Role of the calcium-sensing receptor in extracellular calcium homeostasis

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 27, Issue 3, 2013, Pages 333-343

  Brown, Edward M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

calcitonin; calcium; calcium sensing receptor; extracellular; osteoblast; osteoclast; PTH

Indexed keywords

CALCIUM; CALCIUM SENSING RECEPTOR; MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN; PARATHYROID HORMONE; PHOSPHATE;

APOPTOSIS; CALCIUM HOMEOSTASIS; CELL PROLIFERATION; CONFERENCE PAPER; EXTRACELLULAR CALCIUM; HUMAN; HYPERPARATHYROIDISM; HYPOCALCEMIA; INTESTINE ABSORPTION; MINERALIZATION; OSTEOBLAST; OSTEOCLAST; PHOSPHATE BLOOD LEVEL; PHOSPHATE METABOLISM; PHOSPHATE TRANSPORT; PROTEIN DEGRADATION;

EID: 84880277048     PISSN: 1521690X     EISSN: 15321908     Source Type: Journal    
DOI: 10.1016/j.beem.2013.02.006     Document Type: Conference Paper

References (82)

1. E.M. Brown, and R.J. MacLeod Extracellular calcium sensing and extracellular calcium signaling Physiological Reviews 81 2001 239 297
2. F.R. Bringhurst, M.B. Demay, and H.M. Kronenberg Hormones and disorders of mineral metabolism J.D. Wilson, Williams textbook of endocrinology 9th ed. 1998 W.B. Saunders Philadelphia 1155 1209
3. D. Pietrobon, F. Di Virgilio, and T. Pozzan Structural and functional aspects of calcium homeostasis in eukaryotic cells European Journal of Biochemistry 120 1990 599 622
4. A.M. Hofer, and E.M. Brown Extracellular calcium sensing and signalling Nature Reviews Molecular Cell Biology 4 2003 530 538
5. M.J. Berridge, M.D. Bootman, and H.L. Roderick Calcium signalling: dynamics, homeostasis and remodelling Nature Reviews Molecular Cell Biology 4 2003 517 529
6. Yanez M, Gil-Longo J, Campos-Toimil M. Calcium binding proteins. Advances in Experimental Medicine and Biology;740:461-82.
7. C.B. Klee, and A.R. Means Keeping up with calcium: conference on calcium-binding proteins and calcium function in health and disease EMBO Reports 3 2002 823 827
8. E.M. Brown Clinical lessons from the calcium-sensing receptor Nature Clinical Practice Endocrinology and Metabolism 3 2007 122 133
9. P. Houillier, L. Nicolet-Barousse, and G. Maruani What keeps serum calcium levels stable? Joint Bone Spine 70 2003 407 413
10. A.L. Magno, B.K. Ward, and T. Ratajczak The calcium-sensing receptor: a molecular perspective Endocrine Reviews 32 2011 3 30
11. 2+-sensing receptor from bovine parathyroid Nature 366 1993 575 580
12. T. Berndt, and R. Kumar Novel mechanisms in the regulation of phosphorus homeostasis Physiology (Bethesda) 24 2009 17 25
13. H. Juppner Novel regulators of phosphate homeostasis and bone metabolism Therapeutic Apheresis and Dialysis 11 Suppl. 1 2007 S3 S22
14. J. Hu, and A.M. Spiegel Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators Journal of Cellular and Molecular Medicine 11 2007 908 922
15. M. Freichel, A. Zink-Lorenz, and A. Holloschi Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin secretion Endocrinology 137 1996 3842 3848
16. 2+/polyvalent cation-sensing protein in rat kidney American Journal of Physiology 274 1998 F611 F622
17. 2+-sensing receptor in rat intestine American Journal of Physiology 274 1998 G122 G130
18. 2+-sensing receptors in intestinal epithelium American Journal of Physiology 273 1997 C1168 C1175
19. W. Chang, C. Tu, and T.-H. Chen Expression and signal transduction of calcium-sensing receptors in cartilage and bone Endocrinology 140 1999 5883 5893
20. H.F. DeLuca Overview of general physiologic features and functions of vitamin D American Journal of Clinical Nutrition 80 2004 1689S 1696S
21. J.P. Woodrow, C.J. Sharpe, and N.J. Fudge Calcitonin plays a critical role in regulating skeletal mineral metabolism during lactation Endocrinology 147 2006 4010 4021
22. P.F. Hirsch, and H. Baruch Is calcitonin an important physiological substance? Endocrine 21 2003 201 208
23. P.A. Friedman Calcium transport in the kidney Current Opinion in Nephrology and Hypertension 8 1999 589 595
24. 2+-sensing receptor in divalent mineral ion homeostasis Journal of Experimental Biology 200 1997 295 302
25. M.J. Favus Intestinal absorption of calcium, magnesium and phosphorus F.L. Coe, M.J. Favus, Disorders of bone and mineral metabolism 1992 Raven Press New York 57 81
26. E.M. Brown Four parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue Journal of Clinical Endocrinology and Metabolism 56 1983 572 581
27. J.P. Bilezikian, R.E. Canfield, and T.P. Jacobs Response of 1alpha,25-dihydroxyvitamin D3 to hypocalcemia in human subjects The New England Journal of Medicine 299 1978 437 441
28. J. Huan, G. Martuseviciene, and K. Olgaard Calcium-sensing receptor and recovery from hypocalcaemia in thyroparathyroidectomized rats European Journal of Clinical Investigation 37 2007 214 221
29. E. Lewin, W. Wang, and K. Olgaard Rapid recovery of plasma ionized calcium after acute induction of hypocalcaemia in parathyroidectomized and nephrectomized rats Nephrology Dialysis Transplantation 14 1999 604 609
30. 2+ and other ions as extracellular (first) messengers Physiological Reviews 71 1991 371 411
31. J.J. Morrissey, J.W. Hamilton, and R.R. MacGregor The secretion of parathormone fragments 34-84 and 37-84 by dispersed porcine parathyroid cells Endocrinology 107 1980 164 171
32. T. Naveh-Many, R. Rahamimov, and N. Livni Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D Journal of Clinical Investigation 96 1995 1786 1793
33. J. Ba, and P.A. Friedman Calcium-sensing receptor regulation of renal mineral ion transport Cell Calcium 35 2004 229 237
34. L. Kantham, S.J. Quinn, and O.I. Egbuna The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion American Journal of Physiology - Endocrinology and Metabolism 297 2009 E915 E923
35. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 Nature Genetics 26 2000 345 348
36. T. Shimada, S. Mizutani, and T. Muto Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia Proceedings of the National Academy of Sciences of the United States of America 98 2001 6500 6505
37. A. Shaikh, T. Berndt, and R. Kumar Regulation of phosphate homeostasis by the phosphatonins and other novel mediators Pediatric Nephrology 23 2008 1203 1210
38. F. Perwad, N. Azam, and M.Y. Zhang Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice Endocrinology 146 2005 5358 5364
39. H. Saito, A. Maeda, and S. Ohtomo Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo Journal of Biological Chemistry 280 2005 2543 2549
40. T. Shimada, H. Hasegawa, and Y. Yamazaki FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis Journal of Bone and Mineral Research 19 2004 429 435
41. I.Z. Ben-Dov, H. Galitzer, and V. Lavi-Moshayoff The parathyroid is a target organ for FGF23 in rats Journal of Clinical Investigation 117 2007 4003 4008
42. SJ Quinn, AR Thomsen, and JL Pang Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo American Journal of Physiology - Endocrinology and Metabolism 304 2013 E310 320
43. Rodriguez-Ortiz ME, Lopez I, Munoz-Castaneda JR, et al. Calcium deficiency reduces circulating levels of FGF23. Journal of the American Society of Nephrology;23:1190-7.
44. C.S. Kovacs, and H. Fuleihan Gel Calcium and bone disorders during pregnancy and lactation Endocrinology and Metabolism Clinics of North America 35 2006 21 51 [v]
45. C. Ho, D.A. Conner, and M.R. Pollak A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism [see comments] Nature Genetics 11 1995 389 394
46. O.M. Hauache Extracellular calcium-sensing receptor: structural and functional features and association with diseases Brazilian Journal of Medical and Biological Research 34 2001 577 584
47. E.F. Nemeth Calcimimetic and calcilytic drugs: just for parathyroid cells? Cell Calcium 35 2004 283 289
48. 2+-sensing receptor Molecular Endocrinology 21 2007 274 280
49. A. Bourdeau, M. Moutahir, and J. Souberbielle Effects of lipoxygenase products of arachidonate metabolism on parathyroid hormone secretion Endocrinology 135 1994 1109 1112
50. S. Corbetta, A. Lania, and M. Filopanti Mitogen-activated protein kinase cascade in human normal and tumoral parathyroid cells Journal of Clinical Endocrinology and Metabolism 87 2002 2201 2205
51. S.J. Quinn, O. Kifor, and I. Kifor Role of the cytoskeleton in extracellular calcium-regulated PTH release Biochemical and Biophysical Research 354 2007 8 13
52. R. Levi, I.Z. Ben-Dov, and V. Lavi-Moshayoff Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1 Journal of the American Society of Nephrology 17 2006 107 112
53. S.M. Mallya, and A. Arnold Cyclin D1 in parathyroid disease Frontiers in Bioscience 5 2000 D367 D371
54. M. Cozzolino, D. Brancaccio, and M. Gallieni Pathogenesis of parathyroid hyperplasia in renal failure Journal of Nephrology 18 2005 5 8
55. M.E. Rodriguez, Y. Almaden, and S. Canadillas The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glands American Journal of Physiology - Renal Physiology 292 2007 F1390 F1395
56. N.J. Fudge, and C.S. Kovacs Physiological studies in heterozygous calcium sensing receptor (CaSR) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo BMC Physiology 4 2004 5
57. O'Brien CA, Nakashima T, Takayanagi H. Osteocyte control of osteoclastogenesis. Bone.
58. N. Takahashi, T. Akatsu, and T. Sasaki Induction of calcitonin receptors by 1 alpha, 25-dihydroxyvitamin D3 in osteoclast-like multinucleated cells formed from mouse bone marrow cells Endocrinology 123 1988 1504 1510
59. J.C. Huang, T. Sakata, and L.L. Pfleger PTH differentially regulates expression of RANKL and OPG Journal of Bone and Mineral Research 19 2004 235 244
60. S. Kim, M. Yamazaki, and N.K. Shevde Transcriptional control of receptor activator of nuclear factor-kappaB ligand by the protein kinase A activator forskolin and the transmembrane glycoprotein 130-activating cytokine, oncostatin M, is exerted through multiple distal enhancers Molecular Endocrinology 21 2007 197 214
61. Z. Bar-Shavit The osteoclast: a multinucleated, hematopoietic-origin, bone-resorbing osteoimmune cell Journal of Cellular Biochemistry 102 2007 1130 1139
62. B.F. Boyce, and L. Xing Functions of RANKL/RANK/OPG in bone modeling and remodeling Archives of Biochemistry and Biophysics 473 2008 139 146
63. H. Yoshida, S. Hayashi, and T. Kunisada The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene Nature 345 1990 442 444
64. N. Kim, M. Takami, and J. Rho A novel member of the leukocyte receptor complex regulates osteoclast differentiation Journal of Experimental Medicine 195 2002 201 209
65. D.W. Talmage, and R.V. Talmage Calcium homeostasis: how bone solubility relates to all aspects of bone physiology Journal of Musculoskeletal and Neuronal Interactions 7 2007 108 112
66. J.M. Wozney Overview of bone morphogenetic proteins Spine 27 2002 S2 S8
67. S. Yano, R. Mentaverri, and D. Kanuparthi Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts Endocrinology 146 2005 2324 2335
68. Marie PJ. The calcium-sensing receptor in bone cells: a potential therapeutic target in osteoporosis. Bone;46:571-6.
69. T. Sugimoto, M. Kanatani, and J. Kano IGF-I mediates the stimulatory effect of high calcium concentration on osteoblastic cell proliferation American Journal of Physiology 266 1994 E709 E716
70. T. Sugimoto, M. Kanatani, and J. Kano Effects of high calcium concentration on the functions and interactions of osteoblastic cells and monocytes and on the formation of osteoclast-like cells Journal of Bone and Mineral Research 8 1993 1445 1452
71. M. Kanatani, T. Sugimoto, and M. Kanzawa High extracellular calcium inhibits osteoclast-like cell formation by directly acting on the calcium-sensing receptor existing in osteoclast precursor cells Biochemical and Biophysical Research 261 1999 144 148
72. M. Zaidi, O.A. Adebanjo, and B.S. Moonga Emerging insights into the role of calcium ions in osteoclast regulation Journal of Bone and Mineral Research 14 1999 669 674
73. R. Mentaverri, S. Yano, and N. Chattopadhyay The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis FASEB Journal 20 2006 2562 2564
74. I.A. Silver, R.J. Murrils, and D.J. Etherington Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts Experimental Cell Research 175 1988 266 276
75. T. Yamaguchi, N. Chattopadhyay, and O. Kifor Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2+o)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells Journal of Bone and Mineral Research 13 1998 1530 1538
76. M.M. Dvorak, A. Siddiqua, and D.T. Ward Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones Proceedings of the National Academy of Sciences of the United States of America 101 2004 5140 5145
77. M. Pi, T.K. Hinson, and L. Quarles Failure to detect the extracellular calcium-sensing receptor (CasR) in human osteoblast cell lines Journal of Bone and Mineral Research 14 1999 1310 1319
78. M. Pi, L. Chen, and M.Z. Huang GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome PLoS One 3 2008 e3858
79. 2+ sensing Journal of Clinical Investigation 96 1995 1582 1590
80. W. Chang, C. Tu, and T.H. Chen The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development Science Signaling 1 2008 ra1
81. 2+-sensing receptor regulates bone development, mineralization, and turnover. Journal of Bone and Mineral Research;26:2935-47.
82. Caudrillier A, Hurtel-Lemaire AS, Wattel A, et al. Strontium ranelate decreases receptor activator of nuclear factor-KappaB ligand-induced osteoclastic differentiation in vitro: involvement of the calcium-sensing receptor. Molecular Pharmacology;78:569-76.