Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease. Proc Natl Acad Sci USA 2003; 100: 2512-2517.
19. Heymann PW, Chapman MD, Aalberse RC, Fox JW, Platts-Mills TA. Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp). J Allergy Clin Immunol 1989; 83: 1055-1067.
20. Mueller GA, Benjamin DC, Rule GS. Tertiary structure of the major house dust mite allergen Der p 2: sequential and structural homologies. Biochemistry 1998; 37: 12707-12714.
21. Gruber A, Mancek M, Wagner H, Kirschning CJ, Jerala R. Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition. J Biol Chem 2004; 279: 28475-28482.
22. Altschul SF, Madden TL, Schaffer AA et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997; 25: 3389-3402.
23. Edgar RC. MUSCLE: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinformatics 2004; 5: 113-131.
24. Sali A, Potterton L, Yuan F, van Vlijmen H, Karplus M. Evaluation of comparative protein modeling by MODELLER. Proteins 1995; 23: 318-326.
25. Kennedy MN, Mullen GE, Leifer CA et al. A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4. J Biol Chem 2004; 279: 34698-34704.
26. Cain G, Elderfield AJ, Green R et al. The effect of dry heat on mite, cat, and dog allergens. Allergy 1998; 53: 1213-1215.
27. Mullen GE, Kennedy MN, Visintin A et al. The role of disulfide bonds in the assembly and function of MD-2. Proc Natl Acad Sci USA 2003; 100: 3919-3924.
28. Gioannini TL, Teghanemt A, Zhang D et al. Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations. Proc Natl Acad Sci USA 2004; 101: 4186-4191.
29. Ichikawa S, Hatanaka H, Yuuki T et al. Solution structure of Der f2, the major mite allergen for atopic diseases. J Biol Chem 1998; 273: 356-360.
30. Thomas WR, Chua KY. The major mite allergen Der p 2 - a secretion of the male mite reproductive tract? Clin Exp Allergy 1995; 25: 667-669.
31. Spellman PT, Rubin GM. Evidence for large domains of similarly expressed genes in the Drosophila genome. J Biol 2002; 1: 5-12.
32. Guex N, Peitsch MC. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 1997; 18: 2714-2723.