-
2
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov, R., P. Preston-Hurlburt, and C. A. Janeway, Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397.
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway Jr., C.A.3
-
3
-
-
0035851092
-
MD-2 binds to bacterial lipopolysaccharide
-
Viriyakosol, S., P. S. Tobias, R. L. Kitchens, and T. N. Kirkland. 2001. MD-2 binds to bacterial lipopolysaccharide. J. Biol. Chem. 276: 38044-38051.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38044-38051
-
-
Viriyakosol, S.1
Tobias, P.S.2
Kitchens, R.L.3
Kirkland, T.N.4
-
4
-
-
0033532629
-
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
-
Shimazu, R., S. Akashi, H. Ogata, Y. Nagai, K. Fukudome, K. Miyake, and M. Kimoto. 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189: 1777-1782.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1777-1782
-
-
Shimazu, R.1
Akashi, S.2
Ogata, H.3
Nagai, Y.4
Fukudome, K.5
Miyake, K.6
Kimoto, M.7
-
5
-
-
67349182481
-
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
-
Park, B. S., D. H. Song, H. M. Kim, B.-S. Choi, H. Lee, and J.-O. Lee. 2009. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458: 1191-1195.
-
(2009)
Nature
, vol.458
, pp. 1191-1195
-
-
Park, B.S.1
Song, D.H.2
Kim, H.M.3
Choi, B.-S.4
Lee, H.5
Lee, J.-O.6
-
6
-
-
84860870432
-
NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes
-
Yu, L., R. L. Phillips, D. Zhang, A. Teghanemt, J. P. Weiss, and T. L. Gioannini. 2012. NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes. J. Biol. Chem. 287: 16346-16355.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 16346-16355
-
-
Yu, L.1
Phillips, R.L.2
Zhang, D.3
Teghanemt, A.4
Weiss, J.P.5
Gioannini, T.L.6
-
7
-
-
67649386535
-
Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin
-
Resman, N., J. Vasl, A. Oblak, P. Pristovsek, T. L. Gioannini, J. P. Weiss, and R. Jerala. 2009. Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin. J. Biol. Chem. 284: 15052-15060.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 15052-15060
-
-
Resman, N.1
Vasl, J.2
Oblak, A.3
Pristovsek, P.4
Gioannini, T.L.5
Weiss, J.P.6
Jerala, R.7
-
8
-
-
84860879114
-
Endotoxin· albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of Toll-like receptor-4
-
Esparza, G., A. Teghanemt, D. Zhang, T. L. Gioannini, and J. P. Weiss. 2012. Endotoxin· albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of Toll-like receptor-4. Innate Immun. 18: 478-491.
-
(2012)
Innate Immun.
, vol.18
, pp. 478-491
-
-
Esparza, G.1
Teghanemt, A.2
Zhang, D.3
Gioannini, T.L.4
Weiss, J.P.5
-
9
-
-
34548222514
-
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
-
Kim, H. M., B. S. Park, J.-I. Kim, S. E. Kim, J. Lee, S. C. Oh, P. Enkhbayar, N. Matsushima, H. Lee, O. J. Yoo, and J.-O. Lee. 2007. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130: 906-917.
-
(2007)
Cell
, vol.130
, pp. 906-917
-
-
Kim, H.M.1
Park, B.S.2
Kim, J.-I.3
Kim, S.E.4
Lee, J.5
Oh, S.C.6
Enkhbayar, P.7
Matsushima, N.8
Lee, H.9
Yoo, O.J.10
Lee, J.-O.11
-
10
-
-
0034723186
-
Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharidemimetic signal transduction by Taxol
-
Kawasaki, K., S. Akashi, R. Shimazu, T. Yoshida, K. Miyake, and M. Nishijima. 2000. Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharidemimetic signal transduction by Taxol. J. Biol. Chem. 275: 2251-2254.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2251-2254
-
-
Kawasaki, K.1
Akashi, S.2
Shimazu, R.3
Yoshida, T.4
Miyake, K.5
Nishijima, M.6
-
11
-
-
25444453176
-
Molecular basis of reduced potency of underacylated endotoxins
-
Teghanemt, A., D. Zhang, E. N. Levis, J. P. Weiss, and T. L. Gioannini. 2005. Molecular basis of reduced potency of underacylated endotoxins. J. Immunol. 175: 4669-4676.
-
(2005)
J. Immunol.
, vol.175
, pp. 4669-4676
-
-
Teghanemt, A.1
Zhang, D.2
Levis, E.N.3
Weiss, J.P.4
Gioannini, T.L.5
-
12
-
-
84860832650
-
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
-
Ohto, U., K. Fukase, K. Miyake, and T. Shimizu. 2012. Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. Proc. Natl. Acad. Sci. USA 109: 7421-7426.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 7421-7426
-
-
Ohto, U.1
Fukase, K.2
Miyake, K.3
Shimizu, T.4
-
13
-
-
55749105288
-
Taxanes inhibit human TLR4 signaling by binding to MD-2
-
Resman, N., H. Gradisar, J. Vasl, M. M. Keber, P. Pristovsek, and R. Jerala. 2008. Taxanes inhibit human TLR4 signaling by binding to MD-2. FEBS Lett. 582: 3929-3934.
-
(2008)
FEBS Lett.
, vol.582
, pp. 3929-3934
-
-
Resman, N.1
Gradisar, H.2
Vasl, J.3
Keber, M.M.4
Pristovsek, P.5
Jerala, R.6
-
14
-
-
0141557898
-
Molecular basis for lipopolysaccharide mimetic action of Taxol and flavolipin
-
Kawasaki, K., K. Gomi, Y. Kawai, M. Shiozaki, and M. Nishijima. 2003. Molecular basis for lipopolysaccharide mimetic action of Taxol and flavolipin. J. Endotoxin Res. 9: 301-307.
-
(2003)
J. Endotoxin Res.
, vol.9
, pp. 301-307
-
-
Kawasaki, K.1
Gomi, K.2
Kawai, Y.3
Shiozaki, M.4
Nishijima, M.5
-
15
-
-
0037220924
-
Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis
-
Kawasaki, K., H. Nogawa, and M. Nishijima. 2003. Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis. J. Immunol. 170: 413-420.
-
(2003)
J. Immunol.
, vol.170
, pp. 413-420
-
-
Kawasaki, K.1
Nogawa, H.2
Nishijima, M.3
-
16
-
-
0034857271
-
The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol
-
Byrd-Leifer, C. A., E. F. Block, K. Takeda, S. Akira, and A. Ding. 2001. The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol. Eur. J. Immunol. 31: 2448-2457.
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 2448-2457
-
-
Byrd-Leifer, C.A.1
Block, E.F.2
Takeda, K.3
Akira, S.4
Ding, A.5
-
17
-
-
0036222620
-
Human Toll-like receptor 4 recognizes host-specific LPS modifications
-
Hajjar, A. M., R. K. Ernst, J. H. Tsai, C. B. Wilson, and S. I. Miller. 2002. Human Toll-like receptor 4 recognizes host-specific LPS modifications. Nat. Immunol. 3: 354-359.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 354-359
-
-
Hajjar, A.M.1
Ernst, R.K.2
Tsai, J.H.3
Wilson, C.B.4
Miller, S.I.5
-
18
-
-
77956241008
-
MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA
-
Meng, J., J. R. Drolet, B. G. Monks, and D. T. Golenbock. 2010. MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA. J. Biol. Chem. 285: 27935-27943.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 27935-27943
-
-
Meng, J.1
Drolet, J.R.2
Monks, B.G.3
Golenbock, D.T.4
-
19
-
-
77950591965
-
MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation
-
Meng, J., E. Lien, and D. T. Golenbock. 2010. MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation. J. Biol. Chem. 285: 8695-8702.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 8695-8702
-
-
Meng, J.1
Lien, E.2
Golenbock, D.T.3
-
20
-
-
0035937097
-
Construction of acetate auxotrophs of Neisseria meningitidis to study host-meningococcal endotoxin interactions
-
Giardina, P. C., T. Gioannini, B. A. Buscher, A. Zaleski, D. S. Zheng, L. Stoll, A. Teghanemt, M. A. Apicella, and J. Weiss. 2001. Construction of acetate auxotrophs of Neisseria meningitidis to study host-meningococcal endotoxin interactions. J. Biol. Chem. 276: 5883-5891.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5883-5891
-
-
Giardina, P.C.1
Gioannini, T.2
Buscher, B.A.3
Zaleski, A.4
Zheng, D.S.5
Stoll, L.6
Teghanemt, A.7
Apicella, M.A.8
Weiss, J.9
-
21
-
-
1642529500
-
Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations
-
Gioannini, T. L., A. Teghanemt, D. Zhang, N. P. Coussens, W. Dockstader, S. Ramaswamy, and J. P. Weiss. 2004. Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations. Proc. Natl. Acad. Sci. USA 101: 4186-4191.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4186-4191
-
-
Gioannini, T.L.1
Teghanemt, A.2
Zhang, D.3
Coussens, N.P.4
Dockstader, W.5
Ramaswamy, S.6
Weiss, J.P.7
-
22
-
-
0037033015
-
An essential role for albumin in the interaction of endotoxin with lipopolysaccharide-binding protein and sCD14 and resultant cell activation
-
Gioannini, T. L., D. Zhang, A. Teghanemt, and J. P. Weiss. 2002. An essential role for albumin in the interaction of endotoxin with lipopolysaccharide-binding protein and sCD14 and resultant cell activation. J. Biol. Chem. 277: 47818-47825.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 47818-47825
-
-
Gioannini, T.L.1
Zhang, D.2
Teghanemt, A.3
Weiss, J.P.4
-
23
-
-
33847708375
-
Specific high affinity interactions of monomeric endotoxin. Protein complexes with Toll-like receptor 4 ectodomain
-
Prohinar, P., F. Re, R. Widstrom, D. Zhang, A. Teghanemt, J. P. Weiss, and T. L. Gioannini. 2007. Specific high affinity interactions of monomeric endotoxin. protein complexes with Toll-like receptor 4 ectodomain. J. Biol. Chem. 282: 1010-1017.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 1010-1017
-
-
Prohinar, P.1
Re, F.2
Widstrom, R.3
Zhang, D.4
Teghanemt, A.5
Weiss, J.P.6
Gioannini, T.L.7
-
24
-
-
34250813748
-
Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa
-
Ohto, U., K. Fukase, K. Miyake, and Y. Satow. 2007. Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science 316: 1632-1634.
-
(2007)
Science
, vol.316
, pp. 1632-1634
-
-
Ohto, U.1
Fukase, K.2
Miyake, K.3
Satow, Y.4
-
25
-
-
77953325845
-
Ligand docking and binding site analysis with PyMOL and Autodock/Vina
-
Seeliger, D., and B. L. de Groot. 2010. Ligand docking and binding site analysis with PyMOL and Autodock/Vina. J. Comput. Aided Mol. Des. 24: 417-422.
-
(2010)
J. Comput. Aided Mol. Des.
, vol.24
, pp. 417-422
-
-
Seeliger, D.1
De Groot, B.L.2
-
26
-
-
4444221565
-
UCSF Chimera - A visualization system for exploratory research and analysis
-
Pettersen, E. F., T. D. Goddard, C. C. Huang, G. S. Couch, D. M. Greenblatt, E. C. Meng, and T. E. Ferrin. 2004. UCSF Chimera - a visualization system for exploratory research and analysis. J. Comput. Chem. 25: 1605-1612.
-
(2004)
J. Comput. Chem.
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
Goddard, T.D.2
Huang, C.C.3
Couch, G.S.4
Greenblatt, D.M.5
Meng, E.C.6
Ferrin, T.E.7
-
27
-
-
34250854079
-
The vaccine adjuvant monophosphoryl lipid A as a TRIFbiased agonist of TLR4
-
Mata-Haro, V., C. Cekic, M. Martin, P. M. Chilton, C. R. Casella, and T. C. Mitchell. 2007. The vaccine adjuvant monophosphoryl lipid A as a TRIFbiased agonist of TLR4. Science 316: 1628-1632.
-
(2007)
Science
, vol.316
, pp. 1628-1632
-
-
Mata-Haro, V.1
Cekic, C.2
Martin, M.3
Chilton, P.M.4
Casella, C.R.5
Mitchell, T.C.6
-
28
-
-
38349186906
-
Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin
-
Teghanemt, A., F. Re, P. Prohinar, R. Widstrom, T. L. Gioannini, and J. P. Weiss. 2008. Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin. J. Biol. Chem. 283: 1257-1266.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 1257-1266
-
-
Teghanemt, A.1
Re, F.2
Prohinar, P.3
Widstrom, R.4
Gioannini, T.L.5
Weiss, J.P.6
-
29
-
-
33748875900
-
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
-
Montminy, S. W., N. Khan, S. McGrath, M. J. Walkowicz, F. Sharp, J. E. Conlon, K. Fukase, S. Kusumoto, C. Sweet, K. Miyake, et al. 2006. Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat. Immunol. 7: 1066-1073.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 1066-1073
-
-
Montminy, S.W.1
Khan, N.2
McGrath, S.3
Walkowicz, M.J.4
Sharp, F.5
Conlon, J.E.6
Fukase, K.7
Kusumoto, S.8
Sweet, C.9
Miyake, K.10
-
30
-
-
70450253086
-
Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A
-
Cekic, C., C. R. Casella, C. A. Eaves, A. Matsuzawa, H. Ichijo, and T. C. Mitchell. 2009. Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. J. Biol. Chem. 284: 31982-31991.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 31982-31991
-
-
Cekic, C.1
Casella, C.R.2
Eaves, C.A.3
Matsuzawa, A.4
Ichijo, H.5
Mitchell, T.C.6
-
31
-
-
55549143335
-
Paclitaxel binding to human and murine MD-2
-
Zimmer, S.M., J. Liu, J. L. Clayton, D. S. Stephens, and J. P. Snyder. 2008. Paclitaxel binding to human and murine MD-2. J. Biol. Chem. 283: 27916-27926.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 27916-27926
-
-
Zimmer, S.M.1
Liu, J.2
Clayton, J.L.3
Stephens, D.S.4
Snyder, J.P.5
|