Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma

GLIA

Volumn 58, Issue 11, 2010, Pages 1364-1383

  Mora, Rodrigo ^a   Dokic, Ivana ^a   Kees, Tim ^a   Hüber, Christian M ^a   Keitel, Denise ^a   Geibig, Renate ^a   Brügge, Britta ^b   Zentgraf, Hanswalter ^a   Brady, Nathan R ^b,c   Régnier Vigouroux, Anne ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Astrocyte; Ceramide; Glioma; Mathematical model; Sphingosine 1 phosphate; Toxicity

Indexed keywords

CERAMIDE; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; SPHINGOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL DEATH; CELL ENLARGEMENT; CELL TRANSFORMATION; COMPUTER MODEL; CONTROLLED STUDY; FETUS; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LYSOSOME; MITOCHONDRION; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ASTROCYTES; AUTOPHAGY; BRAIN NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; GLIOMA; HUMANS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LYSOSOMES; MICE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SPHINGOLIPIDS;

EID: 77956505606     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.21013     Document Type: Article

References (32)

1. Apel A, Zentgraf H, Buchler MW, Herr I. 2009. Autophagy-A double-edged sword in oncology. Int J Cancer 125:991-995.
2. Berghe TV, Vanlangenakker N, Parthoens E, Deckers W, Devos M, Festjens N, Guerin CJ, Brunk UT, Declercq W, Vandenabeele P. 2009. Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ. [Epub ahead of print; doi: 10.1038/cdd:184].
3. Bieberich E. 2004. Integration of glycosphingolipid metabolism and cellfate decisions in cancer and stem cells: Review and hypothesis. Glycoconj J 21:315-327.
4. Bolanos JP, Almeida A. 2006. Modulation of astroglial energy metabolism by nitric oxide. Antioxid Redox Signal 8:955-965. (Pubitemid 44036512)
5. Bragadin M, Marton D, Manente S, Toninello A. 2001. The interaction of tributyllead with lysosomes from rat liver. J Inorg Biochem 83:229-232.
6. Brugger B, Glass B, Haberkant P, Leibrecht I, Wieland FT, Krausslich HG. 2006. The HIV lipidome: A raft with an unusual composition. Proc Natl Acad Sci U S A 103:2641-2646. (Pubitemid 43306602)
7. Butler D, Bahr BA. 2006. Oxidative stress and lysosomes: CNS-related consequences and implications for lysosomal enhancement strategies and induction of autophagy. Antioxid Redox Signal 8:185-196.
8. Capper D, Gaiser T, Hartmann C, Habel A, Mueller W, Herold-Mende C, von Deimling A, Siegelin MD. 2009. Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation. Acta Neuropathol 117:445-456.
9. Castillo SS, Levy M, Thaikoottathil JV, Goldkorn T. 2007. Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells. Exp Cell Res 313:2680-2686.
10. Dringen R, Gutterer JM, Hirrlinger J. 2000. Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. Eur J Biochem 267:4912-4916. (Pubitemid 30641287)
11. Ernst A, Hofmann S, Ahmadi R, Becker N, Korshunov A, Engel F, Hartmann C, Felsberg J, Sabel M, Peterziel H, Durchdewald M, Hess J, Barbus S, Campos B, Starzinski-Powitz A, Unterberg A, Reifenberger G, Lichter P, Herold-Mende C, Radlwimmer B. 2009. Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival. Clin Cancer Res 15:6541-6550.
12. French KJ, Upson JJ, Keller SN, Zhuang Y, Yun JK, Smith CD. 2006. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther 318:596-603.
13. Hewett JA. 2009. Determinants of regional and local diversity within the astroglial lineage of the normal central nervous system. J Neurochem 110:1717-1736.
14. Hla T. 2004. Physiological and pathological actions of sphingosine 1-phosphate. Semin Cell Dev Biol 15:513-520. (Pubitemid 38953947)
15. Kirkegaard T, Jaattela M. 2009. Lysosomal involvement in cell death and cancer. Biochim Biophys Acta 1793:746-754.
16. Kitatani K, Idkowiak-Baldys J, Hannun YA. 2008. The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal 20:1010-1018.
17. Kolesnick RN, Goni FM, Alonso A. 2000. Compartmentalization of ceramide signaling: Physical foundations and biological effects. J Cell Physiol 184:285-300.
18. Luzio JP, Pryor PR, Bright NA. 2007. Lysosomes: Fusion and function. Nat Rev Mol Cell Biol 8:622-632.
19. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA. 2001. Malignant glioma: Genetics and biology of a grave matter. Genes Dev 15:1311-1333.
20. Mora R, Abschuetz A, Kees T, Dokic I, Joschko N, Kleber S, Geibig R, Mosconi E, Zentgraf H, Martin-Villalba A, et al. 2009. TNF-α - and TRAIL-resistant glioma cells undergo autophagy-dependent cell death induced by activated microglia. Glia 57:561-581.
21. Mora R, Regnier-Vigouroux A. 2009. Autophagy-driven cell fate decision maker: Activated microglia induce specific death of glioma cells by a blockade of basal autophagic flux and secondary apoptosis/necrosis. Autophagy 5:419-421.
22. Morales A, Lee H, Goni FM, Kolesnick R, Fernandez-Checa JC. 2007. Sphingolipids and cell death. Apoptosis 12:923-939.
23. Ono K, Kim SO, Han J. 2003. Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor α -induced cell death. Mol Cell Biol 23:665-676.
24. Palomba L, Cerioni L, Cantoni O. 2009. Arachidonic acid: A key molecule for astrocyte survival to peroxynitrite. Glia 57:1672-1679.
25. Pchejetski D, Kunduzova O, Dayon A, Calise D, Seguelas MH, Leducq N, Seif I, Parini A, Cuvillier O. 2007. Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. Circ Res 100:41-49. (Pubitemid 46066772)
26. Razi M, Chan EY, Tooze SA. 2009. Early endosomes and endosomal coatomer are required for autophagy. J Cell Biol 185:305-321.
27. Spiegel S, Milstien S. 2003. Sphingosine-1-phosphate: An enigmatic signalling lipid. Nat Rev Mol Cell Biol 4:397-407.
28. Terman A, Kurz T, Gustafsson B, Brunk UT. 2006. Lysosomal labilization. IUBMB Life 58:531-539.
29. Thompson CR, Iyer SS, Melrose N, VanOosten R, Johnson K, Pitson SM, Obeid LM, Kusner DJ. 2005. Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: Inhibition of SK1 translocation by Mycobacterium tuberculosis. J Immunol 174:3551-3561.
30. Van Brocklyn JR. 2007. Sphingolipid signaling pathways as potential therapeutic targets in gliomas. Mini Rev Med Chem 7:984-990.
31. Won JS, Singh I. 2006. Sphingolipid signaling and redox regulation. Free Radic Biol Med 40:1875-1888.
32. Zheng W, Kollmeyer J, Symolon H, Momin A, Munter E, Wang E, Kelly S, Allegood JC, Liu Y, Peng Q, et al. 2006. Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim Biophys Acta 1758:1864-1884.