Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: Role of epidermal growth factor receptor transactivation

Bone

Volumn 35, Issue 3, 2004, Pages 664-672

  Yano, Shozo ^a,c   Macleod, R John ^a   Chattopadhyay, Naibedya ^a   Tfelt Hansen, Jacob ^a,b   Kifor, Olga ^a   Butters, Robert R ^a   Brown, Edward M ^a  

^a Division of Endocrinology Diabetes and Hypertension   (United States)

^b HVIDOVRE HOSPITAL   (Denmark)

^c Division of Endocrinology Diabetes and Hypertension   (United States)

Author keywords

Epidermal growth factor receptor (EGFR); G protein coupled receptor; Parathyroid hormone related protein (PTHrP); Prostate cancer; Transactivation

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CALCIUM SENSING RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ILOMASTAT; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; CANCER CELL; CONTROLLED STUDY; ENZYME ACTIVATION; HORMONE RELEASE; HUMAN; HUMAN CELL; INCUBATION TIME; MALE; PROSTATE CANCER; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; TRANSACTIVATION; WESTERN BLOTTING;

CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MALE; PARATHYROID HORMONE-RELATED PROTEIN; PROSTATIC NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CALCIUM-SENSING; TRANS-ACTIVATION (GENETICS);

EID: 4344565323     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2004.04.014     Document Type: Article

References (56)

1. Feldman D., Skowronski R.J., Peehl D. Vitamin D and prostate cancer. Diet and Cancer. 1995;53-63 Plenum, New York
2. Chiarodo A. National Cancer Institute roundtable on prostate cancer: future research directions. Cancer Res. 51:1991;2498-2505
3. Kramer S., Reynolds F.H. Jr., Castillo M., Valenzuela D.M., Thorikay M., Sorvillo J.M. Immunological identification and distribution of parathyroid hormone-like protein polypeptides in normal and malignant tissues. Endocrinology. 128:1991;1927-1937
4. Iwamura M., di Sant'Agnese P.A., Wu G., Benning C.M., Cockett A.T., Deftos L.J., et al. Immunohistochemical localization of parathyroid hormone-related protein in human prostate cancer. Cancer Res. 53:1993;1724-1726
5. Strewler G.J., Nissenson R.A. Parathyroid hormone-related protein. Primer on the metabolic bone diseases and disorders of mineral metabolism. Fifth ed.:2003;125-129 American Society for Bone and Mineral Research, Washington (DC)
6. Tovar Sepulveda V.A., Falzon M. Hormone-related protein enhances PC-3 prostate cancer cell growth via both autocrine/paracrine and intracrine pathways. Regul. Pept. 105:2002;109-120
7. Iwamura M., Gershagen S., Lapets O., Moynes R., Abrahamsson P.A., Cockett A.T., et al. Immunohistochemical localization of parathyroid hormone-related protein in prostatic intraepithelial neoplasia. Hum. Pathol. 26:1995;797-801
8. Asadi F., Farraj M., Sharifi R., Malakouti S., Antar S., Kukreja S. Enhanced expression of parathyroid hormone-related protein in prostate cancer as compared with benign prostatic hyperplasia. Hum. Pathol. 27:1996;1319-1323
9. Sanders J.L., Chattopadhyay N., Kifor O., Yamaguchi T., Brown E.M. Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy. Biochem. Biophys. Res. Commun. 269:2000;427-432
10. MacLeod R.J., Chattopadhyay N., Brown E.M. PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation. Am. J. Physiol. Endocrinol. Metab. 284:2003;E435-E442
11. Sanders J.L., Chattopadhyay N., Kifor O., Yamaguchi T., Butters R.R., Brown E.M. Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology. 141:2000;4357-4364
12. Sanders J.L., Chattopadhyay N., Kifor O., Yamaguchi T., Brown E.M. Ca(2+)-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells. Am. J. Physiol. Endocrinol. Metab. 281:2001;E1267-E1274
13. Chattopadhyay N., Evliyaoglu C., Heese O., Carroll R., Sanders J., Black P., et al. Regulation of secretion of PTHrP by Ca(2+)-sensing receptor in human astrocytes, astrocytomas, and meningiomas. Am. J. Physiol. Cell Physiol. 279:2000;C691-C699
14. Brown E.M., Gamba G., Riccardi D., Lombardi M., Butters R., Kifor O., et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature. 366(6455):1993;575-580
15. Chattopadhyay N., Mithal A., Brown E.M. The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocr. Rev. 17:1996;289-307
16. Brown E.M., MacLeod R.J. Extracellular calcium sensing and extracellular calcium signaling. Physiol. Rev. 81:2001;239-297
17. Kifor O., MacLeod R.J., Diaz R., Bai M., Yamaguchi T., Yao T., et al. Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells. Am. J. Physiol. Renal. Physiol. 280:2001;F291-F302
18. Yamaguchi T., Chattopadhyay N., Kifor O., Sanders J.L., Brown E.M. Activation of p42/44 and p38 mitogen-activated protein kinases by extracellular calcium-sensing receptor agonists induces mitogenic responses in the mouse osteoblastic MC3T3-E1 cell line. Biochem. Biophys. Res. Commun. 279:2000;363-368
19. Corbetta S., Lania A., Filopanti M., Vicentini L., Ballare E., Spada A. Mitogen-activated protein kinase cascade in human normal and tumoral parathyroid cells. J. Clin. Endocrinol. Metab. 87:2002;2201-2205
20. Ward D.T., McLarnon S.J., Riccardi D. Aminoglycosides increase intracellular calcium levels and ERK activity in proximal tubular OK cells expressing the extracellular calcium-sensing receptor. J. Am. Soc. Nephrol. 13:2002;1481-1489
21. Tfelt-Hansen J., MacLeod R.J., Chattopadhyay N., Yano S., Quinn S., Ren X., et al. Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells. Am. J. Physiol. Endocrinol. Metab. 285:2003;E329-E337
22. Prenzel N., Zwick E., Daub H., Leserer M., Abraham R., Wallasch C., et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature. 402(6764):1999;884-888
23. Wallasch C., Crabtree J.E., Bevec D., Robinson P.A., Wagner H., Ullrich A. Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF. Biochem. Biophys. Res. Commun. 295:2002;695-701
24. Wetzker R., Bohmer F.D. Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat. Rev., Mol. Cell Biol. 4:2003;651-657
25. Nemeth E.F. Calcium receptors as novel drug targets. Bilezikian J.P., Raisz L.G., Rodan G.A. Principles of Bone Biology. Second ed.:2002;1339-1359 Academic press, San Diego
26. Rodan S.B., Wesolowski G., Ianacone J., Thiede M.A., Rodan G.A. Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: stimulation by phorbol esters and epidermal growth factor. J. Endocrinol. 122:1989;219-227
27. Henderson J.E., Kremer R., Rhim J.S., Goltzman D. Identification and functional characterization of adenylate cyclase-linked receptors for parathyroid hormone-like peptides on immortalized human keratinocytes. Endocrinology. 130:1992;449-457
28. Liu B., Goltzman D., Rabbani S.A. Regulation of parathyroid hormone-related peptide production in vitro by the rat hypercalcemic Leydig cell tumor H-500. Endocrinology. 132:1993;1658-1664
29. Ferrari S.L., Rizzoli R., Bonjour J.P. Effects of epidermal growth factor on parathyroid hormone-related protein production by mammary epithelial cells. J. Bone Miner. Res. 9:1994;639-644
30. Sebag M., Henderson J., Goltzman D., Kremer R. Regulation of parathyroid hormone-related peptide production in normal human mammary epithelial cells in vitro. Am. J. Physiol. 267(3 Pt. 1):1994;C723-C730
31. Cramer S.D., Peehl D.M., Edgar M.G., Wong S.T., Deftos L.J., Feldman D. Parathyroid hormone-related protein (PTHrP) is an epidermal growth factor-regulated secretory product of human prostatic epithelial cells. Prostate. 29:1996;20-29
32. Southby J., Murphy L.M., Martin T.J., Gillespie M.T. Cell-specific and regulator-induced promoter usage and messenger ribonucleic acid splicing for parathyroid hormone-related protein. Endocrinology. 137:1996;1349-1357
33. Heath J.K., Southby J., Fukumoto S., O'Keeffe L.M., Martin T.J., Gillespie M.T. Epidermal growth factor-stimulated parathyroid hormone-related protein expression involves increased gene transcription and mRNA stability. Biochem. J. 307(Pt. 1):1995;159-167
34. Falzon M. Serum stimulation of parathyroid hormone-related peptide gene expression in ROS 17/2.8 osteosarcoma cells through transcriptional and posttranscriptional mechanisms. Endocrinology. 137:1996;3681-3688
35. Wu G., Iwamura M., di Sant'Agnese P.A., Deftos L.J., Cockett A.T., Gershagen S. Characterization of the cell-specific expression of parathyroid hormone-related protein in normal and neoplastic prostate tissue. Urology. 51(5A Suppl.):1998;110-120
36. Iwamura M., Abrahamsson P.A., Foss K.A., Wu G., Cockett A.T., Deftos L.J. Parathyroid hormone-related protein: a potential autocrine growth regulator in human prostate cancer cell lines. Urology. 43:1994;675-679
37. Bryden A.A., Hoyland J.A., Freemont A.J., Clarke N.W., George N.J. Parathyroid hormone related peptide and receptor expression in paired primary prostate cancer and bone metastases. Br. J. Cancer. 86:2002;322-325
38. Shen X., Falzon M. PTH-related protein modulates PC-3 prostate cancer cell adhesion and integrin subunit profile. Mol. Cell. Endocrinol. 199:2003;165-177
39. Wysolmerski J.J., Dann P.R., Zelazny E., Dunbar M.E., Insogna K.L., Guise T.A., et al. Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis. J. Bone Miner. Res. 17:2002;1164-1170
40. Guise T.A., Yin J.J., Taylor S.D., Kumagai Y., Dallas M., Boyce B.F., et al. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J. Clin. Invest. 98:1996;1544-1549
41. Gallwitz W.E., Guise T.A., Mundy G.R. Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo. J. Clin. Invest. 110:2002;1559-1572
42. Tovar Sepulveda V.A., Shen X., Falzon M. Intracrine PTHrP protects against serum starvation-induced apoptosis and regulates the cell cycle in MCF-7 breast cancer cells. Endocrinology. 143:2002;596-606
43. Asakura M., Kitakaze M., Takashima S., Liao Y., Ishikura F., Yoshinaka T., et al. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat. Med. 8:2002;35-40
44. Adomeit A., Graness A., Gross S., Seedorf K., Wetzker R., Liebmann C. Bradykinin B(2) receptor-mediated mitogen-activated protein kinase activation in COS-7 cells requires dual signaling via both protein kinase C pathway and epidermal growth factor receptor transactivation. Mol. Cell. Biol. 19:1999;5289-5297
45. Chen W.C., Chen C.C. Signal transduction of arginine vasopressin-induced arachidonic acid release in H9c2 cardiac myoblasts: role of Ca2+ and the protein kinase C-dependent activation of p42 mitogen-activated protein kinase. Endocrinology. 140:1999;1639-1648
46. Melien O., Thoresen G.H., Sandnes D., Ostby E., Christoffersen T. Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms. J. Cell. Physiol. 175:1998;348-358
47. Dabrowski A., VanderKuur J.A., Carter-Su C., Williams J.A. Cholecystokinin stimulates formation of shc-grb2 complex in rat pancreatic acinar cells through a protein kinase C-dependent mechanism. J. Biol. Chem. 271:1996;27125-27129
48. Tapia J.A., Ferris H.A., Jensen R.T., Garcia L.J. Cholecystokinin activates PYK2/CAKbeta by a phospholipase C-dependent mechanism and its association with the mitogen-activated protein kinase signaling pathway in pancreatic acinar cells. J. Biol. Chem. 274:1999;31261-31271
49. Daulhac L., Kowalski-Chauvel A., Pradayrol L., Vaysse N., Seva C. Src-family tyrosine kinases in activation of ERK-1 and p85/p110- phosphatidylinositol 3-kinase by G/CCKB receptors. J. Biol. Chem. 274:1999;20657-20663
50. Yamaguchi T., Yamauchi M., Sugimoto T., Chauhan D., Anderson K.C., Brown E.M., et al. The extracellular calcium Cao2+-sensing receptor is expressed in myeloma cells and modulates cell proliferation. Biochem. Biophys. Res. Commun. 299:2002;532-538
51. Hobson S.A., McNeil S.E., Lee F., Rodland K.D. Signal transduction mechanisms linking increased extracellular calcium to proliferation in ovarian surface epithelial cells. Exp. Cell Res. 258:2000;1-11
52. McNeil S.E., Hobson S.A., Nipper V., Rodland K.D. Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium. J. Biol. Chem. 273:1998;1114-1120
53. Yamaguchi T., Chattopadhyay N., Kifor O., Butters R.R. Jr., Sugimoto T., Brown E.M. Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2+o)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells. J. Bone Miner. Res. 13:1998;1530-1538
54. Chattopadhyay N., Ye C.P., Yamaguchi T., Kifor O., Vassilev P.M., Nishimura R., et al. Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel. Glia. 24:1998;449-458
55. Bilderback T.R., Lee F., Auersperg N., Rodland K.D. Phosphatidylinositol 3-kinase-dependent, MEK-independent proliferation in response to CaR activation. Am. J. Physiol. Cell Physiol. 283:2002;C282-C288
56. Tfelt-Hansen J., Chattopadhyay N., Yano S., Kanuparthi D., Rooney P., Schwarz P., et al. Calcium-sensing receptor induces proliferation through p38 MAPK and PI3 kinase but not ERK in a model of humoral hypercalcemia of malignancy (HHM). Endocrinology. 145:2004;1211-1217