The discovery of niacin, biotin, and pantothenic acid

Annals of Nutrition and Metabolism

Volumn 61, Issue 3, 2012, Pages 246-253

  Lanska, Douglas J ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Biotin; Niacin; Pantothenic acid

Indexed keywords

BIOTIN; EGG WHITE; LIVER EXTRACT; NICOTINIC ACID; PANTOTHENIC ACID; RIBOFLAVIN; TRYPTOPHAN;

AMINO ACID METABOLISM; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; FEEDING BEHAVIOR; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; MEDICAL RESEARCH; MILK; MORBIDITY; MORTALITY; NICOTINIC ACID DEFICIENCY; NOMENCLATURE; NONHUMAN; OBSERVATIONAL STUDY; PANTOTHENIC ACID DEFICIENCY; PELLAGRA; PRIORITY JOURNAL; REVIEW; SCIENTIST; VITAMIN DEFICIENCY; VITAMIN SUPPLEMENTATION;

ANIMALS; BIOTIN; BIOTINIDASE DEFICIENCY; DOGS; HISTORY, 20TH CENTURY; HUMANS; NIACIN; PANTOTHENIC ACID; PELLAGRA; VITAMINS;

ANIMALIA; CANIS FAMILIARIS;

EID: 84870337107     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000343115     Document Type: Review

References (42)

1. Lanska DJ: Historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins. Handb Clin Neurol 2010; 95:445-476.
2. Lanska DJ: Stages in the recognition of epidemic pellagra in the United States: 1865-1960. Neurolog y 1996; 47: 829-834.
3. Etheridge WE: The Butterfly Caste: A Social History of Pellagra in the South. Westport, Greenwood, 1972.
4. Marie A: Pellagra (An authorized abridged version of Lombroso C. Trattato profilattico e clinico della pellagra. Turin, 1892. Translated into English and edited by Lavinder CH and Babcock JW). Columbia, The State Co., 1910.
5. Goldberger J: The etiology of pellagra: the significance of certain epidemiological observations with respect thereto. Public Health Rep 1914; 29:1683-1686.
6. Kraut AM: Goldberger's War: The Life and Work of a Public Health Crusader. New York, Hill and Wang, 2003.
7. Parsons RP: Trail to Light: A Biography of Joseph Goldberger. Indianapolis, The Bobbs-Merrill Co., 1943.
8. Terris M: Goldberger on Pellagra. Baton Rouge, Louisiana State University Press, 1964.
9. Elvehjem CA, Madden RJ, Strong FM, Wool-ley DW: Relation of nicotinic aid and nico-tinic acid amide to canine black tongue. J Am Chem Soc 1937; 59: 1767-1768.
10. Elvehjem CA, Madden RJ, Strong FM, Wool-ley DW: The isolation and identification of the anti-black tongue factor. J Biol Chem 1938; 123:137-149.
11. Fouts PJ, Helmer OM, Lepkovsky S, Jukes TH: Treatment of human pellagra with nico-tinic acid. Proc Soc Ex p Biol Med 1937; 37: 405-407.
12. Spies TD: The response of pellagrins to nico-tinic acid. Lancet 1938;i:252.
13. Spies TD, Cooper C, Blackenhorn MA: The use of nicotinic acid in the treatment of pellagra. JAMA 1938; 110: 622-627.
14. Spies RD, Aring CD, Gelperin J, Bean WB: The mental symptoms of pellagra: their relief with nicotinic acid. Am J Med Sci 1938; 196: 461-475.
15. Vilter RW, Mueller JF, Bean WB: The therapeutic effect of tryptophan in human pellagra. J Lab Clin Med 1949; 34: 409-413.
16. Goldsmith GA: Experimental niacin deficiency. J Am Diet Assn 1956; 32:312-316.
17. Goldsmith GA: Niacin-tryptophan relationships in man and niacin requirement. Am J Clin Nutr 1958; 6:479-486.
18. Goldsmith GA, Miller ON, Unglaub WG: Efficiency of tryptophan as a niacin precursor in man. J Nutr 1961; 73: 172-176.
19. Goldsmith GA, Gibbens J, Unglaub WG, Miller ON: Studies of niacin requirement in man: III. Comparative effects of diets containing lime-treated and untreated corn in the production of experimental pellagra. Am J Clin Nutr 1956; 4:151-160.
20. Boas MA: The effect of desiccation upon the nutritive properties of egg-white. Biochem J 1927; 21: 712-724.
21. Snell E: Nutrition research with lactic acid bacteria: a retrospective review. Ann Rev Nutr 1989; 9: 1-19.
22. Kresge N, Simoni RD, Hill RL: The Discovery of avidin by Esmond E. Snel l. J Biol Chem 2004; 279:e5-e6.
23. György P, Rose C, Eakin RE, Snell EE, Williams RJ: Egg-white injury as the result of nonabsorption or inactivation of biotin. Science 1940; 93: 477-478.
24. György P, Rose C: Cure of egg-white injury in rats by the 'toxic' fraction (avidin) of egg white given parenterally. Science 1941; 94: 261-262.
25. Sydenstricker VA, Singal SA, Briggs AP, De Vaughn NM, Isbel N: Observations on the 'egg white injury' in man and its cure with a biotin concentrate. JAMA 1942; 118:1199-1200.
26. Baugh CN, Malone JH, Butterworth CE: Human biotin deficiency: a case history of bio-tin deficiency inducted by raw egg consumption in a cirrhotic patient. Am J Clin Nutr 1968; 21:173-182.
27. du Vigneaud V, Melville DB, György P, Rose C: On the identity of vitamin H with biotin. Science 1940; 92: 62-63.
28. du Vigneaud V, Hofmann K, Melville DB: On the structure of biotin. J Am Chem Soc 1942; 64: 188-189.
29. Harris SA, Wolf DE, Mozingo R, Folkers K: Sy nthetic biot in. Science 1943; 97: 447-448.
30. Gompertz D, Draffan GH, Watts JL, Hull D: Biotin-responsive beta-methylcrotonylgly-cinuria. Lancet 1971; 2:22-24.
31. Gompertz D, Bartlett K, Blair D, Stern CM: Child with a defect in leucine metabolism associated with beta-hydroxyisovaleric acid-uria and beta-methylcrotonylglycinuria. Arch Dis Child 1973; 48: 975-977.
32. Burri BJ, Sweetman L, Nyhan WL: Mutant holocarboxylase synthetase: evidence for the enzyme defect in early infantile biotin-re-sponsive multiple carboxylase deficiency. J Clin Invest 1981; 68:1491-1495.
33. Wolf B, Grier E, Allen RJ, Goodman SI, Kien CL: Biotinidase deficiency: the enzymatic defect in late-onset multiple carboxylase de-f iciency. Clin Chim Acta 1983; 131: 273-281.
34. Williams RJ, Lyman CM, Goodyear GH, Truesdail JH, Holaday D: Pantothenic acid, a growth determinant of universal biological occurrence. J Am Chem Soc 1933; 55:2912-2927.
35. Stiller ET, Harris SA, Finkelstein J, Keresz-tesy JC, Folkers K: Pantothenic acid. VIII. The total synthesis of pure pantothenic acid. J Am Chem Soc 1940; 62: 1785-1790.
36. Lipmann F: Development of the acetylation problem: a personal account. Nobel Lecture, December 11, 1953. Nobel Lectures, Physiology or Medicine 1942-1962. Amsterdam, Elsev ier P ublishing Company, 1964, pp 413-437.
37. Wakil SJ, Pugh EL, Sauer F: The mechanism of fatty acid synthesis. Proc Natl Acad Sci USA 1964; 52:106-114.
38. Gopalan C: The burning-feet syndrome. Indian Med Gaz 1946; 81: 22-26.
39. Bibile SW, Lionel ND, Dunuwille R, Perera G: Pantothenol and the burning feet syndrome. Br J Nut r 1957; 11: 434-439.
40. Bean WB, Hodges RE, Daum K: Pantothenic acid deficiency induced in human subjects. J Clin Invest 1955; 34: 1073-1084.
41. Hodges RE, Ohlson MA, Bean WB: Panto-thenic acid deficiency in man. J Clin Invest 1958; 37: 1642-1657.
42. Hodges RE, Bean WB, Ohlson MA, Bleiler R: Human pantothenic acid deficiency produced by omega-methyl pantothenic acid. J Clin Invest 1959; 38:1421-1425.