Spermine oxidase SMO(PAOh1), not N1-acetylpolyamine oxidase PAO, is the primary source of Cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines

Journal of Biological Chemistry

Volumn 280, Issue 48, 2005, Pages 39843-39851

  Pledgie, Allison ^a   Huang, Yi ^a   Hacker, Amy ^a   Zhang, Zhe ^a   Woster, Patrick M ^b   Davidson, Nancy E ^a   Casero Jr , Robert A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; ENZYMES; ONCOLOGY; OXIDATION; POLYAMIDES; TOXICITY;

CELLULAR RESPONSE; H2O2; ORNITHINE DECARBOXYLASE; POLYAMINE CATABOLISM;

BIOCHEMISTRY;

HYDROGEN PEROXIDE; N1 ACETYLPOLYAMINE OXIDASE; N1,N11 DIETHYLNORSPERMINE; ORNITHINE DECARBOXYLASE; POLYAMINE OXIDASE; SMALL INTERFERING RNA; SPERMIDINE; SPERMINE; SPERMINE OXIDASE; SPERMINE OXIDASE SMO; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MEDIATOR RELEASE; POLYAMINE METABOLISM; PRIORITY JOURNAL;

ACETYLTRANSFERASES; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; HYDROGEN PEROXIDE; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PEROXISOMES; POLYAMINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SPERMINE; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; TRANSFECTION;

EID: 28844480406     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M508177200     Document Type: Article

References (38)

1. Huang, Y., Pledgie, A., Casero, R. A., Jr., and Davidson, N. E. (2005) Anti-Cancer Drugs 16, 229-241
2. Wallace, H. M., Fraser, A. V., and Hughes, A. (2003) Biochem. J. 376, 1-14
3. Thomas, T., and Thomas, T. J. (2001) Cell. Mol. Life Sci. 58, 244-258
4. Kingsnorth, A. N., Wallace, H. M., Bundred, N. J., and Dixon, J. M. (1984) Br. J. Surg. 71, 352-356
5. Davidson, M. E., Mank, A. R., Prestigiacomo, L. J., Bergeron, R. J., and Casero, R. A., Jr. (1993) Cancer Res. 53, 2071-2075
6. Wallace, H. M., Duthie, J., Evans, D. M., Lamond, S., Nicoll, K. M., and Heys, S. D. (2000) Clin. Cancer Res. 6, 3657-3661
7. Casero, R. A., and Woster, P. M. (2001) J. Med. Chem. 44, 1-26
8. Bacchi, C. J., Weiss, L. M., Lane, S., Frydman, B., Valasinas, A., Reddy, V., Sun, J. S., Marton, L. J., Khan, I. A., Moretto, M., Yarlett, N., and Wittner, M. (2002) Antimicrob. Agents Chemother. 46, 55-61
9. Gabrielson, E. W., Pegg, A. E., and Casero, R. A., Jr. (1999) Clin. Cancer Res. 5, 1638-1641
10. Casero, R. A., Wang, Y., Stewatt, T. M., Devereux, W., Hacker, A., Smith, R., and Woster, P. M. (2003) Biochem. Soc. Trans. 31, 361-365
11. Casero, R. A., Jr., and Pegg, A. E. (1993) FASEB J. 7, 653-661
12. Casero, R. A., Jr., Celano, P., Ervin, S. J., Porter, C. W., Bergeron, R. J., and Libby, P. R. (1989) Cancer Res. 49, 3829-3833
13. Fogel-Petrovic, M., Kramer, D. L., Vujcic, S., Miller, J., McManis, J. S., Bergeron, R. J., and Porter, C. W. (1997) Mol. Pharmacol. 52, 69-74
14. Bergeron, R. J., Neims, A. H., McManis, J. S., Hawthorne, T. R., Vinson, J. R., Bortell, R., and Ingeno, M. J. (1988) J. Med. Chem. 31, 1183-1190
15. McCloskey, D. E., Yang, J., Woster, P. M., Davidson, N. E., and Casero, R. A., Jr. (1996) Clin. Cancer Res. 2, 441-446
16. Ha, H. C., Woster, P. M., Yager, J. D., and Casero, R. A., Jr. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 11557-11562
17. Marton, L. J., and Pegg, A. E. (1995) Annu. Rev. Pharmacol. Toxicol. 35, 55-91
18. Wang, Y., Devereux, W., Woster, P. M., Stewart, T. M., Hacker, A., and Casero, R. A., Jr. (2001) Cancer Res. 61, 5370-5373
19. Vujcic, S., Diegelman, P., Bacchi, C. J., Kramer, D. L., and Porter, C. W. (2002) Biochem. J. 367, 665-675
20. Wang, Y., Murray-Stewart, T., Devereux, W., Hacker, A., Frydman, B., Woster, P. M., and Casero, R. A. (2003) Biochem. Biophys. Res. Commun. 304, 605-611
21. Bellelli, A., Cavallo, S., Nicolini, L., Cervelli, M., Bianchi, M., Mariottini, P., Zelli, M., and Federico, R. (2004) Biochem. Biophys. Res. Commun. 322, 1-8
22. Devereux, W., Wang, Y., Stewart, T. M., Hacker, A., Smith, R., Frydman, B., Valasinas, A. L., Reddy, V. K., Marton, L. J., Ward, T. D., Woster, P. M., and Casero, R. A. (2003) Cancer Chemother. Pharmacol. 52, 383-390
23. Hahm, H. A., Ettinger, D. S., Bowling, K., Hoker, B., Chen, T. L., Zabelina, Y., and Casero, R. A., Jr. (2002) Clin. Cancer Res. 8, 684-690
24. Wolff, A. C., Armstrong, D. K., Petting, J. H., Carducci, M. K., Riley, C. D., Bender, J. F., Casero, R. A., Jr., and Davidson, N. E. (2003) Clin. Cancer Res. 9, 5922-5928
25. Wallace, H. M., and Fraser, A. V. (2004) Amino Acids (Vienna) 26, 353-365
26. Seiler, N. (2004) Amino Acids (Vienna) 26, 317-319
27. Seiler, N., Duranton, B., and Raul, F. (2002) Prog. Drug Res. 59, 1-40
28. Chen, Y., Kramer, D. L., Jell, J., Vujcic, S., and Porter, C. W. (2003) Mol. Pharmacol. 64, 1153-1159
29. Hahm, H. A., Dunn, V. R., Butash, K. A., Devereux, W. L., Woster, P. M., Casero, R. A., and Davidson, N. E. (2001) Clin. Cancer Res. 7, 391-399
30. Bey, P., Bolkenius, F. N., Seiler, N., and Casara, P. (1985) J. Med. Chem. 28, 1-2
31. Kabra, P. M., Lee, H. K., Lubich, W. P., and Marton, L. J. (1986) J. Chromatogr. 380, 19-32
32. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
33. Hockenbery, D. M., Oltvai, Z. N., Yin, X. M., Milliman, C. L., and Korsmeyer, S. J. (2000) Cell. Mol. Life Sci. 75, 241-251
34. Ambrosone, C. B. (2000) Antioxid. Redox Signal. 2, 903-917
35. Chen, Y., Kramer, D. L., Diegelman, P., Vujcic, S., and Porter, C. W. (2001) Cancer Res. 61, 6437-6444
36. Thomas, T., Balabhadrapathruni, S., Gardner, C. R., Hong, J., Faaland, C. A., and Thomas, T. J. (1999) J. Cell. Physiol. 179, 257-266
37. Berchtold, C. M., Tamez, P., Kensler, T. W., and Casero, R. A., Jr. (1998) J. Cell. Physiol. 174, 380-386
38. Luk, G. D., and Casero, R. A., Jr. (1987) Adv. Enzyme Regul. 26, 91-105