Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and adipose tissue

Molecular and Cellular Endocrinology

Volumn 361, Issue 1-2, 2012, Pages 24-30

  Cifuentes, Mariana ^a   Fuentes, Cecilia ^a   Tobar, Nicolas ^a   Acevedo, Ingrid ^a   Villalobos, Elisa ^a   Hugo, Eric ^b   Ben Jonathan, Nira ^b   Reyes, Marcela ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Calcium sensing receptor Obesity Cytokines Inflammation; Calcium sensing receptor; Cytokines; Inflammation; Obesity

Indexed keywords

CALCIUM SENSING RECEPTOR; CINACALCET; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PROINFLAMMATORY FACTOR; SN 50; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADIPOSE TISSUE CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADIPOCYTES; ADIPOSE TISSUE; ADULT; CELL DIFFERENTIATION; CELL LINE; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; NAPHTHALENES; NF-KAPPA B; RECEPTORS, CALCIUM-SENSING; RNA, MESSENGER; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84864345651     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.03.006     Document Type: Article

References (30)

1. Abdullah H.I., Pedraza P.L., Hao S., Rodland K.D., Mcgiff J.C., Ferreri N.R. NFAT regulates calcium-sensing receptor-mediated TNF production. Am. J. Physiol. Renal. Physiol. 2006, 290. F1110-7.
2. Brown E.M., Gamba G., Riccardi D., Lombardi M., Butters R., Kifor O., Sun A., Hediger M.A., Lytton J., Hebert S.C. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 1993, 366:575-580.
3. Calabro P., Golia E., Maddaloni V., Malvezzi M., Casillo B., Marotta C., Calabro R., Golino P. Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease?. Intern. Emerg. Med. 2009, 4:25-34.
4. Canaff L., Hendy G.N. Calcium-sensing receptor gene transcription is up-regulated by the proinflammatory cytokine, interleukin-1beta. Role of the NF-kappaB PATHWAY and kappaB elements. J. Biol. Chem. 2005, 280:14177-14188.
5. Canaff L., Zhou X., Hendy G.N. The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3. J. Biol. Chem. 2008, 283:13586-13600.
6. Ceglia L., Harris S.S., Rasmussen H.M., Dawson-Hughes B. Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants. Osteoporos Int. 2009, 20:71-78.
7. Chakravarti B., Dwivedi S.K., Mithal A., Chattopadhyay N. Calcium-sensing receptor in cancer: good cop or bad cop?. Endocrine 2009, 35:271-284.
8. Cifuentes M., Rojas C.V. Antilipolytic effect of calcium-sensing receptor in human adipocytes. Mol. Cell Biochem. 2008, 319:17-21.
9. Cifuentes M., Albala C., Rojas C. Calcium-sensing receptor expression in human adipocytes. Endocrinology 2005, 146:2176-2179.
10. Cifuentes M., Fuentes C., Mattar P., Tobar N., Hugo E., Ben-Jonathan N., Rojas C., Martinez J. Obesity-associated proinflammatory cytokines increase calcium sensing receptor (CaSR) protein expression in primary human adipocytes and LS14 human adipose cell line. Arch. Biochem. Biophys. 2010, 500:151-156.
11. Fain J.N., Madan A.K. Regulation of monocyte chemoattractant protein 1 (MCP-1) release by explants of human visceral adipose tissue. Int. J. Obes. (Lond.) 2005, 29:1299-1307.
12. Gray E., Muller D., Squires P.E., Asare-Anane H., Huang G.C., Amiel S., Persaud S.J., Jones P.M. Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of langerhans: involvement of protein kinases. J. Endocrinol. 2006, 190:703-710.
13. Guilherme A., Virbasius J.V., Puri V., Czech M.P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 2008, 9:367-377.
14. He Y., Zhang H., Teng J., Huang L., Li Y., Sun C. Involvement of calcium-sensing receptor in inhibition of lipolysis through intracellular cAMP and calcium pathways in human adipocytes. Biochem. Biophys. Res. Commun. 2011, 404:393-399.
15. Hugo E.R., Brandebourg T.D., Comstock C.E., Gersin K.S., Sussman J.J., Ben-Jonathan N. LS14: a novel human adipocyte cell line that produces prolactin. Endocrinology 2006, 147:306-313.
16. Kloting N., Fasshauer M., Dietrich A., Kovacs P., Schon M.R., Kern M., Stumvoll M., Bluher M. Insulin-sensitive obesity. Am. J. Physiol. Endocrinol. Metab. 2010, 299. E506-15.
17. Mack I., Belaiba R.S., Djordjevic T., Gorlach A., Hauner H., Bader B.L. Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFalpha exposure. Am. J. Physiol. Endocrinol. Metab. 2009, 297. E735-48.
18. Magno A.L., Ward B.K., Ratajczak T. The calcium-sensing receptor: a molecular perspective. Endocr. Rev. 2011, 32:3-30.
19. Mentaverri R., Yano S., Chattopadhyay N., Petit L., Kifor O., Kamel S., Terwilliger E.F., Brazier M., Brown E.M. The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. FASEB J. 2006, 20:2562-2564.
20. Nemeth E.F., Heaton W.H., Miller M., Fox J., Balandrin M.F., Van Wagenen B.C., Colloton M., Karbon W., Scherrer J., Shatzen E., Rishton G., Scully S., Qi M., Harris R., Lacey D., Martin D. Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J. Pharmacol. Exp. Ther. 2004, 308:627-635.
21. Nielsen P.K., Rasmussen A.K., Butters R., Feldt-Rasmussen U., Bendtzen K., Diaz R., Brown E.M., Olgaard K. Inhibition of PTH secretion by interleukin-1 beta in bovine parathyroid glands in vitro is associated with an up-regulation of the calcium-sensing receptor mRNA. Biochem. Biophys. Res. Commun. 1997, 238:880-885.
22. Olszak I.T., Poznansky M.C., Evans R.H., Olson D., Kos C., Pollak M.R., Brown E.M., Scadden D.T. Extracellular calcium elicits a chemokinetic response from monocytes in vitro and in vivo. J. Clin. Invest. 2000, 105:1299-1305.
23. Poulain-Godefroy O., Froguel P. Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochem. Biophys. Res. Commun. 2007, 356:662-667.
24. Riccardi D., Finney B.A., Wilkinson W.J., Kemp P.J. Novel regulatory aspects of the extracellular Ca2+-sensing receptor. CaR. Pflugers Arch. 2009, 458:1007-1022.
25. Tilg H., Moschen A.R. Inflammatory mechanisms in the regulation of insulin resistance. Mol. Med. 2008, 14:222-231.
26. Toribio R.E., Kohn C.W., Capen C.C., Rosol T.J. Parathyroid hormone (PTH) secretion, PTH mRNA and calcium-sensing receptor mRNA expression in equine parathyroid cells, and effects of interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha on equine parathyroid cell function. J. Mol. Endocrinol. 2003, 31:609-620.
27. Tu C.L., Oda Y., Komuves L., Bikle D.D. The role of the calcium-sensing receptor in epidermal differentiation. Cell Calc. 2004, 35:265-273.
28. Wang D., Pedraza P.L., Abdullah H.I., Mcgiff J.C., Ferreri N.R. Calcium-sensing receptor-mediated TNF production in medullary thick ascending limb cells. Am. J. Physiol. Renal. Physiol. 2002, 283. F963-70.
29. Wildman R.P., Muntner P., Reynolds K., Mcginn A.P., Rajpathak S., Wylie-Rosett J., Sowers M.R. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch. Intern. Med. 2008, 168:1617-1624.
30. Yamaguchi T., Olozak I., Chattopadhyay N., Butters R.R., Kifor O., Scadden D.T., Brown E.M. Expression of extracellular calcium (Ca2+o)-sensing receptor in human peripheral blood monocytes. Biochem. Biophys. Res. Commun. 1998, 246:501-506.