The impact of autophagy on cell death modalities

International Journal of Cell Biology

Volumn , Issue , 2014, Pages

  Ryter, Stefan W ^a,b   Mizumura, Kenji ^a,b   Choi, Augustine M K ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; CALPAIN; CASPASE; CASPASE 3; CASPASE 8; CRYOPYRIN; GROWTH FACTOR; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 33; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P53;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL ELONGATION; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME INHIBITION; HOMEOSTASIS; INFLAMMATION; LYSOSOME; MACROAUTOPHAGY; MITOPHAGY; MOLECULAR INTERACTION; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; REGULATORY MECHANISM; SELECTIVE AUTOPHAGY; SIGNAL TRANSDUCTION; STARVATION;

EID: 84896867224     PISSN: 16878876     EISSN: 16878884     Source Type: Journal    
DOI: 10.1155/2014/502676     Document Type: Article

References (130)

1. Levine B., Klionsky D. J., Development by self-digestion: molecular mechanisms and biological functions of autophagy. Developmental Cell 2004 6 4 463 477 2-s2.0-1842583789 10.1016/S1534-5807(04)00099-1
2. Mizushima N., Levine B., Cuervo A. M., Klionsky D. J., Autophagy fights disease through cellular self-digestion. Nature 2008 451 7182 1069 1075 2-s2.0-39849109338 10.1038/nature06639
3. Klionsky D. J., Emr S. D., Autophagy as a regulated pathway of cellular degradation. Science 2000 290 5497 1717 1721 2-s2.0-0034537290 10.1126/science.290.5497.1717
4. Eskelinen E. L., Saftig P., Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochimica et Biophysica Acta 2009 1793 4 664 673 2-s2.0-62949091373 10.1016/j.bbamcr.2008.07.014
5. Ravikumar B., Sarkar S., Davies J. E., Futter M., Garcia-Arencibia M., Green-Thompson Z. W., Jimenez-Sanchez M., Korolchuk V. I., Lichtenberg M., Luo S., Massey D. C. O., Menzies F. M., Moreau K., Narayanan U., Renna M., Siddiqi F. H., Underwood B. R., Winslow And A. R., Rubinsztein D. C., Regulation of mammalian autophagy in physiology and pathophysiology. Physiological Reviews 2010 90 4 1383 1435 2-s2.0-78149475088 10.1152/physrev.00030.2009
6. Kelekar A., Autophagy. Annals of the New York Academy of Sciences 2005 1066 259 271 2-s2.0-33749061748 10.1196/annals.1363.015
7. Johansen T., Lamark T., Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011 7 3 279 296 2-s2.0-79952355107 10.4161/auto.7.3.14487
8. Lamark T., Johansen T., Aggrephagy: selective disposal of protein aggregates by macroautophagy. International Journal of Cell Biology 2012 2012 21 2-s2.0-84859736977 10.1155/2012/736905 736905
9. Youle R. J., Narendra D. P., Mechanisms of mitophagy. Nature Reviews Molecular Cell Biology 2011 12 1 9 14 2-s2.0-78650467974 10.1038/nrm3028
10. Sumpter R., Levine B., Autophagy and innate immunity: triggering, targeting and tuning. Seminars in Cell and Developmental Biology 2010 21 7 699 711 2-s2.0-77956180361 10.1016/j.semcdb.2010.04.003
11. Kroemer G., Mariño G., Levine B., Autophagy and the integrated stress response. Molecular Cell 2010 40 2 280 293 2-s2.0-78649338141 10.1016/j.molcel.2010.09.023
12. Nakahira K., Cloonan S. M., Mizumura K., Choi A. M., Ryter S. W., Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease. Antioxidants and Redox Signalling 2013
13. Ryter S. W., Cloonan S. M., Choi A. M., Autophagy: a critical regulator of cellular metabolism and homeostasis. Molecules and Cells 2013 36 1 7 16 10.1007/s10059-013-0140-8
14. Ryter S. W., Choi A. M., Regulation of autophagy in oxygen-dependent cellular stress. Current Pharmaceutical Design 2013 19 15 2747 2756 10.2174/1381612811319150010
15. Levine B., Mizushima N., Virgin H. W., Autophagy in immunity and inflammation. Nature 2011 469 7330 323 335 2-s2.0-78751672975 10.1038/nature09782
16. Deretic V., Levine B., Autophagy, immunity, and microbial adaptations. Cell Host and Microbe 2009 5 6 527 549 2-s2.0-67649607465 10.1016/j.chom.2009. 05.016
17. Choi A. M., Ryter S. W., Levine B., Autophagy in human health and disease. New England Journal of Medicine 2013 368 7 651 662 10.1056/ NEJMra1205406
18. Rubinsztein D. C., Codogno P., Levine B., Autophagy modulation as a potential therapeutic target for diverse diseases. Nature Reviews Drug Discovery 2012 11 9 709 730 10.1038/nrd3802
19. Levine B., Kroemer G., Autophagy in the pathogenesis of disease. Cell 2008 132 1 27 42 2-s2.0-37649005234 10.1016/j.cell.2007.12.018
20. Mizushima N., Komatsu M., Autophagy: renovation of cells and tissues. Cell 2011 147 4 728 741 2-s2.0-81055144784 10.1016/j.cell.2011.10.026
21. Kuma A., Hatano M., Matsui M., Yamamoto A., Nakaya H., Yoshimori T., Ohsumi Y., Tokuhisa T., Mizushima N., The role of autophagy during the early neonatal starvation period. Nature 2004 432 7020 1032 1036 2-s2.0-11144245626 10.1038/nature03029
22. Boya P., González-Polo R., Casares N., Perfettini J., Dessen P., Larochette N., Métivier D., Meley D., Souquere S., Yoshimori T., Pierron G., Codogno P., Kroemer G., Inhibition of macroautophagy triggers apoptosis. Molecular and Cellular Biology 2005 25 3 1025 1040 2-s2.0-19944434059 10.1128/MCB.25.3.1025-1040.2005
23. Galluzzi L., Vicencio J. M., Kepp O., Tasdemir E., Maiuri M. C., Kroemer G., To die or not to die: that is the autophagic question. Current Molecular Medicine 2008 8 2 78 91 2-s2.0-42049089700 10.2174/156652408783769616
24. Maiuri M. C., Zalckvar E., Kimchi A., Kroemer G., Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nature Reviews Molecular Cell Biology 2007 8 9 741 752 2-s2.0-34548188741 10.1038/nrm2239
25. Kroemer G., Levine B., Autophagic cell death: the story of a misnomer. Nature Reviews Molecular Cell Biology 2008 9 12 1004 1010 2-s2.0-56749170677 10.1038/nrm2529
26. Shen H. M., Codogno P., Autophagic cell death: Loch Ness monster or endangered species? Autophagy 2011 7 5 457 465 2-s2.0-79955677000 10.4161/auto.7.5.14226
27. Shimizu S., Kanaseki T., Mizushima N., Mizuta T., Arakawa-Kobayashi S., Thompson C. B., Tsujimoto Y., Role of Bcl-2 family proteins in a non-apoptopic programmed cell death dependent on autophagy genes. Nature Cell Biology 2004 6 12 1221 1228 2-s2.0-10344262564 10.1038/ncb1192
28. Jain M. V., Paczulla A. M., Klonisch T., Dimgba F. N., Rao S. B., Roberg K., Schweizer F., Lengerke C., Davoodpour P., Palicharla V. R., Maddika S., Łos M., Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. Journal of Cellular and Molecular Medicine 2013 17 1 12 29
29. Su M., Mei Y., Sinha S., Role of the crosstalk between autophagy and apoptosis in cancer. Journal of Oncology 2013 2013 14 102735 10.1155/2013/102735
30. Galluzzi L., Maiuri M. C., Vitale I., Zischka H., Castedo M., Zitvogel L., Kroemer G., Cell death modalities: classification and pathophysiological implications. Cell Death and Differentiation 2007 14 7 1237 1243 2-s2.0-34250753161 10.1038/sj.cdd.4402148
31. Kroemer G., Galluzzi L., Vandenabeele P., Abrams J., Alnemri E. S., Baehrecke E. H., Blagosklonny M. V., El-Deiry W. S., Golstein P., Green D. R., Hengartner M., Knight R. A., Kumar S., Lipton S. A., Malorni W., Nuñez G., Peter M. E., Tschopp J., Yuan J., Piacentini M., Zhivotovsky B., Melino G., Classification of cell death: recommendations of the nomenclature committee on cell death 2009. Cell Death and Differentiation 2009 16 1 3 11 2-s2.0-57649149333 10.1038/cdd.2008.150
32. Fink S. L., Cookson B. T., Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infection and Immunity 2005 73 4 1907 1916 2-s2.0-16244362671 10.1128/IAI.73.4.1907-1916.2005
33. Majno G., Joris I., Apoptosis, oncosis, and necrosis: an overview of cell death. American Journal of Pathology 1995 146 1 3 15 2-s2.0-0028891783
34. Galluzzi L., Kroemer G., Necroptosis: a specialized pathway of programmed necrosis. Cell 2008 135 7 1161 1163 2-s2.0-57649167477 10.1016/j.cell.2008.12. 004
35. Vandenabeele P., Galluzzi L., Vanden Berghe T., Kroemer G., Molecular mechanisms of necroptosis: an ordered cellular explosion. Nature Reviews Molecular Cell Biology 2010 11 10 700 714 2-s2.0-77957105977 10.1038/nrm2970
36. Zhang D. W., Shao J., Lin J., Zhang N., Lu B., Lin S., Dong M., Han J., RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009 325 5938 332 336 2-s2.0-67650812332 10.1126/science.1172308
37. He S., Wang L., Miao L., Wang T., Du F., Zhao L., Wang X., Receptor interacting protein kinase-3 determines cellular necrotic response to TNF- α Cell 2009 137 6 1100 1111 2-s2.0-66749183275 10.1016/j.cell.2009.05.021
38. Cho Y. S., Challa S., Moquin D., Genga R., Ray T. D., Guildford M., Chan F. K., Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009 137 6 1112 1123 2-s2.0-66449133280 10.1016/j.cell.2009.05.037
39. Galluzzi L., Vanden Berghe T., Vanlangenakker N., Buettner S., Eisenberg T., Vandenabeele P., Madeo F., Kroemer G., Programmed necrosis. From molecules to health and disease. International Review of Cell and Molecular Biology 2011 289 1 35 2-s2.0-79960110569 10.1016/B978-0-12-386039-2.00001-8
40. Sun L., Wang H., Wang Z., He S., Chen S., Liao D., Wang L., Yan J., Liu W., Lei X., Wang X., Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012 148 1-2 213 227 2-s2.0-84856090067 10.1016/j.cell.2011.11.031
41. Welz P. S., Wullaert A., Vlantis K., Kondylis V., Fernández-Majada V., Ermolaeva M., Kirsch P., Sterner-Kock A., Van Loo G., Pasparakis M., FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 2011 477 7364 330 334 2-s2.0-80052850704 10.1038/nature10273
42. Günther C., Martini E., Wittkopf N., Amann K., Weigmann B., Neumann H., Waldner M. J., Hedrick S. M., Tenzer S., Neurath M. F., Becker C., Caspase-8 regulates TNF- α -induced epithelial necroptosis and terminal ileitis. Nature 2011 477 7364 335 339 2-s2.0-80052845560 10.1038/nature10400
43. Kepp O., Galluzzi L., Zitvogel L., Kroemer G., Pyroptosis-a cell death modality of its kind? European Journal of Immunology 2010 40 3 627 630 2-s2.0-77749260612 10.1002/eji.200940160
44. Cookson B. T., Brennan M. A., Pro-inflammatory programmed cell death. Trends in Microbiology 2001 9 3 113 114 2-s2.0-0035283318
45. Yang Z., Klionsky D. J., Mammalian autophagy: core molecular machinery and signaling regulation. Current Opinion in Cell Biology 2010 22 2 124 131 2-s2.0-77951214016 10.1016/j.ceb.2009.11.014
46. He C., Klionsky D. J., Regulation mechanisms and signaling pathways of autophagy. Annual Review of Genetics 2009 43 67 93 2-s2.0-72549095406 10.1146/annurev-genet-102808-114910
47. Jung C. H., Ro S., Cao J., Otto N. M., Kim Do-Hyung D.-H., MTOR regulation of autophagy. FEBS Letters 2010 584 7 1287 1295 2-s2.0-77950501014 10.1016/j.febslet.2010.01.017
48. Mizushima N., The role of the Atg1/ULK1 complex in autophagy regulation. Current Opinion in Cell Biology 2010 22 2 132 139 2-s2.0-77951221542 10.1016/j.ceb.2009.12.004
49. Chan E. Y., Regulation and function of uncoordinated-51 like kinase proteins. Antioxidants & Redox Signaling 2012 17 5 775 785
50. Hosokawa N., Hara T., Kaizuka T., Kishi C., Takamura A., Miura Y., Iemura S., Natsume T., Takehana K., Yamada N., Guan J., Oshiro N., Mizushima N., Nutrient-dependent mTORCl association with the ULK1-Atg13-FIP200 complex required for autophagy. Molecular Biology of the Cell 2009 20 7 1981 1991 2-s2.0-65249119430 10.1091/mbc.E08-12-1248
51. Ganley I. G., Lam D. H., Wang J., Ding X., Chen S., Jiang X., ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. Journal of Biological Chemistry 2009 284 18 12297 12305 2-s2.0-66449083078 10.1074/jbc.M900573200
52. Jung C. H., Jun C. B., Ro S., Kim Y., Otto N. M., Cao J., Kundu M., Kim D., ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Molecular Biology of the Cell 2009 20 7 1992 2003 2-s2.0-65249176304 10.1091/mbc.E08-12-1249
53. Wong P. M., Puente C., Ganley I. G., Jiang X., The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy 2013 9 124 137 10.4161/auto.23323
54. Hara T., Takamura A., Kishi C., Iemura S., Natsume T., Guan J., Mizushima N., FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. Journal of Cell Biology 2008 181 3 497 510 2-s2.0-43149090064 10.1083/jcb.200712064
55. Mihaylova M. M., Shaw R. J., The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nature Cell Biology 2011 13 9 1016 1023 2-s2.0-80052511813 10.1038/ncb2329
56. Kim J., Kundu M., Viollet B., Guan K., AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nature Cell Biology 2011 13 2 132 141 2-s2.0-79551598347 10.1038/ncb2152
57. He C., Levine B., The Beclin 1 interactome. Current Opinion in Cell Biology 2010 22 2 140 149 2-s2.0-77951237303 10.1016/j.ceb.2010.01.001
58. Itakura E., Kishi C., Inoue K., Mizushima N., Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Molecular Biology of the Cell 2008 19 12 5360 5372 2-s2.0-59249089394 10.1091/mbc.E08-01-0080
59. Wang R. C., Wei Y., An Z., Zou Z., Xiao G., Bhagat G., White M., Reichelt J., Levine B., Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 2012 338 6109 956 959 10.1126/science.1225967
60. Pattingre S., Tassa A., Qu X., Garuti R., Xiao H. L., Mizushima N., Packer M., Schneider M. D., Levine B., Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005 122 6 927 939 2-s2.0-25144457455 10.1016/j.cell.2005.07.002
61. Ohsumi Y., Molecular dissection of autophagy: two ubiquitin-like systems. Nature Reviews Molecular Cell Biology 2001 2 3 211 216 2-s2.0-0035286734 10.1038/35056522
62. Tanida I., Ueno T., Kominami E., LC3 conjugation system in mammalian autophagy. International Journal of Biochemistry and Cell Biology 2004 36 12 2503 2518 2-s2.0-4344624322 10.1016/j.biocel.2004.05.009
63. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T., LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO Journal 2000 19 21 5720 5728 2-s2.0-0034329418
64. Kabeya Y., Mizushima N., Yamamoto A., Oshitani-Okamoto S., Ohsumi Y., Yoshimori T., LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. Journal of Cell Science 2004 117 13 2805 2812 2-s2.0-3242888703 10.1242/jcs.01131
65. He H., Dang Y., Dai F., Guo Z., Wu J., She X., Pei Y., Chen Y., Ling W., Wu C., Zhao S., Liu J. O., Yu L., Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. Journal of Biological Chemistry 2003 278 31 29278 29287 2-s2.0-0042206454 10.1074/jbc.M303800200
66. Satoo K., Noda N. N., Kumeta H., Fujioka Y., Mizushima N., Ohsumi Y., Inagaki F., The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO Journal 2009 28 9 1341 1350 2-s2.0-65649136884 10.1038/emboj.2009.80
67. Zhang H., Bosch-Marce M., Shimoda L. A., Yee S. T., Jin H. B., Wesley J. B., Gonzalez F. J., Semenza G. L., Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. Journal of Biological Chemistry 2008 283 16 10892 10903 2-s2.0-43649104579 10.1074/jbc.M800102200
68. Ding W. X., Ni H. M., Li M., Liao Y., Chen X., Stolz D. B., Dorn G. W. II, Yin X., Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. Journal of Biological Chemistry 2010 285 36 27879 27890 2-s2.0-77956252454 10.1074/jbc.M110.119537
69. Narendra D., Tanaka A., Suen D., Youle R. J., Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. Journal of Cell Biology 2008 183 5 795 803 2-s2.0-58149314211 10.1083/jcb.200809125
70. Geisler S., Holmström K. M., Skujat D., Fiesel F. C., Rothfuss O. C., Kahle P. J., Springer W., PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nature Cell Biology 2010 12 2 119 131 2-s2.0-75949130828 10.1038/ncb2012
71. Morris H. R., Genetics of Parkinson's disease. Annals of Medicine 2005 37 2 86 96 2-s2.0-17844365594 10.1080/07853890510007269
72. Trancikova A., Tsika E., Moore D. J., Mitochondrial dysfunction in genetic animal models of Parkinson's disease. Antioxidants and Redox Signaling 2012 16 9 896 919 2-s2.0-84857953098 10.1089/ars.2011.4200
73. Vives-Bauza C., Zhou C., Huang Y., Cui M., De Vries R. L. A., Kim J., May J., Tocilescu M. A., Liu W., Ko H. S., Magrané J., Moore D. J., Dawson V. L., Grailhe R., Dawson T. M., Li C., Tieu K., Przedborski S., PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proceedings of the National Academy of Sciences of the United States of America 2010 107 1 378 383 2-s2.0-75949098487 10.1073/pnas.0911187107
74. Chen Y., Dorn G. W., PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 2013 340 6131 471 475 10.1126/science.1231031
75. Sarraf S. A., Raman M., Guarani-Pereira V., Sowa M. E., Huttlin E. L., Gygi S. P., Harper J. W., Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature 2013 496 7445 372 376 10.1038/nature12043
76. Ichimura Y., Komatsu M., Selective degradation of p62 by autophagy. Seminars in Immunopathology 2010 32 4 431 436 2-s2.0-79953153831
77. Shaid S., Brandts C. H., Serve H., Dikic I., Ubiquitination and selective autophagy. Cell Death Differentiation 2013 20 1 21 30 10.1038/cdd.2012.72
78. Kirkin V., Lamark T., Sou Y., Bjørkøy G., Nunn J. L., Bruun J., Shvets E., McEwan D. G., Clausen T. H., Wild P., Bilusic I., Theurillat J., Øvervatn A., Ishii T., Elazar Z., Komatsu M., Dikic I., Johansen T., A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Molecular Cell 2009 33 4 505 516 2-s2.0-60849099049 10.1016/j.molcel.2009.01.020
79. Clausen T. H., Lamark T., Isakson P., Finley K., Larsen K. B., Brech A., Øvervatn A., Stenmark H., Bjørkøy G., Simonsen A., Johansen T., p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy 2010 6 3 330 344 2-s2.0-77952914565 10.4161/auto.6.3.11226
80. Deosaran E., Larsen K. B., Hua R., NBR1 acts as an autophagy receptor for peroxisomes. Journal of Cell Science 2013 126 4 939 952 10.1242/jcs.114819
81. MacIntosh G. C., Bassham D. C., The connection between ribophagy, autophagy and ribosomal RNA decay. Autophagy 2011 7 6 662 663 2-s2.0-79957880149 10.4161/auto.7.6.15447
82. Cebollero E., Reggiori F., Kraft C., Reticulophagy and ribophagy: regulated degradation of protein production factories. International Journal of Cell Biology 2012 2012 9 182834 10.1155/2012/182834
83. Liu K., Czaja M. J., Regulation of lipid stores and metabolism by lipophagy. Cell Death and Differentiation 2013 20 1 3 11 10.1038/cdd.2012.63
84. Fujiwara Y., Furuta A., Kikuchi H., Discovery of a novel type of autophagy targeting RNA. Autophagy 2013 9 3 403 409
85. Robert G., Gastaldi C., Puissant A., The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. Autophagy 2012 8 4 637 649 10.4161/auto.19084
86. Zhu Y., Massen S., Terenzio M., Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. Journal of Biological Chemistry 2013 288 2 1099 1113 10.1074/jbc.M112.399345
87. Luo S., Rubinsztein D. C., Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death and Differentiation 2010 17 2 268 277 2-s2.0-74249109983 10.1038/cdd.2009.121
88. Pyo J. O., Jang M., Kwon Y., Lee H., Jun J., Woo H., Cho D., Choi B., Lee H., Kim J., Mizushima N., Oshumi Y., Jung Y., Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. Journal of Biological Chemistry 2005 280 21 20722 20729 2-s2.0-20144381544 10.1074/jbc.M413934200
89. Yousefi S., Perozzo R., Schmid I., Ziemiecki A., Schaffner T., Scapozza L., Brunner T., Simon H., Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nature Cell Biology 2006 8 10 1124 1132 2-s2.0-33749162486 10.1038/ncb1482
90. Rubinstein A. D., Eisenstein M., Ber Y., Bialik S., Kimchi A., The autophagy protein atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis. Molecular Cell 2011 44 5 698 709 2-s2.0-83455225635 10.1016/j.molcel.2011.10.014
91. Betin V. M., Lane J. D., Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. Journal of Cell Science 2009 122 14 2554 2566 2-s2.0-69649090647 10.1242/jcs.046250
92. Oral O., Oz-Arslan D., Itah Z., Naghavi A., Deveci R., Karacali S., Gozuacik D., Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death. Apoptosis 2012 17 8 810 820 10.1007/s10495-012- 0735-0
93. Lee J. S., Li Q., Lee J., Lee S., Jeong J. H., Lee H., Chang H., Zhou F., Gao S., Liang C., Jung J. U., FLIP-mediated autophagy regulation in cell death control. Nature Cell Biology 2009 11 11 1355 1362 2-s2.0-70449529788 10.1038/ncb1980
94. Crighton D., Wilkinson S., O'Prey J., Syed N., Smith P., Harrison P. R., Gasco M., Garrone O., Crook T., Ryan K. M., DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006 126 1 121 134 2-s2.0-33745885329 10.1016/j.cell.2006.05.034
95. Feng Z., Zhang H., Levine A. J., Jin S., The coordinate regulation of the p53 and mTOR pathways in cells. Proceedings of the National Academy of Sciences of the United States of America 2005 102 23 8204 8209 2-s2.0-20444363122 10.1073/pnas.0502857102
96. Tasdemir E., Maiuri M. C., Galluzzi L., Vitale I., Djavaheri-Mergny M., D'Amelio M., Criollo A., Morselli E., Zhu C., Harper F., Nannmark U., Samara C., Pinton P., Vicencio J. M., Carnuccio R., Moll U. M., Madeo F., Paterlini-Brechot P., Rizzuto R., Szabadkai G., Pierron G., Blomgren K., Tavernarakis N., Codogno P., Cecconi F., Kroemer G., Regulation of autophagy by cytoplasmic p53. Nature Cell Biology 2008 10 6 676 687 2-s2.0-44649141966 10.1038/ncb1730
97. Contreras A. U., Mebratu Y., Delgado M., Montano G., Hu C. A., Ryter S. W., Choi A. M., Lin Y., Xiang J., Chand H., Tesfaigzi Y., Deacetylation of p53 induces autophagy by suppressing Bmf expression. Journal of Cell Biology 2013 201 3 427 437 10.1083/jcb.201205064
98. Tasdemir E., Maiuri M. C., Morselli E., Criollo A., D'Amelio M., Djavaheri-Mergny M., Cecconi F., Tavernarakis N., Kroemer G., A dual role of p53 in the control of autophagy. Autophagy 2008 4 6 810 814 2-s2.0-50249145608
99. Levine B., Abrams J., p53: the Janus of autophagy? Nature Cell Biology 2008 10 6 637 639 2-s2.0-44649101436 10.1038/ncb0608-637
100. Chen Z. H., Kim H. P., Sciurba F. C., Lee S., Feghali-Bostwick C., Stolz D. B., Dhir R., Landreneau R. J., Schuchert M. J., Yousem S. A., Nakahira K., Pilewski J. M., Lee J. S., Zhang Y., Ryter S. W., Choi A. M. K., Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS ONE 2008 3 10 2-s2.0-53749087325 10.1371/journal.pone.0003316 e3316
101. Chen Z. H., Lam H. C., Jin Y., Kim H., Cao J., Lee S., Ifedigbo E., Parameswaran H., Ryter S. W., Choi A. M. K., Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proceedings of the National Academy of Sciences of the United States of America 2010 107 44 18880 18885 2-s2.0-78650434097 10.1073/pnas.1005574107
102. Cha H. H., Hwang J. R., Kim H. Y., Choi S. J., Oh S. Y., Roh C. R., Autophagy induced by tumor necrosis factor α mediates intrinsic apoptosis in trophoblastic cells. Reproductive Sciences 2013
103. Wang Y., Singh R., Massey A. C., Kane S. S., Kaushik S., Grant T., Xiang Y., Cuervo A. M., Czaja M. J., Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. Journal of Biological Chemistry 2008 283 8 4766 4777 2-s2.0-41949125675 10.1074/jbc.M706666200
104. Xu Y., Sung O. K., Li Y., Han J., Autophagy contributes to caspase-independent macrophage cell death. Journal of Biological Chemistry 2006 281 28 19179 19187 2-s2.0-33745845126 10.1074/jbc.M513377200
105. Yu L., Wan F., Dutta S., Welsh S., Liu Z., Freundt E., Baehrecke E. H., Lenardo M., Autophagic programmed cell death by selective catalase degradation. Proceedings of the National Academy of Sciences of the United States of America 2006 103 13 4952 4957 2-s2.0-33645521571 10.1073/pnas.0511288103
106. Madden D. T., Egger L., Bredesen D. E., A calpain-like protease inhibits autophagic cell death. Autophagy 2007 3 5 519 522 2-s2.0-34548034107
107. Yu L., Alva A., Su H., Dutt P., Freundt E., Welsh S., Baehrecke E. H., Lenardo M. J., Regulation of an ATG7-beclin 1 program of autophaglic cell death by caspase-8. Science 2004 304 5676 1500 1502 2-s2.0-2642553881 10.1126/science.1096645
108. Wu Y. T., Tan H. L., Huang Q., Kim Y. S., Pan N., Ong W., Liu Z., Ong C., Shen H., Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy 2008 4 4 457 466 2-s2.0-43949085388
109. Shimizu S., Kanaseki T., Mizushima N., Mizuta T., Arakawa-Kobayashi S., Thompson C. B., Tsujimoto Y., Role of Bcl-2 family proteins in a non-apoptopic programmed cell death dependent on autophagy genes. Nature Cell Biology 2004 6 12 1221 1228 2-s2.0-10344262564 10.1038/ncb1192
110. Mathew R., Karantza-Wadsworth V., White E., Role of autophagy in cancer. Nature Reviews Cancer 2007 7 12 961 967 2-s2.0-36448943299 10.1038/nrc2254
111. Degenhardt K., Mathew R., Beaudoin B., Bray K., Anderson D., Chen G., Mukherjee C., Shi Y., Gélinas C., Fan Y., Nelson D. A., Jin S., White E., Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006 10 1 51 64 2-s2.0-33745713171 10.1016/j.ccr.2006.06.001
112. Jin S., DiPaola R. S., Mathew R., White E., Metabolic catastrophe as a means to cancer cell death. Journal of Cell Science 2007 120 3 379 383 2-s2.0-33847400593 10.1242/jcs.03349
113. Lemasters J. J., Nieminen A., Qian T., Trost L. C., Elmore S. P., Nishimura Y., Crowe R. A., Cascio W. E., Bradham C. A., Brenner D. A., Herman B., The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochimica et Biophysica Acta 1998 1366 1-2 177 196 2-s2.0-0032504568 10.1016/S0005-2728(98)00112-1
114. Loos B., Engelbrecht A. M., Lockshin R. A., Klionsky D. J., Zakeri Z., The variability of autophagy and cell death susceptibility: unanswered questions. Autophagy 2013 9 9 1270 1285 10.4161/auto.25560
115. Eisenberg T., Knauer H., Schauer A., Büttner S., Ruckenstuhl C., Carmona-Gutierrez D., Ring J., Schroeder S., Magnes C., Antonacci L., Fussi H., Deszcz L., Hartl R., Schraml E., Criollo A., Megalou E., Weiskopf D., Laun P., Heeren G., Breitenbach M., Grubeck-Loebenstein B., Herker E., Fahrenkrog B., Fröhlich K., Sinner F., Tavernarakis N., Minois N., Kroemer G., Madeo F., Induction of autophagy by spermidine promotes longevity. Nature Cell Biology 2009 11 11 1305 1314 2-s2.0-70449529855 10.1038/ncb1975
116. Bonapace L., Bornhauser B. C., Schmitz M., Cario G., Ziegler U., Niggli F. K., Schäfer B. W., Schrappe M., Stanulla M., Bourquin J., Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. Journal of Clinical Investigation 2010 120 4 1310 1323 2-s2.0-77951171023 10.1172/JCI39987
117. Bell B. D., Leverrier S., Weist B. M., Newton R. H., Arechiga A. F., Luhrs K. A., Morrissette N. S., Walsh C. M., FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proceedings of the National Academy of Sciences of the United States of America 2008 105 43 16677 16682 2-s2.0-55949083821 10.1073/pnas.0808597105
118. Khan M. J., Rizwan Alam M., Waldeck-Weiermair M., Karsten F., Groschner L., Riederer M., Hallstrom S., Rockenfeller P., Konya V., Heinemann A., Madeo F., Graier W. F., Malli R., Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells. Journal of Biological Chemistry 2012 287 25 21110 21120 10.1074/jbc.M111.319129
119. Wang Y. Q., Wang L., Zhang M. Y., Wang T., Bao H. J., Liu W. L., Dai D. K., Zhang L., Chang P., Dong W. W., Chen X. P., Tao L. Y., Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochemical Research 2012 37 9 1849 1858 10.1007/s11064-012-0791-4
120. Lu J. V., Walsh C. M., Programmed necrosis and autophagy in immune function. Immunology Reviews 2012 249 1 205 217 10.1111/j.1600-065X.2012.01147.x
121. Nikoletopoulou V., Markaki M., Palikaras K., Tavernarakis N., Crosstalk between apoptosis, necrosis and autophagy. Biochimica Biophysica Acta 2013 1833 12 3448 3459 10.1016/j.bbamcr.2013.06.001
122. Saitoh T., Fujita N., Jang M. H., Uematsu S., Yang B., Satoh T., Omori H., Noda T., Yamamoto N., Komatsu M., Tanaka K., Kawai T., Tsujimura T., Takeuchi O., Yoshimori T., Akira S., Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1 β production. Nature 2008 456 7219 264 268 2-s2.0-56249090667 10.1038/nature07383
123. Nakahira K., Haspel J. A., Rathinam V. A. K., Lee S., Dolinay T., Lam H. C., Englert J. A., Rabinovitch M., Cernadas M., Kim H. P., Fitzgerald K. A., Ryter S. W., Choi A. M. K., Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nature Immunology 2011 12 3 222 230 2-s2.0-79951642032 10.1038/ni.1980
124. Zhou R., Yazdi A. S., Menu P., Tschopp J., A role for mitochondria in NLRP3 inflammasome activation. Nature 2011 469 7329 221 226 2-s2.0-78651393239 10.1038/nature09663
125. Schroder K., Tschopp J., The Inflammasomes. Cell 2010 140 6 821 832 2-s2.0-77950362382 10.1016/j.cell.2010.01.040
126. Dupont N., Jiang S., Pilli M., Ornatowski W., Bhattacharya D., Deretic V., Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1 β EMBO Journal 2011 30 23 4701 4711 2-s2.0-82455210868 10.1038/emboj.2011.398
127. Shi C. S., Shenderov K., Huang N. N., Kabat J., Abu-Asab M., Fitzgerald K. A., Sher A., Kehrl J. H., Activation of autophagy by inflammatory signals limits IL-1 β production by targeting ubiquitinated inflammasomes for destruction. Nature Immunology 2012 13 3 255 263 2-s2.0-84857195479 10.1038/ni.2215
128. Chuang S. Y., Yang C. H., Chou C. C., Chiang Y. P., Chuang T. H., Hsu L. C., TLR-induced PAI-2 expression suppresses IL-1 β processing via increasing autophagy and NLRP3 degradation. Proceedings of the National Academy of Sciences of the United States of America 2013 110 40 16079 16084 10.1073/pnas.1306556110
129. Byrne B. G., Dubuisson J. F., Joshi A. D., Persson J. J., Swanson M. S., Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection. MBio 2013 4 1 e00620
130. Bortoluci K. R., Medzhitov R., Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cellular and Molecular Life Sciences 2010 67 10 1643 1651 2-s2.0-77951911814 10.1007/s00018-010-0335-5