Gender differences in the membrane transport of endogenous and exogenous compounds

Pharmacological Reviews

Volumn 55, Issue 2, 2003, Pages 229-240

  Morris, Marilyn E ^a   Lee, Hwa Jeong ^a   Predko, Lisa M ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ADRENALIN; AJMALINE; AMANTADINE; AZULETIL; BROMSULFOPHTHALEIN; CALCIUM; CHOLINE; CYCLIC AMP; DEXAMETHASONE; DOPAMINE; ENDOGENOUS COMPOUND; FOLIC ACID; HYDROCORTISONE; INDOMETACIN; METHOTREXATE; N METHYLNICOTINAMIDE; NORADRENALIN; OUABAIN; POLYCYCLIC AROMATIC HYDROCARBON; PROSTAGLANDIN E2; RIFAMYCIN; SALICYLIC ACID; SEROTONIN; TAUROCHOLIC ACID; TYRAMINE; UNINDEXED DRUG; URATE; XENOBIOTIC AGENT; ZENARESTAT;

BRAIN; DRUG DISPOSITION; DRUG RESPONSE; FEMALE; HUMAN; INTESTINE; KIDNEY; LIVER; MALE; MEMBRANE TRANSPORT; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL TRANSPORT, ACTIVE; FEMALE; HUMANS; KIDNEY; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; PHARMACOKINETICS; SEX CHARACTERISTICS; SPECIES SPECIFICITY;

EID: 0038284015     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: 10.1124/pr.55.2.1     Document Type: Review

References (86)

1. Anton FM, Garcia Puig J, Ramos T, Gonzalez P, and Ordas J (1986) Sex differences in uric acid metabolism in adults: evidence for a lack of influence of estradiol-17 beta (E2) on the renal handling of urate. Metabolism 35:343-348.
2. Arceci RJ, Baas F, Raponi R, Horwitz SB, Housman D, and Croop JM (1990) Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus. Mol Reprod Dev 25:101-109.
3. Arjmandi BH, Hollis BW, and Kalu DN (1994) In vivo effect of 17 beta-estradiol on intestinal calcium absorption in rats. Bone Miner 26:181-189.
4. Arjmandi BH, Salih MA, Herbert DC, Sims SH, and Kalu DN (1993) Evidence for estrogen receptor-linked calcium transport in the intestine. Bone Miner 21:63-74.
5. Beierle I, Meibohm B, and Derendorf H (1999) Gender differences in pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol Ther 37:529-547.
6. Benincosa LJ, Sagawa K, Massey LK, and Morris ME (1995) Effects of acute caffeine ingestion and menopause on sulfate homeostasis in women. Life Sci 57:1497-1505.
7. Bertagni P, Hirom PC, Millburn P, Osiyemi FO, Smith RL, Turbert HB, and Williams RT (1972) Sex and species differences in the biliary excretion of tartrazine and lissamine fast yellow in the rat, guinea-pig and rabbit. The influence of sex hormones on tartrazine excretion in the rat. J Pharm Pharmacol 24:620-624.
8. Binnert C, Koistinen HA, Martin G, Andreelli F, Ebeling P, Koivisto VA, Laville M, Auwerx J, and Vidal H (2000) Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans. Am J Physiol Endocrinol Metab 279:E1072-E1079.
9. Bonate PL (1991) Gender-related differences in xenobiotic metabolism. J Clin Pharmacol 31:684-690.
10. Borisova NA, Proshlyakova EV, Sapronova AY, and Ugrumov MV (1996) Androgen-dependent sex differences in the hypothalamic serotoninergic system. Eur J Endocrinol 134:232-235.
11. Bowman HM and Hook JB (1972) Sex differences in organic ion transport by rat kidney. Proc Soc Exp Biol Med 141:258-262.
12. Brommage R, Baxter DC, and Gierke LW (1990) Vitamin D-independent intestinal calcium and phosphorus absorption during reproduction. Am J Physiol 259:G631-G638.
13. Brommage R, Binacua C, and Carrie AL (1993) Ovulation-associated increase in intestinal calcium absorption during the rat estrous cycle is blunted by ovariectomy. Biol Reprod 49:544-548.
14. Bronner F, Pansu D, and Stein WD (1986) An analysis of intestinal calcium transport across the rat intestine. Am J Physiol 250:G5610-G569.
15. Butcher RL, Collins WE, and Fugo NW (1974) Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17beta throughout the 4-day estrous cycle of the rat. Endocrinology 94:1704-1708.
16. Cardinali DP and Gomez E (1977) Changes in hypothalamic noradrenaline, dopamine and serotonin uptake after oestradiol administration to rats. J Endocrinol 73:181-182.
17. Carter AL and Stratman FW (1982) Sex steroid regulation of urinary excretion of carnitine in rats. J Steroid Biochem 17:211-216.
18. Cerrutti JA, Brandoni A, Quaglia NB, and Torres AM (2002) Sex difference in p-aminohippuric acid transport in rat kidney: role of membrane fluidity and expression of OAT1. Mol Cell Biochem 233:175-179.
19. Cerrutti JA, Quaglia NB, and Torres AM (2001) Characterization of the mechanisms involved in the gender differences in p-aminohippurate renal elimination in rats. Can J Physiol Pharmacol 79:805-813.
20. Dagenais C, Zong J, Ducharme J, and Pollack GM (2001) Effect of mdr1a P-glycoprotein gene disruption, gender and substrate concentration on brain uptake of selected compounds. Pharm Res 18:957-963.
21. Dresser MJ, Leabman MK, and Giacomini KM (2001) Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J Pharm Sci 90:397-421.
22. Engele J, Pilgrim C, and Reisert I (1989) Sexual differentiation of mesencephalic neurons in vitro: effects of sex and gonadal hormones. Int J Dev Neurosci 7:603-611.
23. Fink G, Sumner BE, Rosie R, Grace O, and Quinn JP (1996) Estrogen control of central neurotransmission: effect on mood, mental state and memory, Cell Mol Neurobiol 16:325-344.
24. Fletcher CV, Acosta EP, and Strykowski JM (1994) Gender differences in human pharmacokinetics and pharmacodynamics. J Adolesc Health 15:619-629.
25. Foley JE, Kashiwagi A, Chang H, Huecksteadt TP, Lillioja S, Verso MA, and Reaven G (1984) Sex difference in insulin-stimulated glucose transport in rat and human adipocytes. Am J Physiol 246:E211-E215.
26. Furuya KN, Gebhardt R, Schuetz EG, and Schuetz JD (1004) Isolation of rat pgp3 cDNA: evidence for gender and zonal regulation of expression in the liver. Biochim Biophys Acta 1219:636-644.
27. Galinsky RE and Levy G (1984) Absorption and metabolism of acetaminophen shortly before parturition. Drug Intell Clin Pharm 18:977-979.
28. Gallagher JC (1990) The pathogenesis of osteoporosis. Bone Miner 9:215-227.
29. Gallagher JC, Riggs BL, and DeLuca HF (1980) Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J Clin Endocrinol Metab 51:1359-1364.
30. Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, and DeLuca HF (1979) Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Investig 64:729-736.
31. Gaudry SE, Sitar DS, Smyth DD, McKenzie JK and Aoki FY (1993) Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine. Clin Pharmacol Ther 54:23-27.
32. Gentile S, Persico M, Baldini G, Lunazzi G, Tiribelli C, and Sottocasa GL (1985) The implication of bilitranslocase function in the impaired rifamycin SV metabolism in Gilbert's syndrome. Clin Sci (Lond) 68:675-680.
33. Gleiter CH and Gundert-Remy U (1996) Gender differences in pharmacokinetics. Eur J Drug Metab Pharmacokinet 21:123-128.
34. Hanhijarvi H, Ophaug RH, and Singer L (1982) The sex-related difference in per-fluorooctanoate excretion in the rat. Proc Soc Exp Biol Med 171:50-55.
35. Harris RZ, Benet LZ, and Schwartz JB (1995) Gender effects in pharmacokinetics and pharmacodynamics. Drugs 50:222-239.
36. Heaney RP, Recker RR, and Saville PD (1978) Menopausal changes in calcium balance performance. J Lab Clin Med 92:953-963.
37. Ifudu O, Uribarri J, Rajwani I, Vlacich V, Reydel K, Delosreyes G, and Friedman EA (2001) Gender modulates responsiveness to recombinant erythropoietin. Am J Kidney Dis 38:518-522.
38. Kaasinen V, Nagren K, Hietala J, Farde L, and Rinne JO (2001) Sex differences in extrastriatal dopamine d(2)-like receptors in the human brain. Am J Psychiatry 158:308-311.
39. Kashuba AD and Nafziger AN (1998) Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs. Clin Pharmacokinet 34:203-218.
40. Kleinman LI, Loewenstein MS, and Goldstein L (1966) Sex difference in the transport of p-aminohippurate by the rat kidney. Endocrinology 78:403-406.
41. Lee HJ, Balasubramanian SV, and Morris ME (1999a) Effect of pregnancy, postnatal growth and gender on renal sulfate transport. Proc Soc Exp Biol Med 221:336-344.
42. Lee HJ, Balasubramanian SV, Murer H, Biber J, and Morris ME (1999b) Modulation of sulfate renal transport by alterations in cell membrane fluidity. J Pharm Sci 88:976-980.
43. Levy G (1998) Predicting effective drug concentrations for individual patients. Determinants of pharmacodynamic variability. Clin Pharmacokinet 34:323-333.
44. Lieber CS, Gentry RT, and Baraona E (1994) First pass metabolism of ethanol. Alcohol Suppl 2:163-169.
45. Lu R, Kanai N, Bao Y, Wolkoff AW, and Schuster VL (1996) Regulation of renal oatp mRNA expression by testosterone. Am J Physiol 270:F332-F337.
46. Luxon BA, Holly DC, Milliano MT, and Weisiger RA (1998) Sex differences in multiple steps in hepatic transport of palmitate support a balanced uptake mechanism. Am J Physiol 274:G52-G61.
47. Morissette M, Biron D, and Di Paolo T (1990) Effect of estradiol and progesterone on rat striatal dopamine uptake sites. Brain Res Bull 25:419-422.
48. Morissette M and Di Paolo T (1993a) Effect of chronic estradiol and progesterone treatments of ovariectomized rats on brain dopamine uptake sites. J Neurochem 60:1876-1883.
49. Morissette M and Di Paolo T (1993b) Sex and estrous cycle variations of rat striatal dopamine uptake sites. Neuroendocrinology 58:16-22.
50. Nguyen TT, Mijares AH, Johnson CM, and Jensen MD (1996) Postprandial leg and splanchnic fatty acid metabolism in nonobese men and women. Am J Physiol 271:E965-E972.
51. Nuutila P, Knuuti MJ, Maki M, Laine H, Ruotsalainen U, Teras M, Haaparanta M, Solin O, and Yki-Jarvinen H (1995) Gender and insulin sensitivity in the heart and in skeletal muscles. Studies using positron emission tomography. Diabetes 44:31-36.
52. Orihuela D, Carnovale CE, Monti JA, and Carrillo MC (1996) Sex-related differences in the effect of aluminum on calcium transport in the small intestine of the rat. Toxicol Lett 85:165-171.
53. Orzes N, Bellentani S, Aldini R, Simoni P, Ferretti I, Lunazzi GC, Sottocasa GL, and Tiribelli C (1985) Sex differences in the hepatic uptake of sulphobromophthalein in the rat. Clin Sci (Lond) 69:587-593.
54. Palylyk EL and Jamali F (1994) Influence of sex on the stereoselective probenecid-ketoprofen interaction in the rat. J Pharm Sci 83:1184-1185.
55. Pamphlett R, Ewan KB, McQuilty R, and Waley P (1997) Gender differences in the uptake of inorganic mercury by motor neurons. Neurotoxicol Teratol 19:287-293.
56. Piquette-Miller M, Pak A, Kim H, Anari R, and Shahzamani A (1998) Decreased expression and activity of P-glycoprotein in rat liver during acute inflammation. Pharm Res 15:706-711.
57. Pond SM, Gordon RA, and Bass L (1996) Sex differences in initial clearance of palmitate by human hepatocytes. Eur J Clin Investig 26:76-81.
58. Salphati L and Benet LZ (1998) Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochem Pharmacol 55:387-395.
59. Sato M, Suzaka H, and Miyazaki H (2000) Sex-related differences in urinary excretion of egualen sodium in rats. Drug Metab Dispos 28:21-27.
60. Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP, et al. (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502.
61. Schuetz EG, Furuya KN, and Schuetz JD (1995) Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms. J Pharmacol Exp Ther 275:1011-1018.
62. Sekine T, Cha SH, and Endou H (2000) The multispecific organic anion transporter (OAT) family. Pfluegers Arch 440:337-350.
63. Shi J and Simpkins JW (1997) 17β-Estradiol modulation of glucose transporter 1 expression in blood-brain barrier. Am J Physiol 272:E1016-E1022.
64. Sibug R, Kuppers E, Beyer C, Maxson SC, Pilgrim C, and Reisert I (1996) Genotype-dependent sex differentiation of dopaminergic neurons in primary cultures of embryonic mouse brain. Brain Res Dev Brain Res 93:136-142.
65. Simon FR, Fortune J, Iwahashi M, Bowman S, Wolkoff A, and Sutherland E (1999) Characterization of the mechanisms involved in the gender differences in hepatic taurocholate uptake. Am J Physiol 278:G556-G565.
66. Simon FR, Fortune J, Iwahashi M, Gartung C, Wolkoff A, and Sutherland E (1996) Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters. Am J Physiol 271:G1043-G1052.
67. Smith AG and Francis JE (1983) Evidence for the active renal secretion of S-pentachlorophenyl-N-acetyl-L-cysteine by female rats. Biochem Pharmacol 32:3797-3801.
68. Sorrentino D, Licko V, and Weisiger RA (1988) Sex differences in sulfobromophthalein-glutathione transport by perfused rat liver. Biochem Pharmacol 37:3119-3126.
69. Sorrentino D, Zhou SL, Kokkotou E, and Berk PD (1992) Sex differences in hepatic fatty acid uptake reflect a greater affinity of the transport system in females. Am J Physiol 263:G380-G385.
70. Srivastava SK, Hu X, Xia H, Pal A, Guo J, Orchard JL, and Singh SV (1999) Gender related differences in ATP-dependent transport of dinitrophenyl-glutathione conjugate across murine canalicular liver plasma membrane. FEBS Lett 445:291-294.
71. Staley JK, Krishnan-Sarin S, Zoghbi S, Tamagnan G, Fujita M, Seibyl JP, Maciejewski PK, O'Malley S and Innis RB (2001) Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse 41:275-284.
72. Steiner H, Polliack A, Kimchi-Sarfaty C, Libster D, Fibach E, and Rund D (1998) Differences in rhodamine-123 efflux in B-type chronic lymphocytic leukemia suggest possible gender and stage variations in drug-resistance gene activity. Ann Hematol 76:189-194.
73. Tanaka Y, Deguchi Y, Ishii I, and Terai T (1991) Sex differences in excretion of zenarestat in rat. Xenobiotica 21:1119-1125.
74. Tanaka Y, Fujiwara T, and Esumi Y (1992) Sex difference in the excretion of zenarestat in mice, rats, dogs and humans. Xenobiotica 22:941-947.
75. Tanaka Y, Sawamoto T, Suzuki A, and Kimura T (1993) Pharmacokinetics of zenarestat, an aldose reductase inhibitor, in male and female diabetic rats. Drug Metab Dispos 21:677-681.
76. Terashita S, Sawamoto T, Deguchi S, Tokuma Y, and Hata T (1995) Sex-dependent and independent renal excretion of nilvadipine metabolites in rat: evidence for a sex-dependent active secretion in kidney. Xenobiotica 25:37-47.
77. Torres AM (1996) Gender-differential liver plasma membrane affinities in hepatic tetrabromosulfonephthalein (TBS) uptake. Biochem Pharmacol 51:1117-1122.
78. Uhland-Smith A and DeLuca HF (1993) 1,25-dihydroxycholecalciferol analogs cannot replace vitamin D in normocalcemic male rats. J Nutr 123:1777-1785.
79. Urakami Y, Nakamura N, Takahashi K, Okuda M, Saito H, Hashimoto Y, and Inui K (1999) Gender differences in expression of organic cation transporter OCT2 in rat kidney. FEBS Lett 461:339-342.
80. Urakami Y, Okuda M, Saito H, and Inui K (2000) Hormonal regulation of organic cation transporter OCT2 expression in rat kidney. FEBS Lett 473:173-176.
81. Vathy I, Sokol J, and Etgen AM (1997) Gender-related differences exist in cortical [3H]nisoxetine binding and are not affected by prenatal morphine exposure. Neuroscience 76:331-334.
82. Wang RH, Bejar C, and Weinstock M (2000) Gender differences in the effect of rivastigmine on brain cholinesterase activity and cognitive function in rats. Neuropharmacology 39:497-506.
83. Wittner M, Desfleurs E, Pajaud S, Moine G, Simeone S, de Rouffignac C, and Di Stefano A (1997) Calcium and magnesium transport in the cortical thick ascending limb of Henle's loop: influence of age and gender. Pfluegers Arch 434:451-456.
84. Wong LT, Escobar MR, Smyth DD, and Sitar DS (1993) Gender-associated differences in rat renal tubular amantadine transport and absence of stereoselective transport inhibition by quinine and quinidine in distal tubules. J Pharmacol Exp Ther 267:1440-1444.
85. Wong LT, Sitar DS, and Aoki FY (1995) Chronic tobacco smoking and gender as variables affecting amantadine disposition in healthy subjects. Br J Clin Pharmacol 39:81-84.
86. Zhang L, Brett CM, and Giacomini KM (1998) Role of organic cation transporters in drug absorption and elimination. Annu Rev Pharmacol Toxicol 38:431-460.