Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of polycomb group proteins

Molecular and Cellular Biology

Volumn 22, Issue 15, 2002, Pages 5539-5553

  Sewalt, Richard G A B ^a   Lachner, Monika ^a   Vargas, Mark ^a   Hamer, Karien M ^a   Den Blaauwen, Jan L ^a   Hendrix, Thijs ^a   Melcher, Martin ^a   Schweizer, Dieter ^a   Jenuwein, Thomas ^a   Otte, Arie P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; HISTONE DEACETYLASE; HISTONE LYSINE METHYLTRANSFERASE; PROTEIN; PROTEIN HPC2; PROTEIN M33; PROTEIN MPC1; PROTEIN PCG; PROTEIN XPC2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHROMATIN STRUCTURE; CHROMOSOME 1; CONTROLLED STUDY; DEACETYLATION; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; GENE ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE REPRESSION; HETEROCHROMATIN; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL NUCLEUS; CENTROMERE; CHROMOSOMES; CHROMOSOMES, HUMAN, PAIR 1; HELA CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; MACROMOLECULAR SUBSTANCES; METHYLATION; METHYLTRANSFERASES; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TWO-HYBRID SYSTEM TECHNIQUES;

VERTEBRATA;

EID: 0036310641     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.15.5539-5553.2002     Document Type: Article

References (58)

1. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31
2. The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1
3. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
4. The Drosophila Polycomb protein interacts with nucleosomal core particles in vitro via its repression domain
5. Transcriptional repression by Drosophila and mammalian Polycomb group proteins in transfected mammalian cells
6. Signaling to chromatin through histone modifications
7. Cloning of human satellite III DNA: Different components are on different chromosomes
8. The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb
9. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast
10. Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster
11. Functions of mammalian Polycomb group and trithorax group related genes
12. Identification and characterization of interactions between the vertebrate Polycomb-group protein BMI1 and human homologs of Polyhomeotic
13. Mapping of a mouse homolog of a heterochromatin protein gene to the X chromosome, Mamm
14. Structure of a Polycomb response element and in vitro binding of Polycomb group complexes containing GAGA factor
15. Re-SET-ting heterochromatin by histone methyltransferases
16. Translating the histone code
17. A group of genes controlling the spatial expression of the bithorax complex in Drosophila
18. Repression and activation by multiprotein complexes that alter chromatin structure
19. The chromo superfamily: New members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin
20. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
21. Molecular characterisation of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression
22. Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression
23. Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster
24. Transcriptional silencing by the Polycomb protein in Drosophila embryos
25. A Drosophila ESC-E(Z) protein complex is distinct from other Polycomb group complexes and contains covalently modified ESC
26. Imprinting a determined state into the chromatin of Drosophila
27. The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila
28. The mouse has a Polycomb-like chromobox gene
29. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
30. PcG complexes and chromatin silencing
31. Functional analysis of the chromo domain of HP1
32. Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function
33. Regulation of chromatin structure by site-specific histone H3 methyltransferases
34. Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other
35. RING1 is associated with the Polycomb group protein complex and acts as a transcriptional repressor
36. The Polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos
37. Interference with the expression of a novel human Polycomb protein, hPc2, results in cellular transformation and apoptosis
38. Polycomb group protein complexes: Do different complexes regulate distinct target genes?
39. The human polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain
40. Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain
41. Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond
42. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins
43. Characterization of interactions between the mammalian Polycomb group proteins Enx1/EZH2 and EED suggests the existence of different mammalian Polycomb group protein complexes
44. Locking in stable states of gene expression: Transcriptional control during Drosophila development
45. Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products
46. Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster
47. The language of covalent histone modifications
48. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1
49. Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena
50. SET domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methylthansferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3
51. The Drosophila Polycomb group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3
52. Histone acetylation and an epigenetic code
53. Physical association between the histone acetyl transferase CBP and a histone methyl transferase
54. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
55. Interaction of mouse Polycomb group (Pc-G) proteins Enx1 and Enx2 with Eed: Indication for separate Pc-G complexes
56. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging
57. 25 Years after the nucleosome model: Chromatin modifications
58. In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster