Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa

Science

Volumn 316, Issue 5831, 2007, Pages 1632-1634

  Onto, Umeharu ^a   Fukase, Koichi ^b   Miyake, Kensuke ^a,c   Satow, Yoshinori ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ENDOTOXIN; GLUCOSAMINE; LIPID A; LIPOPOLYSACCHARIDE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4;

CRYSTAL STRUCTURE; DRUG DEVELOPMENT; HYDROPHOBICITY; LIGAND; LIPID; POLYSACCHARIDE; TOXICITY;

ARTICLE; BETA SHEET; COMPLEX FORMATION; CRYSTAL STRUCTURE; HUMAN; HYDROPHOBICITY; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FATTY ACIDS; GLYCOLIPIDS; GLYCOSYLATION; HUMANS; HYDROPHOBICITY; LIGANDS; LIPID A; LYMPHOCYTE ANTIGEN 96; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY;

IVA; TETRA;

EID: 34250813748     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1139111     Document Type: Article

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31. Supported by Japanese Ministry of Education, Culture, Sports, Science and Technology grants-in-aid and a Protein 3000 grant (Y.S.), a JST-CREST grant (K.M.), and the JSPS scholarship and its grant (U.O.). We thank K. Hasegawa for technical assistance in the synchrotron experiment at SPring-8 BL38B1. Coordinates and structure amplitudes have been deposited in the Protein Data Bank with accession numbers 2E56 and 2E59 for the native and complexed structures, respectively.