Sequence-defined four-arm oligo(ethanamino)amides for pDNA and siRNA delivery: Impact of building blocks on efficacy

Journal of Controlled Release

Volumn 164, Issue 3, 2012, Pages 380-386

  Salcher, Eveline E ^a   Kos, Petra ^a   Fröhlich, Thomas ^a   Badgujar, Naresh ^a   Scheible, Max ^b   Wagner, Ernst ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b WALTER SCHOTTKY INSTITUT   (Germany)

Author keywords

Gene transfer; pDNA; Polycation; Silencing; siRNA

Indexed keywords

1 ,2-DIAMINOETHANE; BINDING ACTIVITIES; BUILDING BLOCKES; COMPLEX FORMATIONS; DISULFIDE LINKS; GENE SILENCING; GENE TRANSFER ACTIVITY; GOLD STANDARDS; HEXAMINES; N-TERMINALS; PDNA; PENTAETHYLENE; PLASMID DNA (PDNA); POLYCATIONS; POLYPLEXES; REPORTER GENE; SHORT INTERFERING RNA (SIRNA); SILENCING; SIRNA; SIRNA DELIVERY; SOLID-PHASE; TETRAMINES; TRANSFECTION ACTIVITY;

AMIDES; GENE TRANSFER; OLIGOMERS; RNA; STABILIZATION;

AMINO ACIDS;

4 [2 [TERT BUTOXYCARBONYL [2 [TERT BUTOXYCARBONYL [2 [TERT BUTOXYCARBONYL [2 TERT BUTOXYCARBONYL [2 (9H FLUOREN 9 YL METHOXYCARBONYLAMINO]ETHYL]AMINO]ETHYL]AMINO]ETHYL]AMINO]ETHYL]AMINO]ETHYLAMINO] 4 OXO BUTANOIC ACID; AMINO ACID; CYSTEINE; DISULFIDE; ETHANOLAMINE DERIVATIVE; OLIGO(ETHANAMINO)AMIDE DERIVATIVE; PENTAETHYLENE HEXAMINE; PLASMID DNA; POLYAMINE; SMALL INTERFERING RNA; TERT BUTYL N (2 AMINOETHYL) N [2 [2 [2 (2 AMINOETHYL(TERT BUTOXY CARBONYL)AMINO)ETHYL TERT BUTOXYCARBONYL AMINO]ETHYL TERT BUTOXYCARBONYL AMINO]ETHYL]CARBAMATE; TERT BUTYL N [2 [TERT BUTOXYCARBONYL [2 [TERTBUTOXYCARBONYL [2 [TERT BUTOXYCARBONYL [2 [(2,2,2 TRIFLUOROACETYL)AMINO]ETHYL]AMINO]ETHYL]AMINO]ETHYL]AMINO]ETHYL] N [2 [(2,2,2 TRIFLUOROACETYL)AMINO]ETHYL]CARBAMATE; TETRAETHYLENEPENTAMINE; TRIENTINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; CELL LINE; CONFERENCE PAPER; DISULFIDE BOND; DNA BINDING; DNA TRANSFECTION; DRUG STRUCTURE; GENE SILENCING; GENE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE;

AMIDES; ANIMALS; CELL LINE, TUMOR; DNA; DRUG CARRIERS; ETHYLAMINES; GENE SILENCING; GREEN FLUORESCENT PROTEINS; LUCIFERASES; MICE; PLASMIDS; POLYAMINES; RNA, SMALL INTERFERING; SOLID-PHASE SYNTHESIS TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870236447     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.06.023     Document Type: Conference Paper

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