Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension

PLoS Genetics

Volumn 5, Issue 5, 2009, Pages

  Wei, Min ^a,b   Fabrizio, Paola ^a,b   Madia, Federica ^a,b   Hu, Jia ^a,b   Ge, Huanying ^b   Li, Lei M ^b   Longo, Valter D ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; GLYCEROL; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE 1; GLYCEROL 3 PHOSPHATE DEHYDROGENASE 2; PROTEIN KINASE SCH9; RAS PROTEIN; RAS PROTEIN 2; TARGET OF RAPAMYCIN KINASE; TARGET OF RAPAMYCIN KINASE 1; UNCLASSIFIED DRUG; CARBON; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; RAS2 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SCH9 PROTEIN, S CEREVISIAE; TOR1 PROTEIN, S CEREVISIAE;

ARTICLE; BIOSYNTHESIS; CALORIC RESTRICTION; CARBON SOURCE; CITRIC ACID CYCLE; CONTROLLED STUDY; GENE; GENE CONTROL; GENE EXPRESSION; GENE INTERACTION; GLYCOLYSIS; LIFE EXTENSION; LIPID STORAGE; LIPOGENESIS; NONHUMAN; RHR2 GENE; SACCHAROMYCES CEREVISIAE; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CELL RESPIRATION; CULTURE MEDIUM; FUNGAL GENE; GENE EXPRESSION PROFILING; GENETICS; LONGEVITY; METABOLISM; MUTATION; SIGNAL TRANSDUCTION;

MAMMALIA; MUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CALORIC RESTRICTION; CARBON; CELL RESPIRATION; CITRIC ACID CYCLE; CULTURE MEDIA; ETHANOL; GENE EXPRESSION PROFILING; GENES, FUNGAL; GLYCEROL; GLYCOLYSIS; LONGEVITY; MODELS, BIOLOGICAL; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RAS PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

EID: 67149130284     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000467     Document Type: Article

References (61)

1. Longo VD, Finch CE (2003) Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 299: 1342-1346.
2. Kenyon C (2001) A conserved regulatory system for aging. Cell 105: 165-168. (Pubitemid 32429505)
3. Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G (1999) A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 13: 1438-1452. (Pubitemid 29270248)
4. Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292: 288-290. (Pubitemid 32295387)
5. Fabrizio P, Liou LL, Moy VN, Diaspro A, Valentine JS, et al. (2003) SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics 163: 35-46. (Pubitemid 36222651)
6. Longo VD (2004) Ras: the other pro-aging pathway. Sci Aging Knowledge Environ 2004: pe36.
7. Holzenberger M (2004) The GH/IGF-I axis and longevity. Eur J Endocrinol 151 Suppl 1: S23-27.
8. Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, et al. (2003) Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426: 620. (Pubitemid 38009359)
9. Jia K, Chen D, Riddle DL (2004) The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131: 3897-3906. (Pubitemid 39232150)
10. Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, et al. (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14: 885-890. (Pubitemid 38800910)
11. Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, et al. (2007) Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6: 95-110. (Pubitemid 46140143)
12. Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10: 457-468. (Pubitemid 35284167)
13. Mortimer RK, Johnston JR (1959) Life span of individual yeast cells. Nature 183: 1751-1752.
14. Kennedy BK, Austriaco NR Jr., Guarente L (1994) Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J Cell Biol 127: 1985-1993.
15. Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, et al. (2005) Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 1: e69.
16. Kaeberlein M, Kennedy BK (2005) Large-scale identification in yeast of conserved ageing genes. Mech Ageing Dev 126: 17-21. (Pubitemid 40018473)
17. Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20: 174-184. (Pubitemid 43112936)
18. Bonawitz ND, Chatenay-Lapointe M, Pan Y, Shadel GS (2007) Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab 5: 265-277. (Pubitemid 46477854)
19. Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, et al. (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310: 1193-1196.
20. Gray JV, Petsko GA, Johnston GC, Ringe D, Singer RA, et al. (2004) "Sleeping beauty": quiescence in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 68: 187-206.
21. Lillie SH, Pringle JR (1980) Reserve carbohydrate metabolism in Saccharomyces cerevisiae: responses to nutrient limitation. J Bacteriol 143: 1384-1394. (Pubitemid 11255509)
22. Fabrizio P, Longo VD (2003) The chronological life span of Saccharomyces cerevisiae. Aging Cell 2: 73-81.
23. Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, et al. (2005) Sir2 blocks extreme life-span extension. Cell 123: 655-667. (Pubitemid 41608467)
24. Wei M, Fabrizio P, Hu J, Ge H, Cheng C, et al. (2008) Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet 4: e13. (Pubitemid 351230881)
25. Longo VD, Fabrizio P (2002) Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans? Cell Mol Life Sci 59: 903-908.
26. Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D, et al. (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 26: 663-674. (Pubitemid 46856238)
27. Zurita-Martinez SA, Cardenas ME (2005) Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth. Eukaryot Cell 4: 63-71. (Pubitemid 40234423)
28. Ozcan S, Johnston M (1999) Function and regulation of yeast hexose transporters. Microbiol Mol Biol Rev 63: 554-569. (Pubitemid 29422782)
29. Werner-Washburne M, Braun E, Johnston GC, Singer RA (1993) Stationary phase in the yeast Saccharomyces cerevisiae. Microbiol Rev 57: 383-401. (Pubitemid 23170098)
30. Parks LW, Smith SJ, Crowley JH (1995) Biochemical and physiological effects of sterol alterations in yeast-a review. Lipids 30: 227-230.
31. Norbeck J, Pahlman AK, Akhtar N, Blomberg A, Adler L (1996) Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway. J Biol Chem 271: 13875-13881. (Pubitemid 26185434)
32. Granath K, Modig T, Forsmark A, Adler L, Liden G (2005) The YIG1 (YPL201c) encoded protein is involved in regulating anaerobic glycerol metabolism in Saccharomyces cerevisiae. Yeast 22: 1257-1268. (Pubitemid 43125498)
33. Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL, et al. (2004) Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J Cell Biol 166: 1055-1067. (Pubitemid 39304768)
34. Pahlman AK, Granath K, Ansell R, Hohmann S, Adler L (2001) The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress. J Biol Chem 276: 3555-3563. (Pubitemid 37411657)
35. Meng F, Park Y, Zhou H (2001) Role of proline, glycerol, and heparin as protein folding aids during refolding of rabbit muscle creatine kinase. Int J Biochem Cell Biol 33: 701-709. (Pubitemid 32520966)
36. Deocaris CC, Shrestha BG, Kraft DC, Yamasaki K, Kaul SC, et al. (2006) Geroprotection by glycerol: insights to its mechanisms and clinical potentials. Ann N Y Acad Sci 1067: 488-492. (Pubitemid 43806363)
37. Wojda I, Alonso-Monge R, Bebelman JP, Mager WH, Siderius M (2003) Response to high osmotic conditions and elevated temperature in Saccharomyces cerevisiae is controlled by intracellular glycerol and involves coordinate activity of MAP kinase pathways. Microbiology 149: 1193-1204. (Pubitemid 36626168)
38. Parsell DA, Kowal AS, Singer MA, Lindquist S (1994) Protein disaggregation mediated by heat-shock protein Hsp104. Nature 372: 475-478. (Pubitemid 24987319)
39. Albertyn J, Hohmann S, Prior BA (1994) Characterization of the osmotic-stress response in Saccharomyces cerevisiae: osmotic stress and glucose repression regulate glycerol-3-phosphate dehydrogenase independently. Curr Genet 25: 12-18. (Pubitemid 24006197)
40. Kaeberlein M, Andalis AA, Fink GR, Guarente L (2002) High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol Cell Biol 22: 8056-8066. (Pubitemid 35217313)
41. Murakami CJ, Burtner CR, Kennedy BK, Kaeberlein M (2008) A method for high-throughput quantitative analysis of yeast chronological life span. J Gerontol A Biol Sci Med Sci 63: 113-121. (Pubitemid 351738439)
42. Madia F, Gattazzo C, Fabrizio P, Longo VD (2007) A simple model system for age-dependent DNA damage and cancer. Mech Ageing Dev 128: 45-49. (Pubitemid 46073059)
43. Jiang JC, Jaruga E, Repnevskaya MV, Jazwinski SM (2000) An intervention resembling caloric restriction prolongs life span and retards aging in yeast. Faseb J 14: 2135-2137. (Pubitemid 30843905)
44. Lin SJ, Defossez PA, Guarente L (2000) Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128. (Pubitemid 30736519)
45. Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA (2003) Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423: 181-185. (Pubitemid 36569542)
46. Kaeberlein M, Kirkland KT, Fields S, Kennedy BK (2004) Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2: E296. (Pubitemid 39245247)
47. Smith DL Jr., McClure JM, Matecic M, Smith JS (2007) Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. Aging Cell 6: 649-662. (Pubitemid 47400047)
48. Kennedy BK, Steffen KK, Kaeberlein M (2007) Ruminations on dietary restriction and aging. Cell Mol Life Sci 64: 1323-1328. (Pubitemid 46889228)
49. Partridge L, Gems D (2002) Mechanisms of ageing: public or private? Nat Rev Genet 3: 165-175.
50. Jorgensen P, Rupes I, Sharom JR, Schneper L, Broach JR, et al. (2004) A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev 18: 2491-2505. (Pubitemid 39362892)
51. Cheng C, Fabrizio P, Ge H, Longo VD, Li LM (2007) Inference of transcription modification in long-live yeast strains from their expression profiles. BMC Genomics 8: 219. (Pubitemid 47287980)
52. Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, et al. (2002) Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418: 344-348. (Pubitemid 34790687)
53. Kirchman PA, Kim S, Lai CY, Jazwinski SM (1999) Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics 152: 179-190. (Pubitemid 29222525)
54. Rigoulet M, Aguilaniu H, Averet N, Bunoust O, Camougrand N, et al. (2004) Organization and regulation of the cytosolic NADH metabolism in the yeast Saccharomyces cerevisiae. Mol Cell Biochem 256-257: 73-81. (Pubitemid 38181236)
55. Bakker BM, Overkamp KM, van Maris AJ, Kotter P, Luttik MA, et al. (2001) Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae. FEMS Microbiol Rev 25: 15-37. (Pubitemid 32057195)
56. Ansell R, Granath K, Hohmann S, Thevelein JM, Adler L (1997) The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation. Embo J 16: 2179-2187. (Pubitemid 27258621)
57. Easlon E, Tsang F, Skinner C, Wang C, Lin SJ (2008) The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev 22: 931-944.
58. Vemuri GN, Eiteman MA, McEwen JE, Olsson L, Nielsen J (2007) Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 104: 2402-2407. (Pubitemid 46391409)
59. Brachmann CB, Davies A, Cost GJ, Caputo E, Li J, et al. (1998) Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14: 115-132. (Pubitemid 28062863)
60. Li H, Hong F (2001) Cluster-Rasch models for microarray gene expression data. Genome Biol 2: RESEARCH0031.
61. Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100: 9440-9445. (Pubitemid 37033947)