Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications

Virology

Volumn 474, Issue , 2015, Pages 65-81

  Das, Biswajit ^b   Dobrowolski, Curtis ^b   Shahir, Abdel Malek ^a   Feng, Zhimin ^a   Yu, Xiaolan ^a   Sha, Jinfeng ^a   Bissada, Nabil F ^a   Weinberg, Aaron ^a   Karn, Jonathan ^b   Ye, Fengchun ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

EZH2; HIV 1 transactivation; P TEFb; Short chain fatty acids; SIRT1

Indexed keywords

ACETIC ACID; BUTYRIC ACID; HISTONE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE LYSINE METHYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOBUTYRIC ACID; ISOVALERIC ACID; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; PROPIONIC ACID; SHORT CHAIN FATTY ACID; SIRTUIN 1; SUPPRESSOR OF VARIEGATION 3 9 HOMOLOG 1; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; EZH2 PROTEIN, HUMAN; HISTONE DEACETYLASE; METHYLTRANSFERASE; POLYCOMB REPRESSIVE COMPLEX 2; REPRESSOR PROTEIN; SIRT1 PROTEIN, HUMAN; SUV39H1 PROTEIN, HUMAN; VOLATILE FATTY ACID;

ARTICLE; BACTERIUM CULTURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME INHIBITION; FUSOBACTERIUM NUCLEATUM; HISTONE ACETYLATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; JURKAT CELL LINE; LONG TERMINAL REPEAT; PERIODONTAL DISEASE; PORPHYROMONAS GINGIVALIS; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSACTIVATION; VIRUS INDUCTION; VIRUS REPLICATION; ACETYLATION; ANTAGONISTS AND INHIBITORS; BACTERIUM; BIOLOGICAL MODEL; CELL CULTURE; COMPLICATION; GENE SILENCING; GENETICS; HOST PATHOGEN INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PERIODONTITIS; PHYSIOLOGY; SALIVA; TRANSCRIPTION INITIATION; VIROLOGY; VIRUS ACTIVATION; VIRUS LATENCY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ACETYLATION; BACTERIA; CELLS, CULTURED; FATTY ACIDS, VOLATILE; GENE KNOCKDOWN TECHNIQUES; HISTONE DEACETYLASES; HISTONES; HIV INFECTIONS; HIV LONG TERMINAL REPEAT; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; JURKAT CELLS; METHYLTRANSFERASES; MODELS, BIOLOGICAL; PERIODONTITIS; POLYCOMB REPRESSIVE COMPLEX 2; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; REPRESSOR PROTEINS; SALIVA; SIRTUIN 1; T-LYMPHOCYTES; TRANSCRIPTIONAL ACTIVATION; VIRUS ACTIVATION; VIRUS LATENCY;

EID: 84910601220     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2014.10.033     Document Type: Article

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