Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies

Investigational New Drugs

Volumn 19, Issue 1, 2001, Pages 29-39

  Streiff, Richard R ^a   Bender, John F ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b PFIZER INC   (United States)

Author keywords

Diethylnorspermine; Phase I study; Polyamine

Indexed keywords

N1,N11 DIETHYLNORSPERMINE; SODIUM CHLORIDE;

ADULT; ADVANCED CANCER; AGED; ANEMIA; APHASIA; ARTICLE; ASTHENIA; ATAXIA; BLOOD TOXICITY; BRAIN TOXICITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MALE; MAXIMUM TOLERATED DOSE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; SLURRED SPEECH; VERTIGO;

ADULT; AGED; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; NEOPLASMS; SPERMINE;

EID: 0035094510     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006448516938     Document Type: Article

References (28)

1. Regulation of polyamine transport in Chinese hamster ovary cells
2. Regulation of polyamine transport by polyamines and related analogs
3. Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth
4. Combined regulation of omithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine
5. 1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines
6. 1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues
7. Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells
8. 12-bis(ethyl)-spermine, on polyamine metabolism and cell growth in human melanoma cell lines and melanocytes
9. 1,N′-bis-(ethyl)spermine homologues against human MALME-3 melanoma xenografts
10. Establishment and characterization of human solid tumor cell lines of various histogeneses for chemosensitivity evaluations
11. 11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action
12. Antitumor effects of N-alkylated polyamine analogues in human pancreatic adenocarcinoma models
13. 11 diethylnorspermine in patients with advanced malignancy
14. Chemotherapy for pancreatic cancer: A neuroimaging clinico-pathologic correlation
15. Interference with polyamine biosynthesis and/or function by analogs of polyamines and of methionine as a potential anticancer chemotherapy strategy
16. Ornithine decarboxylase as a biological marker in familial colonic polyposis
17. Polyamine biosynthetic activity in normal and neoplastic human colorectal tissues
18. Microbial flora in the gastrointestinal tract abolishes cytostatic effects of ·-difluoro-methylornithine in vivo
19. The gastrointestinal tract as polyamine source for tumor growth
20. Antiproliferative properties of polyamine analogs: A structure-activity study
21. 1-acetyltransferase by polyamines
22. Major increases in spermidine-spermine acetyltransferase activity by spermine analogs and their relationship to polyamine depletion and growth inhibition in L 1210 cells
23. 1 arrest in human melanoma cells
24. In vivo pharmacological study of spermine-induced neurotoxicity
25. Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells
26. Polyamine-enhanced NMDA receptor activity: Effect of ethanol
27. In vivo interaction of a polyamine with the NMDA receptor