Ornithine decarboxylase over-expression stimulates mitogen-activated protein kinase and anchorage-independent growth of human breast epithelial cells

International Journal of Cancer

Volumn 70, Issue 2, 1997, Pages 175-182

  Manni, Andrea ^a,c   Wechter, Rita ^a   Gilmour, Susan ^b   Verderame', Michael F ^a   Mauger, David ^a   Demers, Laurence M ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFLORNITHINE; ORNITHINE DECARBOXYLASE; PUTRESCINE; VIRUS VECTOR;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BREAST EPITHELIUM; CELL TRANSFORMATION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; POLYAMINE SYNTHESIS; PRIORITY JOURNAL;

ACETYLTRANSFERASES; ADENOSYLMETHIONINE DECARBOXYLASE; BREAST; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; COLONY-FORMING UNITS ASSAY; DNA, COMPLEMENTARY; EFLORNITHINE; ENZYME INDUCTION; EPITHELIAL CELLS; EPITHELIUM; FEMALE; GENES, RAS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; ORNITHINE DECARBOXYLASE; POLYAMINES; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0031019072     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970117)70:2<175::AID-IJC7>3.0.CO;2-U     Document Type: Article

References (22)

1. AUVINEN, M., PAASINEN, A., ANDERSSON, L.C. and HOLTTÄ, E., Ornithine decarboxylase activity is critical for cell transformation. Nature (Lond.), 360, 355-358 (1992).
2. BASOLO, F., ELLIOTT, J., TAIT, L., CHEN, X.Q., MALONEY, T., RUSSO, I.H., PAULEY, R., MOMIKI, S., CAAMANO, J., KLEIN-SZANTO, A.J.P., KOSZALKA, M. and RUSSO, J., Transformation of human breast epithelial cells by c-Ha-ras oncogene. 4, 25-35 (1991).
3. CLARK, G.J., and DER, C.J., Aberrant function of the ras signal-transduction pathway in human breast cancer. Breast Cancer Res. Treat., 35, 133-144 (1995).
4. CLIFFORD, A., MORGAN, D., YUSPA, S.H., SOLER, A.P. and GILMOUR, S., Role of ornithine decarboxylase in epidermal tumorigenesis. Cancer Res., 55, 1680-1686 (1995).
5. GHODA, L., VAN DAALEN WETTERS, T., MACRAE, M., ASCHERMAN, D. and COFFINO, P., Prevention of rapid intracellular degradation of ODC by a carboxyl-terminal truncation. Science, 243, 1493-1495 (1989).
6. GILMOUR, S.K., VERMA, A.K., MADARA, T. and O'BRIEN, T.G., Regulation of ornithine-decarboxylase gene expression in mouse epidermis and epidermal tumors during two-stage tumorigenesis. Cancer Res., 47, 1221-1225 (1987).
7. HADDOX, M.K., MAGUN, B.E. and RUSSELL, D.H., Ornithine decarboxylase induction during GI progression of normal and Rous-sarcoma-virus-transformed cells. Cancer Res., 40, 604-608 (1980).
8. v-scr: delineation of molecular events relevant for the transformed phenotype. J. Cell Biol., 122, 903-914 (1993).
9. HÖLTTÄ, E., AUVINEN, M., PAASINEN, A., KANGAS, A. and ANDERSSON, L.C., Ornithine-decarboxylase-induced cellular transformation: the involvement of protein tyrosine kinase(s) and pp130. Biochem. Soc. Trans., 22, 853-859 (1994).
10. LAEMMLI, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond. ), 227, 680 (1970).
11. LEINONEN, P., ALHONEN-HONGISTO, L., LAINE, R., JÄNNE, O.A. and JÄNNE, J., Human myeloma cells acquire resistance to difluoromethylornithine by amplification of ornithine decarboxylase gene. Biochem J., 242, 199-203 (1987).
12. MANNI, A., BADGER, B., GROVE, R., KUNSELMAN, S. and DEMERS, L., Isolation and characterization of human breast-cancer cells over-expressing S-adenosylmethionine decarboxylase. Cancer Lett., 95, 23-28 (1995a).
13. MANNI, A., GROVE, R., KUNSELMAN, S. and ALDAZ, M., Involvement of the polyamine pathway in breast-cancer progression. Cancer Lett., 92, 49-57 (1995b).
14. MANNI, A., WECHTER, R., WEI, L., HEITJAN, D. and DEMERS, L., Phenotypic features of breast-cancer cells over-expressing ornithine decarboxylase. J. cell. Physiol., 163, 129-136 (1995c).
15. MANNI, A. and WRIGHT, C., Polyamines as mediators of estrogen action on the growth of experimental breast cancer in rats. J. nat. Cancer Inst., 73, 511-514 (1984).
16. MANSOUR, S.J., MATTEN, W.T., HERMANN, A.S., CANDIA, J.M., RONG, S., FUKASAWA, K., VANDE WOLDE, G.F. and AHN, N.G., Transformation of mammalian cells by constitutively active MAP kinase. Science, 265, 966-970 (1994).
17. MILLER, F.R., SOULE, H.D., TAIT, L., PARLEY, R.J., WOLMAN, S.R., DAWSON, P.I. and HEPPNER, G.H., Xenograft model of progressive human proliferative breast disease. J. nat. Cancer Inst., 85, 1725-1731 (1993).
18. MOSHIER, J.A., DOSESCU, J., SKUNCA, M., and LUK, G.D., Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression. Cancer Res. 53, 2618-2622 (1993).
19. 1-acetylspermidine in human breast cancer. Cancer Lett., 45, 83-86 (1989).
20. SISTONEN, L., HÖLTTÄ, E., LEHVASLAIHO, H., LETHOLA, L. and ALITALO, K.J., Activation of a chimeric EGF-R/neu tyrosine kinase induces the FOS/JUN transcription factor complex, glucose transporter and ornithine decarboxylase. J. Cell Biol. 109, 1911-1919 (1989).
21. SOULE, H., MALONEY, T.M., WOLMAN, S.R., PETERSON, W.D. JR., BRENZ, R., MCGRATH, C.M., RDSSO, J., PAULEY, R.J., JONES, R.F. and BROOKS, S.C., Isolation and characterization of a spontaneously immortalized human breast epithelial cell line MCF-10. Cancer Res., 50, 6075-6086 (1990).
22. TOME, M.E., FISER, S.M. and GERNER, E.W., Consequences of aberrant ornithine-decarboxylase regulation in rat hepatoma cells. J. cell. Physiol., 158, 237-244 (1994).