Is nuclear factor erythroid 2-Related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in Mice?

Drug Metabolism and Disposition

Volumn 42, Issue 10, 2014, Pages 1663-1674

  Rohrer, Philip R ^a   Rudraiah, Swetha ^a   Goedken, Michael J ^a   Manautou, José E ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; GLUTATHIONE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; OXIDOREDUCTASE; PARACETAMOL; TRANSCRIPTION FACTOR NRF2; MULTIDRUG RESISTANCE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ACETAMINOPHEN INDUCED HEPATOTOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVITY; FEMALE; GCLC GENE; GCLM GENE; GENE; GENETIC SUSCEPTIBILITY; GENOTYPE; HISTOPATHOLOGY; HO 1 GENE; KEAP1 GENE; LIVER; LIVER TOXICITY; MALE; MOUSE; MRP3 GENE; MRP4 GENE; NONHUMAN; NQO1 GENE; NRF2 GENE; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; SEX DIFFERENCE; TISSUE LEVEL; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BLOOD; DIET RESTRICTION; GENETICS; KNOCKOUT MOUSE; METABOLISM; SEXUAL DEVELOPMENT; TOXIC HEPATITIS;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; DRUG-INDUCED LIVER INJURY; FASTING; FEMALE; GLUTATHIONE; MALE; MICE; MICE, KNOCKOUT; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; SEX CHARACTERISTICS;

EID: 84907450477     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.059006     Document Type: Article

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