Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment

OncoImmunology

Volumn 1, Issue 5, 2012, Pages 759-761

  Menetrier Caux, Christine ^a,b,c,d   Faget, Julien ^a,b,c,d   Biota, Cathy ^a,b,c,d   Gobert, Michael ^a,b,c,d   Blay, Jean Yves ^a,b,c,d   Caux, Christophe ^a,b,c,d  

^a UNIVERSITÉ DE LYON   (France)

^b UNIVERSITÉ LYON 1   (France)

^c CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^d CENTRE LÉON BÉRARD   (France)

Author keywords

Breast cancer; Breast epithelial cells; CCL22; Macrophages; NK cells; Regulatory T cells; Tolerance

Indexed keywords

CHEMOKINE RECEPTOR CCR4; GAMMA INTERFERON; INTERLEUKIN 1BETA; MACROPHAGE DERIVED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN RECOGNITION; ARTICLE; BREAST EPITHELIUM; BREAST TUMOR; CANCER PROGNOSIS; CD4+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; INNATE IMMUNITY; LYMPHOCYTIC INFILTRATION; MACROPHAGE ACTIVATION; NATURAL KILLER CELL; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; TUMOR CELL; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT;

EID: 84880908747     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.19680     Document Type: Article

References (10)

1. Liu F, Lang R, Zhao J, Zhang X, Pringle GA, Fan Y, et al. CD8? cytotoxic T cell and FOXP3? regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes. Breast Cancer Res Treat 2011; 130:645-55; PMID:21717105; http://dx.doi.org/10.1007/s10549-011-1647-3
2. Faget J, Biota C, Bachelot T, Gobert M, Treilleux I, Goutagny N, et al. Early detection of tumor cells by innate immune cells leads to T(reg) recruitment through CCL22 production by tumor cells. Cancer Res 2011; 71:6143-52; PMID:21852386; http://dx.doi.org/10.1158/0008-5472.CAN-11-0573
3. Treilleux I, Blay JY, Bendriss-Vermare N, Ray-Coquard I, Bachelot T, Guastalla JP, et al. Dendritic cell infiltration and prognosis of early stage breast cancer. Clin Cancer Res 2004; 10:7466-74; PMID: 15569976; http://dx.doi.org/10.1158/1078-0432.CCR-04-0684
4. Gobert M, Treilleux I, Bendriss-Vermare N, Bachelot T, Goddard-Leon S, Arfi V, et al. Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res 2009; 69:2000-9; PMID:19244125; http://dx.doi.org/10.1158/0008-5472.CAN-08-2360
5. Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010; 22:231-7; PMID:20144856; http://dx.doi.org/10.1016/j.coi.2010.01.009
6. Izcue A, Coombes JL, Powrie F. Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 2009; 27:313-38; PMID:19302043; http://dx.doi.org/10.1146/annurev.immunol.021908.132657
7. Ralainirina N, Poli A, Michel T, Poos L, Andrès E, Hentges F, et al. Control of NK cell functions by CD4+CD25+ regulatory T cells. J Leukoc Biol 2007; 81:144-53; PMID:16959895; http://dx.doi.org/10.1189/jlb.0606409
8. Huang X, Stone DK, Yu F, Zeng Y, Gendelman HE. Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage. J Proteome Res 2010; 9:6759-73; PMID:20954747; http://dx.doi.org/10.1021/pr1009178
9. Beaty SR, Rose CE, Jr., Sung SS. Diverse and potent chemokine production by lung CD11bhigh dendritic cells in homeostasis and in allergic lung inflammation. J Immunol 2007; 178:1882-95; PMID:17237439
10. Pere H, Montier Y, Bayry J, Quintin-Colonna F, Merillon N, Dransart E, et al. A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens. Blood 2011; 118:4853-62; PMID:21908423; http://dx.doi.org/10.1182/blood-2011-01-329656