Short-versus long-term antimicrobial treatment for acute hematogenous osteomyelitis of childhood: Prospective, randomized trial on 131 culture-positive cases

Pediatric Infectious Disease Journal

Volumn 29, Issue 12, 2010, Pages 1123-1128

  Peltola, Heikki ^a   Pääkkönen, Markus ^b,c   Kallio, Pentti ^a   Kallio, Markku J T ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c MIKKELI CENTRAL HOSPITAL   (Finland)

Author keywords

CRP; ESR; osteoarticular infection; osteomyelitis; Staphylococcus aureus

Indexed keywords

AMOXICILLIN; AMPICILLIN; C REACTIVE PROTEIN; CEFADROXIL; CEFALEXIN; CEFALOTIN; CEFRADINE; CEFUROXIME; CLINDAMYCIN; DICLOXACILLIN; ERYTHROMYCIN; PENICILLIN V; TOBRAMYCIN;

ABSCESS DRAINAGE; ACUTE DISEASE; ADOLESCENT; ANTIBIOTIC THERAPY; ARTHROCENTESIS; ARTHROTOMY; ARTICLE; ASPIRATION; BACTERIAL ARTHRITIS; BACTERIUM CULTURE; BLOOD CULTURE; CHILD; CHILDHOOD DISEASE; COMPARATIVE STUDY; DRUG SUBSTITUTION; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FEVER; HAEMOPHILUS INFLUENZAE; HEMATOGENOUS OSTEOMYELITIS; HUMAN; INFANT; LIMB PAIN; LIMB SWELLING; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SHORT COURSE THERAPY; SURGICAL TECHNIQUE; TREATMENT RESPONSE; TREATMENT WITHDRAWAL; VACCINATION;

ADMINISTRATION, ORAL; ADOLESCENT; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; C-REACTIVE PROTEIN; CEPHALOSPORINS; CHILD; CHILD, PRESCHOOL; CLINDAMYCIN; FEMALE; HUMANS; INFANT; INFUSIONS, INTRAVENOUS; MALE; OSTEOMYELITIS; TIME FACTORS; TREATMENT OUTCOME;

EID: 78650399418     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e3181f55a89     Document Type: Article

References (40)

1. Lewis D. Acute osteomyelitis. JAMA. 1929;92:783-786.
2. Green WT, Shannon JG. Osteomyelitis of infants. A disease different from osteomyelitis of older children. Arch Surg. 1936;32:462-493.
3. Kenney WE. The prognosis in acute haematogenous osteomyelitis with and without chemotherapy. Surgery. 1944;16:477-484.
4. Tetzlaff TR, McCracken GH Jr, Nelson JD. Oral antibiotic therapy for skeletal infections of children. II. Therapy of osteomyelitis and suppurative arthritis. J Pediatr. 1978;92:485-490.
5. Kolyvas E, Ahronheim G, Marks MI, et al. Oral antibiotic therapy of skeletal infections in children. Pediatrics. 1980;65:867-871.
6. Karwowska A, Davies D, Jadavji T. Epidemiology and outcome of osteomyelitis in the era of sequential intravenous-oral therapy. Pediatr Infect Dis J. 1998;17:1021-1026.
7. Vinod MB, Matussek J, Curtis N, et al. Duration of antibiotics in children with osteomyelitis and septic arthritis. JPaediatr Child Health. 2002;38:363-367.
8. Gutierrez K. Bone andjoint infections in children. Pediatr Clin North Am. 2005;52:779-794.
9. Mollam RA, Piggott J. Acute osteomyelitis in children. J Bone Joint Surg. 1977;59(-B):2-7.
10. Syrogiannopoulos GA, Nelson JD. Duration of antibiotic therapy for acute suppurative osteoarticular infections. Lancet. 1988;1:37-40.
11. Dahl LB, Hoyland AL, Dramsdahl H, et al. Acute osteomyelitis in children: a population based retrospective study 1965 to 1994. Scand J Infect Dis. 1998;30:573-579.
12. Christiansen P, Frederiksen B, Glazowski MJ, et al. Epidemiologic, bacte-riologic, and long-term follow-up data of children with acute haematog-enous osteomyelitis and septic arthritis: a ten-year review. J Pediatr Orthop. 1999;8:302-305.
13. Bonhoeffer J, Haeberie B, Schaad UB, et al. Diagnosis of acute haemat-ogenous osteomyelitis and septic arthritis: 20 years experience at the University Children's Hospital Basel. Swiss Med Wkly. 2001;131:575-581.
14. Le Saux N, Howard A, Barrowman NJ, et al. Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic review. BMC Infect Dis. 2002;2:16.Available at: http://www.biomedcentral.com/1471-2334/2/16.
15. Lew DP, Waldvogel FA. Osteomyelitis. Lancet. 2004;364:369-379.
16. Malcius D, Trumpulyte G, Barauskas V, et al. Two decades of acute haematogenous osteomyelitis in children; are there any changes? Pediatr Surg Int. 2005;21:356-359.
17. Peltola H, Unkila-Kallio L, Kallio MJ; the Finnish Study Group. Simplified treatment of acute staphylococcal osteomyelitis of childhood. Pediatrics. 1997;99:846-850.
18. Peltola H, Paäkkönen M, Kallio P, et al. The OM-SA Study Group. Prospective, randomized trial of 10 days versus 30 days of antimicrobial treatment, including a short-term course of parenteral therapy, for childhood septic arthritis. Clin Infect Dis. 2009;48:1201-1210.
19. Nicholas P, Meyers BR, Lewy RN, et al. Concentration of clindamycin in human bone. Antimicrob Agents Chemother. 1975;8:220-221.
20. Kaplan SL, Mason EO, Feigin RD. Clindamycin versus nafcillin or meth-icillin in the treatment of Staphylococcus aureus osteomyelitis in children. South Med J. 1982;75:138-142.
21. Zaki A, Schreiber EC, Weliky I, et al. Clinical pharmacology of oral cephradine. J Clin Pharmacol. 1974;14:118-126.
22. Brosof AB, Spitzer TQ. Cephradine for the treatment of bone infections due to Staphylococcus aureus. Curr Ther Res. 1979;26:317-321.
23. Leigh DA. Determination of serum and bone concentrations of cephradine and cefuroxime by HPLC in patients undergoing hip and knee replacement surgery. J Antimicrob Chemother. 1989;23:877-883.
24. Lambert HP, O'Grady FW. Cephalosporins. In: Antibiotic and Chemotherapy. 6th ed. Edinburgh, United Kingdom: Churchill Livingstone; 1992:89-135.
25. Peltola H, Vahvanen V. A comparative study of osteomyelitis and purulent arthritis with special reference to aetiology and recovery. Infection. 1984;12:75-79.
26. Peltola H, Kallio MJ, Unkila-Kallio L. Reduced incidence of septic arthritis in children by Haemophilus influenzae type-b vaccination. Implications for treatment. J Bone Joint Surg. 1998;80(-B):471-473.
27. Peltola H, Rasanen JA. Quantitative C-reactive protein in relation to erythrocyte sedimentation rate, fever, and duration of antibiotic therapy in bacteraemic diseases of childhood. J Infect. 1982;5:257-267.
28. Roine I, Faingezicht I, Arguedas A, et al. Serial serum C-reactive protein to monitor recovery from acute hematogenous osteomyelitis in children. Pediatr Infect Dis J. 1995;14:40-44.
29. Peltola H, Jaakkola M. C-reactive protein in early detection of bacteremic versus viral infections in immunocompetent and compromised children. J Pediatr. 1988;113:641-646.
30. Uckay I, Assal M, Legout L, et al. Recurrent osteomyelitis caused by infection with different bacterial strains without obvious source of reinfection. J Clin Microbiol. 2006;44:194-196.
31. Spindler T, Huenges R, Hoppe JE. Acute haematogenous osteomyelitis in childhood-correlation of clinical aspects, diagnostic parameters, therapy and prognosis. Klin Pädiatr. 1998;210:56-59.
32. Nunn T, Rollinson P. Haematogenous pyogenic bone and joint sepsis- reducing avoidable morbidity. S Afr Med J. 2007;97:456-460.
33. Schultz C, Holterhus PM, Seidel A, et al. Chronic recurrent multifocal osteomyelitis in children. Pediatr Infect Dis J. 1999;18:1008-1013.
34. Ruebner R, Keren R, Coffin S, et al. Complications of central venous catheters used for the treatment of acute hematogenous osteomyelitis. Pediatrics. 2006;117:1210-1215.
35. Martínez-Aguilar G, Hammerman WA, Mason EO Jr, et al. Clindamycin treatment of invasive infections caused by community-acquired, methicil-lin-resistant and methicillin-susceptible Staphylococcus aureus in children. J Pediatr Infect Dis. 2003;22:593-598.
36. Carrillo-Marques MA, Hulten KG, Hammerman W, et al. USA300 is the predominant genotype causing Staphylococcus aureus septic arthritis in children. Pediatr Infect Dis J. 2009;28:1076-1080.
37. Landesdorfer CB, Bulitta JB, Kinzig M, et al. Penetration of antibacterials into bone. Pharmacokinetic, pharmacokinetic and bioanalytical considerations. Clin Pharmacokinet. 2009;48:89-24.
38. Ginsburg I. The role of bacteriolysis in the pathophysiology of inflammation, infection and post-infectious sequelae. APMIS. 2002;110:753-770.
39. Pääkkönen M, Kallio MJ, Kallio PE, et al. Sensitivity of erythrocyte sedimentation rate and C-reactive protein in childhood bone and joint infections. Clin Orthop Relat Res. 2010;468:861-866.
40. Tice AD, Hoaglund PA, Shoultz DA. Risk factors and treatment outcomes in osteomyelitis. J Antimicrob Chemother. 2003;51:1261-1268.