Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells

Molecular Biology Reports

Volumn 41, Issue 1, 2014, Pages 145-154

  Obakan, Pinar ^a   Arisan, Elif Damla ^a   Özfiliz, Pelin ^a   Çoker Gürkan, Ajda ^a   Palavan Ünsal, Narçin ^a  

^a ISTANBUL KULTUR UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Bcl 2; Breast cancer; Polyamines; Purvalanol A

Indexed keywords

CASPASE; POLYAMINE; POLYAMINE OXIDASE; PROTEIN BCL 2; PURVALANOL A; SPERMIDINE; SPERMINE;

APOPTOSIS; ARTICLE; CANCER CELL; CATABOLISM; CELL CYCLE; CELL CYCLE ARREST; CELL SIGNALING ASSAY; CELL VIABILITY; DNA FRAGMENTATION ASSAY; DRUG MECHANISM; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; HUMAN; MITOCHONDRIAL MEMBRANE POTENTIAL; WESTERN BLOTTING;

ACETYLTRANSFERASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FEMALE; HUMANS; MCF-7 CELLS; METABOLIC NETWORKS AND PATHWAYS; MITOCHONDRIA; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYAMINES; PURINES; RECEPTORS, ESTROGEN; UP-REGULATION;

EID: 84891928290     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-013-2847-1     Document Type: Article

References (32)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2008) Estimates of worldwide burden of cancer in 2008: gLOBOCAN 2008. Int J Cancer 127(12):2893-2917
2. Litton JK, Arun BK, Brown PH, Hortobagyi GN (2012) Aromatase inhibitors and breast cancer prevention. Expert Opin Pharmacother 13(3):325-331
3. Shen K, Rice SD, Gingrich DA, Wang D, Mi Z, Tian C, Ding Z, Brower SL, Ervin PR Jr, Gabrin MJ, Tseng G, Song N (2012) Distinct genes related to drug response identified in ER positive and ER negative breast cancer cell lines. PLoS ONE 7(7):e40900
4. Sutherland RL, Musgrove EA (2009) CDK inhibitors as potential breast cancer therapeutics: new evidence for enhanced efficacy in ER+ disease. Breast Cancer Res 11(6):112
5. Wesierska-Gadek J, Borza A, Komina O, Maurer M (2009) Impact of roscovitine, a selective CDK inhibitor, on cancer cells: bi-functionality increases its therapeutic potential. Acta Biochim Pol 56(3):495-501
6. Garrofe-Ochoa X, Cosialls AM, Ribas J, Gil J, Boix J (2011) Transcriptional modulation of apoptosis regulators by roscovitine and related compounds. Apoptosis 16(7):660-670
7. Appleyard MV, O'Neill MA, Murray KE, Paulin FE, Bray SE, Kernohan NM, Levison DA, Lane DP, Thompson AM (2009) Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model. Int J Cancer 124(2):465-472
8. Gray N, Detivaud L, Doerig C, Meijer L (1999) ATP-site directed inhibitors of cyclin-dependent kinases. Curr Med Chem 6(9):859-875
9. Casero RA Jr, Woster PM (2009) Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem 52(15):4551-4573
10. Casero RA, Pegg AE (2009) Polyamine catabolism and disease. Biochem J 421(3):323-338
11. Goodwin AC, Jadallah S, Toubaji A, Lecksell K, Hicks JL, Kowalski J, Bova GS, De Marzo AM, Netto GJ, Casero RA Jr (2008) Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues. Prostate 68(7):766-772
12. Boncher T, Bi X, Varghese S, Casero RA Jr, Woster PM (2007) Polyamine-based analogues as biochemical probes and potential therapeutics. Biochem Soc Trans 35(Pt 2):356-363
13. Babbar N, Murray-Stewart T, Casero RA Jr (2007) Inflammation and polyamine catabolism: the good, the bad and the ugly. Biochem Soc Trans 35(Pt 2):300-304
14. Huang Y, Keen JC, Hager E, Smith R, Hacker A, Frydman B, Valasinas AL, Reddy VK, Marton LJ, Casero RA Jr, Davidson NE (2004) Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells. Mol Cancer Res 2(2):81-88
15. Senanayake MD, Amunugama H, Boncher TD, Casero RA, Woster PM (2009) Design of polyamine-based therapeutic agents: new targets and new directions. Essays Biochem 46:77-94
16. Yamamoto K, Ichijo H, Korsmeyer SJ (1999) BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 19(12):8469-8478
17. Taibi G, Schiavo MR, Gueli MC, Rindina PC, Muratore R, Nicotra CM (2000) Rapid and simultaneous high-performance liquid chromatography assay of polyamines and monoacetylpolyamines in biological specimens. J Chromatogr 745(2):431-437
18. Villerbu N, Gaben AM, Redeuilh G, Mester J (2002) Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int J Cancer 97(6):761-769
19. Iizuka D, Ogura A, Kuwabara M, Inanami O (2008) Purvalanol A induces apoptosis and downregulation of antiapoptotic proteins through abrogation of phosphorylation of JAK2/STAT3 and RNA polymerase II. Anticancer Drugs 19(6):565-572
20. Pennati M, Campbell AJ, Curto M, Binda M, Cheng Y, Wang LZ, Curtin N, Golding BT, Griffin RJ, Hardcastle IR, Henderson A, Zaffaroni N, Newell DR (2005) Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther 4(9):1328-1337
21. Arisan ED, Obakan P, Coker A, Palavan-Unsal N (2012) Inhibition of ornithine decarboxylase alters the roscovitine-induced mitochondrial-mediated apoptosis in MCF-7 breast cancer cells. Mol Med Rep 5(5):1323-1329
22. Mc Gee MM, Hyland E, Campiani G, Ramunno A, Nacci V, Zisterer DM (2002) Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6. FEBS Lett 515(1-3):66-70
23. Vantieghem A, Xu Y, Assefa Z, Piette J, Vandenheede JR, Merlevede W, De Witte PA, Agostinis P (2002) Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Journal Biol Chem 277(40):37718-37731
24. Landau G, Bercovich Z, Park MH, Kahana C (2010) The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation. J Biol Chem 285(17):12474-12481
25. Zaletok S, Alexandrova N, Berdynskykh N, Ignatenko N, Gogol S, Orlovsky O, Tregubova N, Gerner E, Chekhun V (2004) Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells. Exp Oncol 26(3):221-225
26. Gerner EW, Meyskens FL Jr (2004) Polyamines and cancer: old molecules, new understanding. Nat Rev 4(10):781-792
27. Landau G, Bercovich Z, Park MH, Kahana C (2010) The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation. J Biol Chem 285(17):12474-12481
28. Allen WL, McLean EG, Boyer J, McCulla A, Wilson PM, Coyle V, Longley DB, Casero RA Jr, Johnston PG (2007) The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. Mol Cancer Ther 6(1):128-137
29. Hector S, Tummala R, Kisiel ND, Diegelman P, Vujcic S, Clark K, Fakih M, Kramer DL, Porter CW, Pendyala L (2008) Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine. Cancer Chemother Pharmacol 62(3):517-527
30. Moffatt J, Hashimoto M, Kojima A, Kennedy DO, Murakami A, Koshimizu K, Ohigashi H, Matsui-Yuasa I (2000) Apoptosis induced by 1′-acetoxychavicol acetate in Ehrlich ascites tumor cells is associated with modulation of polyamine metabolism and caspase-3 activation. Carcinogenesis 21(12):2151-2157
31. Rider JE, Hacker A, Mackintosh CA, Pegg AE, Woster PM, Casero RA Jr (2007) Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide. Amino Acids 33(2):231-240
32. Marra M, Lombardi A, Agostinelli E, Giuberti G, Zappavigna S, Tempera G, Vitale G, Bifulco M, Abbruzzese A, Caraglia M (2008) Bovine serum amine oxidase and SPM potentiate docetaxel and interferon-alpha effects in inducing apoptosis on human cancer cells through the generation of oxidative stress. Biochim Biophys Acta 1783(12):2269-2278