Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 1. Selective enzyme inhibitors

Current Drug Targets

Volumn 4, Issue 7, 2003, Pages 537-564

  Seiler, Nikolaus ^a  

^a IRCAD   (France)

Author keywords

Cancer; Enzyme inhibitors; Polyamines; Putrescine; Spermidine; Spermine; Structural analogues; Therapy

Indexed keywords

2 METHYLORNITHINE; 3 AMINOOXYPROPYLAMINE; 4 AMIDINO 1 INDANONE 2' AMIDINOHYDRAZONE; 5 AMINOVALERIC ACID; 6 HEPTYNE 2,5 DIAMINE; ADENOSYLMETHIONINE DECARBOXYLASE; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; ANTITRYPANOSOMAL AGENT; CARMUSTINE; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DECARBOXYLASE INHIBITOR; DOXORUBICIN; EFLORNITHINE; ENZYME INHIBITOR; MITOGUAZONE; N,N' BIS(2,3 BUTADIENYL)PUTRESCINE; NEOMYCIN; ORNITHINE DECARBOXYLASE; ORNITHINE DECARBOXYLASE INHIBITOR; ORNITHINE DERIVATIVE; POLYAMINE DERIVATIVE; PUTRESCINE; PUTRESCINE DERIVATIVE; SAM 486A; SPERMIDINE; SPERMINE; UNINDEXED DRUG; VINDESINE;

ANEMIA; ANTINEOPLASTIC ACTIVITY; BIOSYNTHESIS; CANCER CHEMOTHERAPY; CELL FUNCTION; CELL GROWTH; CHEMICAL STRUCTURE; CHEMOPROPHYLAXIS; CLINICAL TRIAL; COLON CANCER; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; EUKARYOTIC CELL; GASTROINTESTINAL DISEASE; HEARING LOSS; HUMAN; KIDNEY CARCINOMA; LEUKEMIA; NEPHROTOXICITY; NONHUMAN; OTOTOXICITY; POLYAMINE METABOLISM; PROSTATE CANCER; REGULATORY MECHANISM; REVIEW; STOMACH CANCER; THROMBOCYTOPENIA; TUMOR CELL; TUMOR GROWTH;

ADENOSYLMETHIONINE DECARBOXYLASE; ANIMALS; ANTINEOPLASTIC AGENTS; BIOGENIC POLYAMINES; CLINICAL TRIALS; ENZYME INHIBITORS; HUMANS; NEOPLASMS; ORNITHINE DECARBOXYLASE; SPERMIDINE SYNTHASE; SPERMINE SYNTHASE; TREATMENT OUTCOME;

EID: 0141633535     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389450033490885     Document Type: Review

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