Mouse spermine oxidase gene splice variants: Nuclear subcellular localization of a novel active isoform

European Journal of Biochemistry

Volumn 271, Issue 4, 2004, Pages 760-770

  Cervelli, Manuela ^a   Bellini, Alessandro ^a   Bianchi, Marzia ^a   Marcocci, Lucia ^b   Nocera, Stefania ^b   Polticelli, Fabio ^a   Federico, Rodolfo ^a   Amendola, Roberto ^c   Mariottini, Paolo ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ENEA   (Italy)

Author keywords

Enzyme isoform; Mouse; Spermine oxidase; Subcellular localization

Indexed keywords

ISOPROTEIN; OXIDOREDUCTASE; RECOMBINANT PROTEIN; SPERMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EVALUATION; GENETIC TRANSFECTION; HETEROLOGOUS EXPRESSION; MALE; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN VARIANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; TRANSCRIPTION INITIATION;

ALTERNATIVE SPLICING; AMINE OXIDASE (COPPER-CONTAINING); AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; EXONS; ISOENZYMES; MALE; MICE; MICE, INBRED DBA; MOLECULAR SEQUENCE DATA; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUBCELLULAR FRACTIONS; TISSUE DISTRIBUTION; TRANSFECTION;

ANIMALIA; MURINAE;

EID: 1342280373     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.03979.x     Document Type: Article

References (36)

1. 1-acetyltransferase - the turning point in polyamine metabolism. FASEB J. 7, 653-661.
2. Niiranen, K., Pietilä, M., Pirttilä, T.J., Järvinen, A., Halmekytö, M., Korhonen, V.-P., Keinänen, T.A., Alhonene, L. & Jänne, J. (2002) Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. J. Biol. Chem. 277, 25323-25328.
3. 1-acetyltransferase in human lung cancer cells by the bis (ethyl) polyamine analogues. Cancer Res. 49, 3829-3833.
4. 1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines. Cancer Res. 51, 3715-3720.
5. 12- bis(ethyl)spermine, on polyamine metabolism and cell growth in human lung melanoma cell lines and melanocytes. Anticancer Res. 12, 1083-1090.
6. 12-bis(ethyl)spermine in human cell lines representing the major forms of lung cancer. Cancer Res. 52, 5359-5363.
7. Mank-Seymour, A.R., Murray, T.R., Berkey, K.A., Xiao, L., Kern, S. & Casero, R.A. Jr (1998) Two active copies of the X-linked gene spermidine/spermine M-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue. Clin. Cancer Res. 4, 2003-2008.
8. Murray-Stewart, T., Wang, Y., Devereux, W. & Casero, R.A. Jr (2002) Cloning and characterization of multiple human polyamine oxidase splice variants that code for isonzymes with different biochemical characteristics. Biochem. J. 368, 673-677.
9. 1-acetyltransferase. Biochem. J. 373, 661-667.
10. McIntire, W.S. & Hartman, C. (1993) Copper containing amine oxidases. In: Principles and Applications of Quinoproteins (Davison, V.L., ed.), pp. 97-171. Marcel Dekker Inc., New York.
11. Seiler, N. (1995) Polyamine oxidase, properties and functions. Prog. Brain Res. 106, 333-344.
12. Van den Munckhof, R.J., Denyn, M., Tigchelaar-Gutter, W., Schipper, R.G., Verhofstad, A.A., Van Noorden, C.J. & Frederiks, W.M. (1995) In situ substrate specificity and ultrastructural localization of polyamine oxidase activity in unfixed rat tissues. J. Histochem. Cytochem. 43, 1155-1162.
13. 1-cetylated polyamine oxidase. J. Biol. Chem. 278, 20514-20525.
14. Hölttä, E. (1977) Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase. Biochemistry 16, 91-100.
15. Libby, P.R. & Porter, C.W. (1985) Separation of two isozymes of polyamine oxidase from murine L1210 leukemia cells. Biochem. Biophys. Res. Commun. 144, 528-535.
16. Tsukada, T., Furusako, S., Maekawa, S., Hibasami, H. & Nakashima, K. (1988) Purification by affinity chromatography and characterization of porcine liver cytoplasmic polyamine oxidase. Int. J. Biochem. 20, 695-702.
17. Vujcic, S., Diegelman, P., Bacchi, C.J., Kramer, D.L. & Porter, C.W. (2002) Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem. J. 367, 665-675.
18. 1- acetyltransferase activity and cell proliferation. Cancer Lett. 95, 247-252.
19. Bergeron, R.J., Feng, Y., Weimar, W.R., McManis, J.S., Dimova, H., Porter, C., Raisler, B. & Phanstiel, O.A. (1997) A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics. J. Med. Chem. 40, 1475-1494.
20. Ha, H.C., Woster, P.M., Yager, J.D. & Casero, R.A. Jr (1997) The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc. Natl Acad. Sci. USA 94, 11557-11562.
21. Casero, R.A. Jr & Woster, P.M. (2001) Terminally alkylated polyamine analogues as chemotherapeutic agents. J. Med. Chem. 44, 1-26.
22. Wang, Y., Devereux, W., Woster, P.M., Stewart, T.M., Hacker, A. & Casero, R.A. Jr (2001) Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Cancer Res. 61, 5370-5373.
23. Wang, Y., Murray-Stewart, T., Devereux, W., Hacker, A., Frydman, B., Woster, P.M. & Casero, R.A. Jr (2003) Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. Biochem. Biophys. Res. Commun. 304, 605-611.
24. Vujcic, S., Liang, P., Diegelman, P., Kramer, D.L. & Porter, C.W. (2002) Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem. J. 370, 19-28.
25. Cervelli, M., Polticelli, F., Rodolfo F. & Mariottini P. (2003) Heterologous expression and characterization of mouse spermine oxidase. J. Biol. Chem. 278, 5271-5276.
26. Seiler, N., Moulinoux, J.P., Havouis, R. & Toujas, L. (1995) Characterization of amine oxidase activities in macrophages from human peripheral blood. Biochem. Cell Biol. 73, 275-281.
27. Markwell, M.A., Haas, S.M., Bieber, L.L. & Tolbert, N.E. (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87, 206-210.
28. Sambrook, J., Fritsch, E.F. & Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
29. + channels in choline acetyltransferase-transfected neuroblastoma clones. J. Neurochem. 75, 1123-1131.
30. Smith, T.A. & Barker, J.H. (1988) The di-and polyamine oxidase of plants. In Progress in Polyamine Research: Novel Biochemical, Pharmacological and Clinical Aspects (Zappia, V. & Pegg, A.E., eds), pp. 573-589. Plenum Press, New York.
31. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
32. Laemmli, U.K. (1970) Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 277, 680-685.
33. Binda, C., Coda, A., Angelini, R., Federico, R., Ascenzi, P. & Mattevi, A. (1999) A 30 Å long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase. Structure 7, 265-276.
34. Binda, C., Newton-Vinson, P., Hubalek, F., Edmondson, D.E. & Mattevi, A. (2002) Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nat. Struct. Biol. 9, 22-26.
35. Sander, C. & Schneider, R. (1991) Database of homology-derived structures and the structural meaning of sequence alignment. Proteins 9, 56-68.
36. Nakielny, S., Shaikh, S., Burke, B. & Dreyfuss, G. (1999) Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. EMBO J. 18, 1982-1995.