Novel activating mutations of the calcium-sensing receptor: The calcilytic NPS-2143 mitigates excessive signal transduction of mutant receptors

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 10, 2010, Pages

  Letz, Saskia ^a   Rus, Ramona ^a   Haag, Christine ^b   Dörr, Helmuth Günther ^a   Schnabel, Dirk ^c   Möhlig, Matthias ^c   Schulze, Egbert ^b   Frank Raue, Karin ^b   Raue, Friedhelm ^b   Mayr, Bernhard ^a   Schöfl, Christof ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Endocrine Practice   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 6 [3 [1,1 DIMETHYL 2 (2 NAPHTHYL)ETHYLAMINO] 2 HYDROXYPROPOXY]BENZONITRILE; CALCIUM; CALCIUM SENSING RECEPTOR; MUTANT PROTEIN; PARATHYROID HORMONE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; AUTOSOMAL DOMINANT DISORDER; AUTOSOMAL DOMINANT HYPOCALCEMIA; CALCIUM BLOOD LEVEL; CALCIUM CELL LEVEL; CALCIUM URINE LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSOL; EMBRYO CELL; EXTRACELLULAR CALCIUM; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HYPOCALCEMIA; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; MISSENSE MUTATION; MUTATIONAL ANALYSIS; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WILD TYPE;

EID: 77957785182     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0651     Document Type: Article

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