Polycation-Mediated Integrated Cell Death Processes

Advances in Genetics

Volumn 88, Issue , 2014, Pages 353-398

  Parhamifar, Ladan ^a   Andersen, Helene ^a   Wu, Linping ^a   Hall, Arnaldur ^a   Hudzech, Diana ^b   Moghimi, Seyed Moien ^a,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Apoptosis; Autophagy; Cell death; Nanomedicine; Necrosis; Polycations; Polyethylenimine

Indexed keywords

CALCIUM; POLYAMINE; POLYCATIONS; POLYETHYLENEIMINE;

ADMINISTRATION AND DOSAGE; ANOIKIS; APOPTOSIS; AUTOPHAGY; CELL DEATH; CHEMISTRY; DRUG EFFECTS; ENDOPLASMIC RETICULUM STRESS; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HUMAN; LYSOSOME; METABOLISM; MITOCHONDRION; NANOMEDICINE; NECROSIS; PHARMACOLOGY; PHYSIOLOGY; PROCEDURES;

ANOIKIS; APOPTOSIS; AUTOPHAGY; CALCIUM; CELL DEATH; ENDOPLASMIC RETICULUM STRESS; GENETIC VECTORS; HUMANS; LYSOSOMES; MITOCHONDRIA; NANOMEDICINE; NECROSIS; POLYAMINES; POLYETHYLENEIMINE; TRANSFECTION;

EID: 84909988484     PISSN: 00652660     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800148-6.00012-2     Document Type: Chapter

References (216)

1. Aits S., Jaattela M. Lysosomal cell death at a glance. Journal of Cell Science 2013, 126(Pt 9):1905-1912.
2. Al-Hanbali O., Rutt K.J., Sarker D.K., Hunter A.C., Moghimi S.M. Concentration dependent structural ordering of poloxamine 908 on polystyrene nanoparticles and their modulatory role on complement consumption. Journal of Nanoscience and Nanotechnology 2006, 6(9-10):3126-3133.
3. Amelio I., Melino G., Knight R.A. Cell death pathology: cross-talk with autophagy and its clinical implications. Biochemical and Biophysical Research Communications 2011, 414(2):277-281.
4. Appelqvist H., Nilsson C., Garner B., Brown A.J., Kagedal K., Ollinger K. Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation. The American Journal of Pathology 2011, 178(2):629-639.
5. Ariga K., Hill J.P., Ji Q. Layer-by-layer assembly as a versatile bottom-up nanofabrication technique for exploratory research and realistic application. Physical Chemistry Chemical Physics 2007, 9(19):2319-2340.
6. Ariga K., Lvov Y.M., Kawakami K., Ji Q., Hill J.P. Layer-by-layer self-assembled shells for drug delivery. Advanced Drug Delivery Reviews 2011, 63(9):762-771.
7. Ariga K., McShane M., Lvov Y.M., Ji Q., Hill J.P. Layer-by-layer assembly for drug delivery and related applications. Expert Opinion on Drug Delivery 2011, 8(5):633-644.
8. Babcock G.T., Wikstrom M. Oxygen activation and the conservation of energy in cell respiration. Nature 1992, 356(6367):301-309.
9. Baehrecke E.H. Autophagy: dual roles in life and death?. Nature Reviews. Molecular Cell Biology 2005, 6(6):505-510.
10. Benjaminsen R.V., Mattebjerg M.A., Henriksen J.R., Moghimi S.M., Andresen T.L. The possible "Proton sponge" effect of polyethylenimine (PEI) does not include change in lysosomal pH. Molecular Therapy 2013, 21(1):149-157.
11. Bernardi P., Rasola A. Calcium and cell death: the mitochondrial connection. Sub-cellular Biochemistry 2007, 45:481-506.
12. Berry D.L., Baehrecke E.H. Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell 2007, 131(6):1137-1148.
13. Boya P., Andreau K., Poncet D., Zamzami N., Perfettini J.L., Metivier D., et al. Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. The Journal of Experimental Medicine 2003, 197(10):1323-1334.
14. Boya P., Gonzalez-Polo R.A., Casares N., Perfettini J.L., Dessen P., Larochette N., et al. Inhibition of macroautophagy triggers apoptosis. Molecular and Cellular Biology 2005, 25(3):1025-1040.
15. Broker L.E., Huisman C., Span S.W., Rodriguez J.A., Kruyt F.A., Giaccone G. Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung Cancer cells. Cancer Research 2004, 64(1):27-30.
16. Brown W.J., DeWald D.B., Emr S.D., Plutner H., Balch W.E. Role for phosphatidylinositol 3-Kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells. The Journal of Cell Biology 1995, 130(4):781-796.
17. Brunk U.T., Ericsson J.L. Cytochemical evidence for the leakage of acid phosphatase through ultrastructurally intact lysosomal membranes. The Histochemical Journal 1972, 4(6):479-491.
18. Burikhanov R., Zhao Y., Goswami A., Qiu S., Schwarze S.R., Rangnekar V.M. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell 2009, 138(2):377-388.
19. de la Cadena S.G., Hernandez-Fonseca K., Camacho-Arroyo I., Massieu L. Glucose deprivation induces reticulum stress by the Perk pathway and caspase-7- and calpain-mediated caspase-12 activation. Apoptosis 2014, 19(3):414-427.
20. Cande C., Cecconi F., Dessen P., Kroemer G. Apoptosis-inducing factor (Aif): key to the conserved caspase-independent pathways of cell death?. Journal of Cell Science 2002, 115(Pt 24):4727-4734.
21. Candi E., Schmidt R., Melino G. The cornified envelope: a model of cell death in the skin. Nature Reviews Molecular Cell Biology 2005, 6(4):328-340.
22. Casares N., Pequignot M.O., Tesniere A., Ghiringhelli F., Roux S., Chaput N., et al. Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. The Journal of Experimental Medicine 2005, 202(12):1691-1701.
23. Chan F.K., Shisler J., Bixby J.G., Felices M., Zheng L., Appel M., et al. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. The Journal of Biological Chemistry 2003, 278(51):51613-51621.
24. Chautan M., Chazal G., Cecconi F., Gruss P., Golstein P. Interdigital cell death can occur through a necrotic and caspase-independent pathway. Current Biology 1999, 9(17):967-970.
25. Chen G.Q. A microbial polyhydroxyalkanoates (Pha) based bio- and materials Industry. Chemical Society Reviews 2009, 38(8):2434-2446.
26. Chen G.Q., Wu Q. The application of polyhydroxyalkanoates as tissue engineering materials. Biomaterials 2005, 26(33):6565-6578.
27. Cheng S.T., Chen Z.F., Chen G.Q. The expression of cross-linked elastin by rabbit blood vessel smooth muscle cells cultured in polyhydroxyalkanoate scaffolds. Biomaterials 2008, 29(31):4187-4194.
28. Cheng K.W., Lahad J.P., Kuo W.L., Lapuk A., Yamada K., Auersperg N., et al. The Rab25 small Gtpase determines aggressiveness of ovarian and breast cancers. Nature Medicine 2004, 10(11):1251-1256.
29. Clarke P.G. Developmental cell death: morphological diversity and multiple mechanisms. Anatomy and Embryology (Berlin) 1990, 181(3):195-213.
30. Couvreur P. Nanoparticles in drug delivery: past, present and future. Advanced Drug Delivery Reviews 2013, 65(1):21-23.
31. Danial N.N., Korsmeyer S.J. Cell death: Critical control points. Cell 2004, 116(2):205-219.
32. Decher G. Layer-by-layer assembly (putting molecules to work) multilayer thin films 2012, Wiley-VCH Verlag GmbH & Co. KGaA.
33. Decher G., Hong J.D., Schmitt J. Buildup of ultrathin multilayer films by a self-assembly process: III. Consecutively alternating adsorption of anionic and cationic polyelectrolytes on charged surfaces. Thin Solid Films 1992, 210-211(Part 2):831-835.
34. Degenhardt K., M0061thew R., Beaudoin B., Bray K., Anderson D., Chen G., et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006, 10(1):51-64.
35. Degterev A., Hitomi J., Germscheid M., Ch'en I.L., Korkina O., Teng X., et al. Identification of Rip1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology 2008, 4(5):313-321.
36. 2+ measurement and imaging in inflammatory cells. Methods in Molecular Biology 2003, 225:47-59.
37. Durymanov M.O., Beletkaia E.A., Ulasov A.V., Khramtsov Y.V., Trusov G.A., Rodichenko N.S., et al. Subcellular trafficking and transfection efficacy of polyethylenimine-polyethylene glycol polyplex nanoparticles with a ligand to melanocortin receptor-1. Journal of Controlled Release 2012, 163(2):211-219.
38. de Duve C. Lysosomes revisited. European Journal of Biochemistry 1983, 137(3):391-397.
39. Elbakry A., Wurster E.C., Zaky A., Liebl R., Schindler E., Bauer-Kreisel P., et al. Layer-by-layer coated gold nanoparticles: size-dependent delivery of DNA into cells. Small 2012, 8(24):3847-3856.
40. Elbakry A., Zaky A., Liebl R., Rachel R., Goepferich A., Breunig M. Layer-by-layer assembled gold nanoparticles for siRNA delivery. Nano Letters 2009, 9(5):2059-2064.
41. Elsabahy M., Wooley K.L. Design of polymeric nanoparticles for biomedical delivery applications. Chemical Society Reviews 2012, 41(7):2545-2561.
42. Erdal H., Berndtsson M., Castro J., Brunk U., Shoshan M.C., Linder S. Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. Proceedings of the National Academy of Sciences of the United States of America 2005, 102(1):192-197.
43. Fehrenbacher N., Bastholm L., Kirkegaard-Sorensen T., Rafn B., Bottzauw T., Nielsen C., et al. Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2. Cancer Research 2008, 68(16):6623-6633.
44. Feng L., Zhu C., Yuan H., Liu L., Lv F., Wang S. Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications. Chemical Society Reviews 2013, 42(16):6620-6633.
45. Feoktistova M., Geserick P., Kellert B., Dimitrova D.P., Langlais C., Hupe M., et al. Ciaps block ripoptosome formation, a Rip1/Caspase-8 containing intracellular cell death complex differentially regulated by cflip isoforms. Molecular Cell 2011, 43(3):449-463.
46. Festjens N., Vanden Berghe T., Cornelis S., Vandenabeele P. Rip1, a kinase on the crossroads of a cell's decision to live or die. Cell Death and Differentiation 2007, 14(3):400-410.
47. Festjens N., Vanden Berghe T., Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochimica et Biophysica Acta 2006, 1757(9-10):1371-1387.
48. Firestone R.A., Pisano J.M., Bonney R.J. Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents. Journal of Medicinal Chemistry 1979, 22(9):1130-1133.
49. Fischer H., Koenig U., Eckhart L., Tschachler E. Human caspase 12 has acquired deleterious mutations. Biochemical and Biophysical Research Communications 2002, 293(2):722-726.
50. Foghsgaard L., Lademann U., Wissing D., Poulsen B., Jaattela M. Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells. Journal of Biological Chemistry 2002, 277(42):39499-39506.
51. Forrest M.L., Pack D.W. On the kinetics of polyplex endocytic trafficking: implications for gene delivery vector design. Molecular Therapy 2002, 6(1):57-66.
52. Galluzzi L., Aaronson S.A., Abrams J., Alnemri E.S., Andrews D.W., Baehrecke E.H., et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher Eukaryotes. Cell Death and Differentiation 2009, 16(8):1093-1107.
53. Galluzzi L., Joza N., Tasdemir E., Maiuri M.C., Hengartner M., Abrams J.M., et al. No death without life: vital functions of apoptotic effectors. Cell Death and Differentiation 2008, 15(7):1113-1123.
54. Galluzzi L., Kepp O., Krautwald S., Kroemer G., Linkermann A. Molecular mechanisms of regulated necrosis. Seminars in Cell and Developmental Biology 2014, pii: S1084-9521(14)00018-4. 10.1016/j.semcdb.2014.02.006.
55. Galluzzi L., Maiuri M.C., Vitale I., Zischka H., Castedo M., Zitvogel L., et al. Cell death modalities: classification and pathophysiological implications. Cell Death and Differentiation 2007, 14(7):1237-1243.
56. Galluzzi L., Vicencio J.M., Kepp O., Tasdemir E., Maiuri M.C., Kroemer G. To die or not to die: that is the autophagic question. Current Molecular Medicine 2008, 8(2):78-91.
57. Gao X., Yao L., Song Q., Zhu L., Xia Z., Xia H., et al. The association of autophagy with polyethylenimine-induced cytotoxicity in nephritic and hepatic cell lines. Biomaterials 2011, 32(33):8613-8625.
58. Gaut J.R., Hendershot L.M. The modification and assembly of proteins in the endoplasmic reticulum. Current Opinion in Cell Biology 1993, 5(4):589-595.
59. Gnaiger E. Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respiration Physiology 2001, 128(3):277-297.
60. Gobeil S., Boucher C.C., Nadeau D., Poirier G.G. Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (Parp-1): Implication of lysosomal proteases. Cell Death and Differentiation 2001, 8(6):588-594.
61. Golstein P., Kroemer G. Redundant cell death mechanisms as relics and backups. Cell Death and Differentiation 2005, 12(Suppl 2):1490-1496.
62. Golstein P., Kroemer G. Cell death by necrosis: towards a molecular definition. Trends in Biochemical Science 2007, 32(1):37-43.
63. Gonzalez-Polo R.A., Boya P., Pauleau A.L., Jalil A., Larochette N., Souquere S., et al. The Apoptosis/Autophagy paradox: autophagic vacuolization before apoptotic death. Journal of Cell Science 2005, 118(Pt 14):3091-3102.
64. Gorman A.M., Healy S.J., Jager R., Samali A. Stress management at the Er: regulators of Er stress-induced apoptosis. Pharmacology & Therapeutics 2012, 134(3):306-316.
65. Grandinetti G., Ingle N.P., Reineke T.M. Interaction of poly(Ethylenimine)-DNA polyplexes with mitochondria: implications for a mechanism of cytotoxicity. Molecular Pharmaceutics 2011, 8(5):1709-1719.
66. Grossmann J. Molecular mechanisms of "detachment-induced apoptosis-anoikis". Apoptosis 2002, 7(3):247-260.
67. Groth-Pedersen L., Aits S., Corcelle-Termeau E., Petersen N.H., Nylandsted J., Jaattela M. Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells. PLoS One 2012, 7(10):e45381.
68. Groth-Pedersen L., Jaattela M. Combating apoptosis and multidrug resistant cancers by targeting lysosomes. Cancer Letters 2013, 332(2):265-274.
69. Groth-Pedersen L., Ostenfeld M.S., Hoyer-Hansen M., Nylandsted J., Jaattela M. Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine. Cancer Research 2007, 67(5):2217-2225.
70. Guicciardi M.E., Leist M., Gores G.J. Lysosomes in cell death. Oncogene 2004, 23(16):2881-2890.
71. Gyrd-Hansen M., Farkas T., Fehrenbacher N., Bastholm L., Hoyer-Hansen M., Elling F., et al. Apoptosome-independent activation of the lysosomal cell death pathway by Caspase-9. Molecular and Cellular Biology 2006, 26(21):7880-7891.
72. Hall A., Larsen A.K., Parhamifar L., Meyle K.D., Wu L.P., Moghimi S.M. High resolution respirometry analysis of polyethylenimine-mediated mitochondrial Energy crisis and cellular stress: mitochondrial proton leak and inhibition of the electron transport system. Biochimica et Biophysica Acta 2013, 1827(10):1213-1225.
73. Hamad I., Al-Hanbali O., Hunter A.C., Rutt K.J., Andresen T.L., Moghimi S.M. Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum Interface: Implications for stealth nanoparticle engineering. ACS Nano 2010, 4(11):6629-6638.
74. Harding H.P., Zhang Y., Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999, 397(6716):271-274.
75. Hartley A., Stone J.M., Heron C., Cooper J.M., Schapira A.H. Complex I inhibitors induce dose-dependent apoptosis in Pc12 cells: relevance to Parkinson's disease. Journal of Neurochemistry 1994, 63(5):1987-1990.
76. Hatefi Y. The mitochondrial electron transport and oxidative phosphorylation system. Annual Review of Biochemistry 1985, 54:1015-1069.
77. Hitomi J., Katayama T., Eguchi Y., Kudo T., Taniguchi M., Koyama Y., et al. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. The Journal of Cell Biology 2004, 165(3):347-356.
78. Holler N., Zaru R., Micheau O., Thome M., Attinger A., Valitutti S., et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase Rip as effector molecule. Nature Immunology 2000, 1(6):489-495.
79. Huang K.T., Chen Y.H., Walker A.M. Inaccuracies in Mts assays: major distorting effects of medium, serum albumin, and fatty acids. Biotechniques 2004, 37(3):406. 408, 410-402.
80. Huang H.M., Ou H.C., Hsieh S.J., Chiang L.Y. Blockage of amyloid beta peptide-induced cytosolic free calcium by fullerenol-1, carboxylate C60 in Pc12 cells. Life Sciences 2000, 66(16):1525-1533.
81. Hunter A.C., Moghimi S.M. Cationic carriers of genetic material and cell death: a mitochondrial tale. Biochimica et Biophysica Acta 2010, 1797(6-7):1203-1209.
82. Ichimura Y., Komatsu M. Selective degradation of P62 by autophagy. Seminars in Immunopathology 2010, 32(4):431-436.
83. Itoh H., Takahashi A., Adachi K., Noji H., Yasuda R., Yoshida M., et al. Mechanically driven ATP synthesis by F1-ATPase. Nature 2004, 427(6973):465-468.
84. Izyumov D.S., Avetisyan A.V., Pletjushkina O.Y., Sakharov D.V., Wirtz K.W., Chernyak B.V., et al. "Wages of fear": transient threefold decrease in intracellular ATP level imposes apoptosis. Biochimica et Biophysica Acta 2004, 1658(1-2):141-147.
85. Jaattela M. Multiple cell death pathways as regulators of tumour initiation and progression. Oncogene 2004, 23(16):2746-2756.
86. Jager R., Bertrand M.J., Gorman A.M., Vandenabeele P., Samali A. The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress. Biology of the Cell 2012, 104(5):259-270.
87. Jin L., Zeng X., Liu M., Deng Y., He N. Current progress in gene delivery technology based on chemical methods and nano-carriers. Theranostics 2014, 4(3):240-255.
88. Johansson A.C., Appelqvist H., Nilsson C., Kagedal K., Roberg K., Ollinger K. Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis 2010, 15(5):527-540.
89. Joyce J.A., Baruch A., Chehade K., Meyer-Morse N., Giraudo E., Tsai F.Y., et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 2004, 5(5):443-453.
90. Kagedal K., Johansson A.C., Johansson U., Heimlich G., Roberg K., Wang N.S., et al. Lysosomal membrane permeabilization during Apoptosis-Involvement of bax?. International Journal of Experimental Pathology 2005, 86(5):309-321.
91. Kalai M., Van Loo G., Vanden Berghe T., Meeus A., Burm W., Saelens X., et al. Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA. Cell Death and Differentiation 2002, 9(9):981-994.
92. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer 1972, 26(4):239-257.
93. Kim H.E., Du F., Fang M., Wang X. Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1. Proceedings of the National Academic Sciences of theUnited States of America 2005, 102(49):17545-17550.
94. Kim J.S., He L., Lemasters J.J. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochemical and Biophysical Research Communications 2003, 304(3):463-470.
95. Kirkegaard T., Jaattela M. Lysosomal involvement in cell death and cancer. Biochimica et Biophysica Acta 2009, 1793(4):746-754.
96. Kirkin V., Lamark T., Sou Y.S., Bjorkoy G., Nunn J.L., Bruun J.A., et al. A role for Nbr1 in autophagosomal degradation of ubiquitinated substrates. Molecular Cell 2009, 33(4):505-516.
97. Kischkel F.C., Hellbardt S., Behrmann I., Germer M., Pawlita M., Krammer P.H., et al. Cytotoxicity-dependent Apo-1 (Fas/Cd95)-associated proteins form a death-inducing signaling complex (Disc) with the receptor. EMBO Journal 1995, 14(22):5579-5588.
98. Klionsky D.J., Abdalla F.C., Abeliovich H., Abraham R.T., Acevedo-Arozena A., Adeli K., et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8(4):445-544.
99. Kristian T., Balan I., Schuh R., Onken M. Mitochondrial dysfunction and nicotinamide dinucleotide catabolism as mechanisms of cell death and promising targets for neuroprotection. J Neurosci Res 2011, 89(12):1946-1955.
100. Kroemer G., El-Deiry W.S., Golstein P., Peter M.E., Vaux D., Vandenabeele P., et al. Classification of cell death: recommendations of the nomenclature committee on cell death. Cell Death and Differentiation 2005, 12(Suppl 2):1463-1467.
101. Kroemer G., Galluzzi L., Vandenabeele P., Abrams J., Alnemri E.S., Baehrecke E.H., et al. Classification of cell death: recommendations of the nomenclature committee on cell death. Cell Death & Differentiation 2009, 16(1):3-11.
102. Kroemer G., Jaattela M. Lysosomes and autophagy in cell death control. Nature Reviews Cancer 2005, 5(11):886-897.
103. Kroemer G., Marino G., Levine B. Autophagy and the integrated stress response. Molecular Cell 2010, 40(2):280-293.
104. Kroemer G., Martin S.J. Caspase-independent cell death. Nature Medicine 2005, 11(7):725-730.
105. Lachelt U., Kos P., Mickler F.M., Herrmann A., Salcher E.E., Rodl W., et al. Fine-tuning of proton sponges by precise diaminoethanes and histidines in pDNA polyplexes. Nanomedicine 2014, 10(1):35-44.
106. Lackner M.R., Kindt R.M., Carroll P.M., Brown K., Cancilla M.R., Chen C., et al. Chemical genetics identifies rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Cancer Cell 2005, 7(4):325-336.
107. Larsen A.K., Malinska D., Koszela-Piotrowska I., Parhamifar L., Hunter A.C., Moghimi S.M. Polyethylenimine-mediated impairment of mitochondrial membrane potential, respiration and membrane integrity: implications for nucleic acid delivery and gene therapy. Mitochondrion 2012, 12(1):162-168.
108. Lee T.H., Shank J., Cusson N., Kelliher M.A. The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced Ikappab kinase or P38 map kinase activation or for the ubiquitination of Rip1 by Traf2. Journal of Biological Chemistry 2004, 279(32):33185-33191.
109. Leist M., Single B., Castoldi A.F., Kuhnle S., Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. Journal of Experimental Medicine 1997, 185(8):1481-1486.
110. Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132(1):27-42.
111. Levine B., Yuan J. Autophagy in cell death: an innocent convict?. Journal of Clinical Investigation 2005, 115(10):2679-2688.
112. Li N., Zheng Y., Chen W., Wang C., Liu X., He W., et al. Adaptor protein LAPF recruits phosphorylated P53 to lysosomes and triggers lysosomal destabilization in apoptosis. Cancer Research 2007, 67(23):11176-11185.
113. Lieberthal W., Menza S.A., Levine J.S. Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells. American Journal of Physiology 1998, 274(2 Pt 2):F315-F327.
114. Lin Y., Devin A., Rodriguez Y., Liu Z.G. Cleavage of the death domain kinase Rip by caspase-8 prompts TNF-induced apoptosis. Genes & Development 1999, 13(19):2514-2526.
115. Lin C.W., Jan M.S., Kuo J.H., Hsu L.J., Lin Y.S. Protective role of autophagy in branched polyethylenimine (25k)- and poly(L-Lysine) (30-70k)-Induced cell death. European Journal of Pharmaceutical Science 2012, 47(5):865-874.
116. Lippens S., Denecker G., Ovaere P., Vandenabeele P., Declercq W. Death penalty for keratinocytes: apoptosis versus cornification. Cell Death and Differentiation 2005, 12(Suppl 2):1497-1508.
117. Liu X., Kim C.N., Yang J., Jemmerson R., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome C. Cell 1996, 86(1):147-157.
118. Liu X., Li P., Widlak P., Zou H., Luo X., Garrard W.T., et al. The 40-Kda subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proceedings of the National Academic Sciences of the United States of America 1998, 95(15):8461-8466.
119. Liu X., Zou H., Slaughter C., Wang X. Dff, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 1997, 89(2):175-184.
120. Logue S.E., Cleary P., Saveljeva S., Samali A. New directions in Er stress-induced cell death. Apoptosis 2013, 18(5):537-546.
121. Luo L., O'Leary D.D. Axon Retraction and degeneration in development and disease. Annual Review of Neuroscience 2005, 28:127-156.
122. Mack A., Furmann C., Hacker G. Detection of caspase-activation in intact lymphoid cells using standard caspase substrates and inhibitors. Journal of Immunological Methods 2000, 241(1-2):19-31.
123. Maiuri M.C., Le Toumelin G., Criollo A., Rain J.C., Gautier F., Juin P., et al. Functional and physical interaction between Bcl-X(L) and a Bh3-like domain in Beclin-1. EMBO Journal 2007, 26(10):2527-2539.
124. Mehrpour M., Esclatine A., Beau I., Codogno P. Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview. American Journal of Physiology Cell Physiology 2010, 298(4):C776-C785.
125. Melino G., Bernassola F., Knight R.A., Corasaniti M.T., Nistico G., Finazzi-Agro A. S-Nitrosylation regulates apoptosis. Nature 1997, 388(6641):432-433.
126. Michallet M.C., Saltel F., Flacher M., Revillard J.P., Genestier L. Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance. Journal of Immunology 2004, 172(9):5405-5414.
127. Mitchell P. Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. 1966. Biochimica et Biophysica Acta 2011, 1807(12):1507-1538.
128. Mizushima N., Levine B., Cuervo A.M., Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 2008, 451(7182):1069-1075.
129. Mizushima N., Ohsumi Y., Yoshimori T. Autophagosome formation in mammalian cells. Cell Structure and Function 2002, 27(6):421-429.
130. Moghimi S.M., Hunter A.C., Andresen T.L. Factors controlling nanoparticle pharmacokinetics: an integrated analysis and perspective. Annual Review of Pharmacology and Toxicology 2012, 52:481-503.
131. Moghimi S.M., Parhamifar L., Ahmadvand D., Wibroe P.P., Andresen T.L., Farhangrazi Z.S., et al. Particulate systems for targeting of macrophages: basic and therapeutic concepts. Journal of Innate Immunity 2012, 4(5-6):509-528.
132. Moghimi S.M., Symonds P., Murray J.C., Hunter A.C., Debska G., Szewczyk A. A two-stage poly(Ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. Molecular Therapy 2005, 11(6):990-995.
133. Mohanam S., Jasti S.L., Kondraganti S.R., Chandrasekar N., Lakka S.S., Kin Y., et al. Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells. Oncogene 2001, 20(28):3665-3673.
134. Moldoveanu T., Grace C.R., Llambi F., Nourse A., Fitzgerald P., Gehring K., et al. Bid-induced structural changes in bak promote apoptosis. Nature Structural & Molecular Biology 2013, 20(5):589-597.
135. Moquin D.M., McQuade T., Chan F.K. Cyld deubiquitinates Rip1 in the TNFalpha-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS One 2013, 8(10):e76841.
136. Mora R., Dokic I., Kees T., Huber C.M., Keitel D., Geibig R., et al. Sphingolipid rheostat alterations related to transformation can Be exploited for specific induction of lysosomal cell death in murine and human glioma. Glia 2010, 58(11):1364-1383.
137. Naahidi S., Jafari M., Edalat F., Raymond K., Khademhosseini A., Chen P. Biocompatibility of engineered nanoparticles for drug delivery. Journal of Controlled Release 2013, 166(2):182-194.
138. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by Amyloid-Beta. Nature 2000, 403(6765):98-103.
139. Neufeld T.P., Baehrecke E.H. Eating on the fly: function and regulation of autophagy during cell growth, survival and death in Drosophila. Autophagy 2008, 4(5):557-562.
140. Nishimura Y., Itoh K., Yoshioka K., Ikeda K., Himeno M. A role for small Gtpase Rhoa in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells. Histochemical Journal 2002, 34(5):189-213.
141. Nishimura Y., Itoh K., Yoshioka K., Tokuda K., Himeno M. Overexpression of rock in human breast Cancer cells: evidence that rock activity mediates intracellular membrane traffic of lysosomes. Pathology Oncology Research 2003, 9(2):83-95.
142. Nishimura Y., Yoshioka K., Bernard O., Himeno M., Itoh K. Lim kinase 1: evidence for a role in the regulation of intracellular vesicle trafficking of lysosomes and endosomes in human breast Cancer cells. European Journal of Cell Biology 2004, 83(7):369-380.
143. Novio F., Simmchen J., Vázquez-Mera N., Amorín-Ferré L., Ruiz-Molina D. Coordination polymer nanoparticles in medicine. Coordination Chemistry Reviews 2013, 257(19-20):2839-2847.
144. Nylandsted J., Gyrd-Hansen M., Danielewicz A., Fehrenbacher N., Lademann U., Hoyer-Hansen M., et al. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. Journal of Experimental Medicine 2004, 200(4):425-435.
145. Nylandsted J., Rohde M., Brand K., Bastholm L., Elling F., Jaattela M. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proceedings of the National Academic Sciences of the United States of America 2000, 97(14):7871-7876.
146. Obeid M., Tesniere A., Ghiringhelli F., Fimia G.M., Apetoh L., Perfettini J.L., et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nature Medicine 2007, 13(1):54-61.
147. Oberle C., Huai J., Reinheckel T., Tacke M., Rassner M., Ekert P.G., et al. Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes. Cell Death and Differentiation 2010, 17(7):1167-1178.
148. Oka S., Hsu C.P., Sadoshima J. Regulation of cell survival and death by pyridine nucleotides. Circulation Research 2012, 111(5):611-627.
149. Orrenius S., Zhivotovsky B., Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nature Reviews. Molecular Cell Biology 2003, 4(7):552-565.
150. Oyadomari S., Mori M. Roles of Chop/Gadd153 in endoplasmic reticulum stress. Cell Death and Differentiation 2004, 11(4):381-389.
151. Parhamifar L., Andersen H., Moghimi S.M. Lactate dehydrogenase assay for assessment of polycation cytotoxicity. Methods in Molecular Biology 2013, 948:13-22.
152. Parhamifar, Larsen A.K., Hunter A.C., Andresen T.L., Moghimi S.M. Polycation cytotoxicity: a delicate matter for nucleic acid therapy-focus on polyethylenimine. Soft Matter 2010, 6(17):4001-4009.
153. Parhamifar L., Wu L., Andersen H., Moghimi S.M. Live-cell fluorescent microscopy platforms for real-time monitoring of polyplex-cell interaction: basic guidelines. Methods 2014, 68(2):300-307.
154. Parsons M.J., Green D.R. Mitochondria in cell death. Essays in Biochemistry 2010, 47:99-114.
155. Parzych K.R., Klionsky D.J. An overview of autophagy: morphology, mechanism, and regulation. Antioxidants & Redox Signaling 2014, 20(3):460-473.
156. Pattingre S., Tassa A., Qu X., Garuti R., Liang X.H., Mizushima N., et al. Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy. Cell 2005, 122(6):927-939.
157. Peltola H., Paakkonen M., Kallio P., Kallio M.J. Short- versus long-term antimicrobial treatment for acute hematogenous osteomyelitis of childhood: prospective, randomized trial on 131 culture-positive cases. Pediatric Infectious Disease Journal 2010, 29(12):1123-1128. Osteomyelitis-Septic Arthritis Study Group.
158. Pesta D., Gnaiger E. High-resolution respirometry: oxphos protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods in Molecular Biology 2012, 810:25-58.
159. Petros R.A., DeSimone J.M. Strategies in the design of nanoparticles for therapeutic applications. Nature Reviews Drug Discovery 2010, 9(8):615-627.
160. Qi L., Yang L., Chen H. Detecting and quantitating physiological endoplasmic reticulum stress. Methods in Enzymology 2011, 490:137-146.
161. Raff M.C., Whitmore A.V., Finn J.T. Axonal self-destruction and neurodegeneration. Science 2002, 296(5569):868-871.
162. Rasola A., Bernardi P. The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis. Apoptosis 2007, 12(5):815-833.
163. 2+-dependent apoptosis and necrosis. Cell Calcium 2011, 50(3):222-233.
164. Repnik U., Cesen M.H., Turk B. The endolysosomal system in cell death and survival. Cold Spring Harbor Perspectives in Biology 2013, 5:a008755.
165. Repnik U., Stoka V., Turk V., Turk B. Lysosomes and lysosomal cathepsins in cell death. Biochimica et Biophysica Acta 2012, 1824(1):22-33.
166. Riedl S.J., Salvesen G.S. The apoptosome: signalling platform of cell death. Nature Reviews. Molecular Cell Biology 2007, 8(5):405-413.
167. Ruppert S.M., Li W., Zhang G., Carlson A.L., Limaye A., Durum S.K., et al. The major isoforms of bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in Interleukin-7 dependent lymphocytes. Biochimica et Biophysica Acta 2012, 1823(10):1877-1893.
168. Ryter S.W., Choi A.M. Regulation of autophagy in oxygen-dependent cellular stress. Current Pharmaceutical Design 2013, 19(15):2747-2756.
169. Ryter S.W., Cloonan S.M., Choi A.M. Autophagy: a critical regulator of cellular metabolism and homeostasis. Molecules and Cells 2013, 36(1):7-16.
170. Ryter S.W., Mizumura K., Choi A.M. The Impact of autophagy on cell death modalities. International Journal of Cell Biology 2014, 2014(502676). http://dx.doi.org/10.1155/2014/502676.
171. Salcher E.E., Kos P., Frohlich T., Badgujar N., Scheible M., Wagner E. Sequence-defined four-arm oligo(ethanamino)amides for pDNA and siRNA delivery: impact of building blocks on efficacy. Journal of Controlled Release 2012, 164(3):380-386.
172. 2+ storage in health and disease: a dynamic equilibrium. Cell Calcium 2010, 47(4):297-314.
173. 2+ thresholds determine cytochrome C release or permeability transition pore opening in Brain mitochondria. FASEB Journal 2001, 15(3):565-567.
174. Schotte P., Declercq W., Van Huffel S., Vandenabeele P., Beyaert R. Non-specific effects of methyl ketone peptide inhibitors of caspases. FEBS Letters 1999, 442(1):117-121.
175. Schroder M., Kaufman R.J. The mammalian unfolded protein response. Annual Review of Biochemistry 2005, 74:739-789.
176. Schulze-Osthoff K., Beyaert R., Vandevoorde V., Haegeman G., Fiers W. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. EMBO Journal 1993, 12(8):3095-3104.
177. Scott R.C., Juhasz G., Neufeld T.P. Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Current Biology 2007, 17(1):1-11.
178. Shimizu S., Kanaseki T., Mizushima N., Mizuta T., Arakawa-Kobayashi S., Thompson C.B., et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nature Cell Biology 2004, 6(12):1221-1228.
179. Smaili S.S., Pereira G.J., Costa M.M., Rocha K.K., Rodrigues L., do Carmo L.G., et al. The role of calcium stores in apoptosis and autophagy. Current Molecular Medicine 2013, 13(2):252-265.
180. Son S.M., Byun J., Roh S.E., Kim S.J., Mook-Jung I. Reduced Ire1alpha mediates apoptotic cell death by disrupting calcium homeostasis via the Insp3 receptor. Cell Death & Disease 2014, 5:e1188.
181. Sperandio S., de Belle I., Bredesen D.E. An alternative, nonapoptotic form of programmed cell death. Proceedings of the National Academic Sciences of the United States of America 2000, 97(26):14376-14381.
182. Strasser A., Cory S., Adams J.M. Deciphering the Rules of programmed cell death to improve therapy of Cancer and other diseases. EMBO Journal 2011, 30(18):3667-3683.
183. Strasser A., O'Connor L., Dixit V.M. Apoptosis signaling. Annual Review of Biochemistry 2000, 69:217-245.
184. Sumoza-Toledo A., Penner R. Trpm2: a multifunctional ion channel for calcium signalling. Journal of Physiology 2011, 589(Pt 7):1515-1525.
185. Symonds P., Murray J.C., Hunter A.C., Debska G., Szewczyk A., Moghimi S.M. Low and high molecular weight poly(L-Lysine)S/poly(L-Lysine)-DNA complexes initiate mitochondrial-mediated apoptosis differently. FEBS Letters 2005, 579(27):6191-6198.
186. Tabata K., Hayashi-Nishino M., Noda T., Yamamoto A., Yoshimori T. Morphological analysis of autophagy. Methods in Molecular Biology 2013, 931:449-466.
187. Taha T.A., Kitatani K., Bielawski J., Cho W., Hannun Y.A., Obeid L.M. Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin b-dependent mechanism. Journal of Biological Chemistry 2005, 280(17):17196-17202.
188. Tait S.W., Green D.R. Mitochondria and cell signalling. Journal of Cell Science 2012, 125(Pt 4):807-815.
189. Takahashi A., Camacho P., Lechleiter J.D., Herman B. Measurement of intracellular calcium. Physiological Reviews 1999, 79(4):1089-1125.
190. Temkin V., Huang Q., Liu H., Osada H., Pope R.M. Inhibition of Adp/Atp Exchange in receptor-interacting protein-mediated necrosis. Molecular and Cellular Biology 2006, 26(6):2215-2225.
191. Tenev T., Bianchi K., Darding M., Broemer M., Langlais C., Wallberg F., et al. The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of iaps. Molecular Cell 2011, 43(3):432-448.
192. Timmer J.C., Salvesen G.S. Caspase substrates. Cell Death and Differentiation 2007, 14(1):66-72.
193. Trambas C.M., Griffiths G.M. Delivering the kiss of death. Nature Immunology 2003, 4(5):399-403.
194. Tripathi L., Wu L.P., Chen J., Chen G.Q. Synthesis of diblock copolymer poly-3-hydroxybutyrate -Block-Poly-3-hydroxyhexanoate [Phb-B-Phhx] by a beta-oxidation weakened Pseudomonas putida Kt2442. Microbial Cell Factories 2012, 11:44. http://www.microbialcellfactories.com/content/11/1/44.
195. Troiber C., Edinger D., Kos P., Schreiner L., Klager R., Herrmann A., et al. Stabilizing effect of tyrosine trimers on pDNA and siRNA polyplexes. Biomaterials 2013, 34(5):1624-1633.
196. Tsujimoto Y., Yunis J., Onorato-Showe L., Erikson J., Nowell P.C., Croce C.M. Molecular cloning of the chromosomal breakpoint of B-Cell lymphomas and leukemias with the T(11;14) chromosome translocation. Science 1984, 224(4656):1403-1406.
197. Vanden Berghe T., Linkermann A., Jouan-Lanhouet S., Walczak H., Vandenabeele P. Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nature Reviews. Molecular Cell Biology 2014, 15(2):135-147.
198. Vaux D.L., Weissman I.L., Kim S.K. Prevention of programmed cell death in Caenorhabditis elegans by human Bcl-2. Science 1992, 258(5090):1955-1957.
199. Virag L., Robaszkiewicz A., Rodriguez-Vargas J.M., Oliver F.J. Poly(ADP-Ribose) signaling in cell death. Molecular Aspects of Medicine 2013, 34(6):1153-1167.
200. Werneburg N., Guicciardi M.E., Yin X.M., Gores G.J. TNF-alpha-mediated lysosomal permeabilization is Fan and caspase 8/Bid dependent. American Journal of Physiology Gastrointestinal and Liver Physiology 2004, 287(2):G436-G443.
201. Wu L., Chen S., Li Z., Xu K., Chen G.-Q. Synthesis, characterization and biocompatibility of novel biodegradable poly[((R)-3-hydroxybutyrate)-block-(D,L-Lactide)-block-([U+0917]-caprolactone)] triblock copolymers. Polymer International 2008, 57(7):939-949.
202. Wu L., Wang L., Wang X., Xu K. Synthesis, characterizations and biocompatibility of novel biodegradable Star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(Epsilon-Caprolactone). Acta Biomaterialia 2010, 6(3):1079-1089.
203. Wu L.-P., You M., Wang D., Peng G., Wang Z., Chen G.-Q. Fabrication of carbon nanotube (Cnt)/poly(3-hydroxybutyrate-Co-3-hydroxyhexanoate) (Phbhhx) nanocomposite films for human mesenchymal stem cell (Hmsc) differentiation. Polymer Chemistry 2013, 4(16):4490-4498.
204. Wu L.P., Wang D., Parhamifar L., Hall A., Chen G.Q., Moghimi S.M. Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticles with polyethylenimine coat as simple, safe, and versatile vehicles for cell targeting: population characteristics, cell uptake, and intracellular trafficking. Adv Healthc Mater 2014, 3(6):817-824.
205. Xia T., Kovochich M., Liong M., Meng H., Kabehie S., George S., et al. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano 2009, 3(10):3273-3286.
206. Xiong Y.C., Yao Y.C., Zhan X.Y., Chen G.Q. Application of polyhydroxyalkanoates nanoparticles as intracellular sustained drug-release vectors. Journal of Biomaterial Science, Polymer Edition 2010, 21(1):127-140.
207. Yamashima T. Hsp70.1 and related lysosomal factors for necrotic neuronal death. Journal of Neurochemistry 2012, 120(4):477-494.
208. Youle R.J., Narendra D.P. Mechanisms of mitophagy. Nature Reviews. Molecular Cell Biology 2011, 12(1):9-14.
209. Yuan X.M., Li W., Dalen H., Lotem J., Kama R., Sachs L., et al. Lysosomal destabilization in p53-induced apoptosis. Proceedings of the National Academic Sciences of the United States of America 2002, 99(9):6286-6291.
210. Zhang R., Piao M.J., Kim K.C., Kim A.D., Choi J.Y., Choi J., et al. Endoplasmic reticulum stress signaling is involved in silver nanoparticles-induced apoptosis. International Journal of Biochemistry & Cell Biology 2012, 44(1):224-232.
211. 2. FEBS Letters 2001, 509(3):399-404.
212. Zhu D.L., Peng H.B. Increase in intracellular calcium induced by the polycation-coated latex bead, a stimulus that causes postsynaptic-type differentiation in cultured Xenopus muscle cells. Developmental Biology 1988, 126(1):63-70.
213. Zintchenko A., Philipp A., Dehshahri A., Wagner E. Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity. Bioconjugate Chemistry 2008, 19(7):1448-1455.
214. Zitvogel L., Casares N., Pequignot M.O., Chaput N., Albert M.L., Kroemer G. Immune response against dying tumor cells. Advances in Immunology 2004, 84:131-179.
215. Zong W.X., Thompson C.B. Necrotic death as a cell fate. Genes & Development 2006, 20(1):1-15.
216. Zou H., Henzel W.J., Liu X., Lutschg A., Wang X. Apaf-1, a human protein homologous to C. elegans Ced-4, participates in cytochrome c-dependent activation of caspase-3. Cell 1997, 90(3):405-413.