A role for small GTPase RhoA in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells

Histochemical Journal

Volumn 34, Issue 5, 2002, Pages 189-213

  Nishimura, Yukio ^a   Itoh, Kazuyuki ^b   Yoshioka, Kiyoko ^b   Ikeda, Kazuhiko ^a   Himeno, Masaru ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BREFELDIN A; CATHEPSIN D; DEXTRAN; MEMBRANE RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSFERRIN RECEPTOR; WORTMANNIN;

ACIDITY; ANIMAL CELL; ARTICLE; CELL MOTILITY; CELL STRUCTURE; CYTOKINESIS; ENDOSOME; ENZYME REGULATION; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE MICROSCOPY; INTRACELLULAR MEMBRANE; LIVER CELL CARCINOMA; LYSOSOME; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ANDROSTADIENES; ANTIGENS, CD36; BREFELDIN A; CARCINOMA, HEPATOCELLULAR; DEXTRANS; ENDOCYTOSIS; ENDOSOMES; ENZYME INHIBITORS; INTRACELLULAR MEMBRANES; LYSOSOMES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; RECEPTORS, TRANSFERRIN; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 12244270337     PISSN: 00182214     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021702812146     Document Type: Article

References (51)

1. Amano M, Chihara K, Kimura Y, Fukata N, Nakamura Y, Matsuura Y, Kaibuchi K (1997) Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275: 1308-1311.
2. Aniento F, Emans N, Griffiths G, Gruenberg J (1993) Cytoplasmic dynein-dependent vesicular transport from early to late endosomes. J Cell Biol 123: 1373-1387.
3. Brown WJ, Emr SD, Plutner H, Balch WE (1995) Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells. J Cell Biol 130: 797-805.
4. Bucci C, Thomsen P, Nicoziani P, McCarthy J, van Deurs B (2000) Rab7: A key to lysosome biogenesis. Mol Biol Cell 11: 467-480.
5. Chavrier P, Goud B (1999) The role of ARF and Rab GTPases in membrane transport. Curr Opin Cell Biol 11: 466-475.
6. Cook TA, Nagasaki T, Gundersen GG (1998) Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid. J Cell Biol 141: 175-185.
7. Davidson H (1995) Wortmannin causes mis-targeting of procathepsin D. Evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes. J Cell Biol 130: 797-805.
8. Griffiths G, Hoflack B, Simons K, Mellman I, Kornfeld S (1988) The mannose 6-phosphate receptor and the biogenesis of lysosomes. Cell 52: 329-341.
9. Hall A (1994) Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu Rev Cell Biol 10: 31-54.
10. Hall A (1998) Rho GTPases and the actin cytoskelton. Science (Washington DC) 279: 509-514.
11. Hirose M, Ishizaki T, Watanabe N, Uehata M, Kranenburg O, Moolenaar WH, Matsumura F, Maekawa M, Bito H, Narumiya S (1998) Molecular dissection of the Rho-associated kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol 141: 1625-1636.
12. Hollenbeck PJ, Swanson JA (1990) Radial extension of macrophage tubular lysosomes supported by kinesin. Nature 346: 864-866.
13. Ishizaki T, Naito M, Fujisawa K, Maekawa M, Watanabe, N, Saito Y, Narumiya S (1997) p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesion. FEBS Lett 404: 118-124.
14. Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S (1999) An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nature Medicine 5: 221-225.
15. Kageshita T, Yoshii A, Kimura T, Maruo K, Ono T, Himeno M, Nishimura Y (1995) Biochemical and immunohistochemical analysis of cathepsins B, H, L and D in human melanocytic tumours. Arch Dermatol Res 287: 266-272.
16. Kishi K, Sasaki T, Kuroda S, Itoh T, Takai Y (1993) Regulation of cytoplasmic division of Xenopus Embryo by rhop21 and its inhibitory GDP/GTP exchange protein (rhoGDI). J Cell Biol 120: 1187-1195.
17. Kornfeld S, Mellman I (1989) The biogenesis of lysosomes. Ann Rev Cell Biol 5: 483-525.
18. Leung T, Manser E, Tan L, Lim L (1995) A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to the peripheral membranes. J Biol Chem 270: 29051-29054.
19. Lin SXH, Collins CA (1992) Immunolocalization of cytoplasmic dynein to lysosomes in cultured cells. J Cell Sci 101: 125-137.
20. Lippincott-Schwartz J, Fambrough DM (1986) Lysosomal membrane dynamics: Structure and interorganellar movement of a major lysosomal membrane glycoprotein. J Cell Biol 102: 1593-1605.
21. Lippincott-Schwartz J, Yuan L, Tripper C, Amherdt M, Orci L, Klausner RD (1991) Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell 67: 601-616.
22. Matsui T, Amano M, Yamamoto T, Chihara K, Nakafuku M, Ito M, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K (1996) Rho-associated kinase, a novel serine threonine kinase, as a putative target for the small GTP binding protein Rho. EMBO J 15: 2208-2216.
23. Matteoni R, Kreis TE (1987) Translocation and clustering of endosomes and lysosomes depends on microtubules. J Cell Biol 105: 1253-1265.
24. Nakagawa O, Fujisawa K, Ishizaki T, Saito Y, Nakao K, Narumiya S (1996) ROCK-I and ROCK-II; two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett 392: 189-193.
25. Nishimura Y, Higaki M, Kato K (1987) Identification of a precursor form of cathepsin D in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro. Biochem Biophys Res Commun 148: 335-343.
26. Nishimura Y, Kawabata T, Kato K (1988) Identification of latent procathepsins B and L in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro. Arch Biochem Biophys 261: 64-71.
27. Nishimura Y, Sameni M, Sloane BF (1998) Malignant transformation alters intracellular trafficking of lysosomal cathepsin D in human breast epithelial cells. Pathol Oncol Res 4: 283-296.
28. Nishimura Y, Itoh K, Yoshioka K, Uehata M, Himeno M (2000) Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells. Cell Tissue Res 342: 341-351.
29. Okazaki I, Himeno M, Ezaki J, Ishikawa T, Kato K (1992) Purification and characterization of an 85 kDa sialoglycoprotein in rat liver. J Biochem 111: 763-769.
30. rho induces rapid changes in cell morphorogy. J Cell Biol 111: 1001-1007.
31. Perona R, Esteve P, Jimenez B, Ballestero RP, Cajal SR, LacaL JC (1993) Tumorigenic activity of rho genes from Aphysia California. Oncogene 8: 1285-1292.
32. Pfeffer SR (1992) GTP-binding proteins in intracellular transport. Trends Cell Biol 2: 41-46.
33. Pfeffer SR (1999) Transport-vesicle targeting: Tethers before SNAREs. Nat Cell Biol 1: E17-E22.
34. Prendergast GC, Khosravi-Far R, Solski PA, Kurzawa H, Lebowitz PF, Der CJ (1995) Critical role of Rho in cell transformation by oncogenic Ras. Oncogene 10: 2289-2296.
35. Press B, Feng Y, Hoflack B, Wandinger-Nes A (1998) Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartment. J Cell Biol 140: 1075-1089.
36. Reaves B, Bright NA, Mullock B, Luzio JP (1996) The effect of wortmannin on the localization of lysosomal type I integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway. J Cell Sci 109: 749-762.
37. Rochefort H, Capony F, Garcia M (1990) Cathepsin D: A protease involved in cancer metastasis. Cancer Metast Rev 9: 321-331.
38. Sameni M, Elliott E, Ziegler G, Fortgens PH, Dennison C, Sloane BF (1995) Cathepsin B and D are localized at the surface of human breast cancer cells. Pathol Oncol Res 1: 43-53.
39. Sandoval IV, Arredondo JJ, Alcalde J, Gonzalez-Noriega A, Vandekerckhove J, Jimenez MA, Rico M (1994) The residues Leu(Ile)475-Ile(Leu)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMPII to lysosomes. J Biol Chem 269: 6622-6631.
40. Shpetner H, Joly M, Hartley D, Corvera S (1996) Potential sites of PI 3-kinase function in the endocytic pathway revealed by the PI 3-kinase inhibitor, wortmannin. J Cell Biol 132: 595-605.
41. Sloane BF, Moin K, Sameni M, Tait LR, Rozhin J, Ziegler G (1994) Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene. J Cell Sci 107: 373-384.
42. Stack JH, Emr SD (1993) Genetic and biochemical studies of protein sorting to the yeast vacuole. Curr Biol 5: 641-646.
43. Tabuchi N, Akasaki K, Tsuji H (2000) Two acidic amino acid residues, Asp(470) and Glu(471), contained in the carboxyl cytoplasmic tail of a major lysosomal membrane protein, LGP85/LIMPII, are important for its accumulation in secondary lysosomes. Biochem Biophys Res Commun 270: 557-563.
44. Takaishi K, Kikuchi A, Kuroda S, Kotani K, Sasaki T, Takai Y (1993) Involvement of rhop21 and its inhibitory GDP/GTP exchange protein (rhoGDI) in cell motility. Mol Cell Biol 13: 72-79.
45. Taniguchi S, Nishimura Y, Takahashi T, Baba T, Kato K (1990) Augmented excretion of procathepsin L of a fos-transferred highly metastatic cell line. Biochem Biophys Res Commun 168: 520-526.
46. Timar J, Tang D, Bazaz R, Kimler V, Taylor JD, Honn KV (1993) PKC mediates 12-(S)-HETE-induced cytoskeletal rearrangement in B16a melanoma cells. Cell Motil Cytoskell 26: 49-65.
47. 3-integrin in melanoma cells. J Cell Sci 108: 2175-2186.
48. ++ sensitization of smooth muscle in hypertension. Nature 389: 990-994.
49. Yoshioka K, Matsumura F, Akedo H, Itoh K (1998) Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells. J Biol Chem 273: 5146-5154.
50. Yoshioka K, Nakamori S, Itoh K (1999) Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells. Cancer Res 59: 2004-2010.
51. Zerial M, Stenmark H (1993) Rab GTPases in vesicular transport. Curr Opin Cell Biol 5: 613-620.