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Volumn 1853, Issue 1, 2015, Pages 166-182

Chemotactic and proangiogenic role of calcium sensing receptor is linked to secretion of multiple cytokines and growth factors in breast cancer MDA-MB-231 cells

Author keywords

Angiogenesis; Breast cancer; Calcium sensing receptor; Chemotactic; G protein coupled receptor; Secretion

Indexed keywords

ANGIOGENIC FACTOR; ANGIOGENIN; CALCITONIN; CALCIUM SENSING RECEPTOR; CHEMOTACTIC FACTOR; CYTOKINE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 4; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE DERIVED CHEMOKINE; MELANOMA GROWTH STIMULATORY ACTIVITY FACTOR; ONCOSTATIN M; PARATHYROID HORMONE; RANTES; SOMATOMEDIN BINDING PROTEIN 2; TECALCET; ANILINE DERIVATIVE; CALCIUM; CHEMOKINE; N-(2-CHLOROPHENYLPROPYL)-1-(3-METHOXYPHENYL)ETHYLAMINE; SIGNAL PEPTIDE;

EID: 84909619996     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2014.10.011     Document Type: Article
Times cited : (39)

References (98)
  • 1
    • 0033020243 scopus 로고    scopus 로고
    • Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function
    • Bai M., Trivedi S., Kifor O., Quinn S.J., Brown E.M. Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:2834-2839.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 2834-2839
    • Bai, M.1    Trivedi, S.2    Kifor, O.3    Quinn, S.J.4    Brown, E.M.5
  • 4
    • 0032483541 scopus 로고    scopus 로고
    • Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells
    • Bai M., Trivedi S., Brown E.M. Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells. J. Biol. Chem. 1998, 273:23605-23610.
    • (1998) J. Biol. Chem. , vol.273 , pp. 23605-23610
    • Bai, M.1    Trivedi, S.2    Brown, E.M.3
  • 5
    • 0033600911 scopus 로고    scopus 로고
    • Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca(2+) receptor critical for dimerization. Implications for function of monomeric Ca(2+) receptor
    • Ray K H.B., Steinbach P.J., Goldsmith P.K., Hauache O., Spiegel A.M. Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca(2+) receptor critical for dimerization. Implications for function of monomeric Ca(2+) receptor. J. Biol. Chem. 1999, 274:27642-27650.
    • (1999) J. Biol. Chem. , vol.274 , pp. 27642-27650
    • Ray, K.H.B.1    Steinbach, P.J.2    Goldsmith, P.K.3    Hauache, O.4    Spiegel, A.M.5
  • 7
    • 18244363907 scopus 로고    scopus 로고
    • The calcium-sensing receptor in normal physiology and pathophysiology: a review
    • B.E., Tfelt-Hansen J. The calcium-sensing receptor in normal physiology and pathophysiology: a review. Crit. Rev. Clin. Lab. Sci. 2005, 42:35-70.
    • (2005) Crit. Rev. Clin. Lab. Sci. , vol.42 , pp. 35-70
    • Tfelt-Hansen, J.B.E.1
  • 8
    • 84865585630 scopus 로고    scopus 로고
    • Minireview: the intimate link between calcium sensing receptor trafficking and signaling: implications for disorders of calcium homeostasis
    • Breitwieser G.E. Minireview: the intimate link between calcium sensing receptor trafficking and signaling: implications for disorders of calcium homeostasis. Mol. Endocrinol. 2012, 26:1482-1495.
    • (2012) Mol. Endocrinol. , vol.26 , pp. 1482-1495
    • Breitwieser, G.E.1
  • 10
    • 65249144951 scopus 로고    scopus 로고
    • The role of the calcium-sensing receptor in the development and progression of cancer
    • Saidak Z., Mentaverri R., Brown E.M. The role of the calcium-sensing receptor in the development and progression of cancer. Endocr. Rev. 2009, 30:178-195.
    • (2009) Endocr. Rev. , vol.30 , pp. 178-195
    • Saidak, Z.1    Mentaverri, R.2    Brown, E.M.3
  • 11
    • 84874881983 scopus 로고    scopus 로고
    • The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions
    • Diez-Fraile A., Lammens T., Benoit Y., D'Herde K.G. The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions. Curr. Mol. Med. 2013, 13:282-295.
    • (2013) Curr. Mol. Med. , vol.13 , pp. 282-295
    • Diez-Fraile, A.1    Lammens, T.2    Benoit, Y.3    D'Herde, K.G.4
  • 12
    • 84873338736 scopus 로고    scopus 로고
    • Calcium nutrition and extracellular calcium sensing: relevance for the pathogenesis of osteoporosis, cancer and cardiovascular diseases
    • Peterlik M., Kallay E., Cross H.S. Calcium nutrition and extracellular calcium sensing: relevance for the pathogenesis of osteoporosis, cancer and cardiovascular diseases. Nutrients 2013, 5:302-327.
    • (2013) Nutrients , vol.5 , pp. 302-327
    • Peterlik, M.1    Kallay, E.2    Cross, H.S.3
  • 13
    • 25444469389 scopus 로고    scopus 로고
    • L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells
    • Busque S.M., Kerstetter J.E., Geibel J.P., Insogna K. L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 289:G664-G669.
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.289 , pp. G664-G669
    • Busque, S.M.1    Kerstetter, J.E.2    Geibel, J.P.3    Insogna, K.4
  • 14
    • 85067704876 scopus 로고    scopus 로고
    • The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule, Kidney Int.
    • G. Capasso, P.J. Geibel, S. Damiano, P. Jaeger, W.G. Richards, J.P. Geibel, The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule, Kidney Int.
    • Capasso, G.1    Geibel, P.J.2    Damiano, S.3    Jaeger, P.4    Richards, W.G.5    Geibel, J.P.6
  • 17
    • 85067720388 scopus 로고    scopus 로고
    • Mammary-Specific Ablation of the Calcium Sensing Receptor during Lactation alters Maternal Calcium Metabolism, Milk Calcium Transport and Neonatal Calcium Accrual
    • R. Mamillapalli, J. Vanhouten, P. Dann, D. Bikle, W. Chang, E. Brown, J. Wysolmerski, Mammary-Specific Ablation of the Calcium Sensing Receptor during Lactation alters Maternal Calcium Metabolism, Milk Calcium Transport and Neonatal Calcium Accrual, Endocrinology.
    • Endocrinology
    • Mamillapalli, R.1    Vanhouten, J.2    Dann, P.3    Bikle, D.4    Chang, W.5    Brown, E.6    Wysolmerski, J.7
  • 18
    • 1642363456 scopus 로고    scopus 로고
    • The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport
    • VanHouten J., Dann P., McGeoch G., Brown E.M., Krapcho K., Neville M., Wysolmerski J.J. The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. J. Clin. Invest. 2004, 113:598-608.
    • (2004) J. Clin. Invest. , vol.113 , pp. 598-608
    • VanHouten, J.1    Dann, P.2    McGeoch, G.3    Brown, E.M.4    Krapcho, K.5    Neville, M.6    Wysolmerski, J.J.7
  • 21
    • 4344565323 scopus 로고    scopus 로고
    • Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation
    • Yano S., Macleod R.J., Chattopadhyay N., Tfelt-Hansen J., Kifor O., Butters R.R., Brown E.M. Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation. Bone 2004, 35:664-672.
    • (2004) Bone , vol.35 , pp. 664-672
    • Yano, S.1    Macleod, R.J.2    Chattopadhyay, N.3    Tfelt-Hansen, J.4    Kifor, O.5    Butters, R.R.6    Brown, E.M.7
  • 22
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: from dissemination to organ-specific colonization
    • Nguyen D.X., Bos P.D., Massague J. Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer 2009, 9:274-284.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 23
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: causes, consequences and therapeutic opportunities
    • Mundy G.R. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat. Rev. Cancer 2002, 2:584-593.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 24
    • 34547689484 scopus 로고    scopus 로고
    • Organotropism of breast cancer metastasis
    • Lu X., Kang Y. Organotropism of breast cancer metastasis. J. Mammary Gland Biol. Neoplasia 2007, 12:153-162.
    • (2007) J. Mammary Gland Biol. Neoplasia , vol.12 , pp. 153-162
    • Lu, X.1    Kang, Y.2
  • 25
    • 79951606631 scopus 로고    scopus 로고
    • The calcium-sensing receptor: a molecular perspective
    • Magno A.L., Ward B.K., Ratajczak T. The calcium-sensing receptor: a molecular perspective. Endocr. Rev. 2011, 32:3-30.
    • (2011) Endocr. Rev. , vol.32 , pp. 3-30
    • Magno, A.L.1    Ward, B.K.2    Ratajczak, T.3
  • 26
    • 84866382665 scopus 로고    scopus 로고
    • Extracellular calcium-sensing receptor inhibition of intestinal epithelialTNF signaling requires CaSR-mediated Wnt5a/Ror2 interaction
    • Kelly J.C., Lungchukiet P., Macleod R.J. Extracellular calcium-sensing receptor inhibition of intestinal epithelialTNF signaling requires CaSR-mediated Wnt5a/Ror2 interaction. Front. Physiol. 2011, 2:17.
    • (2011) Front. Physiol. , vol.2 , pp. 17
    • Kelly, J.C.1    Lungchukiet, P.2    Macleod, R.J.3
  • 27
    • 84855502399 scopus 로고    scopus 로고
    • Negative cross-talk between calcium-sensing receptor and beta-catenin signaling systems in colonic epithelium
    • Rey O., Chang W., Bikle D., Rozengurt N., Young S.H., Rozengurt E. Negative cross-talk between calcium-sensing receptor and beta-catenin signaling systems in colonic epithelium. J. Biol. Chem. 2006, 287:1158-1167.
    • (2006) J. Biol. Chem. , vol.287 , pp. 1158-1167
    • Rey, O.1    Chang, W.2    Bikle, D.3    Rozengurt, N.4    Young, S.H.5    Rozengurt, E.6
  • 28
    • 27844496106 scopus 로고    scopus 로고
    • Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane
    • Bouschet T., Martin S., Henley J.M. Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane. J. Cell Sci. 2005, 118:4709-4720.
    • (2005) J. Cell Sci. , vol.118 , pp. 4709-4720
    • Bouschet, T.1    Martin, S.2    Henley, J.M.3
  • 29
    • 0035860795 scopus 로고    scopus 로고
    • Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein
    • Awata H., Huang C., Handlogten M.E., Miller R.T. Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. J. Biol. Chem. 2001, 276:34871-34879.
    • (2001) J. Biol. Chem. , vol.276 , pp. 34871-34879
    • Awata, H.1    Huang, C.2    Handlogten, M.E.3    Miller, R.T.4
  • 30
    • 0035860748 scopus 로고    scopus 로고
    • Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase
    • Hjalm G., MacLeod R.J., Kifor O., Chattopadhyay N., Brown E.M. Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. J. Biol. Chem. 2001, 276:34880-34887.
    • (2001) J. Biol. Chem. , vol.276 , pp. 34880-34887
    • Hjalm, G.1    MacLeod, R.J.2    Kifor, O.3    Chattopadhyay, N.4    Brown, E.M.5
  • 31
    • 33744958957 scopus 로고    scopus 로고
    • Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin
    • Huang Y., Niwa J., Sobue G., Breitwieser G.E. Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin. J. Biol. Chem. 2006, 281:11610-11617.
    • (2006) J. Biol. Chem. , vol.281 , pp. 11610-11617
    • Huang, Y.1    Niwa, J.2    Sobue, G.3    Breitwieser, G.E.4
  • 33
    • 34250836803 scopus 로고    scopus 로고
    • Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism
    • Reyes-Ibarra A.P., Garcia-Regalado A., Ramirez-Rangel I., Esparza-Silva A.L., Valadez-Sanchez M., Vazquez-Prado J., Reyes-Cruz G. Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism. Mol. Endocrinol. 2007, 21:1394-1407.
    • (2007) Mol. Endocrinol. , vol.21 , pp. 1394-1407
    • Reyes-Ibarra, A.P.1    Garcia-Regalado, A.2    Ramirez-Rangel, I.3    Esparza-Silva, A.L.4    Valadez-Sanchez, M.5    Vazquez-Prado, J.6    Reyes-Cruz, G.7
  • 35
    • 33646820680 scopus 로고    scopus 로고
    • Expression of the calcium receptor in human breast cancer-a potential new marker predicting the risk of bone metastases
    • Mihai R., Stevens J., McKinney C., Ibrahim N.B. Expression of the calcium receptor in human breast cancer-a potential new marker predicting the risk of bone metastases. Eur. J. Surg. Oncol. 2006, 32:511-515.
    • (2006) Eur. J. Surg. Oncol. , vol.32 , pp. 511-515
    • Mihai, R.1    Stevens, J.2    McKinney, C.3    Ibrahim, N.B.4
  • 36
    • 54049137686 scopus 로고    scopus 로고
    • Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells
    • Mamillapalli R., VanHouten J., Zawalich W., Wysolmerski J. Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells. J. Biol. Chem. 2008, 283:24435-24447.
    • (2008) J. Biol. Chem. , vol.283 , pp. 24435-24447
    • Mamillapalli, R.1    VanHouten, J.2    Zawalich, W.3    Wysolmerski, J.4
  • 37
    • 76649136659 scopus 로고    scopus 로고
    • The calcium-sensing receptor couples to Galpha(s) and regulates PTHrP and ACTH secretion in pituitary cells
    • Mamillapalli R., Wysolmerski J. The calcium-sensing receptor couples to Galpha(s) and regulates PTHrP and ACTH secretion in pituitary cells. J. Endocrinol. 2010, 204:287-297.
    • (2010) J. Endocrinol. , vol.204 , pp. 287-297
    • Mamillapalli, R.1    Wysolmerski, J.2
  • 38
    • 67349148557 scopus 로고    scopus 로고
    • Extracellular calcium promotes the migration of breast cancer cells through the activation of the calcium sensing receptor
    • Saidak Z., Boudot C., Abdoune R., Petit L., Brazier M., Mentaverri R., Kamel S. Extracellular calcium promotes the migration of breast cancer cells through the activation of the calcium sensing receptor. Exp. Cell Res. 2009, 315:2072-2080.
    • (2009) Exp. Cell Res. , vol.315 , pp. 2072-2080
    • Saidak, Z.1    Boudot, C.2    Abdoune, R.3    Petit, L.4    Brazier, M.5    Mentaverri, R.6    Kamel, S.7
  • 39
    • 10344262597 scopus 로고    scopus 로고
    • The chemokine system - a major regulator of angiogenesis in health and disease
    • Rosenkilde M.M., Schwartz T.W. The chemokine system - a major regulator of angiogenesis in health and disease. APMIS 2004, 112:481-495.
    • (2004) APMIS , vol.112 , pp. 481-495
    • Rosenkilde, M.M.1    Schwartz, T.W.2
  • 40
    • 40349098612 scopus 로고    scopus 로고
    • Migratory neighbors and distant invaders: tumor-associated niche cells
    • Wels J., Kaplan R.N., Rafii S., Lyden D. Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev. 2008, 22:559-574.
    • (2008) Genes Dev. , vol.22 , pp. 559-574
    • Wels, J.1    Kaplan, R.N.2    Rafii, S.3    Lyden, D.4
  • 41
    • 0035943596 scopus 로고    scopus 로고
    • Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants
    • Reyes-Cruz G., Hu J., Goldsmith P.K., Steinbach P.J., Spiegel A.M. Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants. J. Biol. Chem. 2001, 276:32145-32151.
    • (2001) J. Biol. Chem. , vol.276 , pp. 32145-32151
    • Reyes-Cruz, G.1    Hu, J.2    Goldsmith, P.K.3    Steinbach, P.J.4    Spiegel, A.M.5
  • 42
    • 77149152165 scopus 로고    scopus 로고
    • Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis
    • Carretero-Ortega J., Walsh C.T., Hernandez-Garcia R., Reyes-Cruz G., Brown J.H., Vazquez-Prado J. Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. Mol. Pharmacol. 2010, 77:435-442.
    • (2010) Mol. Pharmacol. , vol.77 , pp. 435-442
    • Carretero-Ortega, J.1    Walsh, C.T.2    Hernandez-Garcia, R.3    Reyes-Cruz, G.4    Brown, J.H.5    Vazquez-Prado, J.6
  • 43
    • 77953203933 scopus 로고    scopus 로고
    • The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice
    • Sassmann A., Gier B., Grone H.J., Drews G., Offermanns S., Wettschureck N. The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice. J. Clin. Invest. 2010, 120:2184-2193.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2184-2193
    • Sassmann, A.1    Gier, B.2    Grone, H.J.3    Drews, G.4    Offermanns, S.5    Wettschureck, N.6
  • 44
    • 33947305423 scopus 로고    scopus 로고
    • The extracellular calcium-sensing receptor reciprocally regulates the secretion of BMP-2 and the BMP antagonist Noggin in colonic myofibroblasts
    • Peiris D., Pacheco I., Spencer C., MacLeod R.J. The extracellular calcium-sensing receptor reciprocally regulates the secretion of BMP-2 and the BMP antagonist Noggin in colonic myofibroblasts. Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 292:G753-G766.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.292 , pp. G753-G766
    • Peiris, D.1    Pacheco, I.2    Spencer, C.3    MacLeod, R.J.4
  • 45
    • 33749473455 scopus 로고    scopus 로고
    • Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis
    • Liao J., Schneider A., Datta N.S., McCauley L.K. Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis. Cancer Res. 2006, 66:9065-9073.
    • (2006) Cancer Res. , vol.66 , pp. 9065-9073
    • Liao, J.1    Schneider, A.2    Datta, N.S.3    McCauley, L.K.4
  • 46
    • 0034526037 scopus 로고    scopus 로고
    • Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines
    • Sanders J.L., Chattopadhyay N., Kifor O., Yamaguchi T., Butters R.R., Brown E.M. Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology 2000, 141:4357-4364.
    • (2000) Endocrinology , vol.141 , pp. 4357-4364
    • Sanders, J.L.1    Chattopadhyay, N.2    Kifor, O.3    Yamaguchi, T.4    Butters, R.R.5    Brown, E.M.6
  • 48
    • 0030720307 scopus 로고    scopus 로고
    • Monoclonal antibodies against synthetic peptides corresponding to the extracellular domain of the human Ca2+ receptor: characterization and use in studying concanavalin A inhibition
    • Goldsmith P.K., Miller JL F.G., Rogers K.V., Spiegel A.M. Monoclonal antibodies against synthetic peptides corresponding to the extracellular domain of the human Ca2+ receptor: characterization and use in studying concanavalin A inhibition. J. Bone Miner. Res. 1997, 12:1780-1788.
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 1780-1788
    • Goldsmith, P.K.1    Miller JL, F.G.2    Rogers, K.V.3    Spiegel, A.M.4
  • 49
    • 0033823249 scopus 로고    scopus 로고
    • Functional interactions between the extracellular domain and the seven-transmembrane domain in Ca2+ receptor activation
    • Hauache O.M., Hu J., Ray K., Spiegel A.M. Functional interactions between the extracellular domain and the seven-transmembrane domain in Ca2+ receptor activation. Endocrine 2000, 13:63-70.
    • (2000) Endocrine , vol.13 , pp. 63-70
    • Hauache, O.M.1    Hu, J.2    Ray, K.3    Spiegel, A.M.4
  • 50
    • 84857386424 scopus 로고    scopus 로고
    • Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor
    • Davey A.E., Leach K., Valant C., Conigrave A.D., Sexton P.M., Christopoulos A. Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor. Endocrinology 2012, 153:1232-1241.
    • (2012) Endocrinology , vol.153 , pp. 1232-1241
    • Davey, A.E.1    Leach, K.2    Valant, C.3    Conigrave, A.D.4    Sexton, P.M.5    Christopoulos, A.6
  • 52
    • 34249718528 scopus 로고    scopus 로고
    • Functional effects of monoclonal antibodies to the purified amino-terminal extracellular domain of the human Ca(2+) receptor
    • Hu J., Reyes-Cruz G., Goldsmith P.K., Gantt N.M., Miller J.L., Spiegel A.M. Functional effects of monoclonal antibodies to the purified amino-terminal extracellular domain of the human Ca(2+) receptor. J. Bone Miner. Res. 2007, 22:601-608.
    • (2007) J. Bone Miner. Res. , vol.22 , pp. 601-608
    • Hu, J.1    Reyes-Cruz, G.2    Goldsmith, P.K.3    Gantt, N.M.4    Miller, J.L.5    Spiegel, A.M.6
  • 54
    • 34248139121 scopus 로고    scopus 로고
    • Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis
    • Huang Y., Breitwieser G.E. Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. J. Biol. Chem. 2007, 282:9517-9525.
    • (2007) J. Biol. Chem. , vol.282 , pp. 9517-9525
    • Huang, Y.1    Breitwieser, G.E.2
  • 55
    • 2442548717 scopus 로고    scopus 로고
    • Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain
    • Petrel C., Kessler A., Dauban P., Dodd R.H., Rognan D., Ruat M. Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain. J. Biol. Chem. 2004, 279:18990-18997.
    • (2004) J. Biol. Chem. , vol.279 , pp. 18990-18997
    • Petrel, C.1    Kessler, A.2    Dauban, P.3    Dodd, R.H.4    Rognan, D.5    Ruat, M.6
  • 59
    • 0031450210 scopus 로고    scopus 로고
    • The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction
    • Ray K., Gao-Feng F., Goldsmith P.K., Spiegel A.M. The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction. J. Biol. Chem. 1997, 272:31355-31361.
    • (1997) J. Biol. Chem. , vol.272 , pp. 31355-31361
    • Ray, K.1    Gao-Feng, F.2    Goldsmith, P.K.3    Spiegel, A.M.4
  • 61
    • 0032545265 scopus 로고    scopus 로고
    • Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction
    • Ray K., Clapp P., Goldsmith P.K., Spiegel A.M. Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction. J. Biol. Chem. 1998, 273:34558-34567.
    • (1998) J. Biol. Chem. , vol.273 , pp. 34558-34567
    • Ray, K.1    Clapp, P.2    Goldsmith, P.K.3    Spiegel, A.M.4
  • 62
    • 85027946178 scopus 로고    scopus 로고
    • Calcium-sensing receptor (CaSR): pharmacological properties and signaling pathways
    • Conigrave A.D., Ward D.T. Calcium-sensing receptor (CaSR): pharmacological properties and signaling pathways. Best Pract. Res. Clin. Endocrinol. Metab. 2013, 27:315-331.
    • (2013) Best Pract. Res. Clin. Endocrinol. Metab. , vol.27 , pp. 315-331
    • Conigrave, A.D.1    Ward, D.T.2
  • 63
    • 85027927133 scopus 로고    scopus 로고
    • The calcium sensing receptor life cycle: trafficking, cell surface expression, and degradation
    • G.E. Breitwieser, The calcium sensing receptor life cycle: trafficking, cell surface expression, and degradation, Best Pract Res Clin Endocrinol Metab 27 303-313.
    • Best Pract Res Clin Endocrinol Metab , vol.27 , pp. 303-313
    • Breitwieser, G.E.1
  • 64
    • 34547103285 scopus 로고    scopus 로고
    • Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells
    • MacLeod R.J., Hayes M., Pacheco I. Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 293:G403-G411.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.293 , pp. G403-G411
    • MacLeod, R.J.1    Hayes, M.2    Pacheco, I.3
  • 65
    • 57349177816 scopus 로고    scopus 로고
    • Macleod, CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia
    • Pacheco R.J. Macleod, CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295:G748-G759.
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.295 , pp. G748-G759
    • Pacheco, R.J.1
  • 66
    • 40449138006 scopus 로고    scopus 로고
    • Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation
    • Schlange T., Matsuda Y., Lienhard S., Huber A., Hynes N.E. Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res. 2007, 9:R63.
    • (2007) Breast Cancer Res. , vol.9 , pp. R63
    • Schlange, T.1    Matsuda, Y.2    Lienhard, S.3    Huber, A.4    Hynes, N.E.5
  • 67
    • 33847389710 scopus 로고    scopus 로고
    • Wnt signaling pathway in mammary gland development and carcinogenesis
    • Turashvili G., Bouchal J., Burkadze G., Kolar Z. Wnt signaling pathway in mammary gland development and carcinogenesis. Pathobiology 2006, 73:213-223.
    • (2006) Pathobiology , vol.73 , pp. 213-223
    • Turashvili, G.1    Bouchal, J.2    Burkadze, G.3    Kolar, Z.4
  • 68
    • 42549096546 scopus 로고    scopus 로고
    • Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
    • Bovolenta P., Esteve P., Ruiz J.M., Cisneros E., Lopez-Rios J. Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J. Cell Sci. 2008, 121:737-746.
    • (2008) J. Cell Sci. , vol.121 , pp. 737-746
    • Bovolenta, P.1    Esteve, P.2    Ruiz, J.M.3    Cisneros, E.4    Lopez-Rios, J.5
  • 70
    • 84873136745 scopus 로고    scopus 로고
    • Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells
    • Stander B.A., Joubert F., Tu C., Sippel K.H., McKenna R., Joubert A.M. Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells. PLoS ONE 2013, 8:e53853.
    • (2013) PLoS ONE , vol.8 , pp. e53853
    • Stander, B.A.1    Joubert, F.2    Tu, C.3    Sippel, K.H.4    McKenna, R.5    Joubert, A.M.6
  • 72
    • 85067715834 scopus 로고    scopus 로고
    • The cancer secretome, current status and opportunities in the lung, breast and colorectal cancer context
    • T.B. Schaaij-Visser, M. de Wit, S.W. Lam, C.R. Jimenez, The cancer secretome, current status and opportunities in the lung, breast and colorectal cancer context, Biochim Biophys Acta.
    • Biochim Biophys Acta
    • Schaaij-Visser, T.B.1    de Wit, M.2    Lam, S.W.3    Jimenez, C.R.4
  • 74
    • 84880346637 scopus 로고    scopus 로고
    • Breast cancer as a systemic disease: a view of metastasis
    • Redig A.J., McAllister S.S. Breast cancer as a systemic disease: a view of metastasis. J. Intern. Med. 2013, 274:113-126.
    • (2013) J. Intern. Med. , vol.274 , pp. 113-126
    • Redig, A.J.1    McAllister, S.S.2
  • 76
    • 84861197166 scopus 로고    scopus 로고
    • New insights into the mechanisms of organ-specific breast cancer metastasis
    • Lorusso G., Ruegg C. New insights into the mechanisms of organ-specific breast cancer metastasis. Semin. Cancer Biol. 2012, 22:226-233.
    • (2012) Semin. Cancer Biol. , vol.22 , pp. 226-233
    • Lorusso, G.1    Ruegg, C.2
  • 77
    • 79952070774 scopus 로고    scopus 로고
    • The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts
    • Peinado H., Lavotshkin S., Lyden D. The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. Semin. Cancer Biol. 2011, 21:139-146.
    • (2011) Semin. Cancer Biol. , vol.21 , pp. 139-146
    • Peinado, H.1    Lavotshkin, S.2    Lyden, D.3
  • 78
    • 84858749792 scopus 로고    scopus 로고
    • Angiogenic activity of classical hematopoietic cytokines
    • Ribatti D. Angiogenic activity of classical hematopoietic cytokines. Leuk. Res. 2012, 36:537-543.
    • (2012) Leuk. Res. , vol.36 , pp. 537-543
    • Ribatti, D.1
  • 79
    • 84880908747 scopus 로고    scopus 로고
    • Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment
    • Menetrier-Caux C., Faget J., Biota C., Gobert M., Blay J.Y., Caux C. Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment. Oncoimmunology 2012, 1:759-761.
    • (2012) Oncoimmunology , vol.1 , pp. 759-761
    • Menetrier-Caux, C.1    Faget, J.2    Biota, C.3    Gobert, M.4    Blay, J.Y.5    Caux, C.6
  • 80
    • 84863433008 scopus 로고    scopus 로고
    • Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis
    • Mapp P.I., Walsh D.A. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat. Rev. Rheumatol. 2012, 8:390-398.
    • (2012) Nat. Rev. Rheumatol. , vol.8 , pp. 390-398
    • Mapp, P.I.1    Walsh, D.A.2
  • 84
    • 59649105074 scopus 로고    scopus 로고
    • Pleiotropic function of FGF-4: its role in development and stem cells
    • Kosaka N., Sakamoto H., Terada M., Ochiya T. Pleiotropic function of FGF-4: its role in development and stem cells. Dev. Dyn. 2009, 238:265-276.
    • (2009) Dev. Dyn. , vol.238 , pp. 265-276
    • Kosaka, N.1    Sakamoto, H.2    Terada, M.3    Ochiya, T.4
  • 85
    • 84867563621 scopus 로고    scopus 로고
    • Importance of chemokine (CC-motif) ligand 2 in breast cancer
    • Steiner J.L., Murphy E.A. Importance of chemokine (CC-motif) ligand 2 in breast cancer. Int. J. Biol. Markers 2012, 27:e179-e185.
    • (2012) Int. J. Biol. Markers , vol.27 , pp. e179-e185
    • Steiner, J.L.1    Murphy, E.A.2
  • 87
    • 84877296919 scopus 로고    scopus 로고
    • The VEGF pathway in cancer and disease: responses, resistance, and the path forward
    • M.W. Kieran, R. Kalluri, Y.J. Cho, The VEGF pathway in cancer and disease: responses, resistance, and the path forward, Cold Spring Harb Perspect Med 2 a006593.
    • Cold Spring Harb Perspect Med , vol.2 , pp. a006593
    • Kieran, M.W.1    Kalluri, R.2    Choc, Y.J.3
  • 90
    • 36849090838 scopus 로고    scopus 로고
    • VEGF in biological control
    • Breen E.C. VEGF in biological control. J. Cell. Biochem. 2007, 102:1358-1367.
    • (2007) J. Cell. Biochem. , vol.102 , pp. 1358-1367
    • Breen, E.C.1
  • 93
    • 48749110858 scopus 로고    scopus 로고
    • Cytokines and atherosclerosis: a comprehensive review of studies in mice
    • Kleemann R., Zadelaar S., Kooistra T. Cytokines and atherosclerosis: a comprehensive review of studies in mice. Cardiovasc. Res. 2008, 79:360-376.
    • (2008) Cardiovasc. Res. , vol.79 , pp. 360-376
    • Kleemann, R.1    Zadelaar, S.2    Kooistra, T.3
  • 94
    • 78049441629 scopus 로고    scopus 로고
    • Targeting inflammatory pathways for tumor radiosensitization
    • Deorukhkar A., Krishnan S. Targeting inflammatory pathways for tumor radiosensitization. Biochem. Pharmacol. 2010, 80:1904-1914.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 1904-1914
    • Deorukhkar, A.1    Krishnan, S.2
  • 95
    • 84867742566 scopus 로고    scopus 로고
    • Expression of the calcium sensing receptor in human peripheral blood T lymphocyte and its contribution to cytokine secretion through MAPKs or NF-kappaB pathways
    • Li T., Sun M., Yin X., Wu C., Wu Q., Feng S., Li H., Luan Y., Wen J., Yan L., Zhao B., Xu C., Sun Y. Expression of the calcium sensing receptor in human peripheral blood T lymphocyte and its contribution to cytokine secretion through MAPKs or NF-kappaB pathways. Mol. Immunol. 2013, 53:414-420.
    • (2013) Mol. Immunol. , vol.53 , pp. 414-420
    • Li, T.1    Sun, M.2    Yin, X.3    Wu, C.4    Wu, Q.5    Feng, S.6    Li, H.7    Luan, Y.8    Wen, J.9    Yan, L.10    Zhao, B.11    Xu, C.12    Sun, Y.13
  • 96
    • 46649107165 scopus 로고    scopus 로고
    • The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3
    • Canaff L., Zhou X., Hendy G.N. The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3. J. Biol. Chem. 2008, 283:13586-13600.
    • (2008) J. Biol. Chem. , vol.283 , pp. 13586-13600
    • Canaff, L.1    Zhou, X.2    Hendy, G.N.3
  • 98
    • 84880277048 scopus 로고    scopus 로고
    • Role of the calcium-sensing receptor in extracellular calcium homeostasis
    • Brown E.M. Role of the calcium-sensing receptor in extracellular calcium homeostasis. Best Pract. Res. Clin. Endocrinol. Metab. 2013, 27:333-343.
    • (2013) Best Pract. Res. Clin. Endocrinol. Metab. , vol.27 , pp. 333-343
    • Brown, E.M.1


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