Activation of MAPK cascades by G-protein-coupled receptors: The case of gonadotropin-releasing hormone receptor

Trends in Endocrinology and Metabolism

Volumn 11, Issue 3, 2000, Pages 91-99

  Naor, Zvi ^a   Benard, Outhiriaradjou ^b   Seger, Rony ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GONADORELIN RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TYROSINE KINASE RECEPTOR;

APOPTOSIS; ENZYME ACTIVATION; GENE EXPRESSION; LIGAND BINDING; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0034119581     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(99)00232-5     Document Type: Review

References (81)

1. Seger R., Krebs E.G. The MAPK signaling cascade. FASEB J. 9:1995;726-735.
2. Lewis T.S.et al. Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74:1998;49-139.
3. Cobb M. MAP kinase pathways. Prog. Biophys. Mol. Biol. 71:1999;479-500.
4. Schaeffer H.J., Weber M.J. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell. Biol. 19:1999;2435-2444.
5. Schlessinger J. How receptor tyrosine kinases activate Ras. Trends Biochem. Sci. 18:1993;273-275.
6. Widmann C.et al. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol. Rev. 79:1999;143-180.
7. Davis R.J. Signal transduction by the c-Jun N-terminal kinase. Biochem. Soc. Symp. 64:1999;1-12.
8. Dikic I., Blaukat A. Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling. Cell. Biochem. Biophys. 1:1999;369-387.
9. Bargmann C.I. Neurobiology of the Caenorhabditis elegans genome. Science. 282:1998;2028-2033.
10. Clapham D.E., Neer E.J. G protein beta gamma subunits. Annu. Rev. Pharmacol. Toxicol. 37:1997;167-203.
11. Gutkind J.S. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J. Biol. Chem. 273:1998;1839-1842.
12. Gutkind J.S. Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene. 17:1998;1331-1342.
13. Luttrell L.M.et al. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr. Opin. Cell Biol. 11:1999;177-183.
14. Hall R.A.et al. Heptahelical receptor signaling: beyond the G protein paradigm. J. Cell Biol. 145:1999;927-932.
15. Birnbaumer L. Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits. Cell. 71:1992;1069-1072.
16. Beebe S.J. The cAMP-dependent protein kinases and cAMP signal transduction. Semin. Cancer Biol. 5:1994;285-294.
17. de Rooij J.et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature. 396:1998;474-477.
18. Impey S.et al. Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity. Neuron. 23:1999;11-14.
19. Chen H.J.et al. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron. 20:1998;895-904.
20. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 258:1992;607-614.
21. Farnsworth C.L.et al. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature. 376:1995;524-527.
22. Zhang C.et al. Protein kinase C and F-actin are essential for stimulation of neuronal FAK tyrosine phosphorylation by G-proteins and amyloid beta protein. FEBS Lett. 386:1996;185-188.
23. Kolch W.et al. Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature. 364:1993;249-252.
24. Marais R.et al. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science. 280:1998;109-112.
25. Slack B.E. Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix. Proc. Natl. Acad. Sci. U. S. A. 95:1998;7281-7286.
26. Levi N.L.et al. Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary alpha T3-1 cell line is mediated by protein kinase C, c-Src, and CDC42. Mol. Endocrinol. 12:1998;815-824.
27. Yao L.et al. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc. Natl. Acad. Sci. U. S. A. 91:1994;9175-9179.
28. Bence K.et al. Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit. Nature. 389:1997;296-299.
29. Gupta S.K.et al. MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts. J. Biol. Chem. 267:1992;7987-7990.
30. Murga C.et al. Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma. J. Biol. Chem. 273:1998;19080-19085.
31. Jordan J.D.et al. Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. J. Biol. Chem. 274:1999;21507-21510.
32. Mochizuki N.et al. Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Galphai. Nature. 400:1999;891-894.
33. Jiang Y.et al. The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. Nature. 395:1998;808-813.
34. Kranenburg O.et al. Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction. Mol. Biol. Cell. 10:1999;1851-1857.
35. Hart M.J.et al. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science. 280:1998;2112-2114.
36. Mao J.et al. Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13. EMBO J. 17:1998;5638-5646.
37. Needham L.K., Rozengurt E. Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate. J. Biol. Chem. 273:1998;14626-14632.
38. Crespo P.et al. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature. 369:1994;418-420.
39. Koch W.J.et al. Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. Proc. Natl. Acad. Sci. U. S. A. 91:1994;12706-12710.
40. van Biesen T.et al. Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature. 376:1995;781-784.
41. Luttrell L.M.et al. G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J Biol Chem. 270:1995;16495-16498.
42. Mattingly R.R., Macara I.G. Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits. Nature. 382:1996;268-272.
43. Bell B.et al. KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. J. Biol. Chem. 274:1999;7982-7986.
44. Stephens L.R.et al. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell. 89:1997;105-114.
45. Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol. 10:1998;262-267.
46. Han J.et al. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science. 279:1998;558-560.
47. Lopez-Ilasaca M.et al. Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation. J. Biol. Chem. 273:1998;2505-2508.
48. Takeda H.et al. PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor. EMBO J. 18:1999;386-395.
49. Bondeva T.et al. Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK. Science. 282:1998;293-296.
50. Hilgenberg L.G.et al. Evidence of an agrin receptor in cortical neurons. J. Neurosci. 19:1999;7384-7393.
51. Malbon C.C., Karoor V. G-protein-linked receptors as tyrosine kinase substrates: new paradigms in signal integration. Cell Signal. 10:1998;523-527.
52. Whitmarsh A.J.et al. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science. 281:1998;1671-1674.
53. Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 80:1995;179-185.
54. Reszka A.A.et al. Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc. Natl. Acad. Sci. U. S. A. 92:1995;8881-8885.
55. Naor Z.et al. Signal transduction of the gonadotropin releasing hormone (GnRH) receptor: cross-talk of calcium, protein kinase C (PKC), and arachidonic acid. Cell. Mol. Neurobiol. 15:1995;527-544.
56. Wei N., Deng X.W. Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human. Trends Genet. 15:1999;98-103.
57. Stojilkovic S.S.et al. Gonadotropin-releasing hormone receptors: structure and signal transduction pathways. Endocr. Rev. 15:1994;462-499.
58. Shacham S.et al. Mechanism of GnRH receptor signaling: from the membrane to the nucleus. Ann. Endocrinol. (Paris). 60:1999;79-88.
59. Reinhart J.et al. Molecular cloning and expression of cDNA encoding the murine gonadotropin-releasing hormone receptor. J. Biol. Chem. 267:1992;21281-21284.
60. Harris D.et al. Differential activation of protein kinase C delta and epsilon gene expression by gonadotropin-releasing hormone in alphaT3-1 cells. Autoregulation by protein kinase C. J. Biol. Chem. 272:1997;13534-13540.
61. Stojilkovic S.S., Catt K.J. Novel aspects of GnRH-induced intracellular signaling and secretion in pituitary gonadotrophs. J. Neuroendocrinol. 7:1995;739-757.
62. Sealfon S.C.et al. Hormonal regulation of gonadotropin-releasing hormone receptors and messenger RNA activity in ovine pituitary culture. Mol. Endocrinol. 4:1990;1980-1987.
63. Reiss N.et al. Mechanism of mitogen-activated protein kinase activation by gonadotropin-releasing hormone in the pituitary of alphaT3-1 cell line: differential roles of calcium and protein kinase C. Endocrinology. 138:1997;1673-1682.
64. Sim P.et al. Activation of MAP kinase in alpha T3-1 cells by luteinising hormone-releasing hormone. Biochem. Soc. Trans. 21:1993;357S.
65. Mitchell R.et al. Activation of MAP kinase associated with the priming effect of LHRH. J. Endocrinol. 140:1994;R15-R18.
66. Roberson M.S.et al. A role for mitogen-activated protein kinase in mediating activation of the glycoprotein hormone alpha-subunit promoter by gonadotropin-releasing hormone. Mol. Cell. Biol. 15:1995;3531-3539.
67. Sim P.J.et al. Activation of MAP kinase by the LHRH receptor through a dual mechanism involving protein kinase C and a pertussis toxin-sensitive G protein. Mol. Cell. Endocrinol. 112:1995;257-263.
68. Sundaresan S.et al. Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone: evidence for the involvement of protein kinase C. Endocrinology. 137:1996;304-311.
69. Haisenleder D.J.et al. Gonadotropin-releasing hormone pulses are required to maintain activation of mitogen-activated protein kinase: role in stimulation of gonadotrope gene expression. Endocrinology. 139:1998;3104-3111.
70. Weck J.et al. Differential gonadotropin-releasing hormone stimulation of rat luteinizing hormone subunit gene transcription by calcium influx and mitogen-activated protein kinase-signaling pathways. Mol. Endocrinol. 12:1998;451-457.
71. 2+ and protein kinase C. Biochem. J. 309:1995;325-329.
72. 2+ release from internal stores controls exocytosis in pituitary gonadotrophs. Neuron. 18:1997;121-132.
73. Delahaye R.et al. Rat gonadotropin-releasing hormone receptor expressed in insect cells induces activation of adenylyl cyclase. Mol. Cell. Endocrinol. 135:1997;119-127.
74. Han X.B., Conn P.M. The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation. Endocrinology. 140:1999;2241-2251.
75. Lin X., Conn P.M. Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH: involvement of multiple signal transduction pathways. Endocrinology. 140:1999;358-364.
76. Ben-Menahem D.et al. Dissociation between release and gene expression of gonadotropin alpha-subunit in gonadotropin-releasing hormone-stimulated alpha T3-1 cell line. Biochemistry. 31:1992;12893-12898.
77. 2+ and protein kinase C. Biochemistry. 33:1994;3698-3704.
78. Roberson M.S.et al. Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone. Endocrinology. 140:1999;1310-1318.
79. Derijard B.et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 76:1994;1025-1027.
80. Strahl B.D.et al. Transcriptional activation of the ovine follicle-stimulating hormone beta-subunit gene by gonadotropin-releasing hormone: involvement of two activating protein-1-binding sites and protein kinase C. Endocrinology. 139:1998;4455-4465.
81. Heckert L.L.et al. The cAMP response elements of the alpha subunit gene bind similar proteins in trophoblasts and gonadotropes but have distinct functional sequence requirements. J. Biol. Chem. 271:1996;31650-31656.