MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation

Journal of Biological Chemistry

Volumn 285, Issue 12, 2010, Pages 8695-8702

  Meng, Jianmin ^a   Lien, Egil ^a   Golenbock, Douglas T ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL LINES; CHARGE REVERSAL; COMPUTATIONAL STUDIES; HUMAN CELLS; HYDROPHOBIC POCKETS; INNATE IMMUNE RESPONSE; INTRACELLULAR SIGNALING; IONIC INTERACTION; LIPID A; LIPOPOLYSACCHARIDES; POSITIVELY CHARGED; PROINFLAMMATORY RESPONSE; RECEPTOR ACTIVATION;

CELL CULTURE; DIMERIZATION; DYES; SIGNALING;

COMPLEXATION;

ARGININE; GLUTAMIC ACID; GLUTAMINE; LIPID; LIPID A; LIPOPOLYSACCHARIDE; LYSINE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; LY96 PROTEIN, HUMAN; LY96 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL COMMUNICATION; CELL LINE; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LIPID INTERACTION; RODENT; SPECIES DIFFERENCE; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

RODENTIA; TETRA;

ANIMALS; DIMERIZATION; HUMANS; LIPID A; LIPIDS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MACROPHAGES; MICE; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 77950591965     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.075127     Document Type: Article

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