The calcium-sensing receptor couples to Gαs and regulates PTHrP and ACTH secretion in pituitary cells

Journal of Endocrinology

Volumn 204, Issue 3, 2010, Pages 287-297

  Mamillapalli, Ramanaiah ^a   Wysolmerski, John ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM SENSING RECEPTOR; CORTICOTROPIN; CYCLIC AMP; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CORTICOTROPIN RELEASE; EXTRACELLULAR CALCIUM; HORMONE RELEASE; HYPOPHYSIS CELL; MOUSE; NONHUMAN; PARATHYROID HORMONE RELEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CELL LINE; CYCLIC AMP; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; MICE; PARATHYROID HORMONE-RELATED PROTEIN; PITUITARY GLAND; RECEPTORS, CALCIUM-SENSING;

EID: 76649136659     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-09-0183     Document Type: Article

References (52)

1. Abbink W, Bevelander GS, Rotllant J, Canario AV & Flik G 2004 Calcium handling in Sparus auratus: effects of water and dietary calcium levels on mineral composition, cortisol and PTHrP levels. Journal of Experimental Biology 207 4077-4084.
2. Abbink W, Bevelander GS, Hang X, Lu W, Guerreiro PM, Spanings T, Canario AV & Flik G 2006 PTHrP regulation and calcium balance in sea bream (Sparus auratus L.) under calcium constraint. Journal of Experimental Biology 209 3550-3557.
3. Akino K, Ohtsuru A, Yano H, Ozeki S, Namba H, Nakashima M, Ito M, Matsumoto T & Yamashita S 1996 Antisense inhibition of parathyroid hormone-related peptide gene expression reduces malignant pituitary tumor progression and metastases in the rat. Cancer Research 56 77-86.
4. Akino K, Ohtsuru A, Kanda K, Yasuda A, Yamamoto T, Akino Y, Naito S, KurokawaM, Iwahori N & Yamashita S 2000 Parathyroid hormone-related peptide is a potent tumor angiogenic factor. Endocrinology 141 4313-4316.
5. Applied Biosystems 1997. ABI Prism 7700. In User Bulletin #2. Foster City, CA: Applied Biosystems.
6. Arthur JM, Collinsworth GP, Gettys TW, Quarles LD & Raymond JR 1997 Specific coupling of a cation-sensing receptor to G protein alpha-subunits in MDCK cells. American Journal of Physiology 273 F129-F135.
7. Asa SL, Henderson J, Goltzman D & Drucker DJ 1990 Parathyroid hormone-like peptide in normal and neoplastic human endocrine tissues. Journal of Clinical Endocrinology and Metabolism 71 1112-1118.
8. Brown EM 2007 The calcium-sensing receptor: physiology, pathophysiology and CaR-based therapeutics. Sub-Cellular Biochemistry 45 139-167.
9. Brown EM & MacLeod RJ 2001 Extracellular calcium sensing and extracellular calcium signaling. Physiological Reviews 81 239-297.
10. Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger MA, Lytton J & Hebert SC 1993 Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 366 575-580.
11. Chattopadhyay N 2006 Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy. American Journal of Physiology. Endocrinology and Metabolism 290 E761-E770.
12. Chattopadhyay N & Brown EM 2006 Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing. Molecular Genetics and Metabolism 89 189-202.
13. Cheng SX, Geibel JP & Hebert SC 2004 Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor. Gastroenterology 126 148-158.
14. Chilco PJ, Leopold V & Zajac JD 1998 Differential regulation of the parathyroid hormone-related protein gene P1 and P3 promoters by cAMP. Molecular and Cellular Endocrinology 138 173-184.
15. Corbetta S, Lania A, Filopanti M, Vicentini L, Ballare E & Spada A 2002 Mitogen-activated protein kinase cascade in human normal and tumoral parathyroid cells. Journal of Clinical Endocrinology and Metabolism 87 2201-2205.
16. Cruciani RA, Dvorkin B, Morris SA, Crain SM &Makman MH 1993 Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells. PNAS 90 3019-3023.
17. Danks JA, McHale JC,Martin TJ & Ingleton PM 1997 Parathyroid hormonerelated protein in tissues of the emerging frog (Rana temporaria): immunohistochemistry and in situ hybridisation. Journal of Anatomy 190 229-238.
18. Emanuel RL, Adler GK, Kifor O, Quinn SJ, Fuller F, Krapcho K & Brown EM 1996 Calcium-sensing receptor expression and regulation by extracellular calcium in the AtT-20 pituitary cell line. Molecular Endocrinology 10 555-565.
19. Ferry S, Chatel B, Dodd RH, Lair C, Gully D, Maffrand JP & Ruat M 1997 Effects of divalent cations and of a calcimimetic on adrenocorticotropic hormone release in pituitary tumor cells. Biochemical and Biophysical Research Communications 238 866-873.
20. Fraser RA, Kaneko T, Pang PK & Harvey S 1991 Hypo- and hypercalcemic peptides in fish pituitary glands. American Journal of Physiology 260 R622-R626.
21. Fuleihan GE, Brown EM, Gleason R, Scott J & Adler GK 1996 Calcium modulation of adrenocorticotropin levels in women - a clinical research center study. Journal of Clinical Endocrinology and Metabolism 81 932-936.
22. + oscillations. Journal of Cellular Biology 171 303-312.
23. Hofer AM & Brown EM 2003 Extracellular calcium sensing and signalling. Nature Reviews. Molecular Cell Biology 4 530-538.
24. Hofle G, Gasser RW, Buchfelder M, Fahlbusch R, Waldenberger P & Finkenstedt G 2001 Elevated inferior petrosal sinus levels of PTHrP in a patient with Cushing's disease. Clinical Endocrinology 54 555-557.
25. Holt EH, Lu C, Dreyer BE, Dannies PS & Broadus AE 1994 Regulation of parathyroid hormone-related peptide gene expression by estrogen in GH4C1 rat pituitary cells has the pattern of a primary response gene. Journal of Neurochemistry 62 1239-1246.
26. +-sensing receptor couples to Galpha12/13 to activate phospholipase D in Madin-Darby canine kidney cells. American Journal of Physiology. Cell Physiology 286 C22-C30.
27. van den Hurk MJ, Cruijsen PM, Schoeber JP, Scheenen WJ, Roubos EW & Jenks BG 2008 Intracellular signal transduction by the extracellular calcium-sensing receptor of Xenopus melanotrope cells. General and Comparative Endocrinology 157 156-164.
28. Ikeda K,Weir EC,Mangin M, Dannies PS, Kinder B, Deftos LJ, Brown EM & Broadus AE 1988 Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas. Molecular Endocrinology 2 1230-1236.
29. Insel PA & Ostrom RS 2003 Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cellular and Molecular Neurobiology 23 305-314.
30. Ito M, Enomoto H, Usa T, Villadolid MC, Ohtsuru A, Namba H, Sekine I & Yamashita S 1993 Expression of parathyroid hormone related peptide in human pituitary tumours. Journal of Clinical Pathology 46 682-683.
31. Kifor O, MacLeod RJ, Diaz R, Bai M, Yamaguchi T, Yao T, Kifor I & Brown EM 2001 Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells. American Journal of Physiology. Renal Physiology 280 F291-F302.
32. King MS & Baertschi AJ 1990 The role of intracellular messengers in adrenocorticotropin secretion in vitro. Experientia 46 26-40.
33. Lawler OA, Miggin SM & Kinsella BT 2001 Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling. Journal of Biological Chemistry 276 33596-33607.
34. Loretz CA 2008 Extracellular calcium-sensing receptors in fishes. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology 149 225-245.
35. Mamillapalli R, VanHouten J, Zawalich W & Wysolmerski J 2008 Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells. Journal of Biological Chemistry 283 24435-24447.
36. Mitsuma T, Rhue N, Kayama M, Mori Y, Adachi K, Yokoi Y, Ping J, Nogimori T & Hirooka Y 1999 Distribution of calcium sensing receptor in rats: an immunohistochemical study. Endocrine Regulations 33 55-59.
37. Quarles LD 2003 Extracellular calcium-sensing receptors in the parathyroid gland, kidney, and other tissues. Current Opinion in Nephrology and Hypertension 12 349-355.
38. +-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, filamin-A, and the actin cytoskeleton. Journal of Biological Chemistry 280 22875-22882.
39. Romoli R, Lania A, Mantovani G, Corbetta S, Persani L & Spada A 1999 Expression of calcium-sensing receptor and characterization of intracellular signaling in human pituitary adenomas. Journal of Clinical Endocrinology and Metabolism 84 2848-2853.
40. Ryan WL & Heidrick ML 1974 Role of cyclic nucleotides in cancer. Advances in Cyclic Nucleotide Research 4 81-116.
41. Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Butters RR & Brown EM 2000 Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology 141 4357-4364.
42. Sidhu A, Sullivan M, Kohout T, Balen P & Fishman PH 1991 D1 dopamine receptors can interact with both stimulatory and inhibitory guanine nucleotide binding proteins. Journal of Neurochemistry 57 1445-1451.
43. Strewler GJ 2000 The physiology of parathyroid hormone-related protein. New England Journal of Medicine 342 177-185.
44. Taylor SS, Kim C, Vigil D, Haste NM, Yang J, Wu J & Anand GS 2005 Dynamics of signaling by PKA. Biochimica et Biophysica Acta 1754 25-37.
45. Tfelt-Hansen J & Brown EM 2005 The calcium-sensing receptor in normal physiology and pathophysiology: a review. Critical Reviews in Clinical Laboratory Sciences 42 35-70.
46. Tucker AL, Jia LG, Holeton D, Taylor AJ & Linden J 2000 Dominance of G(s) in doubly G(s)/G(i)-coupled chimaeric A(1)/A(2A) adenosine receptors in HEK-293 cells. Biochemical Journal 352 203-210.
47. VanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M & Wysolmerski JJ 2004 The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. Journal of Clinical Investigation 113 598-608.
48. Ward DT 2004 Calcium receptor-mediated intracellular signalling. Cell Calcium 35 217-228.
49. Wysolmerski JJ 2008 Parathyroid hormone-related protein. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, pp 127-133. Ed CJ Rosen.Washington, DC: American Society for Bone and Mineral Research.
50. Yamamori E, Iwasaki Y, Aoki Y, Nomura A, Tachikawa K, Ariyoshi Y, Mutsuga N, Morishita M, Yoshida M & Asai M 2001 Polyamine regulation of the rat pro-opiomelanocortin gene expression in AtT-20 cells. Journal of Neuroendocrinology 13 774-778.
51. Zajac JD, Callaghan J, Eldridge C, Diefenbach-Jagger H, Suva LJ, Hudson P, Moseley JM, Michelangeli VP & Pasquini G 1989 Production of parathyroid hormone-related protein by a rat parathyroid cell line. Molecular and Cellular Endocrinology 67 107-112.
52. Zivadinovic D, Tomic M, Yuan D & Stojilkovic SS 2002 Cell-type specific messenger functions of extracellular calcium in the anterior pituitary. Endocrinology 143 445-455.